ATE448207T1 - Mitotische kinesin-hemmer - Google Patents
Mitotische kinesin-hemmerInfo
- Publication number
- ATE448207T1 ATE448207T1 AT03745083T AT03745083T ATE448207T1 AT E448207 T1 ATE448207 T1 AT E448207T1 AT 03745083 T AT03745083 T AT 03745083T AT 03745083 T AT03745083 T AT 03745083T AT E448207 T1 ATE448207 T1 AT E448207T1
- Authority
- AT
- Austria
- Prior art keywords
- mitotic kinesin
- kinesin inhibitors
- compounds
- ksp kinesin
- treating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Ceramic Engineering (AREA)
- Inorganic Chemistry (AREA)
- Materials Engineering (AREA)
- Structural Engineering (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36292202P | 2002-03-08 | 2002-03-08 | |
| PCT/US2003/006403 WO2003079973A2 (en) | 2002-03-08 | 2003-03-04 | Mitotic kinesin inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE448207T1 true ATE448207T1 (de) | 2009-11-15 |
Family
ID=28454585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03745083T ATE448207T1 (de) | 2002-03-08 | 2003-03-04 | Mitotische kinesin-hemmer |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7745639B2 (de) |
| EP (1) | EP1492487B1 (de) |
| JP (1) | JP4399269B2 (de) |
| AT (1) | ATE448207T1 (de) |
| AU (1) | AU2003249597B2 (de) |
| CA (1) | CA2478068C (de) |
| DE (1) | DE60329990D1 (de) |
| WO (1) | WO2003079973A2 (de) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7230000B1 (en) | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
| US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| SI1847534T1 (sl) | 2001-12-11 | 2011-10-28 | Kyowa Hakko Kirin Co Ltd | Tiadiazolinski derivati za zdravljenje raka |
| WO2003070701A2 (en) | 2002-02-15 | 2003-08-28 | Cytokinetics, Inc. | Syntheses of quinazolinones |
| ATE471931T1 (de) | 2002-04-17 | 2010-07-15 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren |
| WO2003094839A2 (en) | 2002-05-09 | 2003-11-20 | Cytokinetics, Inc. | Pyrimidinone compounds, compositions and methods |
| AU2003270015A1 (en) | 2002-05-09 | 2003-12-02 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| JP2005536475A (ja) | 2002-05-23 | 2005-12-02 | サイトキネティクス・インコーポレーテッド | 化合物、組成物、および方法 |
| EP1556357A4 (de) | 2002-06-14 | 2006-09-13 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren |
| WO2004006865A2 (en) | 2002-07-17 | 2004-01-22 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| EP1537089A4 (de) | 2002-07-23 | 2008-04-16 | Cytokinetics Inc | Verbindungen, zusammenstellungen und verfahren |
| EP1558083A4 (de) | 2002-09-30 | 2008-04-16 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren |
| AU2003287057B2 (en) * | 2002-10-18 | 2008-08-21 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
| CN1774428B (zh) | 2003-04-18 | 2010-06-16 | 协和发酵麒麟株式会社 | M期驱动蛋白抑制剂 |
| US20070276017A1 (en) * | 2003-06-10 | 2007-11-29 | Chikara Murakata | Thiadiazoline Derivative |
| DE602004019229D1 (de) * | 2003-08-15 | 2009-03-12 | Merck & Co Inc | Inhibitoren von mitotischem kinesin |
| JP2007513154A (ja) | 2003-12-08 | 2007-05-24 | サイトキネティクス・インコーポレーテッド | 化合物、組成物及び方法 |
| AU2005226670A1 (en) * | 2004-03-22 | 2005-10-06 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
| CA2564215A1 (en) | 2004-05-21 | 2005-12-01 | Chiron Corporation | Substituted quinoline derivatives as mitotic kinesin inhibitors |
| JP4836280B2 (ja) | 2004-06-18 | 2011-12-14 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 癌を治療するためのキネシンスピンドルタンパク質（ｋｓｐ）阻害剤としてのｎ−（１−（１−ベンジル−４−フェニル−１ｈ−イミダゾール−２−イル）−２，２−ジメチルプロピル）ベンズアミド誘導体および関連化合物 |
| CA2571824A1 (en) * | 2004-07-01 | 2006-01-19 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| WO2006007496A2 (en) * | 2004-07-01 | 2006-01-19 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| RU2007103816A (ru) | 2004-07-01 | 2008-08-10 | Мерк энд Ко., Инк. (US) | Ингибиторы митотического кинезина |
| CA2571821A1 (en) * | 2004-07-01 | 2006-01-19 | Merck & Co., Inc. | Prodrugs of mitotic kinesin inhibitors |
| WO2006023083A1 (en) * | 2004-08-12 | 2006-03-02 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
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| KR20070072598A (ko) | 2004-10-19 | 2007-07-04 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 인돌 및 벤지미다졸 유도체 |
