ES2189868T3 - Microesferas y nanoesferas biodegradables de liberacion controlada que contienen ciclosporina. - Google Patents

Microesferas y nanoesferas biodegradables de liberacion controlada que contienen ciclosporina.

Info

Publication number
ES2189868T3
ES2189868T3 ES96909319T ES96909319T ES2189868T3 ES 2189868 T3 ES2189868 T3 ES 2189868T3 ES 96909319 T ES96909319 T ES 96909319T ES 96909319 T ES96909319 T ES 96909319T ES 2189868 T3 ES2189868 T3 ES 2189868T3
Authority
ES
Spain
Prior art keywords
nanoespheres
cyclosporine
microspheres
formulate
controlled release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96909319T
Other languages
English (en)
Inventor
Zebunnissa Ramtoola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Perrigo Co PLC
Original Assignee
Elan Corp PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Corp PLC filed Critical Elan Corp PLC
Application granted granted Critical
Publication of ES2189868T3 publication Critical patent/ES2189868T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/795—Composed of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/931—Medical device coating

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

SE DESCRIBE UN FORMULADO FARMACEUTICO DE LIBERACION CONTROLADA QUE INCLUYE CICLOSPORINA ATRAPADA EN UN POLIMERO BIODEGRADABLE PARA FORMAR MICROESFERAS O NANOESFERAS, DE FORMA QUE LA CICLOSPORINA SE ENCUENTRA SUSTANCIALMENTE EN ESTADO AMORFO, Y EL POLIMERO BIODEGRADABLE INCLUYE MAS DE UN 12,5 % P/P DE POLILACTIDA. DE FORMA ADECUADA, EL POLIMERO BIODEGRADABLE ES POLI D,L STIMIENTO ENTERICO A LAS MICROESFERAS O NANOESFERAS, O A LA FORMA DE DOSIFICACION ORAL QUE INCLUYE LAS MICROESFERAS O NANOESFERAS, PARA PROTEGER EL FORMULADO MIENTRAS PASA A TRAVES DEL ESTOMAGO. UN FORMULADO PARTICULARMENTE ADECUADO INCLUYE UN 50 % P/P DE MICRO MEZCLA 80:20 DE POLI D,L DE LA LIBERACION CASI COMPLETA, PERO RELATIVAMENTE LENTA, DE CICLOSPORINA EN 8 HORAS, Y RESULTA UTIL PARA DIRIGIR LA CICLOSPORINA AL INTESTINO DELGADO CUANDO SE ADMINISTRA POR VIA ORAL.
ES96909319T 1995-04-03 1996-04-02 Microesferas y nanoesferas biodegradables de liberacion controlada que contienen ciclosporina. Expired - Lifetime ES2189868T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IE950233A IE75744B1 (en) 1995-04-03 1995-04-03 Controlled release biodegradable micro- and nanospheres containing cyclosporin

Publications (1)

Publication Number Publication Date
ES2189868T3 true ES2189868T3 (es) 2003-07-16

Family

ID=11040700

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96909319T Expired - Lifetime ES2189868T3 (es) 1995-04-03 1996-04-02 Microesferas y nanoesferas biodegradables de liberacion controlada que contienen ciclosporina.

Country Status (14)

Country Link
US (1) US5641745A (es)
EP (1) EP0818996B1 (es)
JP (1) JP3875721B2 (es)
AT (1) ATE232722T1 (es)
AU (1) AU700612B2 (es)
CA (1) CA2217462C (es)
DE (1) DE69626278T2 (es)
DK (1) DK0818996T3 (es)
ES (1) ES2189868T3 (es)
IE (1) IE75744B1 (es)
NZ (1) NZ304975A (es)
PT (1) PT818996E (es)
WO (1) WO1996031202A1 (es)
ZA (1) ZA962670B (es)

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US20050085498A1 (en) * 1998-05-28 2005-04-21 Byrd Edward A. Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate
US6984404B1 (en) 1998-11-18 2006-01-10 University Of Florida Research Foundation, Inc. Methods for preparing coated drug particles and pharmaceutical formulations thereof
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US6253463B1 (en) 1999-04-26 2001-07-03 Niro A/S Method of spray drying
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US6656504B1 (en) 1999-09-09 2003-12-02 Elan Pharma International Ltd. Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
US6682754B2 (en) 1999-11-24 2004-01-27 Willmar Poultry Company, Inc. Ovo delivery of an immunogen containing implant
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
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US6977085B2 (en) * 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
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US6607784B2 (en) * 2000-12-22 2003-08-19 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
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MXPA04002446A (es) 2001-09-26 2004-07-23 Baxter Int Preparacion de nanoparticulas de tamano de submicras mediante dispersion y remocion de la fase liquida o solvente.
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
HRP20070058B1 (hr) 2001-10-19 2014-05-23 Isotechnika Inc. Sinteza ciklosporinskih analoga
EP1435910B9 (en) * 2001-10-19 2010-02-03 Isotechnika Inc. Novel cyclosporin analog microemulsion preconcentrates
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
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PT1487416E (pt) * 2002-03-26 2010-01-25 Teva Pharma Micropartículas de fármacos
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Also Published As

Publication number Publication date
US5641745A (en) 1997-06-24
AU700612B2 (en) 1999-01-07
PT818996E (pt) 2003-06-30
CA2217462C (en) 2010-08-03
DK0818996T3 (da) 2003-06-10
JPH11503147A (ja) 1999-03-23
CA2217462A1 (en) 1996-10-10
IE75744B1 (en) 1997-09-24
AU5286696A (en) 1996-10-23
DE69626278T2 (de) 2003-07-24
DE69626278D1 (de) 2003-03-27
IE950233A1 (en) 1996-10-16
WO1996031202A1 (en) 1996-10-10
ATE232722T1 (de) 2003-03-15
EP0818996A1 (en) 1998-01-21
ZA962670B (en) 1996-10-09
NZ304975A (en) 1998-09-24
JP3875721B2 (ja) 2007-01-31
EP0818996B1 (en) 2003-02-19

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