ES2184059T3 - Vector retrovirico y su utilizacion en terapia genica. - Google Patents
Vector retrovirico y su utilizacion en terapia genica.Info
- Publication number
- ES2184059T3 ES2184059T3 ES97901179T ES97901179T ES2184059T3 ES 2184059 T3 ES2184059 T3 ES 2184059T3 ES 97901179 T ES97901179 T ES 97901179T ES 97901179 T ES97901179 T ES 97901179T ES 2184059 T3 ES2184059 T3 ES 2184059T3
- Authority
- ES
- Spain
- Prior art keywords
- vector
- retroviric
- gene therapy
- retroviral vector
- reimplantation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000001415 gene therapy Methods 0.000 title 1
- 230000001177 retroviral effect Effects 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 101710172711 Structural protein Proteins 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 108010027225 gag-pol Fusion Proteins Proteins 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
SE DESCRIBEN SECUENCIAS DE ADN PARA CREAR CELULAS PRODUCTORAS DE UN VECTOR RETROVIRICO DEFECTUOSO EN CUANTO A LA REPLICACION IN VIVO O IN VITRO PARA LA REIMPLANTACION. EL VECTOR RETROVIRICO INCLUYE AL MENOS UN GEN HETEROLOGO, Y SE ENCUENTRAN AUSENTES LOS GENES ENV Y GAG-POL FUNCIONAL DEL VECTOR DE FORMA QUE LAS PROTEINAS ESTRUCTURALES DEL RETROVIRUS NO SON EXPRESADAS POR LAS CELULAS DIANA INFECTADAS Y TRANSDUCIDAS POR EL VECTOR.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9601336.2A GB9601336D0 (en) | 1996-01-23 | 1996-01-23 | Retrovirus |
| GBGB9620759.2A GB9620759D0 (en) | 1996-10-04 | 1996-10-04 | Retrovirus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2184059T3 true ES2184059T3 (es) | 2003-04-01 |
Family
ID=26308512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97901179T Expired - Lifetime ES2184059T3 (es) | 1996-01-23 | 1997-01-23 | Vector retrovirico y su utilizacion en terapia genica. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0880594B1 (es) |
| JP (1) | JP3535521B2 (es) |
| KR (1) | KR19990087036A (es) |
| AT (1) | ATE226638T1 (es) |
| AU (1) | AU729934B2 (es) |
| CA (1) | CA2243529A1 (es) |
| DE (1) | DE69716581T2 (es) |
| DK (1) | DK0880594T3 (es) |
| ES (1) | ES2184059T3 (es) |
| NO (1) | NO983375L (es) |
| NZ (1) | NZ326429A (es) |
| PT (1) | PT880594E (es) |
| WO (1) | WO1997027310A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| CA2331599C (en) * | 1998-05-12 | 2005-11-29 | Genecure Llc | Replication defective hiv vaccine |
| US6958226B1 (en) | 1998-09-11 | 2005-10-25 | The Children's Medical Center Corp. | Packaging cells comprising codon-optimized gagpol sequences and lacking lentiviral accessory proteins |
| CA2344208A1 (en) | 2001-04-30 | 2002-10-30 | Oxford Biomedica (Uk) Limited | Method |
| CN100402654C (zh) * | 2003-02-19 | 2008-07-16 | 株式会社载体研究所 | 缺血疾病的治疗方法 |
| GB0526211D0 (en) * | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Viral vectors |
| GB0920775D0 (en) | 2009-11-26 | 2010-01-13 | King S College | Cells |
| GB201415344D0 (en) | 2014-08-29 | 2014-10-15 | Ucl Business Plc | Protein |
| GB201603374D0 (en) | 2016-02-26 | 2016-04-13 | Ucl Business Plc | Packaging cell |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5834256A (en) * | 1993-06-11 | 1998-11-10 | Cell Genesys, Inc. | Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells |
| FR2716459B1 (fr) * | 1994-02-22 | 1996-05-10 | Univ Paris Curie | Système hôte-vecteur utilisable en thérapie génique. |
-
1997
- 1997-01-23 NZ NZ326429A patent/NZ326429A/en active IP Right Revival
