ES2188515T3 - Derivados de 22r-hidroxicolesta-8,14-dieno con actividad inhibidora de la meiosis. - Google Patents

Derivados de 22r-hidroxicolesta-8,14-dieno con actividad inhibidora de la meiosis.

Info

Publication number
ES2188515T3
ES2188515T3 ES00910752T ES00910752T ES2188515T3 ES 2188515 T3 ES2188515 T3 ES 2188515T3 ES 00910752 T ES00910752 T ES 00910752T ES 00910752 T ES00910752 T ES 00910752T ES 2188515 T3 ES2188515 T3 ES 2188515T3
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
hydroxicolesta
dieno
meiosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00910752T
Other languages
English (en)
Inventor
Dirk Leysen
Van Der Jaap Louw
Robert Gerard Jules Marie Hanssen
Anja Wiersma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of ES2188515T3 publication Critical patent/ES2188515T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un derivado de 22R-hidroxicolesta-8, 14-dieno que tiene la fórmula general I**(Fórmula)** donde R1 es OR, OSO3H o =NOR; siendo R H, alquilo C1-C6 o acilo C1-C6; cada uno de R2 y R3 es independientemente hidrógeno o alquilo C1-C6; R4 es hidrógeno, alquilo C1-C6 o acilo C1-C6; R5 es hidrógeno; o R5 designa, junto con R6, un enlace adicional entre los átomos de carbono en los que están colocados R5 y R6; R6 es hidrógeno, hidroxi o halógeno; o R6 designa, junto con R5, un enlace adicional entre los átomos de carbono en los que están colocados R6 y R5; cada uno de R7 y R8 es independientemente hidrógeno o alquilo C1-C4, opcionalmente sustituido con OH, alcoxi C1-C4, o halógeno; o una sal farmacéuticamente aceptable del mismo.
ES00910752T 1999-03-09 2000-03-03 Derivados de 22r-hidroxicolesta-8,14-dieno con actividad inhibidora de la meiosis. Expired - Lifetime ES2188515T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99200680 1999-03-09

Publications (1)

Publication Number Publication Date
ES2188515T3 true ES2188515T3 (es) 2003-07-01

Family

ID=8239958

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00910752T Expired - Lifetime ES2188515T3 (es) 1999-03-09 2000-03-03 Derivados de 22r-hidroxicolesta-8,14-dieno con actividad inhibidora de la meiosis.

Country Status (9)

Country Link
US (1) US6518262B1 (es)
EP (1) EP1163258B1 (es)
JP (1) JP2002539134A (es)
AT (1) ATE229538T1 (es)
AU (1) AU3285000A (es)
DE (1) DE60000978T2 (es)
DK (1) DK1163258T3 (es)
ES (1) ES2188515T3 (es)
WO (1) WO2000053618A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2204613T3 (es) * 1999-04-06 2004-05-01 Akzo Nobel N.V. Androgenos 7-alfa alquilo oralmente activos.
GB9930533D0 (en) * 1999-12-23 2000-02-16 Mitsubishi Tokyo Pharm Inc Nucleic acid delivery
JP2003529378A (ja) * 2000-04-06 2003-10-07 ノボ ノルディスク アクティーゼルスカブ 卵母細胞の細胞質および核成熟の体外成熟方法
US9532994B2 (en) 2003-08-29 2017-01-03 The Regents Of The University Of California Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
AU2007217366A1 (en) 2006-02-27 2007-08-30 The Regents Of The University Of California Oxysterol compounds and the hedgehog pathway
US9526737B2 (en) 2007-12-03 2016-12-27 The Regents Of The University Of California Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling
CA2872751A1 (en) 2012-05-07 2013-11-14 The Regents Of The University Of California Oxysterol analogue oxy133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis
JP2016517888A (ja) 2013-05-02 2016-06-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 骨選択的骨形成のオキシステロール骨標的薬剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH643566A5 (de) * 1977-08-29 1984-06-15 Searle & Co 25-alkylcholesterin-derivate.
US5716777A (en) * 1994-06-23 1998-02-10 Novo Nordisk A/S Regulation of meiosis using sterols
EP0813595A1 (en) * 1995-03-06 1997-12-29 Novo Nordisk A/S Stimulation of meiosis
EP0946584B1 (en) * 1996-12-20 2003-04-23 Novo Nordisk A/S Meiosis regulating compounds

Also Published As

Publication number Publication date
DE60000978T2 (de) 2003-07-17
DE60000978D1 (de) 2003-01-23
EP1163258B1 (en) 2002-12-11
JP2002539134A (ja) 2002-11-19
AU3285000A (en) 2000-09-28
ATE229538T1 (de) 2002-12-15
US6518262B1 (en) 2003-02-11
EP1163258A1 (en) 2001-12-19
WO2000053618A1 (en) 2000-09-14
DK1163258T3 (da) 2003-03-31

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