ES2180433A1 - Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales. - Google Patents

Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales.

Info

Publication number
ES2180433A1
ES2180433A1 ES200101223A ES200101223A ES2180433A1 ES 2180433 A1 ES2180433 A1 ES 2180433A1 ES 200101223 A ES200101223 A ES 200101223A ES 200101223 A ES200101223 A ES 200101223A ES 2180433 A1 ES2180433 A1 ES 2180433A1
Authority
ES
Spain
Prior art keywords
stem cells
generation
hematopoietic stem
neural stem
neural
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200101223A
Other languages
English (en)
Other versions
ES2180433B1 (es
Inventor
Martinez Pedro Alarcon
Jimenez Sonia Bonilla
Gonzalez Augusto Gerardo Silva
Perez Salvador Martinez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad Miguel Hernandez de Elche UMH
Original Assignee
Universidad Miguel Hernandez de Elche UMH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Miguel Hernandez de Elche UMH filed Critical Universidad Miguel Hernandez de Elche UMH
Priority to ES200101223A priority Critical patent/ES2180433B1/es
Priority to IL15435602A priority patent/IL154356A0/xx
Priority to PCT/ES2002/000253 priority patent/WO2002096439A1/es
Publication of ES2180433A1 publication Critical patent/ES2180433A1/es
Application granted granted Critical
Publication of ES2180433B1 publication Critical patent/ES2180433B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Empleo de células madre hematopoyéticas en la generación de células madre neurales. La producción de células madre neurales comprende cultivar células madre hematopoyéticas bajo condiciones que promueven el crecimiento y la diferenciación de dichas células madre hematopoyéticas en células madre neurales, las cuales pueden utilizarse para regenerar poblaciones de células perdidas en el sistema nervioso. La invención también se refiere al empleo de células madre hematopoyéticas en la elaboración de una composición farmacéutica para el tratamiento de enfermedades neurodegenerativas y/o de situaciones patológicas en las que existen células neuronales degeneradas, tanto en procesos localizados como multifocales.
ES200101223A 2001-05-28 2001-05-28 Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales. Expired - Fee Related ES2180433B1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES200101223A ES2180433B1 (es) 2001-05-28 2001-05-28 Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales.
IL15435602A IL154356A0 (en) 2001-05-28 2002-05-27 The use of haematopoietic stem cells in the generation of neural stem cells
PCT/ES2002/000253 WO2002096439A1 (es) 2001-05-28 2002-05-27 Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101223A ES2180433B1 (es) 2001-05-28 2001-05-28 Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales.

Publications (2)

Publication Number Publication Date
ES2180433A1 true ES2180433A1 (es) 2003-02-01
ES2180433B1 ES2180433B1 (es) 2004-05-16

Family

ID=8497869

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200101223A Expired - Fee Related ES2180433B1 (es) 2001-05-28 2001-05-28 Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales.

Country Status (3)

Country Link
ES (1) ES2180433B1 (es)
IL (1) IL154356A0 (es)
WO (1) WO2002096439A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030194454A1 (en) 1998-07-28 2003-10-16 Bessette Steven M. Pesticidal compositions containing rosemary oil and wintergreen oil
US11957713B2 (en) 2016-10-14 2024-04-16 Children's Medical Center Corporation Compositions and methods for treating diseases and disorders of the central nervous system
CA3050690A1 (en) 2017-01-17 2018-07-26 Dana-Farber Cancer Institute, Inc. Compositions and methods for diagnosing and treating peroxisomal diseases
AU2018210853B2 (en) 2017-01-17 2023-09-28 Children's Medical Center Corporation Compositions and methods for treating lysosomal storage diseases and disorders
CN107320495A (zh) * 2017-06-19 2017-11-07 北正赛欧（北京）生物科技有限公司 用于促进细胞损伤修复的组合物及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999056759A1 (en) * 1998-05-07 1999-11-11 University Of South Florida Bone marrow cells as a source of neurons for brain and spinal cord repair
WO2000069448A1 (en) * 1999-05-14 2000-11-23 Henry Ford Health System Bone marrow transplantation for treatment of stroke
WO2001021766A2 (en) * 1999-09-23 2001-03-29 Cell Science Therapeutics Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999056759A1 (en) * 1998-05-07 1999-11-11 University Of South Florida Bone marrow cells as a source of neurons for brain and spinal cord repair
WO2000069448A1 (en) * 1999-05-14 2000-11-23 Henry Ford Health System Bone marrow transplantation for treatment of stroke
WO2001021766A2 (en) * 1999-09-23 2001-03-29 Cell Science Therapeutics Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MEZEY EVA et al. Bone marrow: A possible alternative source of cells in the adult nervous system. (2000) European Journal of Pharmacology, Vol. 405, pßginas 297-302. *
REYES MORAYMA et al. Turning marrow into brain: Generation of glial and neuronal cells from adult bone marrow. (1999) Blood, Vol. 94, 10, Suppl. 1 Part 1, pßgina 377a. *
WOODBURY, DALE et al. Adult rat and human bone marrow stromal cells differentiate into neurons. (2000) Journal of Neuroscience Research, 61 (4), pßginas 364-370. *