- 1997-01-23 KR KR1019980705639A patent/KR19990087036A/ko not_active Ceased
- 1997-01-23 AT AT97901179T patent/ATE226638T1/de not_active IP Right Cessation
- 1997-01-23 ES ES97901179T patent/ES2184059T3/es not_active Expired - Lifetime
- 1997-01-23 JP JP52666797A patent/JP3535521B2/ja not_active Expired - Fee Related
- 1997-01-23 DE DE69716581T patent/DE69716581T2/de not_active Expired - Fee Related
- 1997-01-23 PT PT97901179T patent/PT880594E/pt unknown
- 1997-01-23 DK DK97901179T patent/DK0880594T3/da active
- 1997-01-23 AU AU14522/97A patent/AU729934B2/en not_active Ceased
- 1997-01-23 WO PCT/GB1997/000210 patent/WO1997027310A1/en not_active Ceased
- 1997-01-23 EP EP97901179A patent/EP0880594B1/en not_active Expired - Lifetime
- 1997-01-23 CA CA002243529A patent/CA2243529A1/en not_active Abandoned
-
1998
- 1998-07-22 NO NO983375A patent/NO983375L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0880594B1 (en) | 2002-10-23 |
| JP3535521B2 (ja) | 2004-06-07 |
| DK0880594T3 (da) | 2002-12-16 |
| PT880594E (pt) | 2003-03-31 |
| AU729934B2 (en) | 2001-02-15 |
| NZ326429A (en) | 2001-07-27 |
| ATE226638T1 (de) | 2002-11-15 |
| DE69716581T2 (de) | 2003-03-06 |
| DE69716581D1 (de) | 2002-11-28 |
| WO1997027310A1 (en) | 1997-07-31 |
| AU1452297A (en) | 1997-08-20 |
| KR19990087036A (ko) | 1999-12-15 |
| NO983375L (no) | 1998-09-21 |
| CA2243529A1 (en) | 1997-07-31 |
| NO983375D0 (no) | 1998-07-22 |
| JP2000500986A (ja) | 2000-02-02 |
| EP0880594A1 (en) | 1998-12-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE198910T1 (de) | Retrovirale vektoren | |
| ATE520783T1 (de) | Lentivirale vektoren | |
| EA199800566A1 (ru) | Аденовирусный вектор (варианты), способ его получения, применение, репликационно-компетентное не содержащее аденовирус потомство, способ повышения размножения в комплементирующей клеточной линии аденовирусного вектора, способ генетической модификации клетки, композиция, клетка-хозяин, способ тестирования токсичности аденовирусного вектора, способ тестирования экспрессии чужеродного гена или гена-пассажира аденовирусного вектора | |
| FI951138A0 (fi) | Puuttellisia adenovirusvektoreita ja niiden käyttö geeniterapiassa | |
| CY1107760T1 (el) | Κυτταρα φακοϊικου εγκλεισμου | |
| ATE292983T1 (de) | Chimäres retrovirus/adenovirus system | |
| PT880594E (pt) | Vector retroviral e sua utilizacao em terapia genica | |
| EP1012603A4 (en) | FUNCTIONAL FRAGMENTS OF THE HIV-1 VPR PROTEIN AND A METHOD FOR ITS USE | |
| DE60017141D1 (de) | Replikationskompetente anti-tumor vektoren | |
| AU2149099A (en) | Pseudo-type retroviral vectors with modifiable surface capsid proteins | |
| ATE386130T1 (de) | Adenovirale vektoren für die gentherapie | |
| DE69534948D1 (de) | Retrovirale vektoren zur expression in embryonalen zellen | |
| PT975783E (pt) | "vectores retrovirais, processo para a sua producao e sua utilizacao para a transferencia de genes a celulas cd4-positivas" | |
| ATE473282T1 (de) | Methoden und zusammensetzungen für die produktion von viruspartikeln | |
| ATE328100T1 (de) | Verpackungszellinie zur transkomplementierung von defektiven retroviren-vektoren | |
| DK631387D0 (da) | Virusvektor | |
| Ballaun | Charakterisierung der spezifischen Interaktion transregulatorischer Proteine humaner Retroviren (HIV-1, HTL-VI) mit ihren RNA-Zielsequenzen. | |
| ATE412764T1 (de) | Genetische transduktion von hämatopoietische vorläuferzellen |