ES2189942T3 - Sintesis de nucleosidos aciclicos. - Google Patents

Sintesis de nucleosidos aciclicos.

Info

Publication number
ES2189942T3
ES2189942T3 ES97903709T ES97903709T ES2189942T3 ES 2189942 T3 ES2189942 T3 ES 2189942T3 ES 97903709 T ES97903709 T ES 97903709T ES 97903709 T ES97903709 T ES 97903709T ES 2189942 T3 ES2189942 T3 ES 2189942T3
Authority
ES
Spain
Prior art keywords
saturated
formula
optionally replaced
instituted
mono
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97903709T
Other languages
English (en)
Inventor
Per Engelhardt
Marita Hogberg
Xiao-Xiong Zhou
Bjorn Lindborg
Nils Gunnar Johansson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medivir AB
Original Assignee
Medivir AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9600613A external-priority patent/SE9600613D0/xx
Priority claimed from SE9600614A external-priority patent/SE9600614D0/xx
Application filed by Medivir AB filed Critical Medivir AB
Application granted granted Critical
Publication of ES2189942T3 publication Critical patent/ES2189942T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN METODO PARA LA PREPARACION DE COMPUESTOS ANTIVIRALES DE MAYOR BIODISPONIBILIDAD DE FORMULA (I) EN LA QUE UNO DE ENTRE R 1 Y R 2 ES - C(O)CH(CH(CH 3 ) 2 )NH 2 O - C(O)CH(CH(CH 3 )CH 2 CH 3 )NH 2 Y EL OTRO DE ENTRE R 1 Y R 2 SON ALQUILO OPCIONALMENTE SUSTITUIDO, SATURADO O MONOINSATURADO CON - C(O)C 3 C 21 ; Y R 3 ES OH O H, CONSISTIENDO EL METODO EN: A) LA MONODESACILACION DE UN COMPUESTO DIACILADO CORRESPONDIENTE A LA FORMULA (I) EN LA QUE R 1 U R 2 SON LOS DOS C(O)CH(CH(CH SUB,3 ) 2 )NH 2 O C(O)CH(CH(CH 3 )CH 2 CH 3 )NH 2 (QUE SON OPCIONALMENTE N - PROTEGIDOS) O R 1 Y R 2 SON LOS DOS ALQUILO OPCIONALMENTE SUSTITUIDO, SATURADO O MONOINSATURADO CON - C(O)C 3 - C 21 ; B) ACILAR EL GRUPO 4 - HIDROXI DE CADENA LATERAL O EL GRUPO 2 - HIDROXIMETILO DE CADENA LATERAL ASI LIBERADOS CON EL - C(O)CH(CH(CH 3 ) 2 )NH 2 O C(O)CH(CH(CH 3 )CH 2 CH 3 )NH 2 O ALQUILO OPCIONALMENTE SUSTITUIDO, SATURADO O MONOIN SATURADO CON C(O)C 3 - C 21 PARA PRODUCIR ASI UN COMPUESTO DE FORMULA (I); Y C) DESPROTEGER SEGUN SEA NECESARIO.
ES97903709T 1996-02-16 1997-02-14 Sintesis de nucleosidos aciclicos. Expired - Lifetime ES2189942T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9600613A SE9600613D0 (sv) 1996-02-16 1996-02-16 Acyclic nucleoside derivatives
SE9600614A SE9600614D0 (sv) 1996-02-16 1996-02-16 Antiviral compounds

Publications (1)

Publication Number Publication Date
ES2189942T3 true ES2189942T3 (es) 2003-07-16

Family

ID=26662518

Family Applications (2)

Application Number Title Priority Date Filing Date
ES97903709T Expired - Lifetime ES2189942T3 (es) 1996-02-16 1997-02-14 Sintesis de nucleosidos aciclicos.
ES97903708T Expired - Lifetime ES2189941T3 (es) 1996-02-16 1997-02-14 Derivados de nucleosidos aciclicos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES97903708T Expired - Lifetime ES2189941T3 (es) 1996-02-16 1997-02-14 Derivados de nucleosidos aciclicos.

