ES2184772T3 - Derivados de bifenilo, procedimiento para su preparacion y su utilizacion como medicamentos. - Google Patents

Derivados de bifenilo, procedimiento para su preparacion y su utilizacion como medicamentos.

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Publication number
ES2184772T3
ES2184772T3 ES95104208T ES95104208T ES2184772T3 ES 2184772 T3 ES2184772 T3 ES 2184772T3 ES 95104208 T ES95104208 T ES 95104208T ES 95104208 T ES95104208 T ES 95104208T ES 2184772 T3 ES2184772 T3 ES 2184772T3
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Spain
Prior art keywords
group
halogenated
rent
hydrogen atom
halogen atom
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Expired - Lifetime
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ES95104208T
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English (en)
Inventor
Kozo Akasaka
Masahiro Yonaga
Akiharu Kajiwara
Kunizo Higurashi
Kohshi Ueno
Satoshi Nagato
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Eisai Co Ltd
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Eisai Co Ltd
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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  • Pyridine Compounds (AREA)

Abstract

DERIVADO DE BIFENIL REPRESENTADO POR LA SIGUIENTE FORMULA (I) O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LA MISMA: EN DONDE R1 REPRESENTA UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO HIDROXILO, UN GRUPO AMINO, A UN GRUPO ALQUILO INFERIOR, UN GRUPO ALQUILO INFERIOR HALOGENADO, UN GRUPO ALCOHOXILO INFERIOR, UN GRUPO ALCOHOXILO INFERIOR HALOGENADO, UN GRUPO ALCOHOXIALQUIL INFERIOR, UN GRUPO ALCOHOXIALCOHOXIL INFERIOR, UN GRUPO ARIL, UN GRUPO ARALQUIL, UN GRUPO HETEROARIL, UN GRUPO HETEROARILALQUIL, UN GRUPO HETEROARILALQUIL HALOGENADO, UN GRUPO ALQUIL INFERIOR CIANO, UN GRUPO ALQUIL INFERIOR HIDROXIL, UN GRUPO ALQUIL INFERIOR AMINO, UN GRUPO ALCOXICARBONILO, UN GRUPO ARILOXICARBONILO, UN GRUPO CIANO, UN GRUPO FORMILO, UN GRUPO ACILO INFERIOR, UN GRUPO ARALQUILCARBONILO, UN GRUPO CICLOETER, UN GRUPO ALQUENIL, UN GRUPO ALQUINIL, UN GRUPO ALQUILSULFINIL INFERIOR, UN GRUPO ALQUILSULFONIL INFERIOR, UN GRUPO ALQUILAMINOSULFONIL INFERIOR, UN GRUPO ARILAMINOSULFONIL, UN GRUPO ALQUILOSULFONILAMINO INFERIOR, UN GRUPO ALQUILOSULFONILAMINO INFERIOR HALOGENADO O UN GRUPO ARILOSULFONILAMINIO; R2 Y R3 PUEDEN SER IGUALES O DIFERENTES ENTRE SI Y CADA UNO REPRESENTA UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO ALQUILO INFERIOR, UN GRUPO ALQUIL INFERIOR HALOGENADO, UN GRUPO ALCOHOXIL INFERIOR, UN GRUPO ALCOHOXIL INFERIOR HALOGENADO O UN GRUPO CIANO; R4 REPRESENTA UN ATOMO DE HIDROGENO O UN ATOMO HALOGENO; R5 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUIL INFERIOR, UN GRUPO ALQUIL INFERIOR HALOGENADO, UN GRUPO ALQUIL INFERIOR HIDROXILO, UN GRUPO ALCOXICARBONILO INFERIOR O UN GRUPO ARILOXICARBONILO; Y N ES 0 O UN NUMERO ENTERO DE 1 A 3 , QUE MUESTRA ANTAGONISMO AL RECEPTOR DOPAMINA 2 Y/O ANTAGONISMO AL RECEPTOR SEROTONINA 2, ES UTIL CLINICAMENTE PARA EL TRATAMIENTO Y MEJORA DE LOS TRANSTORNOS MENTALES COMO LOS TRANSTORNOS CEREBROVASCULARES, CONDUCTA AGRESIVA O DEMENCIA SENIL, EXCITACION MENTAL, PORIOMANIA, DELIRIO, ALUCINACION, HIPERCINESIA, ESQUIZOFRENIA, TRANSTORNOS EMOCIONALES,DEPRESION, NEUROSIS, TRANSTORNOS PSICOFISIOLOGICOS Y NEUROSIS DE ANSIEDAD.
ES95104208T 1994-03-29 1995-03-22 Derivados de bifenilo, procedimiento para su preparacion y su utilizacion como medicamentos. Expired - Lifetime ES2184772T3 (es)

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EP0675118A2 (en) 1995-10-04
CN1290700A (zh) 2001-04-11
HU9500896D0 (en) 1995-05-29
FI951417A7 (fi) 1995-09-30
DE69528485D1 (de) 2002-11-14
EP0675118B1 (en) 2002-10-09
HUT72492A (en) 1996-05-28
RU2125051C1 (ru) 1999-01-20
NZ270816A (en) 1996-08-27
NO305986B1 (no) 1999-08-30
FI951417A0 (fi) 1995-03-24
NO951160L (no) 1995-10-02
CN1117966A (zh) 1996-03-06
KR950026866A (ko) 1995-10-16
US5849912A (en) 1998-12-15
KR100199638B1 (ko) 1999-06-15
TW434229B (en) 2001-05-16
US6281214B1 (en) 2001-08-28
AU691561B2 (en) 1998-05-21
CA2144669A1 (en) 1995-09-30
ATE225780T1 (de) 2002-10-15
RU95104322A (ru) 1997-04-27
NO951160D0 (no) 1995-03-27
FI113172B (fi) 2004-03-15
BR9500996A (pt) 1995-10-24
CN1114596C (zh) 2003-07-16
DE69528485T2 (de) 2003-08-14
AU1505895A (en) 1995-10-05
EP0675118A3 (en) 1997-09-03

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