ES2182070T3 - Benzofurilderivados y su empleo. - Google Patents

Benzofurilderivados y su empleo.

Info

Publication number
ES2182070T3
ES2182070T3 ES97921737T ES97921737T ES2182070T3 ES 2182070 T3 ES2182070 T3 ES 2182070T3 ES 97921737 T ES97921737 T ES 97921737T ES 97921737 T ES97921737 T ES 97921737T ES 2182070 T3 ES2182070 T3 ES 2182070T3
Authority
ES
Spain
Prior art keywords
rent
ascellants
cakes
represent
alcoxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97921737T
Other languages
English (en)
Inventor
Michael Boes
Heinz Stadler
Juergen Wichmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2182070T3 publication Critical patent/ES2182070T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

LA INVENCION SE REFIERE AL USO DE COMPUESTOS DE FORMULA GENERAL (I) EN LA QUE DE R 1 A R 4 REPRESENTAN HIDROG ENO, HALOGENO, ALQUILO INFERIOR, ALCOXI INFERIOR, ARILO, BENCILOXI, ALCOXI - INFERIOR - ALQUILO INFERIOR, ALQUILSULFANILO INFERIOR, ALQUILSULFANIL - INFERIOR - ALQUILO INFERIOR O R 1 Y R 2 JUNTOS REPRESENTAN EL GRUPO - O - (CH 2 ) 2 - O (CH 2 ) 2 - O - Y R 5 REPRESENTA HIDROGENO O HIDROXI, ASI COMO SUS SALES FARMACEUTICAMENTE ACEPTABLES PARA EL CONTROL O PREVENCION DE ENFERMEDADES O TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL TALES COMO LA MIGRAÑA, ESQUIZOFRENIA, ESTADOS ANSIOSOS, TRASTORNOS DEL SUEÑO, ANOREXIA, ENFERMEDAD DE ALZHEIMER, ADICIONES (ALCOHOL, NICOTINA, BENZODIAZEPINA, COCAINA, ETC.), ASI COMO TRASTORNOS RESULTANTES DE LESIONES EN LA CABEZA/CEREBRO O EN LA COLUMNA ESPINAL/MEDULA OSEA ASI COMO EN LA PRODUCCION DE MEDICAMENTOS CORRESPONDIENTES.
ES97921737T 1996-05-03 1997-04-24 Benzofurilderivados y su empleo. Expired - Lifetime ES2182070T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96106990 1996-05-03

Publications (1)

Publication Number Publication Date
ES2182070T3 true ES2182070T3 (es) 2003-03-01

Family

ID=8222741

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97921737T Expired - Lifetime ES2182070T3 (es) 1996-05-03 1997-04-24 Benzofurilderivados y su empleo.

Country Status (21)

