ES2190788T3 - Utilizacion de halogenuros aromaticos para tratar la proliferacion de celulas mamarias. - Google Patents

Utilizacion de halogenuros aromaticos para tratar la proliferacion de celulas mamarias.

Info

Publication number
ES2190788T3
ES2190788T3 ES95933137T ES95933137T ES2190788T3 ES 2190788 T3 ES2190788 T3 ES 2190788T3 ES 95933137 T ES95933137 T ES 95933137T ES 95933137 T ES95933137 T ES 95933137T ES 2190788 T3 ES2190788 T3 ES 2190788T3
Authority
ES
Spain
Prior art keywords
treatments
compounds
aromatic
proliferation
halogenures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95933137T
Other languages
English (en)
Inventor
Jose Halperin
Carlo Brugnara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Childrens Hospital
Harvard University
Original Assignee
Boston Childrens Hospital
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Childrens Hospital, Harvard University filed Critical Boston Childrens Hospital
Application granted granted Critical
Publication of ES2190788T3 publication Critical patent/ES2190788T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA METODOS Y PRODUCTOS PARA INHIBIR LA PROLIFERACION CELULAR EN MAMIFEROS. LOS COMPUESTOS, QUE SON ANTIMICOTICOS Y QUE INHIBEN EL CANAL DE POTASIO ACTIVADO CA{SUP,++} DE LOS ERITROCITOS, SE HAN MODIFICADO PARA UTILIZARLOS EN LA PRESENTE INVENCION RETIRANDO EL GRUPO IMIDAZOL. ESTOS COMPUESTOS MODIFICADOS NORMALMENTE TIENEN AL MENOS GRUPOS AROMATICOS SEPARADOS UNOS DE OTROS PERO NO MAS DE CINCO ATOMOS, Y MAS NORMALMENTE NO MAS DE TRES ATOMOS. AL MENOS UNO DE LOS GRUPOS AROMATICOS SE SUSTITUYE CON UNA CLORINA U OTRA FUNCIONALIDAD CON UNA CARGA NEGATIVA NETA EN CONJUNTO. LOS COMPUESTOS PUEDEN UTILIZARSE EN CONEXION CON, ENTRE OTROS, TRATAMIENTOS PARA EL CANCER, TRATAMIENTOS PARA AFECCIONES ARTERIOESCLEROTICAS, TRATAMIENTOS PARA AFECCIONES ANGIOGENICAS Y OTROS TRASTORNOS PROLIFERATIVOS CELULARES.
ES95933137T 1994-09-16 1995-09-15 Utilizacion de halogenuros aromaticos para tratar la proliferacion de celulas mamarias. Expired - Lifetime ES2190788T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30788794A 1994-09-16 1994-09-16

Publications (1)

Publication Number Publication Date
ES2190788T3 true ES2190788T3 (es) 2003-08-16

Family

ID=23191588

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95933137T Expired - Lifetime ES2190788T3 (es) 1994-09-16 1995-09-15 Utilizacion de halogenuros aromaticos para tratar la proliferacion de celulas mamarias.

Country Status (7)

Country Link
EP (1) EP0783303B1 (es)
JP (2) JP4099226B2 (es)
AU (1) AU703863B2 (es)
CA (1) CA2200084C (es)
DE (1) DE69528992T2 (es)
ES (1) ES2190788T3 (es)
WO (1) WO1996008240A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2190788T3 (es) * 1994-09-16 2003-08-16 Harvard College Utilizacion de halogenuros aromaticos para tratar la proliferacion de celulas mamarias.
US6028103A (en) * 1994-09-16 2000-02-22 Children's Medical Center Corporation Triaryl methane compounds and analogues thereof useful for the treatment or prevention of sickle cell disease or diseases characterized by abnormal cell proliferation
US7531573B2 (en) * 1994-09-16 2009-05-12 Children's Medical Center Corporation Use of triaryl methane compounds for inhibiting unwanted cellular proliferation associated with inflammatory disease
US6992079B2 (en) 1997-11-20 2006-01-31 President Fellows of Harvard College Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation
US6800658B2 (en) 1997-11-20 2004-10-05 Children's Medical Center Corporation Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation
CN1119334C (zh) 1997-11-20 2003-08-27 哈佛学院校长及员工 用于治疗或预防以异常细胞增殖为特征之疾病的经取代的11－苯基－二苯并吖庚因化合物
AU1596099A (en) * 1998-11-23 2000-06-13 Eisai Co. Ltd. Aryl and heteroaryl compounds useful as fibroblast growth factor antagonists
WO2002070009A1 (en) * 2001-02-27 2002-09-12 Yasuda, Yoshiko Preventives/remedies for thickened scar, keloid or chronic arthritic diseases
EP1459762B1 (en) * 2001-11-02 2008-07-02 Yoshiko Yasuda Use of emp9 for the prevention of proliferative organ diseases
US8318699B2 (en) 2005-01-31 2012-11-27 The Trustees Of The University Of Pennsylvania Tumor necrosis factor inhibitors
US8158828B2 (en) * 2005-11-28 2012-04-17 Gtx, Inc. Nuclear receptor binding agents
US9409856B2 (en) 2005-11-28 2016-08-09 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US8546451B2 (en) 2005-11-28 2013-10-01 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
ES2465216T3 (es) * 2007-06-04 2014-06-05 Ben Gurion University Of The Negev Research And Development Authority Compuestos de triarilo y composiciones que comprenden los mismos
US9427418B2 (en) 2009-02-23 2016-08-30 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US9624161B2 (en) 2009-02-23 2017-04-18 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
FR2975911A1 (fr) * 2011-06-06 2012-12-07 Univ Strasbourg Bisacodyl et analogues comme medicaments destines au traitement du cancer
CN115703734B (zh) * 2021-08-05 2024-08-09 重庆文理学院 二芳基甲基吡啶类化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0311616B1 (en) * 1986-06-17 1991-09-25 Biogen, Inc. Combinations of gamma interferons and anti-inflammatory or anti-pyretic agents for treating diseases
US5512591A (en) * 1993-02-18 1996-04-30 President And Fellows Of Harvard College Treatments for diseases characterized by neovascularization
US5358959A (en) * 1993-02-18 1994-10-25 President And Fellows Of Harvard University Methods for treating arteriosclerosis
ES2190788T3 (es) * 1994-09-16 2003-08-16 Harvard College Utilizacion de halogenuros aromaticos para tratar la proliferacion de celulas mamarias.

Also Published As

Publication number Publication date
JP4099226B2 (ja) 2008-06-11
AU703863B2 (en) 1999-04-01
EP0783303B1 (en) 2002-11-27
AU3590895A (en) 1996-03-29
CA2200084C (en) 2007-03-27
CA2200084A1 (en) 1996-03-21
DE69528992D1 (de) 2003-01-09
DE69528992T2 (de) 2003-09-18
EP0783303A1 (en) 1997-07-16
JP2007277273A (ja) 2007-10-25
JPH10511080A (ja) 1998-10-27
WO1996008240A1 (en) 1996-03-21

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