ES2185628T3 - Procedimiento para preparar proteinas modificadas. - Google Patents

Procedimiento para preparar proteinas modificadas.

Info

Publication number
ES2185628T3
ES2185628T3 ES93909180T ES93909180T ES2185628T3 ES 2185628 T3 ES2185628 T3 ES 2185628T3 ES 93909180 T ES93909180 T ES 93909180T ES 93909180 T ES93909180 T ES 93909180T ES 2185628 T3 ES2185628 T3 ES 2185628T3
Authority
ES
Spain
Prior art keywords
modified proteins
procedure
prepare modified
terminal
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93909180T
Other languages
English (en)
Inventor
Stephen B H Kent
Martina Schnolzer-Rackwitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Application granted granted Critical
Publication of ES2185628T3 publication Critical patent/ES2185628T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE DESCRIBE PROCESO PARA LA PREPARACION DE PROTEINAS MODIFICADAS QUE COMPRENDEN EL ACOPLAMIENTO DE UN PRIMER SEGMENTO PEPTIDO QUE TIENE UN GRUPO HALOACILO EN EL N TERMINAL DE EL CON UN SEGUNDO SEGMENTO PEPTIDO QUE TIENE UN GRUPO CARBONILTIOL EN EL C TERMINAL DE EL. SE DESCRIBEN TAMBIEN NUEVAS PROTEINAS MODIFICADAS PRODUCIDAS POR EL PROCESO.
ES93909180T 1992-04-07 1993-03-26 Procedimiento para preparar proteinas modificadas. Expired - Lifetime ES2185628T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86536892A 1992-04-07 1992-04-07

Publications (1)

Publication Number Publication Date
ES2185628T3 true ES2185628T3 (es) 2003-05-01

Family

ID=25345347

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93909180T Expired - Lifetime ES2185628T3 (es) 1992-04-07 1993-03-26 Procedimiento para preparar proteinas modificadas.

Country Status (11)

Country Link
US (3) US5854389A (es)
EP (1) EP0635025B1 (es)
JP (1) JP3712261B2 (es)
AT (1) ATE227307T1 (es)
AU (3) AU686999B2 (es)
CA (1) CA2133834C (es)
DE (1) DE69332471T2 (es)
DK (1) DK0635025T3 (es)
ES (1) ES2185628T3 (es)
PT (1) PT635025E (es)
WO (1) WO1993020098A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2290976T3 (es) 1992-06-05 2008-02-16 The Scripps Research Institute D-proteina ligada y metodo para identificar compuestos que modulan la actividad de receptores.
EP2336313A1 (en) 1997-01-08 2011-06-22 Life Technologies Corporation Methods for production of proteins
WO1999011655A1 (en) 1997-09-04 1999-03-11 Gryphon Sciences Modular protein libraries and methods of preparation
CN100506844C (zh) * 1999-07-23 2009-07-01 寒川贤治 新的肽
AU2001284853A1 (en) * 2000-08-11 2002-02-25 Invitrogen Corporation Highly homogeneous molecular markers for electrophoresis
US20040014082A1 (en) * 2000-08-11 2004-01-22 Invitrogen Corporation Highly homogeneous molecular markers for electrophoresis
JP2004507557A (ja) * 2000-09-01 2004-03-11 グリフォン　セラピューティクス，インコーポレーテッド 求核物質に対して安定なチオエステル生成化合物、製造および使用の方法
ATE500838T1 (de) * 2000-09-08 2011-03-15 Amylin Pharmaceuticals Inc ßPSEUDOß-NATIVE CHEMISCHE LIGATION
WO2002081637A2 (en) * 2001-04-06 2002-10-17 Chiron Corporation Peptides incorporating chemoselective functionalities
US20050181464A1 (en) * 2002-04-04 2005-08-18 Affinium Pharmaceuticals, Inc. Novel purified polypeptides from bacteria
US7396913B2 (en) * 2002-10-14 2008-07-08 Abbott Laboratories Erythropoietin receptor binding antibodies
US7674881B2 (en) * 2005-10-07 2010-03-09 The University Of Chicago Convergent synthesis of proteins by kinetically controlled ligation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526716A (en) * 1981-11-20 1985-07-02 The Ohio State University Antigenic modification of polypeptides
US4596675A (en) * 1984-01-16 1986-06-24 Monsanto Company Novel thiopeptolide substrates for vertebrate collagenase
US5453269A (en) * 1986-04-14 1995-09-26 The General Hospital Corporation Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use
US4786684A (en) * 1986-08-21 1988-11-22 The Mount Sinai School Of Medicine Of The City University Of New York Benzylthioether-linked solid support-bound thiol compounds and method for peptide synthesis
US4990504A (en) * 1987-07-17 1991-02-05 Fidia-Georgetown Institute For The Neurosciences Azetidine derivatives to treat memory and learning disorders
US4946839A (en) * 1987-07-17 1990-08-07 Fidia-Georgetown Institute For The Neurosciences Azetidine derivatives, compositions and methods of treating
US5660834A (en) * 1988-03-11 1997-08-26 The Biomembrane Institute Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with carbohydrate-carrier conjugates
US5066716A (en) * 1988-12-13 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
DE3922608A1 (de) * 1989-07-10 1991-01-17 Behringwerke Ag Verbindungen aus biopolymeren und effektorsubstanzen, die ueber optisch aktive aminosaeurederivate verknuepft sind, verfahren zu ihrer herstellung und ihre verwendung
US5387671A (en) * 1990-12-27 1995-02-07 Abbott Laboratories Hexa- and heptapeptide anaphylatoxin-receptor ligands
US5286846A (en) * 1991-06-14 1994-02-15 The Government Of The United States Of America As Represented By The Dept. Of Health And Human Services Amino acid derivative and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
US5371197A (en) * 1991-09-24 1994-12-06 Merck & Co., Inc. Protein-dimeric polysaccharide conjugate vaccine
US5831005A (en) * 1992-09-24 1998-11-03 Chiron Corporation Synthesis of N-substituted oligomers
US5891993A (en) * 1994-08-11 1999-04-06 The Scripps Research Institute Template assembled synthetic protein

Also Published As

Publication number Publication date
AU686999B2 (en) 1998-02-19
DE69332471T2 (de) 2003-08-28
EP0635025A4 (en) 1997-02-26
ATE227307T1 (de) 2002-11-15
EP0635025B1 (en) 2002-11-06
AU3978893A (en) 1993-11-08
US5854389A (en) 1998-12-29
AU6650800A (en) 2000-12-14
CA2133834C (en) 2009-07-21
AU766346B2 (en) 2003-10-16
WO1993020098A1 (en) 1993-10-14
EP0635025A1 (en) 1995-01-25
JPH07505626A (ja) 1995-06-22
DE69332471D1 (de) 2002-12-12
US6642357B1 (en) 2003-11-04
PT635025E (pt) 2003-03-31
US6476190B1 (en) 2002-11-05
AU6710998A (en) 1998-07-09
CA2133834A1 (en) 1993-10-14
DK0635025T3 (da) 2003-01-27
JP3712261B2 (ja) 2005-11-02

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