ES2189993T3 - Sulfamidas de aminoacilo para el tratamiento de trastornos hiperproliferativos. - Google Patents

Sulfamidas de aminoacilo para el tratamiento de trastornos hiperproliferativos.

Info

Publication number
ES2189993T3
ES2189993T3 ES97954582T ES97954582T ES2189993T3 ES 2189993 T3 ES2189993 T3 ES 2189993T3 ES 97954582 T ES97954582 T ES 97954582T ES 97954582 T ES97954582 T ES 97954582T ES 2189993 T3 ES2189993 T3 ES 2189993T3
Authority
ES
Spain
Prior art keywords
treatment
sinophamides
aminoacilo
hyperproliferative disorders
deoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97954582T
Other languages
English (en)
Inventor
Jason M Hill
Arthur F Kluge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cubist Pharmaceuticals LLC
Original Assignee
Cubist Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cubist Pharmaceuticals LLC filed Critical Cubist Pharmaceuticals LLC
Application granted granted Critical
Publication of ES2189993T3 publication Critical patent/ES2189993T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a sulfamidas de tipo aminoácilo. Estos compuestos son efectivos para el tratamiento de los problemas hiperproliferantes, especialmente la soriasis. Los compuestos de esta invención son 5''-desoxi-adenosina 5''-N{(N-L-fenilalanil sulfanida y 5''-desoxi-adenosina 5''-N-{(N-L-triptofanilsulfamida.
ES97954582T 1997-03-18 1997-12-18 Sulfamidas de aminoacilo para el tratamiento de trastornos hiperproliferativos. Expired - Lifetime ES2189993T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/820,249 US5824657A (en) 1997-03-18 1997-03-18 Aminoacyl sulfamides for the treatment of hyperproliferative disorders

Publications (1)

Publication Number Publication Date
ES2189993T3 true ES2189993T3 (es) 2003-07-16

Family

ID=25230298

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97954582T Expired - Lifetime ES2189993T3 (es) 1997-03-18 1997-12-18 Sulfamidas de aminoacilo para el tratamiento de trastornos hiperproliferativos.

Country Status (6)

Country Link
US (1) US5824657A (es)
EP (1) EP0991412B1 (es)
AU (1) AU5899798A (es)
DE (1) DE69719815T2 (es)
ES (1) ES2189993T3 (es)
WO (1) WO1998041215A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9756B (en) * 1996-01-16 1997-07-17 Warner Lambert Co Process for preparing 4,6-disubstituted pyrido[3,4-d]-pyrimidines
EP1000932B9 (en) * 1997-06-27 2005-12-28 Fujisawa Pharmaceutical Co., Ltd. Aromatic ring derivatives
US5939458A (en) * 1997-09-22 1999-08-17 Henry; James P. Reduction of hair growth
WO2000017206A1 (en) * 1998-09-18 2000-03-30 Cubist Pharmaceuticals, Inc. Tetracyclic heterocycles as antimicrobial agents
GB9822241D0 (en) * 1998-10-12 1998-12-09 Smithkline Beecham Plc Novel compounds
US6329344B1 (en) 1998-10-22 2001-12-11 Ranbaxy Laboratories Limited Derivatives of monosaccharides as cell adhesion inhibitors
US6602274B1 (en) 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
US6454789B1 (en) 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
US6624187B1 (en) 2000-06-12 2003-09-23 Health Research, Inc. Long wave length absorbing bacteriochlorin alkyl ether analogs
WO2003089454A2 (en) * 2002-04-19 2003-10-30 California Institute Of Technology Unnatural amino acid containing display libraries
US20040224981A1 (en) * 2003-05-01 2004-11-11 Nebojsa Janjic Antibacterial methods and compositions
PT1848718E (pt) * 2005-02-04 2012-10-11 Millennium Pharm Inc Inibidores de enzimas de activação e1
WO2006113615A2 (en) 2005-04-15 2006-10-26 Sloan-Kettering Institute For Cancer Research Anti-microbial agents and uses thereof
WO2007067559A2 (en) * 2005-12-06 2007-06-14 Regents Of The University Of Minnesota Antibacterial agents
KR101450535B1 (ko) * 2006-02-02 2014-10-14 밀레니엄 파머슈티컬스 인코퍼레이티드 Ｅ１ 활성화 효소의 억제제
SG175929A1 (en) 2009-05-14 2011-12-29 Millennium Pharm Inc Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate
CN104177361B (zh) * 2014-08-25 2016-03-30 合肥工业大学 一种基于植物生长素调节基因gh3的asa型酶抑制剂及其制备方法
EA036995B1 (ru) * 2015-02-13 2021-01-25 Оксфорд Драг Дизайн Лимитед НОВЫЕ N-АЦИЛАРИЛСУЛЬФОНАМИДНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ АМИНОАЦИЛ-тРНК СИНТЕТАЗЫ
WO2016201374A1 (en) * 2015-06-11 2016-12-15 University Of Florida Research Foundation, Incorporated Sulfanide adenosine derivatives and uses thereof
GB201617064D0 (en) 2016-10-07 2016-11-23 Inhibox Limited And Latvian Institute Of Organic Synthesis The Compounds and their therapeutic use

