ATE232879T1 - Erythromycin-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel - Google Patents

Erythromycin-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel

Info

Publication number: ATE232879T1
Authority: AT; Austria
Prior art keywords: production; medicinal products; erythromycin derivatives; erythromycin; derivatives
Prior art date: 1998-11-10

Application number

AT99402783T

Other languages

English (en)

Inventor

Constantin Agouridas

Alexis Denis

Claude Fromentin

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-10

Filing date

1999-11-09

Publication date

2003-03-15

1999-11-09 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2003-03-15 Application granted granted Critical

2003-03-15 Publication of ATE232879T1 publication Critical patent/ATE232879T1/de

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT99402783T 1998-11-10 1999-11-09 Erythromycin-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel ATE232879T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9814145A FR2785612A1 (fr)	1998-11-10	1998-11-10	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number	Publication Date
ATE232879T1 true ATE232879T1 (de)	2003-03-15

Family

ID=9532584

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99402783T ATE232879T1 (de)	1998-11-10	1999-11-09	Erythromycin-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel

Country Status (28)

Country	Link
US (2)	US6455505B2 (de)
EP (1)	EP1016669B1 (de)
JP (1)	JP4698783B2 (de)
KR (1)	KR100567695B1 (de)
CN (2)	CN1240708C (de)
AR (1)	AR025814A1 (de)
AT (1)	ATE232879T1 (de)
AU (1)	AU766138B2 (de)
BR (1)	BR9915236A (de)
CA (1)	CA2350651C (de)
CZ (1)	CZ20011622A3 (de)
DE (1)	DE69905447T2 (de)
DK (1)	DK1016669T3 (de)
EA (1)	EA200100533A1 (de)
ES (1)	ES2189365T3 (de)
FR (1)	FR2785612A1 (de)
HR (1)	HRP20010335B1 (de)
HU (1)	HUP0104035A3 (de)
IL (2)	IL142996A0 (de)
NO (1)	NO20012272L (de)
NZ (1)	NZ511609A (de)
PL (1)	PL348098A1 (de)
PT (1)	PT1016669E (de)
SI (1)	SI20640A (de)
TR (1)	TR200101286T2 (de)
TW (1)	TWI237027B (de)
WO (1)	WO2000027857A2 (de)
ZA (1)	ZA200103801B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1147121T3 (da) *	1999-01-27	2004-04-13	Pfizer Prod Inc	Ketolidantibiotika
EE200100613A (et)	1999-05-24	2003-02-17	Pfizer Products Inc.	13-metüülerütromütsiini derivaadid
EP1167376B1 (de)	2000-06-30	2004-07-14	Pfizer Products Inc.	Makrolid-Antibiotika
JP2004017020A (ja) *	2002-06-20	2004-01-22	Sony Corp	コーティング方法および被コーティング粒子
US7601695B2 (en)	2003-03-10	2009-10-13	Optimer Pharmaceuticals, Inc.	Antibacterial agents
WO2006080954A1 (en) *	2004-07-28	2006-08-03	Ranbaxy Laboratories Limited	Ketolide derivatives as antibacterial agents
WO2006046112A2 (en) *	2004-10-25	2006-05-04	Ranbaxy Laboratories Limited	Ketolide derivatives as antibacterial agents
AU2008316830B2 (en)	2007-10-25	2016-03-17	Cempra Pharmaceuticals, Inc.	Process for the preparation of macrolide antibacterial agents
CN107854477A (zh)	2008-10-24	2018-03-30	森普拉制药公司	使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en)	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
US9480679B2 (en)	2009-09-10	2016-11-01	Cempra Pharmaceuticals, Inc.	Methods for treating malaria, tuberculosis and MAC diseases
HRP20160168T1 (hr)	2010-03-22	2016-03-25	Cempra Pharmaceuticals Inc	Kristalne forme makrolida i njihova uporaba
BR112012029586A2 (pt)	2010-05-20	2016-08-02	Cempra Pharmaceuticals Inc	processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos
KR20130120458A (ko)	2010-09-10	2013-11-04	셈프라 파마슈티컬스, 인크.	질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
WO2013148891A1 (en)	2012-03-27	2013-10-03	Cempra Pharmaceuticals, Inc.	Parenteral formulations for administering macrolide antibiotics
WO2014152326A1 (en)	2013-03-14	2014-09-25	Cempra Pharmaceuticals, Inc.	Methods for treating respiratory diseases and formulations therefor
AU2014233240B2 (en)	2013-03-15	2018-08-09	Cempra Pharmaceuticals, Inc.	Convergent processes for preparing macrolide antibacterial agents
EP4095146A1 (de)	2013-04-04	2022-11-30	President And Fellows Of Harvard College	Makrolide sowie verfahren zu deren herstellung und verwendung
JP2017531663A (ja)	2014-10-08	2017-10-26	プレジデントアンドフェローズオブハーバードカレッジ	１４員ケトライドならびにそれらの調製および使用の方法
WO2016154591A1 (en)	2015-03-25	2016-09-29	President And Fellows Of Harvard College	Macrolides with modified desosamine sugars and uses thereof
EP3190122A1 (de) *	2016-01-08	2017-07-12	LEK Pharmaceuticals d.d.	Neuartiger syntheseweg zu solithromycin und reinigung davon
CN106432383A (zh) *	2016-09-14	2017-02-22	重庆两江药物研发中心有限公司	索利霉素及其中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5671074A (en) *	1979-11-12	1981-06-13	Takeda Chem Ind Ltd	1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
FR2669337B1 (fr) *	1990-11-21	1995-03-24	Roussel Uclaf	Nouveaux derives descladinosyles de l'erythromycine, leur procede de preparation et leur application comme medicaments.
IL99995A (en) *	1990-11-21	1997-11-20	Roussel Uclaf	Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
FR2697524B1 (fr) *	1992-11-05	1994-12-23	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) *	1992-11-05	1996-06-18	Roussel Uclaf	Erythromycin derivatives
FR2719587B1 (fr) *	1994-05-03	1996-07-12	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2727969B1 (fr) *	1994-12-09	1997-01-17	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) *	1995-12-22	1998-01-30	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
DE69733439T2 (de) *	1996-09-04	2006-05-04	Abbott Laboratories, Abbott Park	6-o-Substituierte Ketoliden mit antibakteriellen Wirkung
AU4472897A (en) *	1997-03-10	1998-09-29	Taisho Pharmaceutical Co., Ltd.	Erythromycin a derivatives

