ES2185595T3 - Peptidos antivirales modificados y sus composiciones para la prevencion y/o el tratamiento de infecciones viricas. - Google Patents
Peptidos antivirales modificados y sus composiciones para la prevencion y/o el tratamiento de infecciones viricas.Info
- Publication number
- ES2185595T3 ES2185595T3 ES00932570T ES00932570T ES2185595T3 ES 2185595 T3 ES2185595 T3 ES 2185595T3 ES 00932570 T ES00932570 T ES 00932570T ES 00932570 T ES00932570 T ES 00932570T ES 2185595 T3 ES2185595 T3 ES 2185595T3
- Authority
- ES
- Spain
- Prior art keywords
- peptides
- viric
- infections
- prevention
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 230000000840 anti-viral effect Effects 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 239000012503 blood component Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 108091005601 modified peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Péptido antiviral modificado que comprende: ¿ un péptido que muestra actividad antiviral, y ¿ un grupo maleimido que es reactivo con un grupo tiol en componentes sanguíneos para formar enlaces covalentes estables.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13440699P | 1999-05-17 | 1999-05-17 | |
| US134406P | 1999-05-17 | ||
| US15340699P | 1999-09-10 | 1999-09-10 | |
| US153406P | 1999-09-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2185595T3 true ES2185595T3 (es) | 2003-05-01 |
| ES2185595T5 ES2185595T5 (es) | 2009-12-17 |
Family
ID=26832297
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00932570T Expired - Lifetime ES2185595T5 (es) | 1999-05-17 | 2000-05-17 | Peptidos antivirales modificados y sus composiciones para la prevencion y/o el tratamiento de infecciones viricas. |
| ES02014617T Expired - Lifetime ES2334106T3 (es) | 1999-05-17 | 2000-05-17 | Inhibidores peptidos de fusion de larga vida contra infecciones virales. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02014617T Expired - Lifetime ES2334106T3 (es) | 1999-05-17 | 2000-05-17 | Inhibidores peptidos de fusion de larga vida contra infecciones virales. |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US7582301B1 (es) |
| EP (3) | EP1264840B1 (es) |
| JP (3) | JP4216480B2 (es) |
| CN (1) | CN1351611A (es) |
| AT (2) | ATE443714T1 (es) |
| AU (1) | AU761591B2 (es) |
| BR (1) | BR0010757A (es) |
| CA (1) | CA2372338A1 (es) |
| DE (2) | DE60043021D1 (es) |
| DK (1) | DK1264840T3 (es) |
| ES (2) | ES2185595T5 (es) |
| PT (1) | PT1264840E (es) |
| WO (1) | WO2000069902A1 (es) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
| SI1180121T1 (en) | 1999-05-17 | 2004-04-30 | Conjuchem, Inc. | Long lasting insulinotropic peptides |
| US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
| US20040266673A1 (en) * | 2002-07-31 | 2004-12-30 | Peter Bakis | Long lasting natriuretic peptide derivatives |
| US6514500B1 (en) | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
| BR0010757A (pt) | 1999-05-17 | 2002-02-19 | Conjuchem Inc | Inibidores de peptìdeo de fusão de longa duração de infecção viral |
| US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| ATE396202T1 (de) | 2001-02-16 | 2008-06-15 | Conjuchem Biotechnologies Inc | Lang wirkendes glucagon-ähnliches peptid-2 für die behandlung von gastrointestinalen krankheiten und störungen |
| DK1479691T3 (da) | 2001-05-31 | 2007-03-12 | John Erickson | Langvarigt aktive fuionspeptidinhibitorer for HIV infektion |
