ES2191063T3 - Derivados de acido ciclopropacromencarboxilico. - Google Patents
Derivados de acido ciclopropacromencarboxilico.Info
- Publication number
- ES2191063T3 ES2191063T3 ES95934860T ES95934860T ES2191063T3 ES 2191063 T3 ES2191063 T3 ES 2191063T3 ES 95934860 T ES95934860 T ES 95934860T ES 95934860 T ES95934860 T ES 95934860T ES 2191063 T3 ES2191063 T3 ES 2191063T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atoms
- substituted
- hydrogen atom
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 10
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- VUAKCICNISMYQX-UHFFFAOYSA-N cyclopropa[h]chromene-6-carboxylic acid Chemical class C1=CC2=CC2=C2OC(C(=O)O)=CC=C21 VUAKCICNISMYQX-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 abstract 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxyimino group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
LA PRESENTE INVENCION PROPORCIONA NUEVOS DERIVADOS DE ACIDO CICLOPROPACROMENOCARBOXILICO QUE TIENEN UNA ACTIVIDAD ANTAGONICA FRENTE A RECEPTORES DE GLUTAMATO METABOTROPICOS Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. LOS DERIVADOS DE ACIDO CICLOPROPACROMENOCARBOXILICO Y SUS SALES FARMACEUTICAMENTE ACEPTABLES REPRESENTADOS POR LA SIGUIENTE FORMULA GENERAL (1): [EN DONDE A DENOTA UN ATOMO DE OXIGENO, GRUPO HIDROXIIMINO, UN GRUPO ALQUILOXIMINO QUE TIENE DE 1 A 15 ATOMOS DE CARBONO, O EL GRUPO =N-O-(()CH{SUB,2}()){SUB,N}-NR{SUP,1}R{SUP,2} (DONDE N REPRESENTA UN ENTERO DE 2 A 8, Y CADA UNO DE R{SUP,1} Y R{SUP,2} REPRESENTA INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO QUE TIENE DE 1 A 5 ATOMOS DE CARBONO, RESPECTIVAMENTE); B DENOTA EL GRUPO -COOR{SUP,3} (DONDE R{SUP,3} REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO CON 1 A 5 ATOMOS DE CARBONO) O EL GRUPO -CONR{SUP,4}R{SUP,5} (DONDE R{SUP,4} Y R{SUP,5} INDEPENDIENTEMENTE REPRESENTAN UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO CON 1 A5 ATOMOS DE CARBONO, GRUPO ALQUENILO CON 2 A 5 ATOMOS DE CARBONO, GRUPO AMINOALQUILO CON 1 A 5 ATOMOS DE CARBONO EN DONDE N PUEDE SER SUSTITUIDO, HETEROCICLO SATURADO QUE CONTIENE NITROGENO DEL CUAL N PUEDE SER SUSTITUIDO, GRUPO FENILO QUE PUEDE SER SUSTITUIDO CON UN ATOMO DE HALOGENO O UN GRUPO HIDROXILO QUE A SU VEZ PUEDE SER SUSTITUIDO, GRUPO 2-PIRIDILO, O GRUPO ARALQUILO CON 7 A 10 ATOMOS DE CARBONO, O R{SUP,4} Y R{SUP,5} TOMADOS JUNTO CON EL ATOMO DE NITROGENO AL QUE ESTAN INCORPORADOS FORMAN UN SISTEMA DE ANILLO HETEROCICLICO QUE CONTIENE NITROGENO QUE PUEDE SER SUSTITUIDO); Y X ES UN ATOMO DE HALOGENO O EL GRUPO -OR{SUP,6} (DONDE R{SUP,6} REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO QUE TIENE DE 1 A 5 ATOMOS DE CARBONO, UN GRUPO ALQUENILO QUE TIENE DE 3 A 6 ATOMOS DE CARBONO, O UN GRUPO ARALQUILO QUE TIENE DE 7 A 10 ATOMOS DE CARBONO)].
