ES2062165T3 - Derivado de piperidina, metodo para su preparacion, y una composicion farmaceutica que comprende el mismo. - Google Patents

Derivado de piperidina, metodo para su preparacion, y una composicion farmaceutica que comprende el mismo.

Info

Publication number
ES2062165T3
ES2062165T3 ES90109534T ES90109534T ES2062165T3 ES 2062165 T3 ES2062165 T3 ES 2062165T3 ES 90109534 T ES90109534 T ES 90109534T ES 90109534 T ES90109534 T ES 90109534T ES 2062165 T3 ES2062165 T3 ES 2062165T3
Authority
ES
Spain
Prior art keywords
group
formula
compound
same
piperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90109534T
Other languages
English (en)
Inventor
Yasuo Itoh
Hideo Kato
Eiichi Koshinaka
Nobuo Ogawa
Hiroyuki Nishino
Jun Sakaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Japan Co Ltd
Original Assignee
Hokuriku Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokuriku Pharmaceutical Co Ltd filed Critical Hokuriku Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2062165T3 publication Critical patent/ES2062165T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE PRESENTAN DERIVADOS DE LA PIPERIDINA REPRESENTADOS POR LA FORMULA (I) EN LA QUE R1 Y R2 SON LO MISMO O DIFERENTES Y CADA UNA REPRESENTA INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO ALQUIL INFERIOR O UN GRUPO ALCOXIDO INFERIOR; R3 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALCOXIDO INFERIOR; R3 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUIL INFERIOR; X REPRESENTA UN ATOMO DE OXIGENO O UN ATOMO DE AZUFRE; Y REPRESENTA UN GRUPO ALQUILENO QUE TIENE ENTRE 1 Y 7 ATOMOS DE CARBONO Y PUEDE ESTAR OPCIONALMENTE SUBSTITUIDO POR UN GRUPO ALQUIL INFERIOR; O BIEN Y REPRESENTA UN GRUPO -A-O-B EN EL CUAL A Y B SON LO MISMO O DIFERENTE Y CADA UNA REPRESENTA INDENPENDIENTEMENTE UN GRUPO ALQUILENO QUE TENGA ENTRE 1 Y 3 ATOMOS DE CARBONO QUE PUEDE ESTAR OPCIONALMENTE SUBSTITUIDO POR UN GRUPO ALKIL INFERIOR. TAMBIEN SE PRESENTAN LAS SALES FARMACEUTICAMENTE ACEPTABLES DE UN COMPUESTO DE LA FORMULA (I), UN AGENTE ANTIALERGICO Y ANTIISTAMINICO QUE COMPRENDEN UN COMPUESTO DELA FORMULA (I), UN COMPUESTO FARMACEUTICO QUE COMPRENDE UN COMPUESTO DE LA FORMULA (I), Y UN METODO PARA EL TRATAMIENTO DE ENFERMEDADES ALERGICAS MEDIANTE LA ADMINISTRACION DE UN COMPUESTO DE LA FORMULA (I).
ES90109534T 1989-05-22 1990-05-19 Derivado de piperidina, metodo para su preparacion, y una composicion farmaceutica que comprende el mismo. Expired - Lifetime ES2062165T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12659689 1989-05-22
JP3739790 1990-02-20

Publications (1)

Publication Number Publication Date
ES2062165T3 true ES2062165T3 (es) 1994-12-16

Family

ID=26376528

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90109534T Expired - Lifetime ES2062165T3 (es) 1989-05-22 1990-05-19 Derivado de piperidina, metodo para su preparacion, y una composicion farmaceutica que comprende el mismo.

Country Status (6)

Country Link
US (1) US5153207A (es)
EP (1) EP0399414B1 (es)
KR (1) KR900018027A (es)
CA (1) CA2015949A1 (es)
DE (1) DE69012650T2 (es)
ES (1) ES2062165T3 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231104A (en) * 1988-07-08 1993-07-27 Pfizer Inc. 1-arylethyl-3-substituted piperidines
JP2671059B2 (ja) * 1990-11-30 1997-10-29 富士レビオ株式会社 ナフトエ酸誘導体
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
JP3712208B2 (ja) 1993-06-25 2005-11-02 メレルファーマスーティカルズ インコーポレイテッド 抗ヒスタミン性の４−ジフェニルメチル／ジフェニルメトキシピペリジン誘導体類を製造する新規な中間体
JP3779349B2 (ja) * 1995-04-24 2006-05-24 興和株式会社 ピペリジン誘導体
EP0918767A4 (en) * 1996-05-31 2000-04-26 Allelix Neuroscience Inc PHARMACEUTICAL PRODUCT FOR THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS
US6001854A (en) * 1996-05-31 1999-12-14 Allelix Neuroscience Inc. Pharmaceutical for treating of neurological and neuropsychiatric disorders
FR2815031A1 (fr) * 2000-10-11 2002-04-12 Gilles Fillion Compositions et methodes pour la regulation du systeme nerveux
AU2002347906A2 (en) * 2001-10-16 2003-04-28 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
US7189757B2 (en) * 2001-10-16 2007-03-13 Hypnion, Inc. Treatment of sleep disorders using CNS target modulators
US7355042B2 (en) * 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
JP2006525299A (ja) * 2003-05-01 2006-11-09 ヴァーナリス リサーチ リミテッド アゼチジンカルボキサミド誘導体及びｃｂ１レセプター媒介障害の治療におけるその使用
NZ573129A (en) 2006-06-28 2011-06-30 Amgen Inc Piperazine acetic acid glycine transporter-1 inhibitors
WO2017004485A1 (en) 2015-07-02 2017-01-05 Raptor Pharmaceuticals Inc. Ado-resistant cysteamine analogs and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8321157D0 (en) * 1983-08-05 1983-09-07 Fordonal Sa Piperidine derivatives
JPS61254559A (ja) * 1985-05-07 1986-11-12 Terumo Corp ビニル誘導体およびこれを含有する５−リポキシゲナ−ゼ作用阻害剤
JPH0660160B2 (ja) * 1985-12-13 1994-08-10 テルモ株式会社 アミド誘導体およびこれを含有する抗アレルギ−剤
US4929618A (en) * 1988-03-25 1990-05-29 Ube Industries, Ltd. Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same
JPH0225465A (ja) * 1988-07-15 1990-01-26 Ube Ind Ltd ピペリジン誘導体、その製造方法並びにそれを含む抗ヒスタミン剤

Also Published As

Publication number Publication date
US5153207A (en) 1992-10-06
EP0399414B1 (en) 1994-09-21
DE69012650T2 (de) 1995-03-30
EP0399414A1 (en) 1990-11-28
DE69012650D1 (de) 1994-10-27
CA2015949A1 (en) 1990-11-22
KR900018027A (ko) 1990-12-20

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