BR0112054A - Composição formadora de micelas, e métodos para a administração e a proteção de um agente terapêutico - Google Patents

Composição formadora de micelas, e métodos para a administração e a proteção de um agente terapêutico

Info

Publication number
BR0112054A
BR0112054A BR0112054-9A BR0112054A BR0112054A BR 0112054 A BR0112054 A BR 0112054A BR 0112054 A BR0112054 A BR 0112054A BR 0112054 A BR0112054 A BR 0112054A
Authority
BR
Brazil
Prior art keywords
protection
methods
therapeutic agent
forming composition
micelle
Prior art date
Application number
BR0112054-9A
Other languages
English (en)
Inventor
Jean-Christophe Leroux
Amina Souad Benahmed
Original Assignee
Labopharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labopharm Inc filed Critical Labopharm Inc
Publication of BR0112054A publication Critical patent/BR0112054A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

"COMPOSIçãO FORMADORA DE MICELAS, E MéTODOS PARA A ADMIMSTRAçãO E A PROTEçãO DE UM AGENTE TERAPêUTICO". Novas micelas poliméricas que são usadas para liberar agentes terapêuticos, incluindo drogas anti-tumor.
BR0112054-9A 2000-06-29 2001-06-28 Composição formadora de micelas, e métodos para a administração e a proteção de um agente terapêutico BR0112054A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/606,398 US6338859B1 (en) 2000-06-29 2000-06-29 Polymeric micelle compositions
PCT/CA2001/000963 WO2002000194A2 (en) 2000-06-29 2001-06-28 Polymeric micelle compositions

Publications (1)

Publication Number Publication Date
BR0112054A true BR0112054A (pt) 2003-09-30

Family

ID=24427804

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0112054-9A BR0112054A (pt) 2000-06-29 2001-06-28 Composição formadora de micelas, e métodos para a administração e a proteção de um agente terapêutico

Country Status (22)