Country Status (25)

Country Link
US (5) US5869493A (es)
EP (2) EP0888348B1 (es)
JP (2) JP2000504721A (es)
KR (1) KR100464692B1 (es)
CN (1) CN1067073C (es)
AR (1) AR005827A1 (es)
AT (2) ATE231507T1 (es)
AU (1) AU715062B2 (es)
BG (1) BG64179B1 (es)
CA (1) CA2243826C (es)
CZ (1) CZ292169B6 (es)
DE (2) DE69718619T2 (es)
DK (1) DK0888348T3 (es)
EA (2) EA001404B1 (es)
ES (2) ES2189942T3 (es)
HU (1) HU229865B1 (es)
IL (1) IL124760A (es)
MY (1) MY123083A (es)
NO (1) NO322930B1 (es)
NZ (1) NZ330472A (es)
PL (1) PL184892B1 (es)
SK (1) SK284613B6 (es)
TR (1) TR199801318T2 (es)
TW (1) TW533213B (es)
WO (2) WO1997030052A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
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US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
JP2001503767A (ja) * 1996-11-12 2001-03-21 メディヴィル・アクチボラグ ヌクレオシド
US6184376B1 (en) * 1997-02-10 2001-02-06 Mediver Ab Synthesis of acyclic nucleoside derivatives
CA2572577C (en) * 1997-02-10 2011-04-05 Medivir Ab Synthesis of acyclic nucleoside derivatives
DE69829784T2 (de) * 1997-08-15 2006-02-16 Medivir Ab 3'-Fluorierte Guanosinderivate zur Behandlung oder Prophylaxe von HBV- oder retroviralen Infektionen
WO1999032490A1 (en) * 1997-12-19 1999-07-01 Bristol-Myers Squibb Company Prodrugs of lobucavir and methods of use
TW200510415A (en) * 2003-04-30 2005-03-16 Teva Pharma Process for the preparation of famciclovir
EP1835916B1 (en) 2004-12-30 2009-04-01 Medivir Ab Compounds useful in the treatment of hiv
US20080233053A1 (en) * 2005-02-07 2008-09-25 Pharmalight Inc. Method and Device for Ophthalmic Administration of Active Pharmaceutical Ingredients
CN101033238B (zh) * 2006-03-06 2011-02-16 中国科学院上海药物研究所 嘌呤类化合物双氨基酸酯的制备方法和用途
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
US9296776B2 (en) 2007-07-09 2016-03-29 Eastern Virginia Medical School Substituted nucleoside derivatives with antiviral and antimicrobial properties
MX2010003056A (es) 2007-09-21 2010-04-07 Epiphany Biosciences Inc Polimorfos de valomaciclovir.
WO2011022712A1 (en) * 2009-08-21 2011-02-24 Epiphany Biosciences, Inc. Method of treating infectious mononucleosis with acylic nucleoside derivatives
ES2667425T3 (es) 2011-06-10 2018-05-10 Oregon Health & Science University Glucoproteínas y vectores recombinantes de CMV
KR101763127B1 (ko) 2015-06-23 2017-08-01 (주)농협아그로 끈끈이 엠보싱 트랩 테이프
US20260191871A1 (en) * 2022-11-28 2026-07-09 Epiphany Biosciences Use of antiviral agents, composition of matter, combination preparations/agents to treat chronic diseases associated with epstein-barr virus and other human herpes viruses

Family Cites Families (43)