| CA2450548C (en) | 2001-06-15 | 2012-05-01 | F. Hoffmann-La Roche Ag | Method for the recombinant production of peptidic antiviral fusion inhibitors, and acetylation of gb41 fragments |
| AU2003275116A1 (en) | 2002-09-24 | 2004-04-19 | Frontier Biotechnologies Co., Ltd | Peptide derivative fusion inhibitors of hiv infection |
| US7556813B2 (en) * | 2002-09-27 | 2009-07-07 | Trimeris, Inc. | Antiviral peptide-polymer conjugate comprising a polymer covalently attached to two or more synthetic HIV gp41 HR1 and/or HR2 peptides |
| CA2443365C (en) * | 2002-11-19 | 2010-01-12 | F. Hoffmann-La Roche Ag | Methods for the recombinant production of antifusogenic peptides |
| US8507277B2 (en) | 2003-10-24 | 2013-08-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides |
| WO2005056752A2 (en) | 2003-10-24 | 2005-06-23 | Gencia Corporation | Methods and compositions for delivering polynucleotides |
| US20090123468A1 (en) | 2003-10-24 | 2009-05-14 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
| US8062891B2 (en) | 2003-10-24 | 2011-11-22 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to plants |
| US8133733B2 (en) | 2003-10-24 | 2012-03-13 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to target tissues |
| CA2564031A1 (en) * | 2004-04-23 | 2005-11-03 | Conjuchem Biotechnologies Inc. | Method for the purification of albumin conjugates |
| US7723063B2 (en) * | 2004-04-28 | 2010-05-25 | Intrinsic Lifesciences | Methods for measuring levels of bioactive human hepcidin |
| CA2565658A1 (en) * | 2004-05-06 | 2005-11-17 | Conjuchem Biotechnologies Inc. | Compounds for specific viral target |
| US8039432B2 (en) * | 2005-11-09 | 2011-10-18 | Conjuchem, Llc | Method of treatment of diabetes and/or obesity with reduced nausea side effect |
| EP1976876A4 (en) * | 2005-12-22 | 2010-01-13 | Conjuchem Biotechnologies Inc | PROCESS FOR PRODUCING PREFORMED ALBUMIN CONJUGATES AND THERAPEUTIC AGENT |
| CN101002945B (zh) | 2006-01-20 | 2012-09-05 | 清华大学 | 一种用于肿瘤治疗的新型复合物 |
| CN100475270C (zh) | 2006-01-20 | 2009-04-08 | 清华大学 | 一种治疗肿瘤的药物及其应用 |
| EP1989220B1 (en) | 2006-02-02 | 2011-12-14 | Trimeris, Inc. | Hiv fusion inhibitor peptides with improved biological properties |
| CN100366633C (zh) * | 2006-04-18 | 2008-02-06 | 河北师范大学 | 棕点湍蛙抗病毒多肽及其在制药中的应用 |
| KR101105610B1 (ko) | 2006-08-17 | 2012-01-18 | 에프. 호프만-라 로슈 아게 | Ccr5 에 대한 항체 및 항푸소제닉 펩타이드의 컨쥬게이트 |
| TW200817438A (en) | 2006-08-17 | 2008-04-16 | Hoffmann La Roche | A conjugate of an antibody against CCR5 and an antifusogenic peptide |
| US20090099074A1 (en) * | 2007-01-10 | 2009-04-16 | Conjuchem Biotechnologies Inc. | Modulating food intake |
| US20090088378A1 (en) * | 2007-01-12 | 2009-04-02 | Omar Quraishi | Long lasting inhibitors of viral infection |
| CL2008000707A1 (es) * | 2007-03-13 | 2008-09-22 | Hoffmann La Roche | Conjugado de polipeptidos antifusogenicos y polipeptidos derivados de la cabeza globular del factor del complemento c1q; composicion farmaceutica que lo comprende; su uso para tratar infecciones viricas; y metodo de produccion. |
| BRPI0811864A2 (pt) * | 2007-05-16 | 2014-11-18 | Conjuchem Biotechnologies Inc | Derivados de ácido cistéico de peptídeos antivirais |
| US20090022720A1 (en) | 2007-07-20 | 2009-01-22 | Stephan Fischer | Conjugate of an antibody against CD4 and antifusogenic peptides |
| CA2695830A1 (en) | 2007-08-08 | 2009-02-12 | Novozymes Biopharma Dk A/S | Transferrin variants and conjugates |
| EP2036980A1 (de) * | 2007-09-14 | 2009-03-18 | Gruber, Jens | Herabregulation der Genexpression mittels Nukleinsäure-beladener virusähnlicher Partikel |