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB815381A (en) * 1955-04-27 1959-06-24 American Cyanamid Co Antibiotic designated nucleocidin and preparation thereof
US2914525A (en) * 1957-03-18 1959-11-24 American Cyanamid Co Nucleocidin and the process of obtaining the same
US3854480A (en) * 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3622561A (en) * 1969-08-18 1971-11-23 Univ Utah Nucleoside sugar esters of sulfamic acid and method for preparation of the same
US3928319A (en) * 1971-06-16 1975-12-23 Syntex Inc 4 -Fluoro nucleosides, novel intermediates and methods of preparing same
US3817978A (en) * 1971-06-16 1974-06-18 Syntex Inc 4-fluoro nucleosides and sugar intermediates, and methods of preparing
JPS57206397A (en) * 1981-04-10 1982-12-17 Teruhiko Beppu Preparation of antibiotic substance at-265 and/or at-265-b
US4452775A (en) * 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
JPS6256500A (ja) * 1985-09-05 1987-03-12 Rikagaku Kenkyusho アスカマイシンの合成法
JPS62108897A (ja) * 1985-11-05 1987-05-20 Rikagaku Kenkyusho アスカマイシン誘導体及びその合成法並びに制癌剤
JPS62108896A (ja) * 1985-11-05 1987-05-20 Rikagaku Kenkyusho アスカマイシンの合成法
JPS6351398A (ja) * 1986-08-22 1988-03-04 Kureha Chem Ind Co Ltd ５′−スルフアモイル−２−ブロモアデノシン及びその製造法
US5039660A (en) * 1988-03-02 1991-08-13 Endocon, Inc. Partially fused peptide pellet
US5470967A (en) * 1990-04-10 1995-11-28 The Dupont Merck Pharmaceutical Company Oligonucleotide analogs with sulfamate linkages
DE4215738A1 (de) * 1991-05-16 1993-02-04 Ciba Geigy Ag Mikroorganismus
JPH0560479A (ja) * 1991-09-02 1993-03-09 Fujikura Ltd ループ型ヒートパイプの製造方法
IL108523A0 (en) * 1993-02-03 1994-05-30 Gensia Inc Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain
GB9325810D0 (en) * 1993-12-17 1994-02-23 Zeneca Ltd Herbicidal composition
GB9325809D0 (en) * 1993-12-17 1994-02-23 Zeneca Ltd Herbicidal composition
US5594015A (en) * 1994-06-22 1997-01-14 Regents Of The University Of California Thiazolidine derivatives for the treatment of psoriasis

Also Published As

Publication number Publication date
EP0991412A1 (en) 2000-04-12
US5824657A (en) 1998-10-20
DE69719815T2 (de) 2003-08-28
EP0991412A4 (en) 2000-06-21
AU5899798A (en) 1998-10-12
DE69719815D1 (de) 2003-04-17
EP0991412B1 (en) 2003-03-12
WO1998041215A1 (en) 1998-09-24

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