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US3116282A (en) 1960-04-27 1963-12-31 Upjohn Co Pyrimidine nucleosides and process
FR2040177A1 (en) 1969-01-31 1971-01-22 Robugen Gmbh 2-deoxyribosyl-uracil derivs
US3817982A (en) 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
US4267171A (en) 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
US4247544A (en) 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
JPS57146798A (en) 1981-03-06 1982-09-10 Yamasa Shoyu Co Ltd Hexosyl nucleoside derivative
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4724232A (en) 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
EP0286825A3 (en) 1987-03-18 1989-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of 3'-fluro-3' deoxythymidine for the manufacture of a medicament for the treatment of virus infections
SE8701605D0 (sv) 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.
EP0339075B1 (en) * 1987-10-28 1993-08-18 Pro-Neuron, Inc. Acylated uridine and cytidine and uses thereof
SE8704298D0 (sv) 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy
US5284837A (en) 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
SE8801729D0 (sv) * 1988-05-06 1988-05-06 Astra Ab Purine derivatives for use in therapy
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
SE8802173D0 (sv) 1988-06-10 1988-06-10 Astra Ab Pyrimidine derivatives
US5043339A (en) * 1988-12-19 1991-08-27 Burroughs Wellcome Co. Antiviral compounds
FI95384C (fi) 1989-04-06 1996-01-25 Squibb Bristol Myers Co Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
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SE9003151D0 (sv) 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
GB2260319B (en) * 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
US5874578A (en) 1992-07-13 1999-02-23 Bristol-Myers Squibb Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
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GB9320316D0 (en) * 1993-10-01 1993-11-17 Smithkline Beecham Plc Pharmaceuticals
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US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
JP3906488B2 (ja) 1995-02-21 2007-04-18 味の素株式会社 プリン誘導体の製造方法
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US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
CN1064683C (zh) * 1996-01-26 2001-04-18 弗·哈夫曼-拉罗切有限公司 制备嘌呤衍生物的方法
AU1592897A (en) * 1996-01-26 1997-08-20 F. Hoffmann-La Roche Ag Process for preparing purine derivatives
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) * 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
EP0827960A1 (en) 1996-09-10 1998-03-11 Ajinomoto Co., Inc. Process for producing purine derivatives

Also Published As

Publication number Publication date
AU1818397A (en) 1997-09-02
MY123083A (en) 2006-05-31
CZ232298A3 (cs) 1998-10-14
CZ292169B6 (cs) 2003-08-13
TW533213B (en) 2003-05-21
EP0880521B1 (en) 2003-01-22
WO1997030051A1 (en) 1997-08-21
US20120123119A1 (en) 2012-05-17
HK1015773A1 (en) 1999-10-22
EA002809B1 (ru) 2002-10-31
BG102647A (en) 1999-04-30
SK284613B6 (sk) 2005-07-01
ATE231508T1 (de) 2003-02-15
US6576763B1 (en) 2003-06-10
NZ330472A (en) 2000-02-28
AU1818297A (en) 1997-09-02
DE69718626D1 (de) 2003-02-27
PL328335A1 (en) 1999-01-18
EA200000787A1 (ru) 2001-04-23
BG64179B1 (bg) 2004-03-31
JP4171069B2 (ja) 2008-10-22
US20090076041A1 (en) 2009-03-19
US5869493A (en) 1999-02-09
EA199800729A1 (ru) 1999-02-25
CA2243826C (en) 2005-12-27
JP2000504720A (ja) 2000-04-18
DE69718619D1 (de) 2003-02-27
NO983216L (no) 1998-10-13
US6255312B1 (en) 2001-07-03
ES2189941T3 (es) 2003-07-16
JP2000504721A (ja) 2000-04-18
TR199801318T2 (xx) 1998-10-21
DE69718626T2 (de) 2003-09-11
AR005827A1 (es) 1999-07-14
HUP9900680A2 (hu) 1999-06-28
KR19990082571A (ko) 1999-11-25
PL184892B1 (pl) 2003-01-31
DK0888348T3 (da) 2003-04-14
KR100464692B1 (ko) 2005-06-21
CA2243826A1 (en) 1997-08-21
SK98598A3 (en) 1998-12-02
NO322930B1 (no) 2006-12-18
IL124760A0 (en) 1999-01-26
EP0880521A1 (en) 1998-12-02
NO983216D0 (no) 1998-07-13
EP0888348B1 (en) 2003-01-22
EA001404B1 (ru) 2001-02-26
CN1210537A (zh) 1999-03-10
CN1067073C (zh) 2001-06-13
EP0888348A1 (en) 1999-01-07
AU715062B2 (en) 2000-01-13
US8124609B2 (en) 2012-02-28
HU229865B1 (en) 2014-10-28
IL124760A (en) 2003-09-17
WO1997030052A1 (en) 1997-08-21
AU713916B2 (en) 1999-12-16
ATE231507T1 (de) 2003-02-15
DE69718619T2 (de) 2003-08-21
HUP9900680A3 (en) 2001-02-28

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