Country Link
US (1) US6338859B1 (pt)
EP (1) EP1296647B1 (pt)
JP (1) JP5134179B2 (pt)
KR (1) KR20030039332A (pt)
CN (1) CN1258358C (pt)
AT (1) ATE336229T1 (pt)
AU (2) AU2001270405B2 (pt)
BR (1) BR0112054A (pt)
CA (1) CA2414241C (pt)
CZ (1) CZ302369B6 (pt)
DE (1) DE60122335T2 (pt)
DK (1) DK1296647T3 (pt)
ES (1) ES2271039T3 (pt)
HU (1) HUP0300963A2 (pt)
IL (2) IL153655A0 (pt)
MX (1) MXPA03000065A (pt)
NO (1) NO20026255L (pt)
NZ (1) NZ523645A (pt)
PL (1) PL202475B1 (pt)
PT (1) PT1296647E (pt)
RU (1) RU2308943C2 (pt)
WO (1) WO2002000194A2 (pt)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ260408A (en) 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol
CA2408332C (en) * 2000-05-08 2011-02-15 The University Of British Columbia Supports for photosensitizer formulations
CZ20031262A3 (en) * 2000-10-16 2004-03-17 Neopharm, Inc. Liposomal formulation of mitoxantrone
CN100408099C (zh) * 2000-11-09 2008-08-06 阿斯特拉曾尼卡有限公司 含有嵌段共聚物的口服药物组合物
US6780428B2 (en) * 2001-06-08 2004-08-24 Labopharm, Inc. Unimolecular polymeric micelles with an ionizable inner core
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
CA2451187C (en) 2001-06-22 2012-08-14 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
KR100481540B1 (ko) * 2002-02-26 2005-04-07 한국전자통신연구원 치료 약물 함유된 스마트 나노 입자의 제조 방법
US7635463B2 (en) 2002-02-27 2009-12-22 Pharmain Corporation Compositions for delivery of therapeutics and other materials
CA2476589C (en) * 2002-02-27 2014-02-25 Pharmain, Ltd. Compositions for delivery of therapeutics and other materials, and methods of making and using the same
US6780324B2 (en) * 2002-03-18 2004-08-24 Labopharm, Inc. Preparation of sterile stabilized nanodispersions
US7018655B2 (en) * 2002-03-18 2006-03-28 Labopharm, Inc. Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions
WO2003082303A1 (en) * 2002-03-29 2003-10-09 Wisconsin Alumni Research Foundation Polymeric micelle formulations of hydrophobic compounds and methods
EP1393718A1 (en) * 2002-08-29 2004-03-03 OctoPlus Sciences B.V. Colloidal drug carrier system
US7879351B2 (en) * 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
KR101301653B1 (ko) * 2002-10-29 2013-08-30 트랜세이브, 인코포레이티드 항감염제의 지속적인 방출
KR100508518B1 (ko) * 2002-11-13 2005-08-17 한미약품 주식회사 초임계유체 공정을 이용한 파클리탁셀 고체분산체의 제조방법 및 이 방법으로 제조된 파클리탁셀 고체분산체
US7491395B2 (en) 2002-11-20 2009-02-17 Bestewil Holding B.V. Compositions comprising antigen-complexes, method of making same as well as methods of using the antigen-complexes for vaccination
EP1578443B1 (en) * 2002-11-20 2011-01-12 Bestewil Holding B.V. Compositions comprising antigen-complexes, method for making same as well as methods of using the antigen-complexes for vaccination
WO2004098569A1 (en) * 2003-04-18 2004-11-18 Northeastern University Micelle delivery system loaded with a pharmaceutical agent
US7262253B2 (en) * 2003-12-02 2007-08-28 Labopharm, Inc. Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers
WO2005112977A2 (en) * 2004-04-23 2005-12-01 Pharmain, Ltd. Compositions for treatment with glucagon-like peptide, and methods of making and using the same
CN100386115C (zh) * 2004-10-14 2008-05-07 孔庆忠 一种抗癌药物组合物
JP2008519076A (ja) * 2004-11-02 2008-06-05 テルアビブ ユニバーシティ フューチャー テクノロジー デベロップメント エル．ピー． 脂質化グリコサミノグリカン粒子中の水不溶性又は水難溶性薬物の処方、並びに診断及び治療のためのこれらの使用
US20060198891A1 (en) * 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
WO2007014445A1 (en) * 2005-08-02 2007-02-08 Miv Therapeutics Inc. Microdevices comprising nanocapsules for controlled delivery of drugs and method of manufacturing same
US20070106271A1 (en) * 2005-11-09 2007-05-10 Searete Llc, A Limited Liability Corporation Remote control of substance delivery system
JP5324223B2 (ja) 2005-12-08 2013-10-23 トランセイブ， インク． 肺感染症を治療する抗感染薬の脂質ベースの組成物及びその使用法
EP1971372B1 (en) 2005-12-19 2018-11-14 PharmaIN Corporation Hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same
CA2634830A1 (en) * 2005-12-27 2007-07-05 Labopharm Inc. Degradable polymeric microsphere composition
JPWO2007126110A1 (ja) * 2006-04-24 2009-09-17 ナノキャリア株式会社 低分子薬物内包ポリマーミセルの製造方法
CN100434120C (zh) * 2006-09-14 2008-11-19 同济大学 两亲性荧光靶向纳米胶束及其制备方法
JP2010504318A (ja) * 2006-09-22 2010-02-12 ラボファーム インコーポレイテッド ｐＨ標的化薬剤送達のための組成物及び方法
CA2665343C (en) * 2006-10-05 2014-12-16 The Johns Hopkins University Water-dispersible oral, parenteral, and topical formulations for poorly water soluble drugs using smart polymeric nanoparticles
US7758635B2 (en) * 2007-02-13 2010-07-20 Boston Scientific Scimed, Inc. Medical device including cylindrical micelles
US20100196455A1 (en) * 2007-05-04 2010-08-05 Transave, Inc. Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US7960336B2 (en) 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
US8563527B2 (en) * 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
US9090737B2 (en) * 2007-11-13 2015-07-28 Surmodics, Inc. Viscous terpolymers as drug delivery platform
US20090176892A1 (en) 2008-01-09 2009-07-09 Pharmain Corporation Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same
CA2635187A1 (en) 2008-06-05 2009-12-05 The Royal Institution For The Advancement Of Learning/Mcgill University Oligonucleotide duplexes and uses thereof
US8974808B2 (en) 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
US20100168807A1 (en) * 2008-12-23 2010-07-01 Burton Kevin W Bioactive terpolymer compositions and methods of making and using same
US8951546B2 (en) * 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
US9415197B2 (en) * 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
US9480643B2 (en) 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US8524784B2 (en) 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
US8524783B2 (en) 2009-04-30 2013-09-03 Intezyne Technologies, Incorporated Polymer micelles containing anthracylines for the treatment of cancer
WO2011119262A1 (en) 2010-03-26 2011-09-29 Cerulean Pharma Inc. Methods and systems for generating nanoparticles
JP2013530931A (ja) * 2010-04-23 2013-08-01 ラボファーマ インコーポレイテッド 液状生物学的活性成分の固形製剤を含む非静脈内剤型およびその使用
CA2809825A1 (en) 2010-08-30 2012-03-08 Surmodics Pharmaceuticals, Inc. Biodegradable terpolymers and terpolymer blends as pressure-sensitive adhesives
CN101953804A (zh) * 2010-09-26 2011-01-26 苏州同科生物材料有限公司 基于两亲性嵌段共聚物的壳层可脱落式纳米药物载体制剂及其制备方法
WO2012103182A1 (en) 2011-01-28 2012-08-02 Cerulean Pharma Inc. Method for fabricating nanoparticles
CN102793678B (zh) * 2011-05-26 2017-06-30 邓世明 一种不含吐温的多烯紫杉醇注射剂的制备方法
SG10201510437WA (en) * 2011-10-03 2016-01-28 Univ Nanyang Tech Cationic peptidopolysaccharides with excellent broad-spectrum antimicrobial activities and high selectivity
RU2480479C1 (ru) * 2011-11-01 2013-04-27 Елена Викторовна Свирщевская Гетерологичный пептидный мини-антиген в составе полимерной частицы для создания противоаллергенной вакцины
US9169383B2 (en) * 2012-02-10 2015-10-27 E I Du Pont De Nemours And Company Preparation, purification and use of high-X diblock copolymers
RU2501570C1 (ru) * 2012-05-11 2013-12-20 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) федеральный университет" (ФГАОУВПО КФУ) Трехфункциональные блоксополимеры этиленоксида и пропиленоксида для доставки активных веществ в живые клетки
PL2852391T3 (pl) 2012-05-21 2022-04-11 Insmed Incorporated Układy do leczenia infekcji płuc
MX2015006681A (es) 2012-11-29 2016-04-06 Insmed Inc Formulaciones de vancomicina estabilizadas.
CN104434876B (zh) * 2013-09-13 2018-04-27 布里吉·P·吉里 用于癌症疗法及成像的缺氧-标靶聚合微胞
SMT202000516T1 (it) 2014-05-15 2020-11-10 Insmed Inc Metodi per trattamento di infezioni micobatteriche polmonati non tubercolari
KR102088663B1 (ko) * 2018-03-20 2020-03-13 한국세라믹기술원 친수성 및 소수성 약물의 동시 전달을 위한 온도민감성 나노스펀지 플랫폼 및 이의 용도
WO2019191627A1 (en) 2018-03-30 2019-10-03 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
WO2019213398A1 (en) 2018-05-02 2019-11-07 Insmed Incorporated Methods for the manufacture of liposomal drug formulations
CN111592663B (zh) * 2020-03-27 2022-09-16 青岛大学 一种冠醚修饰的嵌段共聚物胶束的制备方法及其应用
CN114246831B (zh) * 2020-09-22 2024-10-15 鲁南制药集团股份有限公司 一种注射用紫杉烷类抗肿瘤药物的聚合物胶束冻干制剂
CN120346164B (zh) * 2025-06-20 2025-09-26 湖州亚瑟制药有限公司 一种环磷酰胺三元纳米胶束及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3378250D1 (en) * 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
JP2517760B2 (ja) * 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
US5484778C1 (en) * 1990-07-17 2001-05-08 Univ Cleveland Hospitals Phthalocynine photosensitizers for photodynamic therapy and methods for their use
US5817321A (en) * 1992-10-08 1998-10-06 Supratek Pharma, Inc. Biological agent compositions
US5484612A (en) * 1993-09-22 1996-01-16 The Board Of Trustees Of The Leland Stanford Junior University Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin
KR0180334B1 (ko) * 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
WO1997012895A1 (fr) * 1995-09-29 1997-04-10 Japan Science And Technology Corporation Nouveaux derives de composes d'anthracycline, et preparations medicamenteuses les contenant
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
JP3523821B2 (ja) * 2000-02-09 2004-04-26 ナノキャリア株式会社 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物
EP1286643A2 (en) * 2000-05-17 2003-03-05 Labopharm Inc. Drug containing polymeric micelles

