ES2186809T3 - Composiciones de vacunas para administracion intranasal, comprendiendo chitosana y su uso. - Google Patents

Composiciones de vacunas para administracion intranasal, comprendiendo chitosana y su uso.

Info

Publication number
ES2186809T3
ES2186809T3 ES96941743T ES96941743T ES2186809T3 ES 2186809 T3 ES2186809 T3 ES 2186809T3 ES 96941743 T ES96941743 T ES 96941743T ES 96941743 T ES96941743 T ES 96941743T ES 2186809 T3 ES2186809 T3 ES 2186809T3
Authority
ES
Spain
Prior art keywords
compositions
intranasal administration
chitosana
vaccines
understanding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96941743T
Other languages
English (en)
Inventor
Lisbeth Illum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Kirin Services Ltd
Original Assignee
West Pharmaceutical Services Drug Delivery and Clinical Research Center Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by West Pharmaceutical Services Drug Delivery and Clinical Research Center Ltd filed Critical West Pharmaceutical Services Drug Delivery and Clinical Research Center Ltd
Application granted granted Critical
Publication of ES2186809T3 publication Critical patent/ES2186809T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PROPORCIONAN COMPOSICIONES DE VACUNAS PARA ADMINISTRACION INTRANASAL, LAS CUALES COMPRENDEN UNO O MAS ANTIGENOS Y UNA CANTIDAD EFECTIVA COMO ADYUVANTE DE UN QUITOSAN.
ES96941743T 1995-12-07 1996-12-09 Composiciones de vacunas para administracion intranasal, comprendiendo chitosana y su uso. Expired - Lifetime ES2186809T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9525083.3A GB9525083D0 (en) 1995-12-07 1995-12-07 Vaccine compositions

Publications (1)

Publication Number Publication Date
ES2186809T3 true ES2186809T3 (es) 2003-05-16

Family

ID=10785093

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96941743T Expired - Lifetime ES2186809T3 (es) 1995-12-07 1996-12-09 Composiciones de vacunas para administracion intranasal, comprendiendo chitosana y su uso.

Country Status (13)

Country Link
US (2) US6391318B1 (es)
EP (1) EP0865297B1 (es)
JP (1) JP4063876B2 (es)
AT (1) ATE227134T1 (es)
CA (1) CA2237529C (es)
DE (1) DE69624726T2 (es)
DK (1) DK0865297T3 (es)
ES (1) ES2186809T3 (es)
GB (2) GB9525083D0 (es)
NO (1) NO323084B1 (es)
NZ (1) NZ323973A (es)
PT (1) PT865297E (es)
WO (1) WO1997020576A1 (es)

