ES2189365T3 - Nuevos derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos. - Google Patents

Nuevos derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos.

Info

Publication number
ES2189365T3
ES2189365T3 ES99402783T ES99402783T ES2189365T3 ES 2189365 T3 ES2189365 T3 ES 2189365T3 ES 99402783 T ES99402783 T ES 99402783T ES 99402783 T ES99402783 T ES 99402783T ES 2189365 T3 ES2189365 T3 ES 2189365T3
Authority
ES
Spain
Prior art keywords
erythromycin
medicines
application
preparation procedure
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99402783T
Other languages
English (en)
Inventor
Constantin Agouridas
Alexis Denis
Claude Fromentin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of ES2189365T3 publication Critical patent/ES2189365T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Productos químicos, los compuestos de fórmula (I) **fórmula** así como sus sales de adición con ácidos en la que X representa un átomo de hidrógeno o un átomo de halógeno y Z representa un átomo de hidrógeno o el resto de un ácido.
ES99402783T 1998-11-10 1999-11-09 Nuevos derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos. Expired - Lifetime ES2189365T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9814145A FR2785612A1 (fr) 1998-11-10 1998-11-10 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number Publication Date
ES2189365T3 true ES2189365T3 (es) 2003-07-01

Family

ID=9532584

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99402783T Expired - Lifetime ES2189365T3 (es) 1998-11-10 1999-11-09 Nuevos derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos.

Country Status (28)

Country Link
US (2) US6455505B2 (es)
EP (1) EP1016669B1 (es)
JP (1) JP4698783B2 (es)
KR (1) KR100567695B1 (es)
CN (2) CN1240708C (es)
AR (1) AR025814A1 (es)
AT (1) ATE232879T1 (es)
AU (1) AU766138B2 (es)
BR (1) BR9915236A (es)
CA (1) CA2350651C (es)
CZ (1) CZ20011622A3 (es)
DE (1) DE69905447T2 (es)
DK (1) DK1016669T3 (es)
EA (1) EA200100533A1 (es)
ES (1) ES2189365T3 (es)
FR (1) FR2785612A1 (es)
HR (1) HRP20010335B1 (es)
HU (1) HUP0104035A3 (es)
IL (2) IL142996A0 (es)
NO (1) NO20012272L (es)
NZ (1) NZ511609A (es)
PL (1) PL348098A1 (es)
PT (1) PT1016669E (es)
SI (1) SI20640A (es)
TR (1) TR200101286T2 (es)
TW (1) TWI237027B (es)
WO (1) WO2000027857A2 (es)
ZA (1) ZA200103801B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1147121T3 (da) * 1999-01-27 2004-04-13 Pfizer Prod Inc Ketolidantibiotika
EE200100613A (et) 1999-05-24 2003-02-17 Pfizer Products Inc. 13-metüülerütromütsiini derivaadid
EP1167376B1 (en) 2000-06-30 2004-07-14 Pfizer Products Inc. Macrolide antibiotics
JP2004017020A (ja) * 2002-06-20 2004-01-22 Sony Corp コーティング方法および被コーティング粒子
US7601695B2 (en) 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
WO2006080954A1 (en) * 2004-07-28 2006-08-03 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2006046112A2 (en) * 2004-10-25 2006-05-04 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
AU2008316830B2 (en) 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
CN107854477A (zh) 2008-10-24 2018-03-30 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
HRP20160168T1 (hr) 2010-03-22 2016-03-25 Cempra Pharmaceuticals Inc Kristalne forme makrolida i njihova uporaba
BR112012029586A2 (pt) 2010-05-20 2016-08-02 Cempra Pharmaceuticals Inc processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
EP4095146A1 (en) 2013-04-04 2022-11-30 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
JP2017531663A (ja) 2014-10-08 2017-10-26 プレジデント アンド フェローズ オブ ハーバード カレッジ １４員ケトライドならびにそれらの調製および使用の方法
WO2016154591A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
EP3190122A1 (en) * 2016-01-08 2017-07-12 LEK Pharmaceuticals d.d. A novel synthetic pathway towards solithromycin and purification thereof
CN106432383A (zh) * 2016-09-14 2017-02-22 重庆两江药物研发中心有限公司 索利霉素及其中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
FR2669337B1 (fr) * 1990-11-21 1995-03-24 Roussel Uclaf Nouveaux derives descladinosyles de l'erythromycine, leur procede de preparation et leur application comme medicaments.
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2727969B1 (fr) * 1994-12-09 1997-01-17 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
DE69733439T2 (de) * 1996-09-04 2006-05-04 Abbott Laboratories, Abbott Park 6-o-Substituierte Ketoliden mit antibakteriellen Wirkung
AU4472897A (en) * 1997-03-10 1998-09-29 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives

Also Published As

Publication number Publication date
AU766138B2 (en) 2003-10-09
ATE232879T1 (de) 2003-03-15
CA2350651C (fr) 2010-07-20
TWI237027B (en) 2005-08-01
EA200100533A1 (ru) 2001-10-22
US20020013281A1 (en) 2002-01-31
CN1333782A (zh) 2002-01-30
PT1016669E (pt) 2003-07-31
DE69905447T2 (de) 2003-07-24
CN1814592A (zh) 2006-08-09
WO2000027857A2 (fr) 2000-05-18
KR100567695B1 (ko) 2006-04-05
NO20012272D0 (no) 2001-05-09
EP1016669A1 (fr) 2000-07-05
SI20640A (sl) 2002-02-28
HRP20010335B1 (en) 2003-08-31
CN1240708C (zh) 2006-02-08
CZ20011622A3 (cs) 2001-09-12
JP2000143689A (ja) 2000-05-26
WO2000027857A3 (fr) 2000-08-17
HUP0104035A3 (en) 2003-12-29
NZ511609A (en) 2003-07-25
CA2350651A1 (fr) 2000-05-18
DK1016669T3 (da) 2003-05-26
IL142996A0 (en) 2002-04-21
EP1016669B1 (fr) 2003-02-19
KR20010080970A (ko) 2001-08-25
FR2785612A1 (fr) 2000-05-12
US20020028781A1 (en) 2002-03-07
US6407257B1 (en) 2002-06-18
CN100351238C (zh) 2007-11-28
NO20012272L (no) 2001-07-10
JP4698783B2 (ja) 2011-06-08
AR025814A1 (es) 2002-12-18
HRP20010335A2 (en) 2002-06-30
ZA200103801B (en) 2002-05-10
US6455505B2 (en) 2002-09-24
BR9915236A (pt) 2002-01-08
PL348098A1 (en) 2002-05-06
HUP0104035A2 (hu) 2002-02-28
TR200101286T2 (tr) 2001-09-21
AU1052600A (en) 2000-05-29
IL142996A (en) 2006-12-10
DE69905447D1 (de) 2003-03-27

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