Also Published As

Publication number Publication date
JP2004501180A (ja) 2004-01-15
PL360262A1 (pl) 2004-09-06
NO20026255D0 (no) 2002-12-27
CZ20024268A3 (cs) 2003-05-14
PL202475B1 (pl) 2009-06-30
DE60122335T2 (de) 2007-08-30
ES2271039T3 (es) 2007-04-16
CZ302369B6 (cs) 2011-04-13
DK1296647T3 (da) 2006-12-27
CN1447683A (zh) 2003-10-08
ATE336229T1 (de) 2006-09-15
CA2414241A1 (en) 2002-01-03
EP1296647A2 (en) 2003-04-02
PT1296647E (pt) 2006-12-29
IL153655A (en) 2008-11-26
DE60122335D1 (de) 2006-09-28
RU2308943C2 (ru) 2007-10-27
WO2002000194A2 (en) 2002-01-03
AU2001270405B2 (en) 2005-01-20
NZ523645A (en) 2004-09-24
EP1296647B1 (en) 2006-08-16
NO20026255L (no) 2003-02-25
IL153655A0 (en) 2003-07-06
US6338859B1 (en) 2002-01-15
CN1258358C (zh) 2006-06-07
JP5134179B2 (ja) 2013-01-30
WO2002000194A3 (en) 2002-08-08
AU7040501A (en) 2002-01-08
HK1059395A1 (en) 2004-07-02
KR20030039332A (ko) 2003-05-17
HUP0300963A2 (hu) 2003-09-29
MXPA03000065A (es) 2004-04-02
CA2414241C (en) 2011-04-12

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.