ES2187203T3 - Sistema conservante para composiciones farmaceuticas administrables topicamente que contiene un jabon de acido graso/aminoacido. - Google Patents

Sistema conservante para composiciones farmaceuticas administrables topicamente que contiene un jabon de acido graso/aminoacido.

Info

Publication number
ES2187203T3
ES2187203T3 ES99951564T ES99951564T ES2187203T3 ES 2187203 T3 ES2187203 T3 ES 2187203T3 ES 99951564 T ES99951564 T ES 99951564T ES 99951564 T ES99951564 T ES 99951564T ES 2187203 T3 ES2187203 T3 ES 2187203T3
Authority
ES
Spain
Prior art keywords
soap
amino acid
pharmaceutical compositions
grease
administrable pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99951564T
Other languages
English (en)
Inventor
Ernesto J Castillo
Steven Howard Gerson
Wesley Wehsin Han
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Application granted granted Critical
Publication of ES2187203T3 publication Critical patent/ES2187203T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)

Abstract

Una composición farmacéutica administrable tópicamente conservada, que comprende un sistema conservante en la que el sistema conservante consiste esencialmente en i) al menos un jabón de ácido graso/aminoácido que tiene un componente de ácido graso derivado de un ácido graso C8- C24, y un componente aminoácido seleccionado del grupo que consiste en lisina y arginina; ii) uno o más ácidos antifúngicos farmacéuticamente aceptables seleccionados del grupo que consiste en ácido bórico; ácido benzoico; ácido salicílico; ácido sórbico; ácido láctico; ácido acético; y sus sales farmacéuticamente aceptables; y iii) uno o más agentes quelantes farmacéuticamente aceptables seleccionados del grupo que consiste en ácido diaminoetilentetracético; ácido etilenglicol-bis-(b-aminoetiléter) N,N,N¿,N¿¿tetraacético; ácido 1,2-bis(2- aminofenoxi)etano-N,N,N¿,N¿-tetraacético; etilen-N,N¿- diglicocola; ácido 2,2¿-(etilendiimino)-dibutírico; y sus sales farmacéuticamente aceptables.
ES99951564T 1998-10-27 1999-09-21 Sistema conservante para composiciones farmaceuticas administrables topicamente que contiene un jabon de acido graso/aminoacido. Expired - Lifetime ES2187203T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10581998P 1998-10-27 1998-10-27

Publications (1)

Publication Number Publication Date
ES2187203T3 true ES2187203T3 (es) 2003-05-16

Family

ID=22307952

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99951564T Expired - Lifetime ES2187203T3 (es) 1998-10-27 1999-09-21 Sistema conservante para composiciones farmaceuticas administrables topicamente que contiene un jabon de acido graso/aminoacido.

Country Status (13)

Country Link
US (1) US6284749B1 (es)
EP (1) EP1124535B1 (es)
JP (1) JP2002528404A (es)
AT (1) ATE229324T1 (es)
AU (1) AU753462B2 (es)
BR (1) BR9914799A (es)
CA (1) CA2340225A1 (es)
DE (1) DE69904498T2 (es)
DK (1) DK1124535T3 (es)
ES (1) ES2187203T3 (es)
PT (1) PT1124535E (es)
TW (1) TW581688B (es)
WO (1) WO2000024375A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6444710B1 (en) 1998-10-27 2002-09-03 Alcon Manufacturing, Ltd. Use of certain fatty acid/amino acid soaps to enhance antimicrobial effectiveness of topically administrable pharmaceutical compositions
BR0014117A (pt) * 1999-09-21 2002-05-14 Alcon Lab Inc Uso de sabÈes de acido graxo/aminoácido para aumentar a eficácia antimicrobiana de composições farmacêutica tópicas
US6716970B2 (en) 2000-04-21 2004-04-06 Adjuvant Pharmaceuticals, Llc Water soluble, randomly substituted partial N-partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof
AU2001254819A1 (en) * 2001-04-28 2002-11-11 Lamirsa (Laboratorios Miret, S.A.) Antimicrobial composition comprising potassium sorbate and lae
TWI231759B (en) * 2001-06-27 2005-05-01 Alcon Inc Olopatadine formulations for topical administration
US6806213B2 (en) * 2001-12-20 2004-10-19 Kimberly-Clark Worldwide, Inc. Disposable wash cloth and method of using
DE60228615D1 (de) * 2001-12-21 2008-10-09 3M Innovative Properties Co Medizinische aerosolzusammensetzungen mit einer eine amid- und/oder estergruppe enthaltenden exzipientenverbindung
AU2002361850A1 (en) * 2001-12-21 2003-07-30 3M Innovative Properties Company Medicinal aerosol formulations comprising ion pair complexes
DE60231428D1 (de) * 2001-12-21 2009-04-16 3M Innovative Properties Co Medizinische aerosolzusammensetzungen mit einem funktionalisierten polyethylenglykol-hilfsstoff
JP4725699B2 (ja) * 2002-04-08 2011-07-13 ライオン株式会社 眼科用組成物及び眼科用組成物配合用防腐剤
JP2010031052A (ja) * 2002-04-08 2010-02-12 Lion Corp 眼科用組成物、及び眼科製剤用防腐組成物
WO2003086332A1 (en) * 2002-04-11 2003-10-23 Dvm Pharmaceuticals, Inc. Antimicrobial wash and carrier solutions, and uses thereof
US20040266776A1 (en) 2003-06-25 2004-12-30 Gil Daniel W. Methods of preventing and reducing the severity of stress-associated conditions
US8598219B2 (en) 2003-01-30 2013-12-03 Helsinn Healthcare Sa Liquid pharmaceutical formulations of palonosetron
JO2735B1 (en) * 2003-01-30 2013-09-15 هيلسين هيلث كير أس ايه. Liquid pharmaceutical formulations of palonosetron
TWI355936B (en) * 2003-02-18 2012-01-11 Helsinn Healthcare Sa Uses of palonosetron hydrochloride
US7125967B2 (en) * 2003-10-08 2006-10-24 Adjuvant Pharmaceuticals, Llc Water-soluble chitosan having low endotoxin concentration and methods for making and using the same
US20060167072A1 (en) * 2004-01-30 2006-07-27 Helsinn Healthcare Sa Liquid pharmaceutical formulations of palonosetron
ITCR20040004A1 (it) * 2004-02-05 2004-05-05 I C F Ind Chimica Fine S R L Detergente auricolare per animali, in particolare per cani e gatti
EP2219602A1 (en) 2007-11-15 2010-08-25 Amgen, Inc Aqueous formulation of erythropoiesis stimulating protein stablised by antioxidants for parenteral administration
EP2278953B1 (en) * 2008-05-28 2016-05-04 Alcon Research, Ltd Self-preserved emulsions
DE102009034771B4 (de) 2009-07-25 2011-09-01 Martin Schmitt Hautschutzmittel
WO2011017909A1 (zh) * 2009-08-12 2011-02-17 鲁南贝特制药有限公司 盐酸西替利嗪的药物溶液
CN106398905A (zh) * 2016-09-06 2017-02-15 佛山市芊茹化妆品有限公司 2‑氨基‑2‑甲基丙烷的羟基取代物在氨基酸透明皂中的应用

