ES2190466T3 - Gen brca2 de susceptibilidad al cancer de mama ligado al cromosoma 13. - Google Patents

Gen brca2 de susceptibilidad al cancer de mama ligado al cromosoma 13.

Info

Publication number
ES2190466T3
ES2190466T3 ES96309211T ES96309211T ES2190466T3 ES 2190466 T3 ES2190466 T3 ES 2190466T3 ES 96309211 T ES96309211 T ES 96309211T ES 96309211 T ES96309211 T ES 96309211T ES 2190466 T3 ES2190466 T3 ES 2190466T3
Authority
ES
Spain
Prior art keywords
cancer
human
brca2
gene
invention refers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96309211T
Other languages
English (en)
Other versions
ES2190466T5 (es
Inventor
Sean V Tavtigian
Alexander Kamb
Jacques Simard
Fergus Couch
Johanna M Rommens
Barbara L Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Endorecherche Inc
HSC Research and Development LP
Myriad Genetics Inc
University of Pennsylvania Penn
Original Assignee
Endorecherche Inc
HSC Research and Development LP
Myriad Genetics Inc
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27504907&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2190466(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Endorecherche Inc, HSC Research and Development LP, Myriad Genetics Inc, University of Pennsylvania Penn filed Critical Endorecherche Inc
Publication of ES2190466T3 publication Critical patent/ES2190466T3/es
Application granted granted Critical
Publication of ES2190466T5 publication Critical patent/ES2190466T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE GENERALMENTE AL CAMPO DE LA GENETICA HUMANA. ESPECIFICAMENTE, LA PRESENTE INVENCION SE REFIERE A METODOS Y MATERIALES UTILIZADOS PARA AISLAR Y DETECTAR UN GEN DE PREDISPOSICION AL CANCER DE MAMA HUMANO (BRCA2), ALGUNOS ALELOS MUTANTES QUE CAUSAN SUSCEPTIBILIDAD AL CANCER, EN CONCRETO CANCER DE MAMA. EN CONCRETO, LA INVENCION SE REFIERE A MUTACIONES DE LINEA GERMINAL EN EL GEN BRCA2 Y A SU USO EN EL DIAGNOSTICO DE PREDISPOSICION AL CANCER DE MAMA. LA PRESENTE INVENCION SE REFIERE ADEMAS A MUTACIONES SOMATICAS EN EL GEN BRCA2 EN CANCER DE MAMA HUMANO Y A SU USO EN EL DIAGNOSTICO Y PROGNOSIS DE CANCER DE MAMA HUMANO. ADICIONALMENTE, LA INVENCION SE REFIERE A MUTACIONES SOMATICAS EN EL GEN BRCA2 EN OTROS CANCERES HUMANOS Y A SU USO EN EL DIAGNOSTICO Y PROGNOSIS DE CANCERES HUMANOS. LA INVENCION TAMBIEN SE REFIERE A LA TERAPIA DE CANCERES HUMANOS QUE TIENEN UNA MUTACION EN EL GEN BRCA2, INCLUYENDO TERAPIA GENICA, TERAPIA DE SUSTITUCION DE PROTEINA Y MIMETICA DE PROTEINA. LA INVENCION SE REFIERE ADEMAS A LA INVESTIGACION DE FARMACOS PARA TERAPIA DE CANCER. FINALMENTE, LA INVENCION SE REFIERE A LA INVESTIGACION DE LAS MUTACIONES DEL GEN BRCA2, LO CUAL ES UTIL PARA DIAGNOSTICAR LA PREDISPOSICION AL CANCER DE MAMA.
ES96309211T 1995-12-18 1996-12-17 Gen brca2 de susceptibilidad al cancer de mama ligado al cromosoma 13. Expired - Lifetime ES2190466T5 (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US57377995A 1995-12-18 1995-12-18
US573779 1995-12-18
US57535995A 1995-12-20 1995-12-20
US575359 1995-12-20
US57655995A 1995-12-21 1995-12-21
US576559 1995-12-21
US58539196A 1996-01-11 1996-01-11
US585391 1996-01-11
US639501 1996-04-29

Publications (2)

Publication Number Publication Date
ES2190466T3 true ES2190466T3 (es) 2003-08-01
ES2190466T5 ES2190466T5 (es) 2007-02-16

Family

ID=27504907

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96309211T Expired - Lifetime ES2190466T5 (es) 1995-12-18 1996-12-17 Gen brca2 de susceptibilidad al cancer de mama ligado al cromosoma 13.

