ES2188808T3 - Aldehido deshidrogenasa. - Google Patents

Aldehido deshidrogenasa.

Info

Publication number
ES2188808T3
ES2188808T3 ES97102079T ES97102079T ES2188808T3 ES 2188808 T3 ES2188808 T3 ES 2188808T3 ES 97102079 T ES97102079 T ES 97102079T ES 97102079 T ES97102079 T ES 97102079T ES 2188808 T3 ES2188808 T3 ES 2188808T3
Authority
ES
Spain
Prior art keywords
aldehyde dehydrogenase
microorganism
aldehyde
gluconobacter
sorbosone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97102079T
Other languages
English (en)
Inventor
Tatsuo Hoshino
Teruhide Sugisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2188808T3 publication Critical patent/ES2188808T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Cereal-Derived Products (AREA)
  • Amplifiers (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UNA NUEVA DESHIDROGENASA DE ALDEHIDO QUE TIENE LAS PROPIEDADES FISICO-QUIMICAS DE: -PESO MOLECULAR: 91.000 (MAS MENOS) 5.000; ESPECIFICIDAD DE SUSTRATO: ACTIVA EN COMPUESTOS DE ALDEHIDO; INHIBICION: POR CU{SUP,2+}, ZN{SUP,2+}, NI{SUP,2+} Y EDTA; PH OPTIMO: 6.0-8.5; TEMPERATURA OPTIMA: 20-40 (GRADOS) C; Y ESTIMULADOR; CA{SUP,2+} Y PQQ, ESTA DERIVADO DE UN MICROORGANISMO QUE PERTENECE AL GENERO GLUCONOBACTER. DICHA DESHIDROGENASA DE ALDEHIDO PUEDE SER PRODUCIDA MEDIANTE EL CULTIVO DE UN MICROORGANISMO DEL GENERO GLUCONOBACTER QUE ES CAPAZ DE PRODUCIR DESHIDROGENASA DE ALDEHIDO QUE TIENEN LAS PROPIEDADES ANTERIORES, EN UN MEDIO NUTRIENTE ACUOSO BAJO CONDICIONES AEROBICAS, INTERRUMPIENDO LAS CELULAS DEL MICROORGANISMO Y AISLANDO Y PURIFICANDO LA DESHIDROGENASA DE ALDEHIDO DEL EXTRACTO LIBRE DE CELULA DE LAS CELULAS INTERRUMPIDAS DEL MICROORGANISMO. PUEDE PRODUCIRSE ACIDO 2-CETO-L-GULONICO (2-KGA) A PARTIR DE LSORBOSONA MEDIANTE EL CONTACTO DE L-SORBOSONA CON (I) LA DESHIDROGENASA DE ALDEHIDO ENPRESENCIA DE UN ACEPTOR DE ELECTRONES, (II) UN MICROORGANISMO DE GLUCONOBACTER CAPAZ DE PRODUCIR LA DESHIDROGENASA DE ALDEHIDO EN UN MEDIO ACUOSO BAJO CONDICIONES AEROBICAS O (III) UN EXTRACTO LIBRE DE CELULA DE DICHO MICROORGANISMO, EN CADA CASO AISLANDO EL 2-KGA RESULTANTE DE LA MEZCLA DE REACCION.
ES97102079T 1996-02-19 1997-02-10 Aldehido deshidrogenasa. Expired - Lifetime ES2188808T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96102440 1996-02-19

Publications (1)

Publication Number Publication Date
ES2188808T3 true ES2188808T3 (es) 2003-07-01

Family

ID=8222487

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97102079T Expired - Lifetime ES2188808T3 (es) 1996-02-19 1997-02-10 Aldehido deshidrogenasa.

Country Status (9)

Country Link
US (1) US5776742A (es)
EP (1) EP0790301B1 (es)
JP (1) JPH09224660A (es)
CN (1) CN1099461C (es)
AT (1) ATE231183T1 (es)
DE (1) DE69718360T2 (es)
DK (1) DK0790301T3 (es)
ES (1) ES2188808T3 (es)
ID (1) ID15955A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0922759B1 (en) * 1997-12-01 2004-01-28 F. Hoffmann-La Roche Ag Aldehyde dehydrogenase
CN1314799C (zh) * 2002-04-22 2007-05-09 Dsmip资产有限公司 醛脱氢酶ii
KR101070110B1 (ko) * 2002-09-27 2011-10-05 디에스엠 아이피 어셋츠 비.브이. 알데히드 데하이드로게나제 유전자
WO2011145518A1 (ja) * 2010-05-18 2011-11-24 国立大学法人東北大学 アルデヒド除去組成物
CN106047826B (zh) * 2016-07-06 2019-08-20 华东理工大学 醛脱氢酶、其重组表达转化体及在他汀前体合成中的应用
CN118477686B (zh) * 2024-05-08 2025-09-12 安阳师范学院 一种有机分子模拟酶及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907639A (en) * 1972-08-31 1975-09-23 Hoffmann La Roche Method for producing 2-keto-L-gulonic acid
DK270087A (da) * 1986-06-03 1987-12-04 Hoffmann La Roche Enzym og fremgangsmaade til fremstilling deraf
US5085993A (en) * 1987-12-24 1992-02-04 Hoffmann-La Roche Inc. Coenzyme-independent l-sorbosone dehydrogenase from pseudomonas putida
EP0373181B1 (en) * 1988-01-14 1995-11-08 F. Hoffmann-La Roche Ag Novel coenzyme independent l-sorbosone dehydrogenase
RU2102481C1 (ru) * 1991-06-13 1998-01-20 Ф.Хоффманн-Ля Рош, Аг Способ получения 2-кето-l-гулоновой кислоты или ее соли
US5437989A (en) * 1992-12-30 1995-08-01 Hoffmann-La Roche Inc. Alcohol/aldehyde dehydrogenase from Gluconobacter oxydans DSM 4025 FERM BP-3812

Also Published As

Publication number Publication date
JPH09224660A (ja) 1997-09-02
DE69718360T2 (de) 2003-10-16
CN1171441A (zh) 1998-01-28
EP0790301A2 (en) 1997-08-20
DE69718360D1 (de) 2003-02-20
DK0790301T3 (da) 2003-05-05
EP0790301A3 (en) 1999-02-10
ATE231183T1 (de) 2003-02-15
US5776742A (en) 1998-07-07
CN1099461C (zh) 2003-01-22
ID15955A (id) 1997-08-21
EP0790301B1 (en) 2003-01-15

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