ES2191733T3 - Procedimiento para producir etoposido. - Google Patents

Procedimiento para producir etoposido.

Info

Publication number
ES2191733T3
ES2191733T3 ES96119336T ES96119336T ES2191733T3 ES 2191733 T3 ES2191733 T3 ES 2191733T3 ES 96119336 T ES96119336 T ES 96119336T ES 96119336 T ES96119336 T ES 96119336T ES 2191733 T3 ES2191733 T3 ES 2191733T3
Authority
ES
Spain
Prior art keywords
protected
halogen
type
epipodofilotoxina
demetil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96119336T
Other languages
English (en)
Inventor
Yukihiro Fusauchi
Hiroshi Yoshikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Application granted granted Critical
Publication of ES2191733T3 publication Critical patent/ES2191733T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UNA 4''-DEMETIL-4-EPIPODOFILOTOXINA PROTEGIDA SE HACE REACCIONAR CON UN DERIVADO DE GLUCOSA PROTEGIDO EN UN SOLVENTE ORGANICO DE TIPO NO HALOGENO EN UNA PARTE DE 0,1 A 7 PARTES POR VOLUMEN BASADO EN 1 PARTE POR PESO DE LA 4''-DEMETIL-4-EPIPODOFILOTOXINA PROTEGIDA PARA PROPORCIONAR UN DERIVADO DE ETOPOSIDO DE FORMULA (3) QUE ESTE PROTEGIDO EN SUS GRUPOS FUNCIONALES: EN DONDE CADA R{SUB,1} Y R{SUB,2} ES CADA UNO UN GRUPO PROTECTOR, SEGUIDO DE LA RETIRADA DE ESTOS GRUPOS PROTECTORES. MEDIANTE EL USO DEL SOLVENTE ORGANICO DE TIPO NO HALOGENO EN LUGAR DE CUALQUIER SOLVENTE DE TIPO HALOGENO PELIGROSO, LA FORMACION DE SUBPRODUCTOS NO DESEABLES PUEDE SER MINIMIZADA DE FORMA QUE LOS ETOPOSIDOS PUEDAN OBTENERSE EN UN ALTO RENDIMIENTO Y ELEVADA PUREZA.
ES96119336T 1995-12-04 1996-12-03 Procedimiento para producir etoposido. Expired - Lifetime ES2191733T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33772095 1995-12-04
JP34511495 1995-12-08

Publications (1)

Publication Number Publication Date
ES2191733T3 true ES2191733T3 (es) 2003-09-16

Family

ID=26575893

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96119336T Expired - Lifetime ES2191733T3 (es) 1995-12-04 1996-12-03 Procedimiento para producir etoposido.

Country Status (9)

Country Link
US (1) US5821348A (es)
EP (1) EP0778282B1 (es)
KR (1) KR100414706B1 (es)
CN (1) CN1067402C (es)
AU (1) AU712060B2 (es)
DE (1) DE69627277T2 (es)
ES (1) ES2191733T3 (es)
IL (1) IL119749A (es)
TW (1) TW416959B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5612399A (en) 1998-09-10 2000-04-03 Phytogen Life Sciences Inc. Synthetic method for the preparation of the antineoplastic agent etoposide
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
CN1101819C (zh) * 1999-10-21 2003-02-19 国家医药管理局上海医药工业研究院 具有抗肿瘤活性的4－β－碳取代－4－脱氧－4'－去甲表鬼臼毒素衍生物及合成方法和中间体
AU2002222695A1 (en) * 2000-11-20 2002-05-27 Song-Bae Kim Novel 4'-demethyl-4'-o-substituted-1-deoxypodophyllotoxin derivative and geometric isomer thereof, process for the preparation thereof and anti-cancer composition comprising the same
CN105566412A (zh) * 2016-01-18 2016-05-11 江西师范大学 一种依托泊苷和替尼泊苷及其类似物的制备方法
CN112079879B (zh) * 2020-08-21 2022-01-14 华润双鹤药业股份有限公司沧州分公司 一种替尼泊苷中间体的合成新方法及替尼泊苷的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
DE3913327A1 (de) * 1989-04-22 1990-10-25 Behringwerke Ag Verfahren zur herstellung von glucosaminyl-epi-podo-phyllotoxin-derivaten
DE3913326A1 (de) 1989-04-22 1990-11-08 Behringwerke Ag Verfahren zur herstellung von etoposiden
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
CA2017916C (en) * 1989-06-07 1999-02-02 Minoru Aoki Etoposide preparations
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide

Also Published As

Publication number Publication date
AU7414196A (en) 1997-06-12
EP0778282B1 (en) 2003-04-09
DE69627277D1 (de) 2003-05-15
AU712060B2 (en) 1999-10-28
KR970042580A (ko) 1997-07-24
TW416959B (en) 2001-01-01
DE69627277T2 (de) 2004-03-04
IL119749A (en) 2001-03-19
US5821348A (en) 1998-10-13
CN1067402C (zh) 2001-06-20
CN1154968A (zh) 1997-07-23
KR100414706B1 (ko) 2004-07-27
IL119749A0 (en) 1997-03-18
EP0778282A1 (en) 1997-06-11

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