ES2180648T3 - Paraoxonasa serica. - Google Patents

Paraoxonasa serica.

Info

Publication number
ES2180648T3
ES2180648T3 ES95925340T ES95925340T ES2180648T3 ES 2180648 T3 ES2180648 T3 ES 2180648T3 ES 95925340 T ES95925340 T ES 95925340T ES 95925340 T ES95925340 T ES 95925340T ES 2180648 T3 ES2180648 T3 ES 2180648T3
Authority
ES
Spain
Prior art keywords
polypeptide
disclosed
present
paroxonase
serica
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95925340T
Other languages
English (en)
Inventor
Peter L Hudson
Wei Wu He
Steven M Ruben
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Human Genome Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Application granted granted Critical
Publication of ES2180648T3 publication Critical patent/ES2180648T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE PRESENTAN UNA ENZIMA DE PARAOXONASA DEL SUERO HUMANO Y UN ADN (ARN) QUE CODIFICA TALES ENZIMAS DE PARAOXONASA DEL SUERO. TAMBIEN SE PRESENTA EL PROCEDIMIENTO PARA LA PRODUCCION DE TALES POLIPEPTIDOS MEDIANTE TECNICAS RECOMBINANTES. LOS USOS DE TALES POLIPEPTIDOS INCLUYEN SU USO COMO ANTIDOTO CONTRA EL ENVENENAMIENTO DE ORGANOFOSFATOS Y PARA PREVENIR LA MUERTE DE CELULAS NEURONALES. TAMBIEN SE PRESENTAN ENSAYOS DE DIAGNOSTICO PARA IDENTIFICAR LAS MUTACIONES EN UNA SECUENCIA DE ACIDOS NUCLEICOS QUE CODIFICA UN POLIPEPTIDO DE LA PRESENTE INVENCION Y PARA DETECTAR LOS NIVELES ALTERADOS DEL POLIPEPTIDO DE LA PRESENTE INVENCION.
ES95925340T 1994-07-05 1995-06-28 Paraoxonasa serica. Expired - Lifetime ES2180648T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/270,583 US5629193A (en) 1994-07-05 1994-07-05 Paraoxonase

Publications (1)

Publication Number Publication Date
ES2180648T3 true ES2180648T3 (es) 2003-02-16

Family

ID=23031914

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95925340T Expired - Lifetime ES2180648T3 (es) 1994-07-05 1995-06-28 Paraoxonasa serica.

Country Status (13)

Country Link
US (4) US5629193A (es)
EP (2) EP1217007A2 (es)
JP (2) JPH10502255A (es)
KR (1) KR970704887A (es)
CN (1) CN1151760A (es)
AT (1) ATE224953T1 (es)
CA (1) CA2194390A1 (es)
DE (1) DE69528379T2 (es)
DK (1) DK0804591T3 (es)
ES (1) ES2180648T3 (es)
NZ (1) NZ289607A (es)
PT (1) PT804591E (es)
WO (1) WO1996001322A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629193A (en) 1994-07-05 1997-05-13 Human Genome Sciences, Inc. Paraoxonase
GB9511412D0 (en) * 1995-06-06 1995-08-02 Johnson Matthey Plc Improvements in emission control
US7541519B2 (en) * 1995-12-14 2009-06-02 Cargill, Incorporated Fatty acid desaturases and mutant sequences thereof
EP0998484B1 (en) * 1997-06-30 2004-03-03 Glaxo Group Limited Method of identifying compounds having reduced systemic effects
US6414223B1 (en) 1998-08-03 2002-07-02 Cargill, Incorporated Plants, seeds and oils having an elevated total monounsaturated fatty acid content
US6391298B1 (en) * 1998-11-25 2002-05-21 Bayer Corporation Method of using PON-1 to decrease atheroma formation
JP2000333674A (ja) * 1999-05-24 2000-12-05 Bml Inc パラオキソナーゼに対するモノクローナル抗体及びこれを用いる動脈硬化の判定方法
US6573370B1 (en) * 2000-05-19 2003-06-03 Regents Of The University Of Michigan PON3 and uses thereof
US20020151068A1 (en) * 2001-01-03 2002-10-17 Board Of Regents, The University Of Texas System Compositions and methods for the diagnosis and treatment of organophosphate toxicity
RU2255975C1 (ru) * 2003-12-19 2005-07-10 Химический факультет МГУ им. М.В. Ломоносова (Химфак МГУ) Рекомбинантная плазмидная днк ptes-his-oph, кодирующая полипептид со свойствами органофосфатгидролазы, и штамм бактерий e.coli - продуцент полипептида со свойствами органофосфатгидролазы
CN1854300B (zh) * 2005-04-29 2013-04-17 中国人民解放军军事医学科学院毒物药物研究所 含pon基因的重组质粒及其应用
US20100041077A1 (en) * 2006-11-13 2010-02-18 Jon Owen Nagy Pesticide biomarker
CN101939339A (zh) * 2007-11-14 2011-01-05 阿特瑞斯技术有限公司 生物标记的检测
US20130071394A1 (en) 2011-09-16 2013-03-21 John K. Troyer Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and methods of use
CN108196064A (zh) * 2017-12-26 2018-06-22 黑龙江八农垦大学 一种牛pon1蛋白的双抗夹心elisa检测试剂盒及检测方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260203A (en) * 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5629193A (en) 1994-07-05 1997-05-13 Human Genome Sciences, Inc. Paraoxonase

Also Published As

Publication number Publication date
EP0804591A4 (en) 1998-07-29
EP0804591A1 (en) 1997-11-05
EP1217007A2 (en) 2002-06-26
US7026140B2 (en) 2006-04-11
JP2003088364A (ja) 2003-03-25
AU2950795A (en) 1996-01-25
DK0804591T3 (da) 2003-01-20
EP0804591B1 (en) 2002-09-25
DE69528379T2 (de) 2003-06-12
WO1996001322A1 (en) 1996-01-18
US5629193A (en) 1997-05-13
KR970704887A (ko) 1997-09-06
PT804591E (pt) 2002-12-31
CA2194390A1 (en) 1996-01-18
JPH10502255A (ja) 1998-03-03
CN1151760A (zh) 1997-06-11
ATE224953T1 (de) 2002-10-15
US6140093A (en) 2000-10-31
US5792639A (en) 1998-08-11
NZ289607A (en) 1998-11-25
AU704834B2 (en) 1999-05-06
US20050026226A1 (en) 2005-02-03
DE69528379D1 (de) 2002-10-31

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