| US20090186819A1 (en) * | 2007-12-11 | 2009-07-23 | Marieve Carrier | Formulation of insulinotropic peptide conjugates |
| WO2010092135A2 (en) | 2009-02-11 | 2010-08-19 | Novozymes Biopharma Uk Ltd. | Albumin variants and conjugates |
| CN103977394B (zh) * | 2009-07-17 | 2016-03-09 | 翰林大学校产学协力团 | 包含脂质体包胶的寡核苷酸和表位的免疫刺激性组合物 |
| CN102741280B (zh) | 2009-10-30 | 2015-12-02 | 诺维信生物制药丹麦公司 | 白蛋白变体 |
| CN106977608A (zh) | 2010-04-09 | 2017-07-25 | 阿尔布麦狄克斯公司 | 白蛋白衍生物和变体 |
| JP5757639B2 (ja) | 2010-09-14 | 2015-07-29 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | セルピンフィンガー融合ポリペプチド |
| US20130225496A1 (en) | 2010-11-01 | 2013-08-29 | Novozymes Biopharma Dk A/S | Albumin Variants |
| MX353816B (es) | 2011-05-05 | 2018-01-30 | Albumedix As | Variantes de albumina. |
| WO2013039861A2 (en) | 2011-09-12 | 2013-03-21 | modeRNA Therapeutics | Engineered nucleic acids and methods of use thereof |
| HK1200842A1 (en) | 2011-11-18 | 2015-08-14 | Albumedix Ltd | Proteins with improved half-life and other properties |
| MX2014010278A (es) | 2012-03-16 | 2015-03-05 | Novozymes Biopharma Dk As | Variantes de albumina. |
| WO2013151663A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of membrane proteins |
| CN108949772A (zh) | 2012-04-02 | 2018-12-07 | 现代泰克斯公司 | 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 |
| EP2834264A1 (en) | 2012-04-04 | 2015-02-11 | Yeda Research and Development Co. Ltd. | Lipopeptide conjugates comprising sphingolipid and hiv gp41 derived peptides |
| WO2014072481A1 (en) | 2012-11-08 | 2014-05-15 | Novozymes Biopharma Dk A/S | Albumin variants |
| WO2014125082A1 (en) | 2013-02-16 | 2014-08-21 | Novozymes Biopharma Dk A/S | Pharmacokinetic animal model |
| EP2981334A4 (en) * | 2013-04-03 | 2016-11-23 | Univ California | COMPOSITIONS AND METHODS FOR INHIBITING VIRAL ACTIVITY |
| JP6306700B2 (ja) | 2013-11-01 | 2018-04-04 | ユニバーシティ オブ オスロUniversity of Oslo | アルブミン改変体及びその使用 |
| CN103864921B (zh) * | 2014-01-16 | 2017-12-26 | 苏州大学 | 双重靶向治疗癌症的叶酸‑阿霉素免疫制剂及其制备方法 |
| US20170107294A1 (en) | 2014-03-21 | 2017-04-20 | Nordlandssykehuset Hf | Anti-cd14 antibodies and uses thereof |
| WO2015164615A1 (en) | 2014-04-24 | 2015-10-29 | University Of Oslo | Anti-gluten antibodies and uses thereof |
| WO2017029407A1 (en) | 2015-08-20 | 2017-02-23 | Albumedix A/S | Albumin variants and conjugates |
| US11168131B2 (en) | 2015-11-10 | 2021-11-09 | Visterra, Inc. | Antibody molecule-drug conjugates and uses thereof |
| JP2020500306A (ja) | 2016-11-04 | 2020-01-09 | オーフス ウニベルシテット | 新生児Fc受容体の過剰発現により特徴づけられる腫瘍の同定と治療 |
| WO2018096396A1 (en) | 2016-11-22 | 2018-05-31 | University Of Oslo | Albumin variants and uses thereof |
| ES2994374T3 (en) | 2017-01-18 | 2025-01-23 | Visterra Inc | Antibody molecule-drug conjugates and uses thereof |
| CN111303245B (zh) * | 2020-02-21 | 2023-06-27 | 成都奥达生物科技有限公司 | 一种抗合胞病毒膜融合抑制剂 |
| EP4126064A1 (en) | 2020-04-03 | 2023-02-08 | Visterra, Inc. | Antibody molecule-drug conjugates and uses thereof |
| WO2021211303A1 (en) * | 2020-04-14 | 2021-10-21 | Contrafect Corporation | Antiviral, bacteriophage-derived polypeptides and their use against viruses |
| EP4442251A1 (en) | 2023-04-05 | 2024-10-09 | Albumedix Ltd | Formulations and uses thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3719667A (en) | 1970-08-24 | 1973-03-06 | Lilly Co Eli | Epimerization of 6-acylamido and 6-imido penicillin sulfoxide esters |
