ES2189356T3 - Furopiridinas antibactericidas. - Google Patents

Furopiridinas antibactericidas.

Info

Publication number
ES2189356T3
ES2189356T3 ES99308611T ES99308611T ES2189356T3 ES 2189356 T3 ES2189356 T3 ES 2189356T3 ES 99308611 T ES99308611 T ES 99308611T ES 99308611 T ES99308611 T ES 99308611T ES 2189356 T3 ES2189356 T3 ES 2189356T3
Authority
ES
Spain
Prior art keywords
hydroxy
alkenyl
proviso
hydroxymethyl
absent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99308611T
Other languages
English (en)
Inventor
Yutaka Sugie
Susan Jane Truesdell
John Wing Wong
Nobuji Yoshikawa
Akemi Sugiura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2189356T3 publication Critical patent/ES2189356T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Esta invención proporciona un compuesto de fórmula (I): o sales farmacéuticamente aceptables del mismo, en la que X{sup,1} y X{sup,2} son C o N, respectivamente; R{sup,1} y R{sup,2} son, independientemente, fenilo opcionalmente sustituido con un grupo hidroxi siempre y cuando X{sup,1} y X{sup,2} no sean C o N al mismo tiempo, cuando X{sup,1} sea N, R{sup,1} no se encuentre presente y cuando X{sup,2} sea N, R{sup,2} no se encuentre presente; R{sup,3} es metilo o hidroximetilo; R{sup,4} es formilo, hidroximetilo o hidroxialquenilo C{sub,3-6}; R{sup,5} es hidroxi, alquenilo C{sub,3-6} o hidroxialquenilo C{sub,3-6}; o R{sup,4} y R{sup,5}, junto con los átomos de carbono del anillo de furopiridina al que están unidos, pueden formar el anillo siguiente (a fusionar con el anillo de furopiridina): con la condición de que si R{sup,3} es metilo y R{sup,5} es 2-buten-2-ilo, X{sup,2} no sea N. Estos compuestos y las composiciones farmacéuticas que los contienen son útiles en el tratamiento de enfermedades infecciosas provocadas por bacterias.
ES99308611T 1998-11-02 1999-10-29 Furopiridinas antibactericidas. Expired - Lifetime ES2189356T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9801748 1998-11-02

Publications (1)

Publication Number Publication Date
ES2189356T3 true ES2189356T3 (es) 2003-07-01

Family

ID=11004771

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99308611T Expired - Lifetime ES2189356T3 (es) 1998-11-02 1999-10-29 Furopiridinas antibactericidas.

Country Status (7)

Country Link
EP (1) EP0999212B1 (es)
JP (2) JP3564543B2 (es)
AT (1) ATE230750T1 (es)
CA (1) CA2287736C (es)
DE (1) DE69904797T2 (es)
DK (1) DK0999212T3 (es)
ES (1) ES2189356T3 (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2231833A1 (en) * 1995-09-20 1997-03-27 Novo Nordisk A/S New furyl-pyridone compounds, useful as fungicides and obtained from the fungus cladobotryum

Also Published As

Publication number Publication date
EP0999212A1 (en) 2000-05-10
JP2003342277A (ja) 2003-12-03
EP0999212B1 (en) 2003-01-08
CA2287736A1 (en) 2000-05-02
CA2287736C (en) 2004-12-07
DE69904797D1 (de) 2003-02-13
DE69904797T2 (de) 2003-09-18
JP3564543B2 (ja) 2004-09-15
ATE230750T1 (de) 2003-01-15
JP2000143666A (ja) 2000-05-26
DK0999212T3 (da) 2003-05-05

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