ES2183714B1 - Un procedimiento para la fabricacion de oxalato de (1r,2r-ciclohexanodiamina)-platino (ii). - Google Patents
Un procedimiento para la fabricacion de oxalato de (1r,2r-ciclohexanodiamina)-platino (ii).Info
- Publication number
- ES2183714B1 ES2183714B1 ES200101213A ES200101213A ES2183714B1 ES 2183714 B1 ES2183714 B1 ES 2183714B1 ES 200101213 A ES200101213 A ES 200101213A ES 200101213 A ES200101213 A ES 200101213A ES 2183714 B1 ES2183714 B1 ES 2183714B1
- Authority
- ES
- Spain
- Prior art keywords
- aqueous solution
- oxalate
- cyclohexanediamine
- platinum
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000012153 distilled water Substances 0.000 abstract 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- SSJXIUAHEKJCMH-PHDIDXHHSA-N (1r,2r)-cyclohexane-1,2-diamine Chemical compound N[C@@H]1CCCC[C@H]1N SSJXIUAHEKJCMH-PHDIDXHHSA-N 0.000 abstract 1
- JKFYKCYQEWQPTM-UHFFFAOYSA-N 2-azaniumyl-2-(4-fluorophenyl)acetate Chemical compound OC(=O)C(N)C1=CC=C(F)C=C1 JKFYKCYQEWQPTM-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 229910021612 Silver iodide Inorganic materials 0.000 abstract 1
- 201000000053 blastoma Diseases 0.000 abstract 1
- 210000001072 colon Anatomy 0.000 abstract 1
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 abstract 1
- 201000008184 embryoma Diseases 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 230000000771 oncological effect Effects 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- MUTQTHUBSRXFQO-UHFFFAOYSA-L oxalate;platinum(2+) Chemical compound [Pt+2].[O-]C(=O)C([O-])=O MUTQTHUBSRXFQO-UHFFFAOYSA-L 0.000 abstract 1
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 230000001698 pyrogenic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940045105 silver iodide Drugs 0.000 abstract 1
- 229910001961 silver nitrate Inorganic materials 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un procedimiento para la fabricación de oxalato de (1R, 2R- ciclohexanodiamina)-platino (II) que consiste en proceder según las siguientes etapas. a- Tratar una solución acuosa de una sal neutra de elevada pureza óptica de (1R, 2R)- ciclohexanodiamina, b- La solución acuosa resultante de la etapa "a" se mezcla con una solución acuosa de tetraiodoplatinito de potasio(I{sub,4} PtK {sub,2}), obteniéndose(1R, 2R)- ciclohexanodiaminadiiodoplatino (II) (compuesto D) que precipita y se separa por filtración. c- El compuesto D se suspende en agua destilada apirógena y se trata con una solución acuosa de nitrato de plata obtenida empleando agua destilada apirógena, calentando y agitando durante todo el tiempo necesario para transformar todo el iodo del compuesto D en ioduro de plata. La mezcla resultante se enfría y se filtra. d- A la solución acuosa de nitrato de (1R, 2R)-ciclohexanodiamindiacuoplatino (II) se le agrega, un exceso de solución acuosa de oxalato de potasio, cristalizando el productofinal, oxalato (1R, 2R-ciclohexanodiamina) platino (II), e- Separar el oxalato de (1R, 2R-ciclohexanodiamina) platino (II) cristalizado en la etapa (d). El producto fabricado mediante el procedimiento de la presente invención tiene aplicación terapéutica oncológica y está especialmente indicado para el tratamiento de blastomas sólidos tales como el de colón.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200101213A ES2183714B1 (es) | 2001-05-25 | 2001-05-25 | Un procedimiento para la fabricacion de oxalato de (1r,2r-ciclohexanodiamina)-platino (ii). |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200101213A ES2183714B1 (es) | 2001-05-25 | 2001-05-25 | Un procedimiento para la fabricacion de oxalato de (1r,2r-ciclohexanodiamina)-platino (ii). |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2183714A1 ES2183714A1 (es) | 2003-03-16 |
| ES2183714B1 true ES2183714B1 (es) | 2004-01-16 |
Family
ID=8497855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200101213A Expired - Fee Related ES2183714B1 (es) | 2001-05-25 | 2001-05-25 | Un procedimiento para la fabricacion de oxalato de (1r,2r-ciclohexanodiamina)-platino (ii). |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2183714B1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR072238A1 (es) * | 2009-01-13 | 2010-08-18 | Eriochem Sa | Proceso para preparar derivados antineoplasicos neutros de platino (ii) grado farmaceutico con bajo contenido de plata |
| EP2208731B1 (en) | 2009-06-26 | 2012-08-15 | Umicore AG & Co. KG | Process for preparation of 1,2-diamino-cyclohexane-platinum(II) complexes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0776230B2 (ja) * | 1992-01-13 | 1995-08-16 | 田中貴金属工業株式会社 | 白金化合物の製造方法 |
| JPH06287021A (ja) * | 1992-04-22 | 1994-10-11 | Tanaka Kikinzoku Kogyo Kk | 光学活性な白金錯化合物の光学的分割方法 |
| JP3025602B2 (ja) * | 1993-05-21 | 2000-03-27 | デビオファーム エス．アー． | 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法 |
-
2001
- 2001-05-25 ES ES200101213A patent/ES2183714B1/es not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2183714A1 (es) | 2003-03-16 |
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Legal Events
| Date | Code | Title | Description |
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| EC2A | Search report published |
Date of ref document: 20030316 Kind code of ref document: A1 |
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