| US3840556A (en) | 1971-05-28 | 1974-10-08 | Lilly Co Eli | Penicillin conversion by halogen electrophiles and anti-bacterials derived thereby |
| US4652629A (en) * | 1985-07-03 | 1987-03-24 | The Salk Institute For Biological Studies | Synthetic peptide-based anti-rabies compositions and methods |
| US5116944A (en) * | 1989-12-29 | 1992-05-26 | Neorx Corporation | Conjugates having improved characteristics for in vivo administration |
| US5612034A (en) | 1990-10-03 | 1997-03-18 | Redcell, Inc. | Super-globuling for in vivo extended lifetimes |
| CA2106314A1 (en) | 1991-04-05 | 1992-10-06 | John P. Burnier | Platelet aggregation inhibitors having high specification for gpiibiiia |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| AU688733B2 (en) | 1992-07-20 | 1998-03-19 | Duke University | Compounds which inhibit HIV replication |
| GB9316895D0 (en) * | 1993-08-13 | 1993-09-29 | Guy S And St Thomas Hospitals | Hepatoselective insulin analogues |
| EP0602290B1 (en) * | 1992-12-04 | 1999-08-25 | ConjuChem, Inc. | Antibody-conjugated Hepatitis B surface antigen and use thereof |
| US5614487A (en) | 1993-05-28 | 1997-03-25 | Genentech, Inc. | Sustained release pharmaceutical composition |
| US6479055B1 (en) | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
| US6017536A (en) | 1993-06-07 | 2000-01-25 | Trimeris, Inc. | Simian immunodeficiency virus peptides with antifusogenic and antiviral activities |
| US5464933A (en) * | 1993-06-07 | 1995-11-07 | Duke University | Synthetic peptide inhibitors of HIV transmission |
| US6518013B1 (en) * | 1993-06-07 | 2003-02-11 | Trimeris, Inc. | Methods for the inhibition of epstein-barr virus transmission employing anti-viral peptides capable of abrogating viral fusion and transmission |
| US6342225B1 (en) * | 1993-08-13 | 2002-01-29 | Deutshces Wollforschungsinstitut | Pharmaceutical active conjugates |
| JP3871713B2 (ja) | 1995-05-10 | 2007-01-24 | 協和醗酵工業株式会社 | 新規毒素複合体 |
| US6576636B2 (en) * | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| JP4086936B2 (ja) | 1996-10-03 | 2008-05-14 | 株式会社ブリヂストン | ダミーウェハ |
| US6150088A (en) * | 1997-04-17 | 2000-11-21 | Whitehead Institute For Biomedical Research | Core structure of gp41 from the HIV envelope glycoprotein |
| ATE218892T1 (de) | 1997-11-07 | 2002-06-15 | Conjuchem Inc | Affinitätsmarkierer für menschliches serum albumin |
| JP2001522863A (ja) | 1997-11-07 | 2001-11-20 | コンジュケム,インコーポレーテッド | Rgd含有ペプチドおよび内因性担体の新規コンジュゲート |
| US6107489A (en) * | 1998-03-17 | 2000-08-22 | Conjuchem, Inc. | Extended lifetimes in vivo renin inhibitors |
| CA2291066A1 (en) | 1998-03-23 | 1999-09-30 | Conjuchem, Inc. | Local delivery of long lasting therapeutic agents |
| US6258782B1 (en) * | 1998-05-20 | 2001-07-10 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
| US20030190740A1 (en) * | 1998-10-13 | 2003-10-09 | The University Of Georgia Research Foundation, Inc | Stabilized bioactive peptides and methods of identification, synthesis, and use |
| KR20020002354A (ko) * | 1998-10-13 | 2002-01-09 | 추후제출 | 안정화된 생활성 펩티드 및 이들을 동정, 합성 및이용하는 방법 |
| BR0010757A (pt) | 1999-05-17 | 2002-02-19 | Conjuchem Inc | Inibidores de peptìdeo de fusão de longa duração de infecção viral |
| US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
| DE19926154A1 (de) | 1999-06-09 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Verfahren zur Herstellung einer injizierbaren Arzneimittelzubereitung |
| DE19926475A1 (de) | 1999-06-10 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Träger-Pharmaka-Konjugate |
