ES2183399T3 - Metodo para la determinacion del funcionamiento del higado. - Google Patents

Metodo para la determinacion del funcionamiento del higado.

Info

Publication number
ES2183399T3
ES2183399T3 ES98936568T ES98936568T ES2183399T3 ES 2183399 T3 ES2183399 T3 ES 2183399T3 ES 98936568 T ES98936568 T ES 98936568T ES 98936568 T ES98936568 T ES 98936568T ES 2183399 T3 ES2183399 T3 ES 2183399T3
Authority
ES
Spain
Prior art keywords
liver
determination
patient
acid derivative
bile acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98936568T
Other languages
English (en)
Inventor
Charles Oswald Mills
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Norgine Europe BV
Original Assignee
Norgine Europe BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norgine Europe BV filed Critical Norgine Europe BV
Application granted granted Critical
Publication of ES2183399T3 publication Critical patent/ES2183399T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/583—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with non-fluorescent dye label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/728—Bilirubin; including biliverdin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/146666—Bile pigment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

La invención se refiere a un procedimiento para evaluar las funciones hepáticas de un paciente. Este procedimiento consiste (i)en tratar una serie de muestras de sangre que han atravesado el hígado del paciente, SINDO tomas estas muestras a intervalos de tiempo determinados después de que un derivado de ácido biliar coloreado o fluorescente haya sido administrado al paciente por vía intravenosa; y a continuación (ii) en evaluar el color o la fluorescencia del derivado de ácido biliar en cada muestra mediante las siguientes etapas: a) se trata la muestra de sangre para obtener un plasma sanguínea que contiene el derivado de ácido biliar, b) se mide el color o la fluorescencia del derivado de ácido biliar presente en el plasma sanguíneo, y c) se establece una curva de eliminación de plasma mediante mediciones obtenidas durante la etapa b) y se compara esta curva de eliminación del plasma con las curvas de eliminación de plasma tomadas en individuos cuyas funciones hepáticas son conocidas, para evaluar las funciones hepáticas de un paciente.
ES98936568T 1997-08-12 1998-08-03 Metodo para la determinacion del funcionamiento del higado. Expired - Lifetime ES2183399T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9716962.7A GB9716962D0 (en) 1997-08-12 1997-08-12 Liver function test

Publications (1)

Publication Number Publication Date
ES2183399T3 true ES2183399T3 (es) 2003-03-16

Family

ID=10817313

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98936568T Expired - Lifetime ES2183399T3 (es) 1997-08-12 1998-08-03 Metodo para la determinacion del funcionamiento del higado.

Country Status (14)

Country Link
US (1) US6030841A (es)
EP (1) EP1003458B1 (es)
JP (1) JP3477616B2 (es)
KR (1) KR100444564B1 (es)
CN (2) CN1275060A (es)
AT (1) ATE226415T1 (es)
AU (1) AU732900B2 (es)
CA (1) CA2300097C (es)
DE (1) DE69808930T2 (es)
DK (1) DK1003458T3 (es)
ES (1) ES2183399T3 (es)
GB (1) GB9716962D0 (es)
PT (1) PT1003458E (es)
WO (1) WO1999007325A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6640129B1 (en) * 1998-07-01 2003-10-28 Andreas Hoeft Determination of liver function using the rate at which plasma disappears
SE521014C2 (sv) 1999-02-04 2003-09-23 Prostalund Operations Ab Anordning för värmebehandling av prostata
SE521275C2 (sv) 1999-05-07 2003-10-14 Prostalund Operations Ab Anordning vid värmebehandling av kroppsvävnad
GB0017822D0 (en) * 2000-07-21 2000-09-06 Norgine Europe Bv Pharmaceutically active compound
US6868290B2 (en) 2001-11-05 2005-03-15 Prostalund Operations Ab Thermotherapy catheter and method of prostate thermotherapy with improved guide and heat confinement
WO2003045315A2 (en) * 2001-11-26 2003-06-05 Cortex Pharmaceuticals, Inc. Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses
CN100502763C (zh) * 2002-12-09 2009-06-24 味之素株式会社 生物体状态信息处理装置和其方法、以及生物体状态信息管理系统
GB0808777D0 (en) 2008-05-15 2008-06-18 Norgine Bv Prognostic method
GB2467902A (en) 2009-02-12 2010-08-18 Norgine Bv Preparation of Cholyl-L-lysine from N-E-CBZ-cholyl-L-lysine
JP2010261871A (ja) * 2009-05-08 2010-11-18 Geno Membrane:Kk 標識化胆汁酸
CN102488525B (zh) * 2011-12-14 2014-04-16 吉林大学 一种去血氧波动干扰的肝储备功能检测装置
US20150212068A1 (en) * 2012-08-20 2015-07-30 Novassay Sa Cholyl-L-Lysyl-Fluorescein Assay
CN104688234A (zh) * 2015-03-17 2015-06-10 吉林大学 一种icg色素浓度谱的无创、抗扰动检测方法
KR101882485B1 (ko) 2016-06-30 2018-07-27 강경찬 체내 간기능효소 및 지질 함유량 측정방법
CN106749473B (zh) * 2017-01-13 2018-08-17 常德云港生物科技有限公司 一种从鸭胆汁中提取鹅去氧胆酸和别胆酸的方法
CN116183565A (zh) * 2022-12-09 2023-05-30 青岛大学 快速检测小分子化合物与fxr受体结合能力的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4264514A (en) * 1977-11-14 1981-04-28 Abbott Laboratories Method and reagents for measuring the level of conjugated bile acids
US4848349A (en) * 1987-04-29 1989-07-18 Sherman Igor A Substance and method for measuring hepatic blood flow
JPH0657216B2 (ja) * 1988-09-14 1994-08-03 住友電気工業株式会社 肝機能検査装置
GB9517043D0 (en) * 1995-08-19 1995-10-25 Univ Birmingham The use of bile acid derivatives

Also Published As

Publication number Publication date
KR100444564B1 (ko) 2004-08-16
WO1999007325A1 (en) 1999-02-18
EP1003458B1 (en) 2002-10-23
CA2300097A1 (en) 1999-02-18
HK1024413A1 (en) 2000-10-13
ATE226415T1 (de) 2002-11-15
DK1003458T3 (da) 2002-11-18
CA2300097C (en) 2004-10-12
CN1991367A (zh) 2007-07-04
CN1275060A (zh) 2000-11-29
AU8553098A (en) 1999-03-01
DE69808930T2 (de) 2003-08-07
GB9716962D0 (en) 1997-10-15
WO1999007325A8 (en) 1999-03-25
AU732900B2 (en) 2001-05-03
DE69808930D1 (de) 2002-11-28
KR20010022806A (ko) 2001-03-26
US6030841A (en) 2000-02-29
JP2001513584A (ja) 2001-09-04
EP1003458A2 (en) 2000-05-31
JP3477616B2 (ja) 2003-12-10
PT1003458E (pt) 2003-01-31

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