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25646894 | 1994-10-21 | ||
| JP22536595A JP3993651B2 (ja) | 1994-10-21 | 1995-09-01 | シクロプロパクロメンカルボン酸誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2191063T3 true ES2191063T3 (es) | 2003-09-01 |
Family
ID=26526593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95934860T Expired - Lifetime ES2191063T3 (es) | 1994-10-21 | 1995-10-20 | Derivados de acido ciclopropacromencarboxilico. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5843988A (es) |
| EP (1) | EP0787723B1 (es) |
| JP (1) | JP3993651B2 (es) |
| AT (1) | ATE231142T1 (es) |
| DE (1) | DE69529418T2 (es) |
| ES (1) | ES2191063T3 (es) |
| WO (1) | WO1996012715A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19801636A1 (de) | 1998-01-17 | 1999-07-22 | Bayer Ag | Substituierte bicyclische Lactone |
| DE19801646A1 (de) * | 1998-01-17 | 1999-07-22 | Bayer Ag | Substituierte alpha,beta-annellierte Butyrolactone |
| DE19801647A1 (de) | 1998-01-17 | 1999-07-22 | Bayer Ag | Substituierte beta,gamma-annellierte Lactone |
| WO1999044639A1 (en) * | 1998-03-03 | 1999-09-10 | Yamanouchi Pharmaceutical Co., Ltd. | Remedies for brain infarction |
| GB9823845D0 (en) * | 1998-11-02 | 1998-12-23 | Lilly Co Eli | Pharmaceutical compounds |
| AU2241400A (en) | 1999-04-06 | 2000-10-12 | Yamanouchi Pharmaceutical Co., Ltd. | Novel thiazolobenzoimidazole derivative |
| GB0007193D0 (en) * | 2000-03-25 | 2000-05-17 | Univ Manchester | Treatment of movrmrnt disorders |
| US6660858B2 (en) * | 2001-03-28 | 2003-12-09 | Lion Bioscience Ag | 2-aminobenzoxazole derivatives and combinatorial libraries thereof |
| US20060166972A1 (en) * | 2003-07-11 | 2006-07-27 | Conn P J | Treatment of movement disorders with a metabotropic glutamate 4 receptor positive allosteric modulator |
| WO2006025070A2 (en) | 2004-07-30 | 2006-03-09 | Torrent Pharmaceuticals Limited | Nebivolol and its pharmaceutically acceptable salts, process for preparation and pharmaceutical compositions of nebivolol |
| DE102005011534A1 (de) * | 2005-03-10 | 2006-09-21 | Merck Patent Gmbh | Chromen-4-on-Derivate |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP2275096A3 (en) | 2005-08-26 | 2011-07-13 | Braincells, Inc. | Neurogenesis via modulation of the muscarinic receptors |
| WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| EP2314289A1 (en) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| DE102005062990A1 (de) * | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte Thiazole und ihre Verwendung zur Herstellung von Arzneimitteln |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| WO2008030651A1 (en) * | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2011051478A1 (en) | 2009-10-30 | 2011-05-05 | Domain Therapeutics | Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors |
| AU2015308438B2 (en) | 2014-08-27 | 2018-12-13 | Prexton Therapeutics Sa | Novel chromone oxime derivative and its use as allosteric modulator of metabotropic glutamate receptors |
| KR20180041234A (ko) | 2015-08-27 | 2018-04-23 | 프렉스톤 테라퓨틱스 에스에이 | 레보도파로 유발된 이상운동증 치료용 뇌 침투성 크로몬 옥심 유도체 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0723367B2 (ja) * | 1986-02-27 | 1995-03-15 | サントリー株式会社 | オキサビシクロヘプタン誘導体 |
| CA2037188A1 (en) * | 1990-06-06 | 1991-12-07 | Toshio Tatsuoka | Agent for treating disorders from cerebral neuro-degeneration |
| CA2037187A1 (en) * | 1990-06-06 | 1991-12-07 | Toshio Tatsuoka | Cyclopropachromen derivatives |
| DE4018468A1 (de) * | 1990-06-08 | 1991-12-12 | Ultrakust Electronic Gmbh | Verfahren und vorrichtung zur entnahme einer repraesentativen milchprobe |
-
1995
- 1995-09-01 JP JP22536595A patent/JP3993651B2/ja not_active Expired - Fee Related
- 1995-10-20 ES ES95934860T patent/ES2191063T3/es not_active Expired - Lifetime
- 1995-10-20 WO PCT/JP1995/002163 patent/WO1996012715A1/ja not_active Ceased
- 1995-10-20 DE DE69529418T patent/DE69529418T2/de not_active Expired - Lifetime
- 1995-10-20 AT AT95934860T patent/ATE231142T1/de not_active IP Right Cessation
- 1995-10-20 EP EP95934860A patent/EP0787723B1/en not_active Expired - Lifetime
- 1995-10-20 US US08/817,389 patent/US5843988A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996012715A1 (en) | 1996-05-02 |
| DE69529418T2 (de) | 2003-08-14 |
| ATE231142T1 (de) | 2003-02-15 |
| DE69529418D1 (de) | 2003-02-20 |
| EP0787723A4 (en) | 1998-02-04 |
| JPH08169884A (ja) | 1996-07-02 |
| JP3993651B2 (ja) | 2007-10-17 |
| US5843988A (en) | 1998-12-01 |
| EP0787723A1 (en) | 1997-08-06 |
| EP0787723B1 (en) | 2003-01-15 |
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