ES2187216T3 - Sistema de tratamiento de un microvolumen de lquido. - Google Patents

Sistema de tratamiento de un microvolumen de lquido.

Info

Publication number
ES2187216T3
ES2187216T3 ES99971352T ES99971352T ES2187216T3 ES 2187216 T3 ES2187216 T3 ES 2187216T3 ES 99971352 T ES99971352 T ES 99971352T ES 99971352 T ES99971352 T ES 99971352T ES 2187216 T3 ES2187216 T3 ES 2187216T3
Authority
ES
Spain
Prior art keywords
solvent
microarea
microchannel
reservoir
microvolumen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99971352T
Other languages
English (en)
Inventor
Marten Stjernstrom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gyros Protein Technologies AB
Original Assignee
Gyros AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyros AB filed Critical Gyros AB
Application granted granted Critical
Publication of ES2187216T3 publication Critical patent/ES2187216T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00079—Evaporation covers for slides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2525—Stabilizing or preserving
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25625—Dilution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

Abstract

Un dispositivo microfluídico que comprende un microcanal (2,4), que facilita el contacto del líquido entre una microárea de reacción abierta o una cámara de reacción que porta un microvolumen (1) de un disolvente y un depósito (3; 8) para el disolvente, formando parte dicho microvolumen y dicho disolvente del mencionado dispositivo microfluídico y dicho microvolumen comprende uno o más reactivos para producir una reacción en el disolvente presente en la microárea o en la cámara, y estando adaptados el mencionado depósito (3; 8) y el mencionado microcanal (2,4) para que el disolvente evaporado de la mencionada microárea se pueda sustituir de forma continuada por disolvente del depósito (3; 8) a través del mencionado microcanal (2, 4).
ES99971352T 1998-10-30 1999-10-29 Sistema de tratamiento de un microvolumen de lquido. Expired - Lifetime ES2187216T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9803734A SE9803734D0 (sv) 1998-10-30 1998-10-30 Liquid handling system

Publications (1)

Publication Number Publication Date
ES2187216T3 true ES2187216T3 (es) 2003-05-16

Family

ID=20413144

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99971352T Expired - Lifetime ES2187216T3 (es) 1998-10-30 1999-10-29 Sistema de tratamiento de un microvolumen de lquido.

Country Status (8)

Country Link
US (1) US7323345B1 (es)
EP (1) EP1124638B1 (es)
JP (1) JP2002528264A (es)
AT (1) ATE224231T1 (es)
DE (1) DE69903054T2 (es)
ES (1) ES2187216T3 (es)
SE (1) SE9803734D0 (es)
WO (1) WO2000025921A1 (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9808836D0 (en) * 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
US6555389B1 (en) 1999-05-11 2003-04-29 Aclara Biosciences, Inc. Sample evaporative control
SE9902474D0 (sv) 1999-06-30 1999-06-30 Amersham Pharm Biotech Ab Polymer valves
SE0004296D0 (sv) 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
US7759067B2 (en) 2001-03-19 2010-07-20 Gyros Patent Ab Method for determining the amount of an analyte with a disc-shaped microfluidic device
WO2002074438A2 (en) * 2001-03-19 2002-09-26 Gyros Ab Structural units that define fluidic functions
EP2269736B1 (en) 2001-08-28 2013-04-24 Gyros Patent Ab Retaining microfluidic microcavity and other microfluidic structures
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US7189368B2 (en) 2001-09-17 2007-03-13 Gyros Patent Ab Functional unit enabling controlled flow in a microfluidic device
US7459127B2 (en) 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
DE10222228A1 (de) 2002-05-16 2003-11-27 Roche Diagnostics Gmbh Mikropumpe mit Heizelementen für einen pulsierten Betrieb
US7094354B2 (en) 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
US7125711B2 (en) 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
JP4519124B2 (ja) 2003-01-30 2010-08-04 ユィロス・パテント・アクチボラグ 微小流動性デバイスの内部の壁
SE0300823D0 (sv) 2003-03-23 2003-03-23 Gyros Ab Preloaded Microscale Devices
JP2007502218A (ja) 2003-05-23 2007-02-08 ユィロス・パテント・アクチボラグ 親水性／疎水性表面
US7435381B2 (en) 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US7347617B2 (en) 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
DE10354806A1 (de) * 2003-11-21 2005-06-02 Boehringer Ingelheim Microparts Gmbh Probenträger
SE0400181D0 (sv) 2004-01-29 2004-01-29 Gyros Ab Segmented porous and preloaded microscale devices
EP1849005A1 (en) * 2005-01-17 2007-10-31 Gyros Patent Ab A method for detecting an at least bivalent analyte using two affinity reactants
US7998418B1 (en) * 2006-06-01 2011-08-16 Nanotek, Llc Evaporator and concentrator in reactor and loading system
WO2011137533A1 (en) 2010-05-05 2011-11-10 The Governing Council Of The University Of Toronto Method of processing dried samples using digital microfluidic device
US9993819B2 (en) 2014-12-30 2018-06-12 Stmicroelectronics S.R.L. Apparatus for actuating and reading a centrifugal microfluidic disk for biological and biochemical analyses, and use of the apparatus
WO2016197106A1 (en) 2015-06-05 2016-12-08 Miroculus Inc. Evaporation management in digital microfluidic devices
US10464067B2 (en) 2015-06-05 2019-11-05 Miroculus Inc. Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling
JP2020501107A (ja) 2016-08-22 2020-01-16 ミロキュラス インコーポレイテッド デジタルマイクロ流体デバイスにおける並行小滴制御のためのフィードバックシステム
WO2018126082A1 (en) 2016-12-28 2018-07-05 Miroculis Inc. Digital microfluidic devices and methods
WO2018156460A1 (en) * 2017-02-22 2018-08-30 The Trustees Of Columbia University In The City Of New York Method and apparatus for computer-vision guided targeted delivery of small liquid volumes into selected lung regions
US11623219B2 (en) 2017-04-04 2023-04-11 Miroculus Inc. Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets
WO2019023133A1 (en) 2017-07-24 2019-01-31 Miroculus Inc. DIGITAL MICROFLUIDIC SYSTEMS AND METHODS WITH INTEGRATED PLASMA COLLECTION DEVICE
JP7341124B2 (ja) 2017-09-01 2023-09-08 ミロキュラス インコーポレイテッド デジタルマイクロ流体デバイスおよびその使用方法
WO2019226919A1 (en) 2018-05-23 2019-11-28 Miroculus Inc. Control of evaporation in digital microfluidics
CN113543883A (zh) 2019-01-31 2021-10-22 米罗库鲁斯公司 非结垢组合物以及用于操控和处理包封的微滴的方法
WO2020176816A1 (en) 2019-02-28 2020-09-03 Miroculus Inc. Digital microfluidics devices and methods of using them
CN119158636A (zh) 2019-04-08 2024-12-20 米罗库鲁斯公司 多盒式数字微流控装置和使用方法
WO2021016614A1 (en) 2019-07-25 2021-01-28 Miroculus Inc. Digital microfluidics devices and methods of use thereof
CN114279907B (zh) * 2021-12-14 2022-11-15 中国科学院地质与地球物理研究所 一种月尘颗粒样品的无损筛分系统及其筛分方法
US11857961B2 (en) 2022-01-12 2024-01-02 Miroculus Inc. Sequencing by synthesis using mechanical compression