1998
- 1998-11-10 FR FR9814145A patent/FR2785612A1/fr active Pending
1999
- 1999-11-03 US US09/433,146 patent/US6455505B2/en not_active Expired - Lifetime
- 1999-11-08 TW TW088119491A patent/TWI237027B/zh not_active IP Right Cessation
- 1999-11-09 DK DK99402783T patent/DK1016669T3/da active
- 1999-11-09 CA CA2350651A patent/CA2350651C/fr not_active Expired - Lifetime
- 1999-11-09 EA EA200100533A patent/EA200100533A1/ru unknown
- 1999-11-09 EP EP99402783A patent/EP1016669B1/de not_active Expired - Lifetime
- 1999-11-09 DE DE69905447T patent/DE69905447T2/de not_active Expired - Lifetime
- 1999-11-09 SI SI9920091A patent/SI20640A/sl not_active IP Right Cessation
- 1999-11-09 CN CNB998154393A patent/CN1240708C/zh not_active Expired - Lifetime
- 1999-11-09 WO PCT/FR1999/002718 patent/WO2000027857A2/fr not_active Ceased
- 1999-11-09 TR TR2001/01286T patent/TR200101286T2/xx unknown
- 1999-11-09 PT PT99402783T patent/PT1016669E/pt unknown
- 1999-11-09 HU HU0104035A patent/HUP0104035A3/hu unknown
- 1999-11-09 ES ES99402783T patent/ES2189365T3/es not_active Expired - Lifetime
- 1999-11-09 CN CNB200510128838XA patent/CN100351238C/zh not_active Expired - Lifetime
- 1999-11-09 HR HR990077A patent/HRP20010335B1/xx not_active IP Right Cessation
- 1999-11-09 BR BR9915236-3A patent/BR9915236A/pt active Search and Examination
- 1999-11-09 KR KR1020017005854A patent/KR100567695B1/ko not_active Expired - Lifetime
- 1999-11-09 AU AU10526/00A patent/AU766138B2/en not_active Expired
- 1999-11-09 IL IL14299699A patent/IL142996A0/xx active IP Right Grant
- 1999-11-09 JP JP31801599A patent/JP4698783B2/ja not_active Expired - Lifetime
- 1999-11-09 NZ NZ511609A patent/NZ511609A/en unknown
- 1999-11-09 PL PL99348098A patent/PL348098A1/xx not_active Application Discontinuation
- 1999-11-09 AT AT99402783T patent/ATE232879T1/de active
- 1999-11-09 CZ CZ20011622A patent/CZ20011622A3/cs unknown
- 1999-11-10 AR ARP990105702A patent/AR025814A1/es not_active Application Discontinuation
2000
- 2000-12-11 US US09/734,162 patent/US6407257B1/en not_active Expired - Lifetime
2001
- 2001-05-06 IL IL142996A patent/IL142996A/en not_active IP Right Cessation
- 2001-05-09 NO NO20012272A patent/NO20012272L/no not_active Application Discontinuation
- 2001-05-10 ZA ZA200103801A patent/ZA200103801B/en unknown