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AU762078B2 (en) * 1999-03-24 2003-06-19 Secretary Of State For Defence, The Vaccine composition
GB9914412D0 (en) * 1999-06-22 1999-08-18 Worrall Eric E Method for the preservation of viruses,bacteria and biomolecules
US20030206958A1 (en) * 2000-12-22 2003-11-06 Cattaneo Maurizio V. Chitosan biopolymer for the topical delivery of active agents
EP1315672A4 (en) 2000-06-22 2006-04-26 Rxkinetix Inc ADMINISTRATIVE COMPOSITION COMPOSITION AND METHOD FOR THE ADMINISTRATION OF ANTIGENES AND OTHER ACTIVE SUBSTANCES
AU2002210407A1 (en) * 2000-10-27 2002-05-06 Pharmexa A/S Therapeutic vaccine formulations containing chitosan
US6777000B2 (en) * 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
US7494669B2 (en) * 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
AU2002324124B2 (en) 2001-08-16 2007-01-04 Mucovax Inc. Chitin microparticles and their medical uses
CN100333792C (zh) 2001-09-28 2007-08-29 南佛罗里达大学 Rsv基因表达疫苗
EP1458362A4 (en) * 2001-11-19 2006-01-18 Becton Dickinson Co PHARMACEUTICAL COMPOSITIONS IN PARTICULAR FORM
MXPA04011249A (es) * 2002-05-14 2005-06-06 Chiron Srl Vacunas mucosales con adyuvante de quitosano y antigenos meningococicos.
CN1816350B (zh) * 2002-05-14 2010-11-10 莱顿大学 带有几丁聚糖佐剂和/或脑膜炎抗原的粘膜疫苗
GB0302218D0 (en) 2003-01-30 2003-03-05 Chiron Sri Vaccine formulation & Mucosal delivery
EP1539208A2 (en) * 2002-06-28 2005-06-15 Nastech Pharmaceutical Company Inc. Compositions and methods for modulating physiology of epithelial junctional adhesion molecules for enhanced mucosal delivery of therapeutic compounds
JP4675317B2 (ja) * 2003-01-30 2011-04-20 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド アジュバント化インフルエンザワクチン
JP2006516609A (ja) * 2003-01-30 2006-07-06 カイロン ソチエタ ア レスポンサビリタ リミタータ 粘膜髄膜炎菌性ワクチン
EP1594547A2 (en) 2003-02-14 2005-11-16 University Of South Florida Research Foundation, Inc. Chitosan-microparticles for ifn gene delivery
US8796235B2 (en) * 2003-02-21 2014-08-05 University Of South Florida Methods for attenuating dengue virus infection
WO2004098647A2 (en) * 2003-04-30 2004-11-18 Nastech Pharmaceutical Company Inc. Claudins’ underexpression as markers of tumor metastasis
JP2006525354A (ja) * 2003-05-01 2006-11-09 アルキメデス・ディヴェロップメント・リミテッド Ｌｈ−ｒｈアナログロイプロイドの経鼻投与
WO2005000222A2 (en) * 2003-05-30 2005-01-06 Amylin Pharmaceuticals, Inc. Novel methods and compositions for enhanced transmucosal delivery of peptides and proteins
GB0315632D0 (en) * 2003-07-04 2003-08-13 West Pharm Serv Drug Res Ltd Pharmaceutical formulations
WO2005056021A1 (en) * 2003-12-04 2005-06-23 University Of South Florida Polynucleotides for reducing respiratory syncytial virus gene expression
US7968122B2 (en) * 2003-12-10 2011-06-28 Adventrx Pharmaceuticals, Inc. Anti-viral pharmaceutical compositions
US20050129679A1 (en) * 2003-12-15 2005-06-16 Nastech Pharmaceutical Company Inc. Method for opening tight junctions
US7740883B2 (en) * 2004-03-28 2010-06-22 University Of Debrecen Nanoparticles from chitosan
AU2005240189A1 (en) * 2004-05-06 2005-11-17 Ivrea Pharmaceuticals, Inc. Particles for the delivery of active agents
US20090069226A1 (en) * 2004-05-28 2009-03-12 Amylin Pharmaceuticals, Inc. Transmucosal delivery of peptides and proteins
US20050283004A1 (en) * 2004-06-18 2005-12-22 Hopax Chemicals Manufacturing Co., Ltd. Alkylsulfonated polyaminosaccharides
CA2577336A1 (en) * 2004-09-15 2006-03-23 Otsuka Pharmaceutical Co., Ltd. Permucosal composition and method of improving permucosal absorption
US20070036867A1 (en) * 2005-05-23 2007-02-15 University Of South Florida Controlled and Sustained Gene Transfer Mediated by Thiol-Modified Polymers
US20080184618A1 (en) * 2005-08-03 2008-08-07 Amcol International Virus-Interacting Layered Phyllosilicates and Methods of Use
US20070031512A1 (en) * 2005-08-03 2007-02-08 Amcol International Corporation Virus-interacting layered phyllosilicates and methods of inactivating viruses
US20100272769A1 (en) * 2005-08-03 2010-10-28 Amcol International Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use
US8536324B2 (en) * 2005-10-21 2013-09-17 University Of South Florida Method of drug delivery by carbon nanotube-chitosan nanocomplexes
WO2007059605A1 (en) * 2005-11-04 2007-05-31 Bio Syntech Canada Inc. Composition and method for efficient delivery of nucleic acids to cells using chitosan
US7501452B2 (en) 2005-11-30 2009-03-10 Endo Pharmaceuticals Inc. Treatment of xerostomia
AU2007285472B2 (en) * 2006-03-30 2013-10-24 Engene, Inc. Non-viral compositions and methods for transfecting gut cells in vivo
CN101472598A (zh) 2006-06-20 2009-07-01 Cmp医疗有限公司 包含壳多糖微粒的组合物及其医药用途
WO2008042789A1 (en) 2006-09-29 2008-04-10 Ligocyte Pharmaceuticals, Inc. Norovirus vaccine formulations
EP2112923A1 (en) 2007-01-22 2009-11-04 Targacept Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
US20080182819A1 (en) * 2007-01-29 2008-07-31 Act Iii Licensing, Llc Chitosan compositions and methods for using chitosan compositions in the treatment of health disorders
ATE530178T1 (de) 2007-05-23 2011-11-15 Amcol International Corp Mit cholesterin interagierende phyllosilikate und verfahren zur reduktion von hypercholesterinämie bei einem säuger
US10130696B2 (en) 2007-09-18 2018-11-20 Takeda Vaccines, Inc. Method of conferring a protective immune response to norovirus
US20100266636A1 (en) 2007-09-18 2010-10-21 Ligocyte Pharmaceuticals, Inc. Method of conferring a protective immune response to norovirus
CN101969976A (zh) * 2008-01-11 2011-02-09 美国政府健康与人类服务部秘书处 针对分枝杆菌的多肽疫苗和接种策略
EP2257173B1 (en) 2008-02-27 2014-07-30 Amcol International Corporation Protonated hydrogen ion-exchanged layered phyllosilicate material for use in treating atherosclerosis
EP3382011A1 (en) 2008-08-08 2018-10-03 Takeda Vaccines, Inc. Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity
WO2010119112A1 (en) * 2009-04-15 2010-10-21 Ceva Sante Animale Recombinant avian herpes virus vectors and vaccine for immunizing waterfowl species
CN108567975A (zh) 2011-07-11 2018-09-25 武田疫苗股份有限公司 胃肠外诺如病毒疫苗配制剂
CA2871786C (en) 2012-04-24 2021-11-16 Ohio State Innovation Foundation Compositions and methods for treating and preventing porcine reproductive and respiratory syndrome
US10279028B2 (en) 2012-04-24 2019-05-07 Ohio State Innovation Foundation Compositions and methods for treating and preventing porcine reproductive and respiratory syndrome
CN108715607B (zh) * 2018-04-12 2021-12-10 华南农业大学 重组霍乱毒素b亚基蛋白、pedv灭活疫苗及制备与应用
CN109172817B (zh) * 2018-08-16 2021-10-26 华中农业大学 猪流行性腹泻病毒减毒活疫苗壳聚糖微球的制备方法及其应用
EP3698773A1 (en) 2019-02-21 2020-08-26 Università degli Studi di Parma Composition and manufacturing of powders containing nanoadjuvants for mucosal vaccination