Country Link
US (1) US5955495A (es)
EP (1) EP0906301B1 (es)
JP (1) JP3148253B2 (es)
KR (1) KR100343060B1 (es)
CN (1) CN100347164C (es)
AR (1) AR006915A1 (es)
AT (1) ATE225342T1 (es)
AU (1) AU712056B2 (es)
BR (1) BR9708902A (es)
CA (1) CA2253547C (es)
CO (1) CO4940471A1 (es)
DE (1) DE69716062T2 (es)
DK (1) DK0906301T3 (es)
ES (1) ES2182070T3 (es)
HR (1) HRP970225A2 (es)
MA (1) MA24168A1 (es)
PE (1) PE64698A1 (es)
PT (1) PT906301E (es)
TR (1) TR199802206T2 (es)
WO (1) WO1997042183A1 (es)
ZA (1) ZA973708B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2786184B1 (fr) * 1998-11-24 2002-09-20 Hoechst Marion Roussel Inc Nouveaux derives du benzofurane, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
HUP0303316A2 (hu) 2000-12-20 2004-01-28 Bristol-Myers Squibb Pharma Company Aril- és amino-aril-szubsztituált szerotoninreceptor agonista és antagonista ligandumok és ezeket tartalmazó gyógyszerkészítmények
FR2822463B1 (fr) 2001-03-21 2004-07-30 Lipha Derives bicycliques de guanidines et leurs applications en therapeutique
AU2003216954A1 (en) * 2002-03-29 2003-10-13 Orion Corporation Treatment of dependence and dependence related withdrawal symptoms
FR2845992B1 (fr) * 2002-10-16 2005-02-04 Pf Medicament Derives de 3-(cyclopenten-1yl)-benzyl-ou3-(cyclopenten-1yl)- heteroarylmethyl-amines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie
DE10257357A1 (de) 2002-12-09 2004-06-24 Bayer Ag Fluorhaltige Benzaldehyde
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050215644A1 (en) * 2004-03-19 2005-09-29 Interhealth Nutraceuticals, Inc. Methods for increasing neurotransmitter levels using hydroxycitric acid
EP2248524A3 (en) 2004-08-25 2011-03-09 Takeda Pharmaceutical Company Limited Preventives/remedies for stress urinary incontinence and method of screening the same
PL1879573T3 (pl) 2005-05-10 2013-05-31 Incyte Holdings Corp Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania
CA2634198C (en) 2005-12-20 2014-06-03 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
EP2742936A1 (en) 2006-05-16 2014-06-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
ES2444574T3 (es) 2006-09-19 2014-02-25 Incyte Corporation N-hidroxiamidinoheterociclos como moduladores de la indolamina 2,3-dioxigenasa
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
EP2650288A1 (en) * 2007-05-29 2013-10-16 Osaka Bioscience Institute Sleep-improving agent
EP2789338A3 (en) 2007-11-15 2015-01-14 Takeda Pharmaceutical Company Limited Condensed pyridine derivate and use thereof
PL2315756T3 (pl) 2008-07-08 2015-02-27 Incyte Holdings Corp 1,2,5-oksadiazole jako inhibitory 2,3-dioksygenazy indoloaminy
UY32940A (es) 2009-10-27 2011-05-31 Bayer Cropscience Ag Amidas sustituidas con halogenoalquilo como insecticidas y acaricidas
JPWO2011071136A1 (ja) 2009-12-11 2013-04-22 アステラス製薬株式会社 線維筋痛症治療剤
CN104045631A (zh) * 2013-03-13 2014-09-17 无锡万全医药技术有限公司 一种制备5-(4-(4-(5-氰基-1h-吲哚-3-基)丁基)哌嗪-1-基)苯并呋喃-2-甲酰胺的新方法
CN103360374B (zh) * 2013-07-12 2016-03-09 苏州永健生物医药有限公司 维拉唑酮及其盐的合成方法
DK3066085T3 (da) 2013-11-08 2020-06-02 Incyte Holdings Corp Fremgangsmåde til syntesen af en indolamin-2,3-dioxygenaseinhibitor
EP3733204A4 (en) 2017-12-27 2021-09-15 Takeda Pharmaceutical Company Limited THERAPEUTIC AGENT FOR URINARY INCONTINENCE OF STRESS AND FECAL INCONTINENCE
CN114315773B (zh) * 2020-09-29 2024-01-16 广东东阳光药业股份有限公司 一种哌嗪化合物及其制备方法
WO2024206712A1 (en) * 2023-03-31 2024-10-03 Tactogen Inc. Advantageous fluorobenzofurans for the treatment of mental disorders or enhancement

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4420476A (en) 1982-05-24 1983-12-13 Averst McKenna & Harrison, Inc. Benzofuro[3,2-c]pyrazol-3-amine derivatives
DE68901424D1 (de) * 1988-07-05 1992-06-11 Akzo Nv Verbindungen mit bronchodilatatorischer aktivitaet.
US5026726A (en) * 1989-12-11 1991-06-25 The University Of New Mexico Gossylic iminolactones and gossylic lactones and their anti-viral activities

Also Published As

Publication number Publication date
ZA973708B (en) 1997-11-03
AU2769697A (en) 1997-11-26
DK0906301T3 (da) 2003-02-10
DE69716062D1 (de) 2002-11-07
DE69716062T2 (de) 2003-06-18
EP0906301B1 (en) 2002-10-02
PT906301E (pt) 2003-02-28
TR199802206T2 (xx) 2001-12-21
AU712056B2 (en) 1999-10-28
JPH11508283A (ja) 1999-07-21
ATE225342T1 (de) 2002-10-15
CN1217720A (zh) 1999-05-26
BR9708902A (pt) 1999-08-03
EP0906301A1 (en) 1999-04-07
HRP970225A2 (en) 1998-04-30
KR20000010708A (ko) 2000-02-25
PE64698A1 (es) 1998-10-27
KR100343060B1 (ko) 2002-09-18
US5955495A (en) 1999-09-21
CO4940471A1 (es) 2000-07-24
CA2253547A1 (en) 1997-11-13
WO1997042183A1 (en) 1997-11-13
CN100347164C (zh) 2007-11-07
MA24168A1 (fr) 1997-12-31
JP3148253B2 (ja) 2001-03-19
AR006915A1 (es) 1999-09-29
CA2253547C (en) 2006-10-17

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