ES2184561B1 - Forma farmaceutica solida de administracion oral dispersable en agua para el tratamiento de la tuberculosis conteniendo rifampicina, isoniazida, pirazinamida y piridoxina hidrocloruro, procedimiento para su obtencion y forma de presentacion de dicha forma farmaceutica. - Google Patents
Forma farmaceutica solida de administracion oral dispersable en agua para el tratamiento de la tuberculosis conteniendo rifampicina, isoniazida, pirazinamida y piridoxina hidrocloruro, procedimiento para su obtencion y forma de presentacion de dicha forma farmaceutica.Info
- Publication number
- ES2184561B1 ES2184561B1 ES200001483A ES200001483A ES2184561B1 ES 2184561 B1 ES2184561 B1 ES 2184561B1 ES 200001483 A ES200001483 A ES 200001483A ES 200001483 A ES200001483 A ES 200001483A ES 2184561 B1 ES2184561 B1 ES 2184561B1
- Authority
- ES
- Spain
- Prior art keywords
- pyrazinamide
- obtaining
- water
- pharmaceutical form
- presentation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229960003350 isoniazid Drugs 0.000 title abstract 5
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 title abstract 5
- 229960005206 pyrazinamide Drugs 0.000 title abstract 5
- IPEHBUMCGVEMRF-UHFFFAOYSA-N pyrazinecarboxamide Chemical compound NC(=O)C1=CN=CC=N1 IPEHBUMCGVEMRF-UHFFFAOYSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 239000007787 solid Substances 0.000 title abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 3
- 201000008827 tuberculosis Diseases 0.000 title abstract 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 title 2
- 235000008160 pyridoxine Nutrition 0.000 title 1
- 239000011677 pyridoxine Substances 0.000 title 1
- 229940011671 vitamin b6 Drugs 0.000 title 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 abstract 4
- 229960004172 pyridoxine hydrochloride Drugs 0.000 abstract 4
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 abstract 4
- 239000011764 pyridoxine hydrochloride Substances 0.000 abstract 4
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 abstract 4
- 229960001225 rifampicin Drugs 0.000 abstract 4
- 239000008187 granular material Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Forma farmacéutica sólida de administración oral dispersable en agua para el tratamiento de la tuberculosis conteniendo rifampicina, isoniazida, pirazinamida y piridoxina hidrocloruro, procedimiento para su obtención y forma de presentación de dicha forma farmacéutica. La forma farmacéutica contiene rifampicina, isoniazida, pirazinamida y piridoxina hidrocloruro como principios activos, en una matriz sólida granular dispersable en agua, que una vez reconstituida en agua da lugar a una suspensión de sabor agradable. El procedimiento de obtención comprende la mezcla simple de los componentes o bien obtener, por separado unos granulados de rifampicina y otros de isoniazida y pirazinamida, y, opcionalmente piridoxina hidrocloruro, mezclar y homogeneizar dichos granulados. La forma farmacéutica es adecuada para elaborar una forma de presentación de un medicamento que contiene rifampicina, isoniazida, pirazinamida y piridoxina hidrocloruro, por ejemplo, en forma de sobres monodosis que contienendicha forma farmacéutica en una dosificación terapéuticamente eficaz.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200001483A ES2184561B1 (es) | 2000-06-13 | 2000-06-13 | Forma farmaceutica solida de administracion oral dispersable en agua para el tratamiento de la tuberculosis conteniendo rifampicina, isoniazida, pirazinamida y piridoxina hidrocloruro, procedimiento para su obtencion y forma de presentacion de dicha forma farmaceutica. |
| PCT/ES2001/000241 WO2001095887A1 (es) | 2000-06-13 | 2001-06-12 | Forma farmaceutica solida de administracion oral dispersable en agua para el tratamiento de la tuberculosis conteniendo rifampicina, isoniazida, pirazinamida y piridoxina hidrocloruro, procedimiento para su obtencion y forma de presentacion de dicha forma farmaceutica |