Country Status (3)

Country Link
US (1) US5837492A (es)
EP (2) EP2338913A1 (es)
ES (1) ES2190466T5 (es)

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US20090269814A1 (en) * 1998-05-22 2009-10-29 Murphy Patricia D Method of Analyzing a BRCA2 Gene in a Human Subject
EP1801240A1 (en) * 2001-06-05 2007-06-27 Auckland Uniservices Limited Methods and compositions for assessment of pulmonary function and disorders
KR20060123702A (ko) * 2003-08-21 2006-12-04 큐 세라퓨틱스, 아이엔씨. 리소좀성 축적병에서 결핍된 리소좀 효소전구체의 지속된분비를 위한 유전자 변형 체세포
US20060269946A1 (en) * 2005-05-10 2006-11-30 Young Robert P Methods and compositions for assessment of pulmonary function and disorders
KR20080011292A (ko) * 2005-05-19 2008-02-01 시너젠즈 바이오사이언스 리미티드 유전자 다형 분석을 사용하여 폐암 발생 위험을 평가하는방법
JP2008545389A (ja) * 2005-05-19 2008-12-18 シナージェンズ バイオサイエンス リミティド 肺機能及び肺障害の評価のための方法及び組成物
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US20080085243A1 (en) * 2006-10-05 2008-04-10 Sigma-Aldrich Company Molecular markers for determining taxane responsiveness
US20100129358A1 (en) 2006-12-22 2010-05-27 University Of Utah Research Foundation Method of detecting ocular diseases and pathologic conditions and treatment of same
CN102232117A (zh) * 2008-10-14 2011-11-02 卡里斯Mpi公司 描绘肿瘤类型生物标志模式和特征集的基因靶和基因表达的蛋白靶
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CN103917556B (zh) 2011-10-14 2018-02-06 霍夫曼-拉罗奇有限公司 抗HtrA1抗体及使用方法
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WO2015073922A2 (en) 2013-11-15 2015-05-21 Northwestern University Inhibition of oxidative stress in atrial fibrillation
EP3080292B1 (en) 2013-12-09 2022-02-02 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
EP4674963A3 (en) 2013-12-09 2026-04-29 Baylor College of Medicine Hippo and dystrophin complex signaling in cardiomyocyte renewal
US10133996B2 (en) * 2014-04-22 2018-11-20 International Business Machines Corporation Object lifecycle analysis tool
CN104111339B (zh) * 2014-06-26 2015-11-25 武汉市畜牧兽医科学研究所 基于BRCA2蛋白、mRNA诊断奶牛是否妊娠的方法及用途
EP4234711B1 (en) 2014-08-15 2025-05-28 Myriad Genetics, Inc. Methods and materials for assessing homologous recombination deficiency
EP3259346B1 (en) 2015-02-20 2024-08-07 Baylor College of Medicine P63 inactivation for the treatment of heart failure
CN104962613B (zh) * 2015-06-02 2019-12-03 南京医科大学 一种用于乳腺癌辅助诊断的突变基因及其应用
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Also Published As

Publication number Publication date
EP2338913A1 (en) 2011-06-29
EP1260520B1 (en) 2014-09-10
EP1260520A2 (en) 2002-11-27
ES2190466T5 (es) 2007-02-16
US5837492A (en) 1998-11-17
EP1260520A3 (en) 2002-12-04

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