ES2185964T3 - Reactivos complejantes de compuestos boronicos y complejos altamente estables. - Google Patents

Reactivos complejantes de compuestos boronicos y complejos altamente estables.

Info

Publication number
ES2185964T3
ES2185964T3 ES97935178T ES97935178T ES2185964T3 ES 2185964 T3 ES2185964 T3 ES 2185964T3 ES 97935178 T ES97935178 T ES 97935178T ES 97935178 T ES97935178 T ES 97935178T ES 2185964 T3 ES2185964 T3 ES 2185964T3
Authority
ES
Spain
Prior art keywords
reagents
general formula
boron compound
complexes
civ
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97935178T
Other languages
English (en)
Inventor
Mark L Stolowitz
Robert J Kaiser
Kevin P Lund
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prolinx Inc
Original Assignee
Prolinx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/689,283 external-priority patent/US5837878A/en
Priority claimed from US08/691,930 external-priority patent/US5777148A/en
Application filed by Prolinx Inc filed Critical Prolinx Inc
Application granted granted Critical
Publication of ES2185964T3 publication Critical patent/ES2185964T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/49—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02—Compounds containing any of the groups, e.g. carbazates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

EN LA PRESENTE INVENCION SE DESCRIBEN REACTIVOS COMPLEJANTES DE COMPUESTOS DE BORO, REACTIVOS INTERMEDIARIOS DE DICHOS REACTIVOS COMPLEJANTES Y PROCEDIMIENTOS PARA SINTETIZAR DICHOS REACTIVOS. TALES REACTIVOS, INCLUYENDO AQUELLOS REPRESENTADOS POR LAS FORMULAS GENERALES (I) Y (II), PUEDEN SER UTILIZADOS, DESPUES DE REACCIONES ADICIONALES DESCRITAS EN LA PRESENTE INVENCION, PARA COMPLEJARSE CON COMPUESTOS BORICOS TALES COMO EL ACIDO FENILBORICO O DERIVADOS DE DICHO ACIDO. SE DESCRIBEN REACTIVOS COMPLEJANTES DE COMPUESTOS DE BORO, COMPLEJOS DE COMPUESTOS A BASE DE BORO Y PROCEDIMIENTOS PARA SINTETIZAR TALES REACTIVOS Y COMPLEJOS. DICHOS REACTIVOS Y COMPLEJOS INCLUYEN AQUELLOS QUE SE DESCRIBEN EN LA FORMULA GENERAL (CIII), EN LA FORMULA GENERAL (CIV) Y EN LA FORMULA (CVI). EN UNA REALIZACION DE LA INVENCION, LOS REACTIVOS DE LA FORMULA (CIII) PUEDEN UTILIZARSE PARA PRODUCIR, DESPUES DE LA CONDENSACION CON UNA ESPECIE BIOACTIVA (BAS), EL REACTIVO DE FORMULA (CIV). DICHO REACTIVO DE FORMULA (CIV) PUEDE UTILIZARSE PARA FORMAR UN COMPLEJO CON UN COMPUESTO DE BORO, TAL COMO EL COMPLEJO DESCRITO EN LA FORMULA GENERAL (CIV).
ES97935178T 1996-08-05 1997-07-24 Reactivos complejantes de compuestos boronicos y complejos altamente estables. Expired - Lifetime ES2185964T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/689,283 US5837878A (en) 1994-01-28 1996-08-05 Boronic compound complexing reagents and highly stable complexes
US08/691,930 US5777148A (en) 1994-01-28 1996-08-05 Boronic compound complexing reagents and highly stable complexes

Publications (1)

Publication Number Publication Date
ES2185964T3 true ES2185964T3 (es) 2003-05-01

Family

ID=27104375

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97935178T Expired - Lifetime ES2185964T3 (es) 1996-08-05 1997-07-24 Reactivos complejantes de compuestos boronicos y complejos altamente estables.

Country Status (12)

