ES2190205T3 - Combinacion para el tratamiento de la dependencia del alcohol que contiene un antagonista opioide y un modulador del complejo receptor de nmda. - Google Patents

Combinacion para el tratamiento de la dependencia del alcohol que contiene un antagonista opioide y un modulador del complejo receptor de nmda.

Info

Publication number
ES2190205T3
ES2190205T3 ES99916907T ES99916907T ES2190205T3 ES 2190205 T3 ES2190205 T3 ES 2190205T3 ES 99916907 T ES99916907 T ES 99916907T ES 99916907 T ES99916907 T ES 99916907T ES 2190205 T3 ES2190205 T3 ES 2190205T3
Authority
ES
Spain
Prior art keywords
treatment
nmda receptor
receptor complex
combination
opioid antagonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99916907T
Other languages
English (en)
Inventor
Martine Daoust
Yves Le Buclay Bonhomme
Philippe Durbin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
Merck Sante SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sante SAS filed Critical Merck Sante SAS
Application granted granted Critical
Publication of ES2190205T3 publication Critical patent/ES2190205T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Uso de una combinación sinérgica de: (i) un antagonista opioide, y (ii) un modulador del complejo receptor NMDA, para la preparación de una composición farmacéutica para el tratamiento de la dependencia del alcohol.
ES99916907T 1998-03-26 1999-03-26 Combinacion para el tratamiento de la dependencia del alcohol que contiene un antagonista opioide y un modulador del complejo receptor de nmda. Expired - Lifetime ES2190205T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98400723A EP0945133A1 (en) 1998-03-26 1998-03-26 Combination for the treatment of alcohol and drug dependence containing an opioid antagonist and a NMDA receptor complex modulator

Publications (1)

Publication Number Publication Date
ES2190205T3 true ES2190205T3 (es) 2003-07-16

Family

ID=8235311

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99916907T Expired - Lifetime ES2190205T3 (es) 1998-03-26 1999-03-26 Combinacion para el tratamiento de la dependencia del alcohol que contiene un antagonista opioide y un modulador del complejo receptor de nmda.

Country Status (17)

