ES2188509T3 - N-oxidos triciclicos de piridina como agonistas de la vasopresina. - Google Patents
N-oxidos triciclicos de piridina como agonistas de la vasopresina.Info
- Publication number
- ES2188509T3 ES2188509T3 ES00906915T ES00906915T ES2188509T3 ES 2188509 T3 ES2188509 T3 ES 2188509T3 ES 00906915 T ES00906915 T ES 00906915T ES 00906915 T ES00906915 T ES 00906915T ES 2188509 T3 ES2188509 T3 ES 2188509T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- chain alkyl
- branched chain
- hydrogen
- vasopresine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000556 agonist Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 14
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Compuesto de fórmula general (I):**(Fórmula)** en la que: R1 se selecciona a partir del grupo formado por:**(Fórmula)** R2, R3 y R5 son, independientemente, hidrógeno, alquilo de cadena lineal de 1 a 6 átomos de carbono, alquilo de cadena ramificada de 3 a 7 átomos de carbono, cicloalquilo de 3 a 7 átomos de carbono, o perfluoroalquilo de 1 a 6 carbonos; R4 es hidrógeno, alquilo de cadena lineal de 1 a 6 átomos de carbono, alquilo de cadena ramificada de 3 a 7 átomos de carbono, cicloalquilo de 3 a 7 átomos de carbono, o un aralquilo opcionalmente sustituido de 7 a 15 átomos de carbono; X e Y son, independientemente, hidrógeno, alquilo de cadena lineal de 1 a 6 átomos de carbono, alquilo de cadena ramificada de 3 a 7 átomos de carbono, cicloalquilo de 3 a 7 átomos de carbono, alcoxialquilo de 2 a 7 átomos de carbono, halógeno, alcoxi de cadena lineal o ramificada de 1 a 6 átomos de carbono, CF3, o perfluoroalquilo de 2 a 6 carbonos; y Z es hidrógeno o un grupo alquilo de cadena lineal de 1a 6 átomos de carbono, o alquilo de cadena ramificada de 3 a 7 átomos de carbono.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24468099A | 1999-02-04 | 1999-02-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2188509T3 true ES2188509T3 (es) | 2003-07-01 |
Family
ID=22923704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00906915T Expired - Lifetime ES2188509T3 (es) | 1999-02-04 | 2000-01-13 | N-oxidos triciclicos de piridina como agonistas de la vasopresina. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1149096B1 (es) |
| JP (1) | JP2002536374A (es) |
| CN (1) | CN1347415A (es) |
| AR (1) | AR020559A1 (es) |
| AT (1) | ATE229956T1 (es) |
| AU (1) | AU2849500A (es) |
| CA (1) | CA2358894A1 (es) |
| DE (1) | DE60001054T2 (es) |
| DK (1) | DK1149096T3 (es) |
| ES (1) | ES2188509T3 (es) |
| PT (1) | PT1149096E (es) |
| WO (1) | WO2000046224A2 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6455554B1 (en) | 1999-06-07 | 2002-09-24 | Targacept, Inc. | Oxopyridinyl pharmaceutical compositions and methods for use |
| GB0115515D0 (en) * | 2001-06-25 | 2001-08-15 | Ferring Bv | Oxytocin agonisys |
| SI1619185T1 (sl) | 2003-04-28 | 2011-09-30 | Astellas Pharma Inc | 4,4-difluoro-1,2,3,4-tetrahidro-5H-1-benzazepinski derivat ali njegova sol |
| TWI436988B (zh) * | 2007-03-05 | 2014-05-11 | Transform Pharmaceuticals Inc | ７-〔（３-氯-６，１１-二氫-６-甲基二苯并〔ｃ，ｆ〕〔１，２〕噻氮呯-１１-基）胺〕庚酸ｓ，ｓ二氧化物之多晶型及其製造與使用方法 |
| GB201005623D0 (en) | 2010-04-01 | 2010-05-19 | Vantia Ltd | New polymorph |
| CN105102448B (zh) | 2013-02-28 | 2018-03-06 | 百时美施贵宝公司 | 作为rock1和rock2抑制剂的苯基吡唑衍生物 |
| AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849735A (en) * | 1995-01-17 | 1998-12-15 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| AU8592598A (en) * | 1997-07-30 | 1999-02-22 | Wyeth | Tricyclic vasopressin agonists |
-
2000
- 2000-01-13 DE DE60001054T patent/DE60001054T2/de not_active Expired - Fee Related
- 2000-01-13 PT PT00906915T patent/PT1149096E/pt unknown
- 2000-01-13 DK DK00906915T patent/DK1149096T3/da active
- 2000-01-13 EP EP00906915A patent/EP1149096B1/en not_active Expired - Lifetime
- 2000-01-13 CN CN00805995A patent/CN1347415A/zh active Pending
- 2000-01-13 ES ES00906915T patent/ES2188509T3/es not_active Expired - Lifetime
- 2000-01-13 AT AT00906915T patent/ATE229956T1/de not_active IP Right Cessation
- 2000-01-13 AU AU28495/00A patent/AU2849500A/en not_active Abandoned
- 2000-01-13 WO PCT/US2000/000885 patent/WO2000046224A2/en not_active Ceased
- 2000-01-13 CA CA002358894A patent/CA2358894A1/en not_active Abandoned
- 2000-01-13 JP JP2000597294A patent/JP2002536374A/ja active Pending
- 2000-02-03 AR ARP000100464A patent/AR020559A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1347415A (zh) | 2002-05-01 |
| JP2002536374A (ja) | 2002-10-29 |
| AU2849500A (en) | 2000-08-25 |
| EP1149096A2 (en) | 2001-10-31 |
| CA2358894A1 (en) | 2000-08-10 |
| WO2000046224A2 (en) | 2000-08-10 |
| DE60001054T2 (de) | 2003-07-24 |
| ATE229956T1 (de) | 2003-01-15 |
| DK1149096T3 (da) | 2003-04-07 |
| PT1149096E (pt) | 2003-03-31 |
| WO2000046224A3 (en) | 2000-12-07 |
| EP1149096B1 (en) | 2002-12-18 |
| AR020559A1 (es) | 2002-05-15 |
| DE60001054D1 (de) | 2003-01-30 |
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