ES2146247T3 - Procedimiento para preparar fosfato de etoposido y etoposido. - Google Patents

Procedimiento para preparar fosfato de etoposido y etoposido.

Info

Publication number
ES2146247T3
ES2146247T3 ES94308115T ES94308115T ES2146247T3 ES 2146247 T3 ES2146247 T3 ES 2146247T3 ES 94308115 T ES94308115 T ES 94308115T ES 94308115 T ES94308115 T ES 94308115T ES 2146247 T3 ES2146247 T3 ES 2146247T3
Authority
ES
Spain
Prior art keywords
ethoposide
phosphate
etoposide
ethoposide phosphate
produce
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94308115T
Other languages
English (en)
Inventor
Lee J Silverberg
Purushotham Vemishetti
John L Dillon Jr
John J Usher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2146247T3 publication Critical patent/ES2146247T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

FOSFATO ETOPOSIDO SE PREPARA ACOPLANDO DIBENZIL 4'' TIL ZIL EL FOSFATO ETOPOSIDO PROTEGIDO POR TETRA-BENCILO ES RECRISTALIZADO DE METANOL O CRISTALIZADO DIRECTAMENTE DESDE ACETONITRILO AÑADIENDO METANOL PARA PRODUCIR FORMA C-1'''' ALMENTE PURA. LOS GRUPOS PROTECTORES BENCILO SON SIMULTANEAMENTE ELIMINADOS POR HIDROGENACION PARA PRODUCIR FOSFATO ETOPOSIDO CON ELEVADOS RENDIMIENTOS. EN UNA FORMA DE REALIZACION FISICA ADICIONAL, FOSFATO ETOPOSIDO ES TRATADO CON UN ENZIMA DE FOSFATASA PARA PRODUCIR ETOPOSIDO.
ES94308115T 1993-11-04 1994-11-03 Procedimiento para preparar fosfato de etoposido y etoposido. Expired - Lifetime ES2146247T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/145,517 US5459248A (en) 1993-11-04 1993-11-04 Process of preparing etoposide phosphate and etoposide

Publications (1)

Publication Number Publication Date
ES2146247T3 true ES2146247T3 (es) 2000-08-01

Family

ID=22513464

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94308115T Expired - Lifetime ES2146247T3 (es) 1993-11-04 1994-11-03 Procedimiento para preparar fosfato de etoposido y etoposido.

Country Status (20)

Country Link
US (2) US5459248A (es)
EP (1) EP0652226B1 (es)
JP (2) JP2801152B2 (es)
KR (1) KR100351325B1 (es)
CN (4) CN1046290C (es)
AT (1) ATE193018T1 (es)
AU (1) AU692472B2 (es)
CA (1) CA2133594C (es)
CY (1) CY2201B1 (es)
DE (1) DE69424504T2 (es)
DK (1) DK0652226T3 (es)
ES (1) ES2146247T3 (es)
FI (1) FI115913B (es)
GR (1) GR3034213T3 (es)
HK (1) HK1003302A1 (es)
HU (1) HU221969B1 (es)
IL (1) IL111483A (es)
PT (1) PT652226E (es)
SG (1) SG50571A1 (es)
TW (1) TW420687B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
ES2191733T3 (es) * 1995-12-04 2003-09-16 Nippon Kayaku Kk Procedimiento para producir etoposido.
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
ATE250620T1 (de) * 1997-06-02 2003-10-15 Bristol Myers Squibb Co Verfahren zur herstellung von etoposid
EP1117671A2 (en) 1998-09-10 2001-07-25 Phytogen Life Sciences Inc. Synthetic method for the preparation of the antineoplastic agent etoposide
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CN1626533A (zh) * 2000-04-19 2005-06-15 盐野义制药株式会社 磺酰胺衍生物的制备方法及其晶体
US20030082618A1 (en) * 2001-10-15 2003-05-01 Guangshan Li Methods for detecting genetic aberrations
US20150246137A1 (en) * 2012-09-27 2015-09-03 The University Of North Carolina At Chapel Hill Lipid coated nanoparticles containing agents having low aqueous and lipid solubilities and methods thereof
CN113121618A (zh) * 2021-04-07 2021-07-16 梯尔希（南京）药物研发有限公司 两种依托泊苷杂质的制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2666778A (en) * 1950-05-10 1954-01-19 George M Steinberg Method for the synthesis of organic phosphates
NL6613143A (es) * 1965-09-21 1967-03-22
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
JPS62209089A (ja) * 1986-03-08 1987-09-14 Kuraray Co Ltd ドリシルグリコピラノシルクロロホスフエイト誘導体およびその製造方法
NZ225599A (en) * 1987-08-04 1991-09-25 Bristol Myers Co Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4888419A (en) * 1987-08-31 1989-12-19 Bristol-Myers Company 3'-demethoxyepipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
CA2041280A1 (en) * 1990-05-10 1991-11-11 Yosuke Sawada Arylsulfatase
CN1025918C (zh) * 1990-06-07 1994-09-14 国家医药管理局上海医药工业研究院 抗肿瘤药表鬼臼毒吡喃糖甙的合成新工艺
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (es) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5375555A (en) * 1992-10-06 1994-12-27 Dolan; George D. Non-furling flag fasteners
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide

Also Published As

Publication number Publication date
CN1046290C (zh) 1999-11-10
US5688926A (en) 1997-11-18
CY2201B1 (en) 2002-11-08
EP0652226B1 (en) 2000-05-17
FI945149A0 (fi) 1994-11-01
DE69424504D1 (de) 2000-06-21
CN1058017C (zh) 2000-11-01
US5459248A (en) 1995-10-17
KR950014128A (ko) 1995-06-15
CN1061047C (zh) 2001-01-24
CN1056378C (zh) 2000-09-13
CN1189497A (zh) 1998-08-05
TW420687B (en) 2001-02-01
KR100351325B1 (ko) 2002-10-31
HUT72461A (en) 1996-04-29
AU692472B2 (en) 1998-06-11
PT652226E (pt) 2000-09-29
CN1189500A (zh) 1998-08-05
JP3810906B2 (ja) 2006-08-16
GR3034213T3 (en) 2000-12-29
ATE193018T1 (de) 2000-06-15
DK0652226T3 (da) 2000-08-07
HU221969B1 (hu) 2003-03-28
EP0652226A1 (en) 1995-05-10
FI115913B (fi) 2005-08-15
CA2133594C (en) 1999-02-23
SG50571A1 (en) 1998-07-20
CN1189499A (zh) 1998-08-05
CA2133594A1 (en) 1995-05-05
IL111483A (en) 1998-12-06
AU7762794A (en) 1995-05-18
DE69424504T2 (de) 2000-09-21
CN1106016A (zh) 1995-08-02
JPH07196680A (ja) 1995-08-01
HK1003302A1 (en) 1998-10-23
JP2801152B2 (ja) 1998-09-21
IL111483A0 (en) 1995-01-24
HU9403157D0 (en) 1994-12-28
JPH10152499A (ja) 1998-06-09
FI945149L (fi) 1995-05-05

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