| AU74116/01A AU7411601A (en) | 2000-06-13 | 2001-06-12 | Solid, orally administered, water-dispersible pharmaceutical form for the treatment of tuberculosis, containing rifampicin, isoniazid, pirazinamide and pyridoxine hydrochloride, method for obtaining and presentation form of said pharmaceutical form |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200001483A ES2184561B1 (es) | 2000-06-13 | 2000-06-13 | Forma farmaceutica solida de administracion oral dispersable en agua para el tratamiento de la tuberculosis conteniendo rifampicina, isoniazida, pirazinamida y piridoxina hidrocloruro, procedimiento para su obtencion y forma de presentacion de dicha forma farmaceutica. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2184561A1 ES2184561A1 (es) | 2003-04-01 |
| ES2184561B1 true ES2184561B1 (es) | 2003-12-16 |
Family
ID=8493880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200001483A Expired - Fee Related ES2184561B1 (es) | 2000-06-13 | 2000-06-13 | Forma farmaceutica solida de administracion oral dispersable en agua para el tratamiento de la tuberculosis conteniendo rifampicina, isoniazida, pirazinamida y piridoxina hidrocloruro, procedimiento para su obtencion y forma de presentacion de dicha forma farmaceutica. |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU7411601A (es) |
| ES (1) | ES2184561B1 (es) |
| WO (1) | WO2001095887A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2247560C1 (ru) * | 2003-12-29 | 2005-03-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Комбинированный состав с противотуберкулёзным действием |
| RU2247561C1 (ru) * | 2003-12-29 | 2005-03-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Комбинированная фармацевтическая композиция с противотуберкулёзным действием |
| RU2247559C1 (ru) * | 2003-12-29 | 2005-03-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Противотуберкулёзное средство |
| RU2430724C2 (ru) * | 2009-09-16 | 2011-10-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Комбинированный противотуберкулезный препарат |
| CN101785771A (zh) * | 2010-03-05 | 2010-07-28 | 张徐红 | 复合异烟肼片 |
| WO2012013756A2 (fr) * | 2010-07-28 | 2012-02-02 | Laboratoires Pharma 5 | Procédé de préparation de comprimés contenant en association la rifampicine, l'isoniazide, la pyrazinamide, et éventuellement l'ethambutol |
| FR2963236B1 (fr) * | 2010-07-28 | 2013-03-01 | Pharma 5 Lab | Procede de preparation d'une composition pharmaceutique contenant en association la rifampicine, l'isoniazide, la pyrazinamide, et eventuellement l'ethambutol |
| CN103816545A (zh) * | 2013-10-30 | 2014-05-28 | 安徽万邦医药科技有限公司 | 含有利福平和十二烷基硫酸钠的药物组合物 |
| ES2886019T3 (es) | 2013-12-20 | 2021-12-16 | Campillo Ramiro Moises Vergara | Combinación de piridoxina, ácido fólico e iones magnesio para el tratamiento del cáncer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3784553A (en) * | 1972-01-17 | 1974-01-08 | Made Labor Sa | Pyridoxine alpha-ketoglutarate and its derivatives |
| IT1289883B1 (it) * | 1996-10-09 | 1998-10-19 | Lupin Lab Ltd | Composizione farmaceutica antitubercolare e procedimento per la sua produzione |
| RO114406B1 (ro) * | 1997-12-12 | 1999-04-30 | Univ De Vest Vasile Goldis | MEDICAMENT PENTRU TRATAMENTUL TUBERCULOZEI Șl PROCEDEU DE PREPARARE A ACESTUIA |
-
2000
- 2000-06-13 ES ES200001483A patent/ES2184561B1/es not_active Expired - Fee Related
-
2001
- 2001-06-12 WO PCT/ES2001/000241 patent/WO2001095887A1/es not_active Ceased
- 2001-06-12 AU AU74116/01A patent/AU7411601A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2184561A1 (es) | 2003-04-01 |
| WO2001095887A1 (es) | 2001-12-20 |
| AU7411601A (en) | 2001-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20030401 Kind code of ref document: A1 |
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| FG2A | Definitive protection |
Ref document number: 2184561B1 Country of ref document: ES |
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| PC2A | Transfer of patent |
Free format text: CHIESI ESPANA, S.A. |
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| FD2A | Announcement of lapse in spain |
Effective date: 20200925 |