Also Published As

Publication number	Publication date
AU766138B2 (en)	2003-10-09
CA2350651C (fr)	2010-07-20
TWI237027B (en)	2005-08-01
EA200100533A1 (ru)	2001-10-22
US20020013281A1 (en)	2002-01-31
CN1333782A (zh)	2002-01-30
PT1016669E (pt)	2003-07-31
DE69905447T2 (de)	2003-07-24
CN1814592A (zh)	2006-08-09
WO2000027857A2 (fr)	2000-05-18
KR100567695B1 (ko)	2006-04-05
NO20012272D0 (no)	2001-05-09
EP1016669A1 (de)	2000-07-05
SI20640A (sl)	2002-02-28
HRP20010335B1 (en)	2003-08-31
CN1240708C (zh)	2006-02-08
CZ20011622A3 (cs)	2001-09-12
JP2000143689A (ja)	2000-05-26
WO2000027857A3 (fr)	2000-08-17
HUP0104035A3 (en)	2003-12-29
NZ511609A (en)	2003-07-25
CA2350651A1 (fr)	2000-05-18
DK1016669T3 (da)	2003-05-26
IL142996A0 (en)	2002-04-21
ES2189365T3 (es)	2003-07-01
EP1016669B1 (de)	2003-02-19
KR20010080970A (ko)	2001-08-25
FR2785612A1 (fr)	2000-05-12
US20020028781A1 (en)	2002-03-07
US6407257B1 (en)	2002-06-18
CN100351238C (zh)	2007-11-28
NO20012272L (no)	2001-07-10
JP4698783B2 (ja)	2011-06-08
AR025814A1 (es)	2002-12-18
HRP20010335A2 (en)	2002-06-30
ZA200103801B (en)	2002-05-10
US6455505B2 (en)	2002-09-24
BR9915236A (pt)	2002-01-08
PL348098A1 (en)	2002-05-06
HUP0104035A2 (hu)	2002-02-28
TR200101286T2 (tr)	2001-09-21
AU1052600A (en)	2000-05-29
IL142996A (en)	2006-12-10
DE69905447D1 (de)	2003-03-27

Similar Documents

Publication	Publication Date	Title
ATE302754T1 (de)	2005-09-15	Sulfonylcarboxamidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE172203T1 (de)	1998-10-15	Erythromycinderivate, ihre verfahren zur herstellung und ihre verwendung als arzneimittel
ATE234853T1 (de)	2003-04-15	Erythromycin-derivate, verfahren zur herstellung und ihre verwendung als arzneimittel
ATE228499T1 (de)	2002-12-15	Benzamidoxim-derivate, zwischenprodukte und verfahren zu deren herstellung und deren verwendung als fungizide
ATE332898T1 (de)	2006-08-15	Neue dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel
DE59908522D1 (de)	2004-03-18	Benzothiepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
ATE342899T1 (de)	2006-11-15	Diphenylazetidinonderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
ATE338039T1 (de)	2006-09-15	Diphenylazetidinonderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
DE50114874D1 (de)	2009-06-10	Chinazolinderivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
DE59909418D1 (de)	2004-06-09	Arylsubstituierte propanolaminderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
ATE370946T1 (de)	2007-09-15	16-halogen-epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung
ATE265424T1 (de)	2004-05-15	Acylphenylharnstoffderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE69922186D1 (de)	2004-12-30	1-(1-subst.-4-piperidinyl)methyl]-4-piperidin-derivate, verafhren zu deren herstellung, pharmazeutische mixturen und intermediate zu deren herstellung
DE69905447D1 (de)	2003-03-27	Erythromycin-Derivate, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE69712610D1 (de)	2002-06-20	Erythramicin-derivate, ihre verfahren zur herstellung und ihre verwendung als arzneimittel
DE59707976D1 (de)	2002-09-19	Neue guanidinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE234842T1 (de)	2003-04-15	Epithilonderivate, verfahren zu deren herstellung und deren verwendung
ATE267825T1 (de)	2004-06-15	Mit heterocyclen substituierte propanolaminderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
DE59610963D1 (de)	2004-05-06	Neue phenylamidinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE304534T1 (de)	2005-09-15	Aminocarbonyl-substituierte benzimidazolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE59909606D1 (de)	2004-07-01	Substituierte 1,3-diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)-propanolderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
ATE301645T1 (de)	2005-08-15	Polycyclische thiazolidin-2-yliden amine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE267811T1 (de)	2004-06-15	Substituierte 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin- 0-ole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE69901098D1 (de)	2002-05-02	Hypnotische beta-carbolin derivate verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE209212T1 (de)	2001-12-15	Aromatische ribose-substituierte derivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel

Legal Events

Date

Code

Title

Description

2003-09-15

UEP

Publication of translation of european patent specification

Ref document number: 1016669

Country of ref document: EP