Also Published As

Publication number Publication date
IL154356A0 (en) 2003-09-17
WO2002096439A1 (es) 2002-12-05
ES2180433B1 (es) 2004-05-16

Similar Documents

Publication Publication Date Title
Viswanath et al. Cellular models to study bipolar disorder: a systematic review
ATE370225T1 (de) Differenzierung von knochenmarkzellen in neuronale zellen und deren verwendungen
WO2011130675A3 (en) Dopaminergic neurons differentiated from pluripotent stem cells and uses of thereof
BRPI0408733A (pt) derivação de neurÈnios dopaminérgicos terminalmente diferenciados de células tronco embriÈnicas humanas
IL192762A0 (en) Method for identifying cell differentiation factors
CY1120115T1 (el) Προερχομενα απο μυελο των οστων μεσεγχυματικα αρχεγονα κυτταρα ως μια πηγη νευρικων προγονων
WO2003055992A3 (en) A method for the establishment of a pluripotent human blastocyst-derived stem cell line
IL186228A0 (en) Preparation of autologous haematopoietic stem cells, the methods of production, cryopreservation and use for therapy of traumatic diseases of the central nervous system
WO2005063976A3 (en) Methods for inducing differentiation of undifferentiated mammalian cells into osteoblasts
GB2452667A (en) Efficient generation of neural progenitors, neurons and dopaminergic neurons from human embryonic stem cells
WO2003004605A3 (en) Mesenchymal cells and osteoblasts from human embryonic stem cell
WO2001088104A3 (en) Neural progenitor cell populations
WO2008024996A3 (en) Production of neural protective and regenerative factors from stem cells and treatment of nervous system conditions therewith
WO2013124815A3 (en) Mesenchymal stem cells for in vitro modeling and cell-based therapy of human diseases and banks thereof
WO2003024472A3 (en) Prolactin induced increase in neutral stem cell numbers and therapeutical use thereof
NO20092741L (no) DR6-antagonister og anvendelse derav ved behandling av neurologiske forstyrrelser
BRPI0413406A (pt) geração in vitro de neurÈnios gabaérgicos de células tronco embriÈnicas e seu uso no tratamento de distúrbios neurológicos
MX387025B (es) Compuestos de anillo de siete miembros de pirimidina
WO2005017131A3 (en) Methods for the differentiation of human stem cells
WO2004053084A3 (en) Dopaminergic neurons differentiated from embryonic cells for treating neurodegenerative diseases
Osinalde et al. Impaired proteostasis in rare neurological diseases
DE60044655D1 (de) Angereicherte Zellpopulationen des zentralen Nervensystems
ES2180433A1 (es) Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales.
ATE420101T1 (de) Isolierung von nervenstammzellen unter verwendung von gangliosiden und anderen oberflächenmarkern
Davey et al. Peroxiredoxin 5 links mitochondrial redox signalling with calcium dynamics: impact on Parkinson's disease

Legal Events

Date Code Title Description
FA2A Application withdrawn

Effective date: 20010704

EC2A Search report published

Date of ref document: 20030201

Kind code of ref document: A1

FG2A Definitive protection

Ref document number: 2180433B1

Country of ref document: ES

FD2A Announcement of lapse in spain

Effective date: 20210903