| US7090851B1 (en) | 1999-09-10 | 2006-08-15 | Conjuchem Inc. | Long lasting fusion peptide inhibitors of viral infection |
| DK1479691T3 (da) | 2001-05-31 | 2007-03-12 | John Erickson | Langvarigt aktive fuionspeptidinhibitorer for HIV infektion |
| CA2564031A1 (en) * | 2004-04-23 | 2005-11-03 | Conjuchem Biotechnologies Inc. | Method for the purification of albumin conjugates |
| CA2565658A1 (en) | 2004-05-06 | 2005-11-17 | Conjuchem Biotechnologies Inc. | Compounds for specific viral target |
-
2000
- 2000-05-17 BR BR0010757-3A patent/BR0010757A/pt not_active IP Right Cessation
- 2000-05-17 ES ES00932570T patent/ES2185595T5/es not_active Expired - Lifetime
- 2000-05-17 JP JP2000618318A patent/JP4216480B2/ja not_active Expired - Fee Related
- 2000-05-17 ES ES02014617T patent/ES2334106T3/es not_active Expired - Lifetime
- 2000-05-17 EP EP02014617A patent/EP1264840B1/en not_active Expired - Lifetime
- 2000-05-17 AT AT02014617T patent/ATE443714T1/de active
- 2000-05-17 EP EP09009474A patent/EP2110381A1/en not_active Withdrawn
- 2000-05-17 DE DE60043021T patent/DE60043021D1/de not_active Expired - Lifetime
- 2000-05-17 WO PCT/US2000/013651 patent/WO2000069902A1/en not_active Ceased
- 2000-05-17 AU AU50271/00A patent/AU761591B2/en not_active Ceased
- 2000-05-17 CA CA002372338A patent/CA2372338A1/en not_active Abandoned
- 2000-05-17 DE DE60000665T patent/DE60000665T3/de not_active Expired - Lifetime
- 2000-05-17 AT AT00932570T patent/ATE226593T1/de not_active IP Right Cessation
- 2000-05-17 EP EP00932570A patent/EP1179012B2/en not_active Expired - Lifetime
- 2000-05-17 DK DK02014617T patent/DK1264840T3/da active
- 2000-05-17 CN CN00807671A patent/CN1351611A/zh active Pending
- 2000-05-17 PT PT02014617T patent/PT1264840E/pt unknown
- 2000-05-17 US US09/623,533 patent/US7582301B1/en not_active Expired - Fee Related
-
2004
- 2004-09-24 US US10/950,010 patent/US7608271B2/en not_active Expired - Fee Related
-
2007
- 2007-10-23 US US11/877,221 patent/US20080199483A1/en not_active Abandoned
- 2007-10-23 US US11/877,300 patent/US20080176794A1/en not_active Abandoned
- 2007-12-17 JP JP2007325307A patent/JP2008101021A/ja not_active Withdrawn
-
2009
- 2009-04-16 JP JP2009100410A patent/JP2009167208A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1179012B9 (en) | 2003-09-10 |
| EP1179012A1 (en) | 2002-02-13 |
| DE60000665T3 (de) | 2009-10-29 |
| CN1351611A (zh) | 2002-05-29 |
| US20050070475A1 (en) | 2005-03-31 |
| WO2000069902A1 (en) | 2000-11-23 |
| ATE226593T1 (de) | 2002-11-15 |
| BR0010757A (pt) | 2002-02-19 |
| ES2334106T3 (es) | 2010-03-05 |
| PT1264840E (pt) | 2010-01-04 |
| EP1179012B2 (en) | 2009-07-15 |
| EP1179012B1 (en) | 2002-10-23 |
| JP2002544287A (ja) | 2002-12-24 |
| DE60043021D1 (de) | 2009-11-05 |
| AU761591B2 (en) | 2003-06-05 |
| DK1264840T3 (da) | 2009-11-16 |
| US20080199483A1 (en) | 2008-08-21 |
| HK1053128A1 (en) | 2003-10-10 |
| ATE443714T1 (de) | 2009-10-15 |
| US7582301B1 (en) | 2009-09-01 |
| US20080176794A1 (en) | 2008-07-24 |
| CA2372338A1 (en) | 2000-11-23 |
| US7608271B2 (en) | 2009-10-27 |
| EP1264840A1 (en) | 2002-12-11 |
| AU5027100A (en) | 2000-12-05 |
| JP2009167208A (ja) | 2009-07-30 |
| JP4216480B2 (ja) | 2009-01-28 |
| DE60000665T2 (de) | 2003-06-26 |
| DE60000665D1 (de) | 2002-11-28 |
| JP2008101021A (ja) | 2008-05-01 |
| EP1264840B1 (en) | 2009-09-23 |
| ES2185595T5 (es) | 2009-12-17 |
| EP2110381A1 (en) | 2009-10-21 |
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