Country Link
US (1) US6512009B1 (es)
EP (2) EP0945133A1 (es)
KR (1) KR20010034678A (es)
AT (1) ATE230993T1 (es)
AU (1) AU758569B2 (es)
BR (1) BR9909138A (es)
CA (1) CA2325739C (es)
CZ (1) CZ296367B6 (es)
DE (1) DE69904922T2 (es)
DK (1) DK1063995T3 (es)
ES (1) ES2190205T3 (es)
HU (1) HU226555B1 (es)
NO (1) NO319313B1 (es)
PL (1) PL193241B1 (es)
RU (1) RU2226107C2 (es)
SK (1) SK284623B6 (es)
WO (1) WO1999048500A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1243543C (zh) * 1998-07-20 2006-03-01 派普泰克有限公司 生物植入物配方
US8052982B2 (en) 1998-07-20 2011-11-08 Peptech Animal Health Pty Limited Bioimplant formulation comprising lecithin and stearin
WO2001052851A1 (en) * 2000-01-22 2001-07-26 Albert Shulman Methods for the treatment of substance abuse
EP1262196A3 (en) * 2001-05-23 2002-12-18 Pfizer Products Inc. Combination of a monoamine reuptake inhibitor and an opioid antagonist for use in alcoholism and alcohol dependence
DE10129265A1 (de) * 2001-06-18 2003-01-02 Hf Arzneimittelforsch Gmbh Wirkstoff-Kombination zur medikamentösen Sucht- oder Rauschmitteltherapie
ES2187288B1 (es) * 2001-09-24 2004-09-16 Garbil Pharma Investigacion Chile Ltda Aminas como agentes anti-alcoholismo.
SI2561860T1 (en) * 2002-05-31 2018-05-31 Titan Pharmaceuticals, Inc. An implantable polymeric device for prolonged release of buprenorphine
ATE482695T1 (de) 2002-12-13 2010-10-15 Durect Corp Orale darreichungsform mit flüssigen hochviskosen trägersystemen
AU2003301121A1 (en) * 2002-12-18 2004-07-14 Pain Therapeutics, Inc. Oral dosage forms with therapeutically active agents in controlled release cores and immediate release gelatin capsule coats
PT1610791E (pt) 2003-03-31 2011-05-23 Titan Pharmaceuticals Inc Dispositivo polim?rico implant?vel para liberta??o sustentada de agonista da dopamina
CA2526101A1 (en) * 2003-05-30 2004-12-23 Titan Pharmaceuticals, Inc. Implantable polymeric device for sustained release of nalmefene
US20070099947A1 (en) * 2005-11-03 2007-05-03 Alkermes, Inc. Methods and compositions for the treatment of brain reward system disorders by combination therapy
JP2010513569A (ja) * 2006-12-19 2010-04-30 ユニバーシティ オブ バージニア パテント ファウンデーション アルコール摂取に対するトピラメートおよびオンダンセトロンの併用効果
EP2219622A1 (en) 2007-12-06 2010-08-25 Durect Corporation Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition
PL2255184T3 (pl) 2008-02-28 2013-12-31 Univ Virginia Patent Foundation Gen transportera serotoniny i leczenie alkoholizmu
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
PL2801625T3 (pl) 2010-07-02 2018-06-29 University Of Virginia Patent Foundation Molekularne, genetyczne podejście do leczenia i diagnozy uzależnienia od alkoholu i leków
EP3045173A3 (en) 2011-09-09 2016-09-14 The University of Virginia Patent Foundation Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence
RU2476209C1 (ru) * 2012-02-29 2013-02-27 Станислав Анатольевич Кедик Имплантируемое лекарственное средство на основе налтрексона для лечения пациентов, зависимых от алкоголя или опиатов
TW201521769A (zh) 2013-03-15 2015-06-16 Durect Corp 具有流變改質劑以減少溶解變異性之組成物
GB201308440D0 (en) * 2013-05-10 2013-06-19 Dalgleish Angus Therapeutic
SG11201811760VA (en) 2016-07-06 2019-01-30 Durect Corp Oral dosage form with drug composition, barrier layer and drug layer
US20240350433A1 (en) * 2021-08-17 2024-10-24 Yale University Treatment compositions and methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882335A (en) * 1988-06-13 1989-11-21 Alko Limited Method for treating alcohol-drinking response
WO1997033581A1 (en) * 1996-03-13 1997-09-18 Yale University Smoking cessation treatments using naltrexone and related compounds

Also Published As

Publication number Publication date
EP0945133A1 (en) 1999-09-29
US6512009B1 (en) 2003-01-28
EP1063995B1 (en) 2003-01-15
CZ20003525A3 (cs) 2001-04-11
HUP0101546A2 (hu) 2001-09-28
HK1032542A1 (en) 2001-07-27
ATE230993T1 (de) 2003-02-15
CZ296367B6 (cs) 2006-02-15
AU3522699A (en) 1999-10-18
AU758569B2 (en) 2003-03-27
DE69904922T2 (de) 2004-01-08
HU226555B1 (en) 2009-03-30
CA2325739A1 (en) 1999-09-30
RU2226107C2 (ru) 2004-03-27
KR20010034678A (ko) 2001-04-25
HUP0101546A3 (en) 2002-10-28
NO20004788L (no) 2000-11-24
WO1999048500A1 (en) 1999-09-30
NO319313B1 (no) 2005-07-11
PL343069A1 (en) 2001-07-30
BR9909138A (pt) 2000-12-05
DK1063995T3 (da) 2003-03-10
NO20004788D0 (no) 2000-09-25
EP1063995A1 (en) 2001-01-03
SK284623B6 (sk) 2005-08-04
CA2325739C (en) 2007-05-15
DE69904922D1 (de) 2003-02-20
SK14282000A3 (sk) 2001-05-10
PL193241B1 (pl) 2007-01-31

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