ATE543515T1 - Konjugate von hydroxyalkyl-stärke und einer wirksubstanz, hergestellt durch chemische ligation über thiazolidin - Google Patents

Konjugate von hydroxyalkyl-stärke und einer wirksubstanz, hergestellt durch chemische ligation über thiazolidin

Info

Publication number
ATE543515T1
ATE543515T1 AT06791990T AT06791990T ATE543515T1 AT E543515 T1 ATE543515 T1 AT E543515T1 AT 06791990 T AT06791990 T AT 06791990T AT 06791990 T AT06791990 T AT 06791990T AT E543515 T1 ATE543515 T1 AT E543515T1
Authority
AT
Austria
Prior art keywords
conjugates
active substance
hydroxyalkyl starch
thiazolidine
chemical ligation
Prior art date
Application number
AT06791990T
Other languages
English (en)
Inventor
Norbert Zander
Helmut Knoller
Original Assignee
Fresenius Kabi De Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Kabi De Gmbh filed Critical Fresenius Kabi De Gmbh
Application granted granted Critical
Publication of ATE543515T1 publication Critical patent/ATE543515T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Materials Engineering (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT06791990T 2005-09-12 2006-09-12 Konjugate von hydroxyalkyl-stärke und einer wirksubstanz, hergestellt durch chemische ligation über thiazolidin ATE543515T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05019768A EP1762250A1 (de) 2005-09-12 2005-09-12 Konjugate welche durch chemische Ligation zwischen Hydroxyalkylstärken und aktiven Substanzen mit Bildung eines Thiazolidin-Ringes entstehen
PCT/EP2006/008858 WO2007031266A2 (en) 2005-09-12 2006-09-12 Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine

Publications (1)

Publication Number Publication Date
ATE543515T1 true ATE543515T1 (de) 2012-02-15

Family

ID=35426984

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06791990T ATE543515T1 (de) 2005-09-12 2006-09-12 Konjugate von hydroxyalkyl-stärke und einer wirksubstanz, hergestellt durch chemische ligation über thiazolidin

Country Status (14)

Country Link
US (1) US20080207562A1 (de)
EP (2) EP1762250A1 (de)
JP (1) JP5242398B2 (de)
KR (1) KR20080065602A (de)
CN (2) CN101262889B (de)
AT (1) ATE543515T1 (de)
AU (1) AU2006291527B2 (de)
BR (1) BRPI0615732A2 (de)
CA (1) CA2619036A1 (de)
EA (1) EA013910B1 (de)
ES (1) ES2382303T3 (de)
IL (1) IL189466A0 (de)
WO (1) WO2007031266A2 (de)
ZA (1) ZA200802252B (de)

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PL1660134T3 (pl) * 2003-08-08 2011-05-31 Fresenius Kabi Deutschland Gmbh Koniugaty hydroksyalkiloskrobi i G-CSF
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CN102245572B (zh) * 2008-12-11 2015-03-25 盐野义制药株式会社 氨甲酰基吡啶酮hiv整合酶抑制剂的方法和中间体
TWI518084B (zh) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
TWI582097B (zh) 2010-03-23 2017-05-11 Ｖｉｉｖ醫療保健公司 製備胺甲醯吡啶酮衍生物及中間體之方法
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CN113214620B (zh) * 2021-05-25 2022-06-21 湖北工业大学 一种环氧基有机改性蒙脱土的制备方法及应用
CN115385973B (zh) * 2022-07-13 2023-06-06 康龙化成(宁波)科技发展有限公司 寡聚核酸-四氢噻唑类化合物在基因编码化合物库合成上的应用
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EP2070950A1 (de) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkylstärkederivate und deren Herstellungsverfahren
EP2070951A1 (de) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Verfahren zur Herstellung eines Hydroxyalkylstärkederivats mit zwei Linkern

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AU2006291527A1 (en) 2007-03-22
CN101262889B (zh) 2013-02-06
BRPI0615732A2 (pt) 2011-05-24
EP1933878B1 (de) 2012-02-01
KR20080065602A (ko) 2008-07-14
IL189466A0 (en) 2008-08-07
JP5242398B2 (ja) 2013-07-24
CN102492047A (zh) 2012-06-13
EA200800822A1 (ru) 2008-08-29
HK1119395A1 (en) 2009-03-06
WO2007031266A3 (en) 2007-09-20
EP1762250A1 (de) 2007-03-14
WO2007031266A2 (en) 2007-03-22
JP2009507973A (ja) 2009-02-26
EA013910B1 (ru) 2010-08-30
ES2382303T3 (es) 2012-06-07
ZA200802252B (en) 2009-08-26
CN101262889A (zh) 2008-09-10
US20080207562A1 (en) 2008-08-28
EP1933878A2 (de) 2008-06-25
CA2619036A1 (en) 2007-03-22
AU2006291527B2 (en) 2012-03-22

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