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| US11098059B2 (en) | 2017-11-08 | 2021-08-24 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
| WO2019148412A1 (en) | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anti-pd-1/lag3 bispecific antibodies |
| WO2020033285A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| CA3108388A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
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| CN109020888B (zh) * | 2018-09-07 | 2021-11-16 | 南京大学 | 一种含吡唑啉结构的微管聚合抑制剂及其应用 |
| CN113302183A (zh) * | 2018-11-20 | 2021-08-24 | 圣瑞诺有限公司 | 环脲 |
| CN109988114B (zh) * | 2019-04-04 | 2020-07-24 | 浙江理工大学 | 一种多取代的4,5-二氢吡唑化合物的制备方法 |
| EP4076460B1 (de) | 2019-12-17 | 2026-01-21 | Merck Sharp & Dohme LLC | 1,4-dihydro-2h-spiro[isoquinoline-3,4'-piperidin]-derivate als prmt5 inhibitoren zur behandlung von krebs |
| JP7589247B2 (ja) | 2019-12-17 | 2024-11-25 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｐｒｍｔ５阻害剤 |
| WO2021126728A1 (en) | 2019-12-17 | 2021-06-24 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| US20230416226A1 (en) * | 2020-05-20 | 2023-12-28 | Sironax Ltd. | Azetidine Cyclic Ureas |
| CN115697972B (zh) * | 2020-05-20 | 2024-11-22 | 维泰瑞隆有限公司 | 包括哌嗪杂环酰胺脲的受体-相互作用蛋白1抑制剂 |
| IL298188A (en) | 2020-05-20 | 2023-01-01 | Sironax Ltd | Circular structures of piperazine |
| WO2021252307A1 (en) * | 2020-06-12 | 2021-12-16 | Merck Sharp & Dohme Corp. | Ripk1 inhibitors and methods of use |
| CN117355506A (zh) * | 2021-05-20 | 2024-01-05 | 维泰瑞隆有限公司 | 包括氮杂环丁烷环脲的rip1调节剂、其制备和用途 |
| WO2026027944A1 (en) | 2024-07-30 | 2026-02-05 | Sairopa B.V. | Anti-sirp alpha antibody formulations and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1900349A1 (de) * | 1969-01-04 | 1970-08-06 | Basf Ag | Neue Pyrazolinderivate |
| PH27357A (en) * | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
| JPH05112555A (ja) | 1991-10-18 | 1993-05-07 | Nippon Bayeragrochem Kk | 選択的殺虫性ピラゾリン類 |
| JPH05112556A (ja) | 1991-10-18 | 1993-05-07 | Nippon Bayeragrochem Kk | 殺虫性ピラゾリン類 |
| US6376519B1 (en) * | 1999-06-16 | 2002-04-23 | Temple University-Of The Commonwealth Of Higher Education | 1-(4-sulfamylaryl)-3-substituted-5-aryl-2-pyrazolines and inhibitors of cyclooxygenase-2 |
| WO2000076983A1 (en) | 1999-06-16 | 2000-12-21 | Temple University - Of The Commonwealth System Of Higher Education | 1-(4-arylsulfonyl)-3-substituted-5-aryl-2-pyrazolines as inhibitors of cyclooxygenase-2 |
| WO2001032173A1 (en) | 1999-10-29 | 2001-05-10 | Yamanouchi Pharmaceutical Co., Ltd. | Kainic acid neurocytotoxicity inhibitors |
| WO2001056993A2 (en) | 2000-02-05 | 2001-08-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of erk |
| US20020103192A1 (en) | 2000-10-26 | 2002-08-01 | Curtin Michael L. | Inhibitors of histone deacetylase |
-
2003
- 2003-03-04 WO PCT/US2003/006403 patent/WO2003079973A2/en not_active Ceased
- 2003-03-04 JP JP2003577806A patent/JP4399269B2/ja not_active Expired - Fee Related
- 2003-03-04 CA CA2478068A patent/CA2478068C/en not_active Expired - Fee Related
- 2003-03-04 DE DE60329990T patent/DE60329990D1/de not_active Expired - Lifetime
- 2003-03-04 EP EP03745083A patent/EP1492487B1/de not_active Expired - Lifetime
- 2003-03-04 AT AT03745083T patent/ATE448207T1/de not_active IP Right Cessation
- 2003-03-04 US US10/506,702 patent/US7745639B2/en not_active Expired - Fee Related
- 2003-03-04 AU AU2003249597A patent/AU2003249597B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1492487A2 (de) | 2005-01-05 |
| AU2003249597B2 (en) | 2007-06-28 |
| AU2003249597A1 (en) | 2003-10-08 |
| CA2478068C (en) | 2011-02-08 |
| WO2003079973A2 (en) | 2003-10-02 |
| EP1492487A4 (de) | 2006-01-11 |
| US20050119484A1 (en) | 2005-06-02 |
| JP4399269B2 (ja) | 2010-01-13 |
| US7745639B2 (en) | 2010-06-29 |
| DE60329990D1 (de) | 2009-12-24 |
| JP2005526091A (ja) | 2005-09-02 |
| CA2478068A1 (en) | 2003-10-02 |
| WO2003079973A3 (en) | 2004-11-11 |
| EP1492487B1 (de) | 2009-11-11 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |