ES2189443T3 - Ligantes a base de arilsulfona para analisis por espectrometria de masa. - Google Patents

Ligantes a base de arilsulfona para analisis por espectrometria de masa.

Info

Publication number
ES2189443T3
ES2189443T3 ES99933033T ES99933033T ES2189443T3 ES 2189443 T3 ES2189443 T3 ES 2189443T3 ES 99933033 T ES99933033 T ES 99933033T ES 99933033 T ES99933033 T ES 99933033T ES 2189443 T3 ES2189443 T3 ES 2189443T3
Authority
ES
Spain
Prior art keywords
analyte
arilsulfone
mass spectrometry
spectrometry analysis
reporter group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99933033T
Other languages
English (en)
Inventor
Gunter Schmidt
Andrew Hugin Thompson
Robert Alexander Walker Johnstone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xzillion GmbH and Co KG
Original Assignee
Xzillion GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xzillion GmbH and Co KG filed Critical Xzillion GmbH and Co KG
Application granted granted Critical
Publication of ES2189443T3 publication Critical patent/ES2189443T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un método para caracterizar un analito, consistiendo dicho método en: (a) proporcionar un compuesto en el que se une el analito mediante un agente de unión segmentable a un grupo indicador capaz de identificar el analito, consistiendo el grupo indicador en un marcador de masa detectable por espectrometría de masas, presentando dicho compuesto la siguiente fórmula: **(Fórmula)** en la que R representa el grupo indicador y R¿ representa el analito, o R representa el analito y R¿ representa el grupo indicador, y en la que n es 1 ó 2; (b) segmentación del grupo indicador del analito; y (c) identificación del grupo indicador, caracterizando así el analito.
ES99933033T 1998-07-13 1999-07-13 Ligantes a base de arilsulfona para analisis por espectrometria de masa. Expired - Lifetime ES2189443T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9815163.2A GB9815163D0 (en) 1998-07-13 1998-07-13 Compounds

Publications (1)

Publication Number Publication Date
ES2189443T3 true ES2189443T3 (es) 2003-07-01

Family

ID=10835417

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99933033T Expired - Lifetime ES2189443T3 (es) 1998-07-13 1999-07-13 Ligantes a base de arilsulfona para analisis por espectrometria de masa.

Country Status (12)

Country Link
EP (1) EP1095053B1 (es)
JP (1) JP3692299B2 (es)
AT (1) ATE229537T1 (es)
AU (1) AU769966B2 (es)
CA (2) CA2337761A1 (es)
DE (1) DE69904478T2 (es)
DK (1) DK1095053T3 (es)
ES (1) ES2189443T3 (es)
GB (2) GB9815163D0 (es)
NZ (1) NZ509518A (es)
PT (1) PT1095053E (es)
WO (1) WO2000002895A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0006141D0 (en) * 2000-03-14 2000-05-03 Brax Group Ltd Mass labels
AU2001296645A1 (en) 2000-10-06 2002-04-15 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding dna and rna
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US20050247001A1 (en) * 2002-03-15 2005-11-10 Nuevolution A/S Building block forming a c-c or a c-hetero atom bond uponreaction
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
WO2004018497A2 (en) 2002-08-23 2004-03-04 Solexa Limited Modified nucleotides for polynucleotide sequencing
GB0317123D0 (en) * 2003-07-22 2003-08-27 Xzillion Gmbh & Co Kg Characterising polypeptides
JP2005140755A (ja) * 2003-11-10 2005-06-02 Japan Science & Technology Agency 質量分析用プローブ及びそれを用いた質量分析方法
GB0515323D0 (en) 2005-07-26 2005-08-31 Electrophoretics Ltd Mass labels
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
GB0518585D0 (en) 2005-09-12 2005-10-19 Electrophoretics Ltd Mass labels
WO2008042067A2 (en) 2006-09-28 2008-04-10 Illumina, Inc. Compositions and methods for nucleotide sequencing
GB2457402B (en) 2006-12-01 2011-10-19 Univ Columbia Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
GB0704764D0 (en) 2007-03-12 2007-04-18 Electrophoretics Ltd Isobarically labelled reagents and methods of their use
WO2009051807A1 (en) 2007-10-19 2009-04-23 The Trustees Of Columbia University In The City Of New York Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis
DK2725107T3 (da) 2007-10-19 2019-01-02 Univ Columbia DNA-sekventering med ikke-fluorescerende nukleotidreversible terminatorer og ddNTP'er modificeret med spaltbart mærke og nukleinsyre omfattende inosin med reversible terminatorer
GB0809488D0 (en) 2008-05-23 2008-07-02 Electrophoretics Ltd Mass spectrometric analysis
GB0916881D0 (en) 2009-09-25 2009-11-11 Electrophoretics Ltd Mass labels
US9624539B2 (en) 2011-05-23 2017-04-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by synthesis using Raman and infrared spectroscopy detection
WO2014139596A1 (en) 2013-03-15 2014-09-18 Illumina Cambridge Limited Modified nucleosides or nucleotides
WO2014144883A1 (en) 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
GB201322567D0 (en) 2013-12-19 2014-02-05 Electrophoretics Ltd Mass labels
US20170089915A1 (en) * 2015-09-30 2017-03-30 Agilent Technologies, Inc. Methods of analyte derivatization and enhanced soft ionization

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4960700A (en) * 1986-12-24 1990-10-02 Genentech, Inc. Compositions and methods for the synthesis and assay of a mammalian enkephalinase
US5216141A (en) * 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
WO1994013319A1 (en) * 1992-12-16 1994-06-23 Miles Inc. Cathepsin d is an amyloidogenic protease in alzheimer's disease
DE69701671T3 (de) * 1996-01-23 2006-08-17 Qiagen Genomics, Inc., Bothell Verfahren und zusammenstellungen zur sequenzbestimmung von nukleinsäuremolekülen
DE69700902T2 (de) * 1996-01-23 2000-07-20 Rapigene, Inc. Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit
JP3884087B2 (ja) * 1997-01-15 2007-02-21 イクスツィリオン ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 質量標識結合ハイブリダイゼーションプローブ
EP1002128A1 (en) * 1997-07-11 2000-05-24 Brax Genomics Limited Characterising nucleic acids
GB9823646D0 (en) * 1997-12-19 1998-12-23 Brax Genomics Ltd Compounds for mass spectrometry

Also Published As

Publication number Publication date
AU769966B2 (en) 2004-02-12
JP3692299B2 (ja) 2005-09-07
JP2002520580A (ja) 2002-07-09
WO2000002895A1 (en) 2000-01-20
GB9815163D0 (en) 1998-09-09
CA2385987A1 (en) 2000-01-20
CA2337761A1 (en) 2000-01-20
ATE229537T1 (de) 2002-12-15
EP1095053A1 (en) 2001-05-02
GB2340602A (en) 2000-02-23
AU4921099A (en) 2000-02-01
EP1095053B1 (en) 2002-12-11
DK1095053T3 (da) 2003-04-07
DE69904478T2 (de) 2003-09-25
DE69904478D1 (de) 2003-01-23
PT1095053E (pt) 2003-04-30
NZ509518A (en) 2003-07-25
GB9916405D0 (en) 1999-09-15

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