Country Link
EP (1) EP0915832B1 (es)
JP (1) JP2001501592A (es)
AT (1) ATE225330T1 (es)
AU (1) AU726875B2 (es)
CA (1) CA2262682A1 (es)
CY (1) CY2430B1 (es)
DE (1) DE69716085T2 (es)
DK (1) DK0915832T3 (es)
ES (1) ES2185964T3 (es)
PT (1) PT915832E (es)
RU (2) RU2001110940A (es)
WO (1) WO1998005627A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9902217A3 (en) * 1999-06-29 2002-07-29 Szegoe Peter Polycation based bioconjugates and process for producing thereof
AU7730500A (en) * 1999-09-30 2001-04-30 Nanogen, Inc. Biomolecular attachment sites on microelectronic arrays and methods thereof
WO2002081752A2 (en) * 2001-04-03 2002-10-17 Thermo Finnigan Corporation Methods and kits useful for the simplification of complex peptide mixtures
US6960298B2 (en) 2001-12-10 2005-11-01 Nanogen, Inc. Mesoporous permeation layers for use on active electronic matrix devices
US7098241B2 (en) 2002-12-16 2006-08-29 Hoffmann-La Roche Inc. Thiophene hydroxamic acid derivatives
US7332164B2 (en) * 2003-03-21 2008-02-19 Enzon Pharmaceuticals, Inc. Heterobifunctional polymeric bioconjugates
CN111729661B (zh) * 2020-06-09 2023-05-05 苏州赛分科技股份有限公司 用于分离含硼物质的层析介质
CN118496226B (zh) * 2024-04-11 2025-10-28 深圳威科森生物医药科技有限公司 具有烷硫基或烷二硫基的咪唑并喹啉化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3293252A (en) * 1963-03-20 1966-12-20 Squibb & Sons Inc Benzazaborinone derivatives and related compounds
CA2019335C (en) * 1989-06-27 2000-08-01 Mitoshi Konno Phenylalkan (en)oic acids
PT741734E (pt) * 1994-01-28 2001-09-28 Prolinx Inc Complexos de acido fenilboronico

Also Published As

Publication number Publication date
RU2001110940A (ru) 2003-02-10
DE69716085D1 (de) 2002-11-07
DE69716085T2 (de) 2003-06-12
JP2001501592A (ja) 2001-02-06
RU99103923A (ru) 2004-03-20
AU726875B2 (en) 2000-11-23
ATE225330T1 (de) 2002-10-15
EP0915832A1 (en) 1999-05-19
EP0915832B1 (en) 2002-10-02
CA2262682A1 (en) 1998-02-12
AU3817997A (en) 1998-02-25
DK0915832T3 (da) 2003-02-03
CY2430B1 (en) 2004-11-12
PT915832E (pt) 2003-02-28
RU2171250C2 (ru) 2001-07-27
WO1998005627A1 (en) 1998-02-12

Similar Documents

Publication Publication Date Title
EP2186910A3 (en) Methods and compositions for improved luminescence assays using microparticles
ES2103755T3 (es) Complejos metalicos de aductos de acidos con ligandos de dioxima utiles en marcacion de proteinas y otros compuestos que contienen amina.
DE60012485D1 (de) Salicylamid-lanthanid komplexe zur verwendung als lumineszenzmarker
FI880719L (fi) Homogeenisia fluorimetrisiä määritysmenetelmiä, joissa käytetään fluoresoivan taustan poissulkemista ja fluoroforeina vesiliukoisia harvinaisten maametallien kelaatteja
PT920413E (pt) Reagentes complexantes e complexos com compostos boronicos
DE69307495D1 (en) Oligothionukleotide
DE60123933D1 (de) Fluoreszierende proben zur quantitativen bestimmung von zink
BR0016380A (pt) Complexo metálico,processo de hidrossililação de olefinas ou de derivados acetilênicos e composição catalìtica
DE69534300D1 (de) Neues multimerisierendes reagenz
LU91252I2 (fr) Pegaptanib de préférence sous forme de son sel de sodium (MACUGENr)
EP1019414A4 (en) METHOD FOR PRODUCING ORGANIC BORONIC ACID DERIVATIVES WITH THE AID OF DIBORONIC ACID
DE69008371D1 (de) Zusammensetzungen für strapazierfähige, organische Siliciumverbindungen enthaltende Überzüge.
ES2185964T3 (es) Reactivos complejantes de compuestos boronicos y complejos altamente estables.
ES2158085T3 (es) Complejos de acido fenilboronico.
ES2148535T3 (es) Valoracion de glucoproteinas.
BR8805566A (pt) Composicao de metais nobres para decoracoes brilhantes e resistentes a microondas sobre pecas de louca
DE3750084D1 (de) Anordnung für Einführung von Vorrissen in Keramikproben.
EP0247848A3 (en) Water-compatible reducible compounds and their use in analytical compositions and methods
TR200200995T2 (tr) 7-amino-3-metksimetil-3-sefem-4-karbosilik asitin hazırlanmasına yönelik proses.
ATE226730T1 (de) Verfahren und reagenz zur störungsfreien bestimmung von eisen
ID27440A (id) Proses untuk menyiapkan penengah-penengah
ATE301664T1 (de) Boronsäurehaltige reagenzien und oligonukleotide
WO2001018548A3 (en) Protecting alkylating reagents used for quantifying homocysteine
IT1286879B1 (it) Leganti 1,3-difosfinopropanici e complessi da essi formati con metalli di transizione,loro preparazione e uso
TR199902447T2 (xx) Bir klav�lanik asit metal tuzunun haz�rlanma prosesi.