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507463A (en) * 1983-05-11 1985-03-26 Ciba-Geigy Corporation Process for producing polyesters from aliphatic dicarboxylic acids and polyalkylpiperidyldiols
US4659677A (en) 1983-05-26 1987-04-21 Eastman Kodak Company Method providing liquid mixing outside containers
CA1333850C (en) 1987-08-27 1995-01-10 Michael M. Gorin Apparatus and method for dilution and mixing of liquid samples
GB8816443D0 (en) * 1988-07-11 1988-08-17 Albright & Wilson Liquid enzymatic detergents
AU642444B2 (en) * 1989-11-30 1993-10-21 Mochida Pharmaceutical Co., Ltd. Reaction vessel
US5171989A (en) * 1992-01-24 1992-12-15 Board Of Trustees Of Leland Stanford Jr. University Method and apparatus for continuous sample ice matrix production for laser desorption in mass spectrometry
CA2143365A1 (en) * 1994-03-14 1995-09-15 Hugh V. Cottingham Nucleic acid amplification method and apparatus
DE69533554T2 (de) * 1994-11-10 2005-01-27 Orchid Biosciences, Inc. Flüssigkeitsverteilungssystem
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US6143247A (en) * 1996-12-20 2000-11-07 Gamera Bioscience Inc. Affinity binding-based system for detecting particulates in a fluid
US5785926A (en) 1995-09-19 1998-07-28 University Of Washington Precision small volume fluid processing apparatus
US20010055812A1 (en) * 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US5879632A (en) * 1996-04-09 1999-03-09 Sarnoff Corporation Apportioning system
US6033544A (en) * 1996-10-11 2000-03-07 Sarnoff Corporation Liquid distribution system
US5863801A (en) * 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
US6143248A (en) * 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
SE9700207D0 (sv) 1997-01-24 1997-01-24 Erik Litborn A method of preventing evaporation from liquid samples in small volumes
US6090251A (en) * 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
CA2330119C (en) 1998-03-04 2008-01-15 Ortho-Mcneil Pharmaceutical, Inc. System for performing assays on a levitated droplet
US6086740A (en) * 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US6416642B1 (en) * 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
US6555389B1 (en) 1999-05-11 2003-04-29 Aclara Biosciences, Inc. Sample evaporative control
US6642061B2 (en) * 2000-09-25 2003-11-04 Picoliter Inc. Use of immiscible fluids in droplet ejection through application of focused acoustic energy

Also Published As

Publication number Publication date
JP2002528264A (ja) 2002-09-03
SE9803734D0 (sv) 1998-10-30
DE69903054D1 (de) 2002-10-24
ATE224231T1 (de) 2002-10-15
DE69903054T2 (de) 2003-04-24
EP1124638B1 (en) 2002-09-18
WO2000025921A1 (en) 2000-05-11
EP1124638A1 (en) 2001-08-22
US7323345B1 (en) 2008-01-29

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