ES2180433B1 - Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales. - Google Patents

Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales.

Info

Publication number
ES2180433B1
ES2180433B1 ES200101223A ES200101223A ES2180433B1 ES 2180433 B1 ES2180433 B1 ES 2180433B1 ES 200101223 A ES200101223 A ES 200101223A ES 200101223 A ES200101223 A ES 200101223A ES 2180433 B1 ES2180433 B1 ES 2180433B1
Authority
ES
Spain
Prior art keywords
cells
stem cells
mother cells
neural
generation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200101223A
Other languages
English (en)
Other versions
ES2180433A1 (es
Inventor
Pedro Alarcon Martinez
Sonia Bonilla Jimenez
Augusto Gerardo Silva Gonzalez
Salvador Martinez Perez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Miguel Hernandez University
Original Assignee
Miguel Hernandez University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miguel Hernandez University filed Critical Miguel Hernandez University
Priority to ES200101223A priority Critical patent/ES2180433B1/es
Priority to IL15435602A priority patent/IL154356A0/xx
Priority to PCT/ES2002/000253 priority patent/WO2002096439A1/es
Publication of ES2180433A1 publication Critical patent/ES2180433A1/es
Application granted granted Critical
Publication of ES2180433B1 publication Critical patent/ES2180433B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Empleo de células madre hematopoyéticas en la generación de células madre neurales.
La producción de células madre neurales comprende cultivar células madre hematopoyéticas bajo condiciones que promueven el crecimiento y la diferenciación de dichas células madre hematopoyéticas en células madre neurales, las cuales pueden utilizarse para regenerar poblaciones de células perdidas en el sistema nervioso. La invención también se refiere al empleo de células madre hematopoyéticas en la elaboración de una composición farmacéutica para el tratamiento de enfermedades neurodegenerativas y/o de situaciones patológicas en las que existen células neuronales degeneradas, tanto en procesos localizados como multifocales.
ES200101223A 2001-05-28 2001-05-28 Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales. Expired - Fee Related ES2180433B1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES200101223A ES2180433B1 (es) 2001-05-28 2001-05-28 Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales.
IL15435602A IL154356A0 (en) 2001-05-28 2002-05-27 The use of haematopoietic stem cells in the generation of neural stem cells
PCT/ES2002/000253 WO2002096439A1 (es) 2001-05-28 2002-05-27 Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101223A ES2180433B1 (es) 2001-05-28 2001-05-28 Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales.

Publications (2)

Publication Number Publication Date
ES2180433A1 ES2180433A1 (es) 2003-02-01
ES2180433B1 true ES2180433B1 (es) 2004-05-16

Family

ID=8497869

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200101223A Expired - Fee Related ES2180433B1 (es) 2001-05-28 2001-05-28 Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales.

Country Status (3)

Country Link
ES (1) ES2180433B1 (es)
IL (1) IL154356A0 (es)
WO (1) WO2002096439A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030194454A1 (en) 1998-07-28 2003-10-16 Bessette Steven M. Pesticidal compositions containing rosemary oil and wintergreen oil
CN110621774A (zh) 2016-10-14 2019-12-27 儿童医疗中心有限公司 用于治疗中枢神经系统疾病和病症的组合物和方法
JP7225115B2 (ja) 2017-01-17 2023-02-20 ザ チルドレンズ メディカル センター コーポレーション リソソーム蓄積症およびリソソーム蓄積障害を処置するための組成物および方法
CA3050690A1 (en) 2017-01-17 2018-07-26 Dana-Farber Cancer Institute, Inc. Compositions and methods for diagnosing and treating peroxisomal diseases
CN107320495A (zh) * 2017-06-19 2017-11-07 北正赛欧（北京）生物科技有限公司 用于促进细胞损伤修复的组合物及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999056759A1 (en) * 1998-05-07 1999-11-11 University Of South Florida Bone marrow cells as a source of neurons for brain and spinal cord repair
WO2000069448A1 (en) * 1999-05-14 2000-11-23 Henry Ford Health System Bone marrow transplantation for treatment of stroke
WO2001021766A3 (en) * 1999-09-23 2001-06-28 Cell Science Therapeutics Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999056759A1 (en) * 1998-05-07 1999-11-11 University Of South Florida Bone marrow cells as a source of neurons for brain and spinal cord repair
WO2000069448A1 (en) * 1999-05-14 2000-11-23 Henry Ford Health System Bone marrow transplantation for treatment of stroke
WO2001021766A3 (en) * 1999-09-23 2001-06-28 Cell Science Therapeutics Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MEZEY EVA et al. Bone marrow: A possible alternative source of cells in the adult nervous system. (2000) European Journal of Pharmacology, Vol. 405, páginas 297-302. *
REYES MORAYMA et al. Turning marrow into brain: Generation of glial and neuronal cells from adult bone marrow. (1999) Blood, Vol. 94, 10, Suppl. 1 Part 1, página 377a. *
WOODBURY, DALE et al. Adult rat and human bone marrow stromal cells differentiate into neurons. (2000) Journal of Neuroscience Research, 61 (4), páginas 364-370. *

Also Published As

Publication number Publication date
ES2180433A1 (es) 2003-02-01
WO2002096439A1 (es) 2002-12-05
IL154356A0 (en) 2003-09-17

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