ES2191834T3 - Agentes que facilitan la permeacion y destinados para composiciones, dispositivos y procedimientos de aporte transdermico de medicamentos. - Google Patents

Agentes que facilitan la permeacion y destinados para composiciones, dispositivos y procedimientos de aporte transdermico de medicamentos.

Info

Publication number
ES2191834T3
ES2191834T3 ES97912815T ES97912815T ES2191834T3 ES 2191834 T3 ES2191834 T3 ES 2191834T3 ES 97912815 T ES97912815 T ES 97912815T ES 97912815 T ES97912815 T ES 97912815T ES 2191834 T3 ES2191834 T3 ES 2191834T3
Authority
ES
Spain
Prior art keywords
drug
transdermal
permeation enhancer
compositions
permeation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97912815T
Other languages
English (en)
Inventor
Eun Soo Lee
Su Il Yum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ES2191834T3 publication Critical patent/ES2191834T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A LA ADMINISTRACION TRANSDERMICA DE, POR LO MENOS, UN MEDICAMENTO ASOCIADO A UNA CANTIDAD INDICADA DE UN AGENTE QUE FACILITA LA PERMEACION Y QUE COMPRENDE MONOALQUILOETERES DE POLIETILENOGLICOL Y SUS ESTERES DE ACIDO ALQUILO O ARILO CARBOXILICO Y ESTERES DE CARBOXIMETILO. ESTA INVENCION SE REFIERE TAMBIEN A UN DISPOSITIVO DE APORTACION TRANSDERMICA DE UN MEDICAMENTO QUE COMPRENDE UNA MATRIZ ADAPTADA PARA COLOCARLA EN UNA POSICION DE TRANSMISION DE MEDICAMENTO Y DE AGENTE QUE FACILITA LA PERMEACION EN UN LUGAR DE LA PIEL. LA MATRIZ CONTIENE CANTIDADES SUFICIENTES DE AGENTE QUE FACILITAN LA PERMEACION, COMBINADAS CON UN MEDICAMENTO, PARA APORTAR CONTINUAMENTE UN MEDICAMENTO A LA CIRCULACION SANGUINEA GENERAL DE UN PACIENTE A UN RITMO EFICAZ DESDE EL PUNTO DE VISTA TERAPEUTICO. ESTA INVENCION SE REFIERE FINALMENTE A UNAS COMPOSICIONES Y PROCEDIMIENTOS QUE PERMITEN LA ADMINISTRACION TRANSDERMICA DE, COMO MINIMO, UN MEDICAMENTO COMBINADO CON UN AGENTE QUE FACILITA LA PERMEACION SEGUN LA PRESENTE INVENCION, SOLO O COMBINADO CON OTROS AGENTES DE ESTE TIPO.
ES97912815T 1996-10-24 1997-10-23 Agentes que facilitan la permeacion y destinados para composiciones, dispositivos y procedimientos de aporte transdermico de medicamentos. Expired - Lifetime ES2191834T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3042496P 1996-10-24 1996-10-24

Publications (1)

Publication Number Publication Date
ES2191834T3 true ES2191834T3 (es) 2003-09-16

Family

ID=21854141

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97912815T Expired - Lifetime ES2191834T3 (es) 1996-10-24 1997-10-23 Agentes que facilitan la permeacion y destinados para composiciones, dispositivos y procedimientos de aporte transdermico de medicamentos.

Country Status (10)

Country Link
US (1) US6004578A (es)
EP (1) EP0934078B1 (es)
JP (1) JP2001502693A (es)
AT (1) ATE229817T1 (es)
AU (1) AU4990797A (es)
CA (1) CA2264687C (es)
DE (1) DE69718037T2 (es)
DK (1) DK0934078T3 (es)
ES (1) ES2191834T3 (es)
WO (1) WO1998017315A2 (es)

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AU4990797A (en) 1998-05-15
DK0934078T3 (da) 2003-04-14
US6004578A (en) 1999-12-21
WO1998017315A3 (en) 1998-07-02
DE69718037T2 (de) 2003-07-10
CA2264687C (en) 2006-04-25
EP0934078B1 (en) 2002-12-18
JP2001502693A (ja) 2001-02-27
WO1998017315A2 (en) 1998-04-30
DE69718037D1 (de) 2003-01-30
ATE229817T1 (de) 2003-01-15
CA2264687A1 (en) 1998-04-30
EP0934078A2 (en) 1999-08-11

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