ES2158085T3 - Complejos de acido fenilboronico. - Google Patents

Complejos de acido fenilboronico.

Info

Publication number
ES2158085T3
ES2158085T3 ES95909329T ES95909329T ES2158085T3 ES 2158085 T3 ES2158085 T3 ES 2158085T3 ES 95909329 T ES95909329 T ES 95909329T ES 95909329 T ES95909329 T ES 95909329T ES 2158085 T3 ES2158085 T3 ES 2158085T3
Authority
ES
Spain
Prior art keywords
phenylboronic acid
bas
different
same
bioconjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95909329T
Other languages
English (en)
Inventor
Mark L Stolowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prolinx Inc
Original Assignee
Prolinx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/188,531 external-priority patent/US5594151A/en
Priority claimed from US08/189,176 external-priority patent/US5623055A/en
Priority claimed from US08/188,958 external-priority patent/US5594111A/en
Application filed by Prolinx Inc filed Critical Prolinx Inc
Application granted granted Critical
Publication of ES2158085T3 publication Critical patent/ES2158085T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA INVENCION PROPORCIONA NUEVOS COMPLEJOS BIOCONJUGADOS ENLAZANDO DOS ESPECIES BIOACTIVAS (QUE PUEDEN SER IGUALES O DIFERENTES) EN DONDE EL ENLACE COMPRENDE AL MENOS UN ATOMO DE BORO, P.EJ., AL MENOS UN COMPLEJO DE ACIDO FENILBORONICO. EL COMPLEJO BIOCONJUGADO DE LA INVENCION ES PREFERIBLEMENTE UN COMPUESTO DE LA FORMULA GENERAL (A) :BAS-L-BC-L`-(BC`L``){SUB,N}-BAS'', EN DONDE BAS Y BAS'' SON ESPECIES BIOACTIVAS (QUE PUEDEN SER IGUALES O DIFERENTES); L, L'', Y L`` Y ENLAZADORES (QUE PUEDEN SER IGUALES O DIFERENTES); BC Y BC'' SON COMPLEJOS DE ACIDO FENILBORONICO (LOS CUALES PUEDEN SER IGUALES O DIFERENTES) DE FORMULA D-E O E-D EN DONDE D ES UNA PORCION DE ACIDO FENILBORONICO Y E ES UNA PORCION COMPLEXANTE DE ACIDO FENILBORONICO, Y N ES 0 O 1. TAMBIEN SON PROPORCIONADOS REACTIVOS Y SEMICONJUGADOS PARA LA FABRICACION DE LOS COMPLEJOS BIOCONJUGADOS DE LA INVENCION, Y LOS MATERIALES NECESARIOS Y METODOS QUE UTILIZAN LOS COMPLEJOS BIOCONJUGADOS DE LA INVENCION.
ES95909329T 1994-01-28 1995-01-27 Complejos de acido fenilboronico. Expired - Lifetime ES2158085T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18846094A 1994-01-28 1994-01-28
US08/188,531 US5594151A (en) 1994-01-28 1994-01-28 Phenylboronic acid complexing reagents derived from aminosalicylic acid
US08/189,176 US5623055A (en) 1994-01-28 1994-01-28 Phenylboronic acid complexes derived from aminosalicylic acid for bioconjugate preparation
US08/188,958 US5594111A (en) 1994-01-28 1994-01-28 Phenylboronic acid complexes for bioconjugate preparation

Publications (1)

Publication Number Publication Date
ES2158085T3 true ES2158085T3 (es) 2001-09-01

Family

ID=27497759

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95909329T Expired - Lifetime ES2158085T3 (es) 1994-01-28 1995-01-27 Complejos de acido fenilboronico.

Country Status (15)

Country Link
EP (1) EP0741734B1 (es)
JP (1) JPH09508389A (es)
AT (1) ATE200292T1 (es)
AU (1) AU702017B2 (es)
CA (1) CA2181252A1 (es)
CZ (1) CZ220196A3 (es)
DE (1) DE69520561T2 (es)
DK (1) DK0741734T3 (es)
ES (1) ES2158085T3 (es)
GR (1) GR3036119T3 (es)
PL (1) PL315911A1 (es)
PT (1) PT741734E (es)
RU (1) RU2202555C2 (es)
SK (1) SK98996A3 (es)
WO (1) WO1995020591A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5777148A (en) * 1994-01-28 1998-07-07 Prolinx, Inc. Boronic compound complexing reagents and highly stable complexes
US5847192A (en) * 1994-01-28 1998-12-08 Prolinx, Inc. Boronic compound complexing reagents and complexes
US5831046A (en) * 1996-08-05 1998-11-03 Prolinx, Incorporated Boronic acid-contaning nucleic acid monomers
EP0915832B1 (en) * 1996-08-05 2002-10-02 Prolinx, Inc. Boronic compound complexing reagents and highly stable complexes
EP0920413B1 (en) * 1996-08-05 2002-11-13 Prolinx, Inc. Boronic compound complexing reagents and complexes
US6838238B1 (en) 1996-10-17 2005-01-04 Invitrogen Corporation Morphatides: novel shape and structure libraries
FR2758560B1 (fr) * 1997-01-20 2000-02-04 Adir Nouveaux derives d'acides aminophenylboronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2325399A1 (en) * 1998-03-23 1999-09-30 Invitrogen Corporation Modified nucleotides and methods useful for nucleic acid sequencing
US7208322B2 (en) * 2001-04-02 2007-04-24 Agilent Technologies, Inc. Sensor surfaces for detecting analytes
EP1921081A1 (en) * 2006-11-06 2008-05-14 Koninklijke Philips Electronics N.V. Use of arylboronic acids in protein labelling
US20130157926A1 (en) 2010-06-18 2013-06-20 Johannes Franciscus Joseph Engbersen Boronated polymers
US9732101B2 (en) 2012-01-18 2017-08-15 Wisconsin Alumni Research Foundation Bioreversible boronates for delivery of molecules into cells
US9234048B2 (en) 2012-01-18 2016-01-12 Wisconsin Alumni Research Foundation Boronate-mediated delivery of molecules into cells

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496722A (en) * 1981-05-01 1985-01-29 The Children's Medical Center Corporation Reporter compounds
NO890029D0 (no) * 1989-01-04 1989-01-04 Axis Research Nye modifiserte peptider og proteiner for in vitro diagnoser (diabetes).
GB9024775D0 (en) * 1990-11-14 1991-01-02 Axis Research Chemical compounds

Also Published As

Publication number Publication date
AU702017B2 (en) 1999-02-11
PL315911A1 (en) 1996-12-09
AU1732495A (en) 1995-08-15
ATE200292T1 (de) 2001-04-15
WO1995020591A1 (en) 1995-08-03
DE69520561D1 (de) 2001-05-10
EP0741734B1 (en) 2001-04-04
EP0741734A1 (en) 1996-11-13
DE69520561T2 (de) 2001-09-13
CA2181252A1 (en) 1995-08-03
JPH09508389A (ja) 1997-08-26
PT741734E (pt) 2001-09-28
GR3036119T3 (en) 2001-09-28
RU2202555C2 (ru) 2003-04-20
SK98996A3 (en) 1997-02-05
DK0741734T3 (da) 2001-07-30
CZ220196A3 (en) 1996-12-11

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