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CA1261264A (en) * 1984-11-29 1989-09-26 Shigeo Suzuki Immunopotentiating agents and method
US4950740A (en) * 1987-03-17 1990-08-21 Cetus Corporation Recombinant diphtheria vaccines
GB8904370D0 (en) * 1989-02-25 1989-04-12 Cosmas Damian Ltd Liquid delivery compositions
US5554388A (en) * 1989-02-25 1996-09-10 Danbiosyst Uk Limited Systemic drug delivery compositions comprising a polycationi substance
GB9202464D0 (en) * 1992-02-05 1992-03-18 Danbiosyst Uk Composition for nasal administration
JP3365635B2 (ja) 1994-09-23 2003-01-14 ゾナジェン，インコーポレイテッド キトサン誘導性免疫強化
US5912000A (en) * 1994-09-23 1999-06-15 Zonagen, Inc. Chitosan induced immunopotentiation
GB9419979D0 (en) * 1994-10-04 1994-11-16 Medeva Holdings Bv Vaccine compositions
AU6400796A (en) * 1995-06-26 1997-01-30 Research Triangle Pharmaceuticals Limited Novel adjuvant compositions and vaccine formulations comprising same
GB9522351D0 (en) * 1995-11-01 1996-01-03 Medeva Holdings Bv Vaccine compositions

Also Published As

Publication number Publication date
US6391318B1 (en) 2002-05-21
US7323183B2 (en) 2008-01-29
PT865297E (pt) 2003-03-31
ATE227134T1 (de) 2002-11-15
NO982497D0 (no) 1998-06-02
JP4063876B2 (ja) 2008-03-19
DK0865297T3 (da) 2003-03-03
CA2237529C (en) 2008-10-14
GB2322801A (en) 1998-09-09
NO323084B1 (no) 2006-12-27
DE69624726D1 (de) 2002-12-12
NO982497L (no) 1998-06-02
US20030039665A1 (en) 2003-02-27
JP2000501412A (ja) 2000-02-08
GB9811810D0 (en) 1998-07-29
NZ323973A (en) 2004-12-24
AU705452B2 (en) 1999-05-20
AU1102597A (en) 1997-06-27
CA2237529A1 (en) 1997-06-12
EP0865297B1 (en) 2002-11-06
GB2322801B (en) 2000-01-19
EP0865297A1 (en) 1998-09-23
DE69624726T2 (de) 2003-09-18
WO1997020576A1 (en) 1997-06-12
GB9525083D0 (en) 1996-02-07

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