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Publication number Priority date Publication date Assignee Title
US3275503A (en) 1964-08-26 1966-09-27 Patterson Co C Method for the protection of loci susceptible to the growth of undesired microorganisms
US4380637A (en) 1978-11-30 1983-04-19 Johnson & Johnson/Mona Industries, Inc. Imidazoline phosphobetaines
US4485029A (en) 1984-03-19 1984-11-27 Minnesota Mining And Manufacturing Company Disinfecting method and compositions
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
DE3670569D1 (de) 1985-03-01 1990-05-31 Procter & Gamble Milder reinigungsschaum.
CA1302280C (en) 1986-04-21 1992-06-02 Jon Joseph Kabara Topical antimicrobial pharmaceutical compositions and methods
US5000868A (en) 1987-04-03 1991-03-19 Wittpenn Jr John R Surfactant compositions
US5093126A (en) 1987-09-26 1992-03-03 Alcon Laboratories, Inc. Glaucoma formulations comprising an anionic, polysulfonic acid polymer having mucomimetic properties and a polystyrene sulfonic polymer
JPH0665058A (ja) * 1992-08-24 1994-03-08 Pola Chem Ind Inc 洗浄剤組成物
US5520920A (en) * 1992-08-28 1996-05-28 Alcon Laboratories, Inc. Use of certain anionic surfactants to enhance antimicrobial effectiveness of ophthalmic compositions
US5504113A (en) 1994-03-02 1996-04-02 Allergan, Inc. Enhancement of benzalkonium chloride preservative activity in formulations containing an incompatible drug
US5536305A (en) 1994-06-08 1996-07-16 Yu; Bing Low leaching compositions for wood
DE69513170T2 (de) 1994-06-20 2000-03-09 Unilever N.V. Verbesserungen bezüglich antimikrobieller reinigungsmittel
AU3070395A (en) 1994-07-22 1996-02-22 Alcon Laboratories, Inc. Use of low molecular weight amino acids in ophthalmic compositions
US5494937A (en) 1994-07-22 1996-02-27 Alcon Laboratories, Inc. Saline solution for treating contact lenses
US5641480A (en) 1994-12-08 1997-06-24 Lever Brothers Company, Division Of Conopco, Inc. Hair care compositions comprising heteroatom containing alkyl aldonamide compounds

Also Published As

Publication number Publication date
PT1124535E (pt) 2003-04-30
AU753462B2 (en) 2002-10-17
US6284749B1 (en) 2001-09-04
AU6398199A (en) 2000-05-15
DK1124535T3 (da) 2003-01-06
CA2340225A1 (en) 2000-05-04
EP1124535B1 (en) 2002-12-11
JP2002528404A (ja) 2002-09-03
DE69904498T2 (de) 2003-04-24
TW581688B (en) 2004-04-01
ATE229324T1 (de) 2002-12-15
BR9914799A (pt) 2001-07-10
DE69904498D1 (de) 2003-01-23
EP1124535A1 (en) 2001-08-22
WO2000024375A1 (en) 2000-05-04

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