ES2180636T3 - Emulsiones antimicrobianas de aceite en agua. - Google Patents

Emulsiones antimicrobianas de aceite en agua.

Info

Publication number
ES2180636T3
ES2180636T3 ES95920506T ES95920506T ES2180636T3 ES 2180636 T3 ES2180636 T3 ES 2180636T3 ES 95920506 T ES95920506 T ES 95920506T ES 95920506 T ES95920506 T ES 95920506T ES 2180636 T3 ES2180636 T3 ES 2180636T3
Authority
ES
Spain
Prior art keywords
emulsion
chloride
antimicrobial
glicerol
bromide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95920506T
Other languages
English (en)
Inventor
D Craig Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novavax Inc
Original Assignee
Novavax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/246,868 external-priority patent/US5547677A/en
Priority claimed from US08/322,827 external-priority patent/US5549901A/en
Application filed by Novavax Inc filed Critical Novavax Inc
Application granted granted Critical
Publication of ES2180636T3 publication Critical patent/ES2180636T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Colloid Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE MUESTRA UNA EMULSION OLEOSA ANTIMICROBIANA QUE INCLUYE UN AGENTE SELECCIONADO A PARTIR DEL GRUPO INTEGRADO POR MONOOLEATO DE GLICEROL, TRIOLEATO DE GLICEROL, MONOLAURATO DE GLICEROL, Y DILAURATO DE GLICEROL COMO EMULSIONANTE PRIMARIO Y UN COMPUESTO QUE CONTIENE HALOGENO CATIONICO QUE TIENE UNA CADENA C{SUB,12}C{SUB,16} COMO AGENTE PRODUCTOR DE UNA CARGA POSITIVA. LA EMULSION PUEDE INCLUIR ADEMAS UN ESTEROL, PREFERIBLEMENTE FITOSTEROL. LOS COMPUESTOS CATIONICOS QUE CONTIENEN HALOGENO PREFERIDOS PARA USAR EN LA INVENCION INCLUYEN CLORURO DE CETILPIRIDINA, BROMURO DE CETILPIRIDINA, BROMURO DE CETILTRIMETILAMONIO, BROMURO DE CETILDIMETIETILAMONIO, Y CLORURO DE BENZOLCONIO. LA EMULSION ANTIMICROBIANA PUEDE USARSE EN LA FORMA DE UN PREPARADO FARMACEUTICO PARA INHIBIR EL CRECIMIENTO DE UNA AMPLIA VARIEDAD DE PATOGENOS INFECCIOSOS, INCLUYENDO BACTERIAS, HONGOS, Y VIRUS.
ES95920506T 1994-05-20 1995-05-18 Emulsiones antimicrobianas de aceite en agua. Expired - Lifetime ES2180636T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/246,868 US5547677A (en) 1994-05-20 1994-05-20 Antimicrobial oil-in-water emulsions
US08/322,827 US5549901A (en) 1994-05-20 1994-10-13 Antimicrobial oil-in-water emulsions
US32973094A 1994-10-26 1994-10-26

Publications (1)

Publication Number Publication Date
ES2180636T3 true ES2180636T3 (es) 2003-02-16

Family

ID=27399981

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95920506T Expired - Lifetime ES2180636T3 (es) 1994-05-20 1995-05-18 Emulsiones antimicrobianas de aceite en agua.

Country Status (10)

Country Link
US (1) US5618840A (es)
EP (2) EP0765151B1 (es)
JP (2) JPH10500687A (es)
CN (2) CN1158069C (es)
AU (2) AU2593695A (es)
BR (2) BR9507742A (es)
CA (2) CA2190606A1 (es)
DE (2) DE69524953T2 (es)
ES (1) ES2180636T3 (es)
WO (2) WO1995031966A1 (es)

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US5908862A (en) * 1996-07-31 1999-06-01 Abbot Laboratories Water-miscible esters of mono--and diglycerides having antibacterial activity and their use in inhibiting infection
US5958974A (en) 1996-07-31 1999-09-28 Abbott Laboratories Nutritional formulations containing water-miscible lipid derivatives as antibacterial agents
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WO1995031966A1 (en) 1995-11-30
JPH10500687A (ja) 1998-01-20
JPH10500686A (ja) 1998-01-20
AU687562B2 (en) 1998-02-26
CA2190606A1 (en) 1995-11-30
EP0765151A1 (en) 1997-04-02
EP0760650B1 (en) 2002-07-31
WO1995031956A1 (en) 1995-11-30
DE69524953D1 (de) 2002-02-14
BR9507669A (pt) 1997-10-07
EP0765151A4 (en) 1998-11-25
EP0760650A4 (en) 1998-11-25
CN1158069C (zh) 2004-07-21
AU2593695A (en) 1995-12-18
AU2593795A (en) 1995-12-18
CA2190604A1 (en) 1995-11-30
DE69527624T2 (de) 2003-04-03
EP0760650A1 (en) 1997-03-12
DE69524953T2 (de) 2002-08-29
BR9507742A (pt) 1997-10-07
CN1156404A (zh) 1997-08-06
CN1159158A (zh) 1997-09-10
EP0765151B1 (en) 2002-01-09
US5618840A (en) 1997-04-08
DE69527624D1 (de) 2002-09-05

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