ES2192221T3 - Monoesteres de oleato de estrogenos para el tratamiento de la obesidad o el sobrepeso. - Google Patents

Monoesteres de oleato de estrogenos para el tratamiento de la obesidad o el sobrepeso.

Info

Publication number
ES2192221T3
ES2192221T3 ES96500140T ES96500140T ES2192221T3 ES 2192221 T3 ES2192221 T3 ES 2192221T3 ES 96500140 T ES96500140 T ES 96500140T ES 96500140 T ES96500140 T ES 96500140T ES 2192221 T3 ES2192221 T3 ES 2192221T3
Authority
ES
Spain
Prior art keywords
overweight
obesity
treatment
group
estrone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96500140T
Other languages
English (en)
Inventor
Maria Alemany
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OLEOYL ESTRONE DEVELOPMENTS S
Original Assignee
OLEOYL ESTRONE DEVELOPMENTS S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OLEOYL ESTRONE DEVELOPMENTS S filed Critical OLEOYL ESTRONE DEVELOPMENTS S
Application granted granted Critical
Publication of ES2192221T3 publication Critical patent/ES2192221T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/533—Monocarboxylic acid esters having only one carbon-to-carbon double bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/28—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with dihydroxylic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/533—Monocarboxylic acid esters having only one carbon-to-carbon double bond
    • C07C69/58—Esters of straight chain acids with eighteen carbon atoms in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/587—Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

EL ESTROGENO SE SELECCIONA DEL GRUPO QUE CONSTA DE ESTRONA, DIETILESTILBESTROL, ESTRIOL, ESTRADIOL Y ETINILESTRADIOL; EL ACIDO GRASO SE SELECCIONA DEL GRUPO QUE CONSTA DE ACIDOS OLEICOS, LINOLEICOS, LINOLENICOS, ESTEARICOS, PALMITICOS, PALMITOLEICOS Y ARAQUIDONICOS. IMITAN LA FUNCION DE MONOOLEATO DE ESTRONA, COMO UNA SEÑAL QUE INFORMA AL CEREBRO DEL TAMAÑO DE LA MASA DE TEJIDO GRASO. COMPOSICIONES PREFERIDAS PARA INYECCION INTRAVENOSA COMPRENDEN EL MONOESTER INCORPORADO EN UNA SUSPENSION LIPIDICA, PREPARADA A PARTIR DE LIPOPROTEINAS O A PARTIR DE COMPONENTES DE LIPOSOMA COMO ACEITE DE SOJA Y FOSFOLIPIDOS DE HUEVO. CUANDO SE ADMINISTRA A RATAS CON UN 15% DE TEJIDO ADIPOSO TOTAL, PRODUCEN REDUCCION DE PESO DE ALREDEDOR DEL 10%, MEDIANTE UN NUEVO E INESPERADO MECANISMO. SON UTILES PARA EL TRATAMIENTO DE OBESIDAD Y/O SOBREPESO EN MAMIFEROS, CON LAS VENTAJAS DE ALTA EFICACIA Y BAJA TOXICIDAD.
ES96500140T 1995-10-30 1996-10-28 Monoesteres de oleato de estrogenos para el tratamiento de la obesidad o el sobrepeso. Expired - Lifetime ES2192221T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9502101 1995-10-30

Publications (1)

Publication Number Publication Date
ES2192221T3 true ES2192221T3 (es) 2003-10-01

Family

ID=8291993

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96500140T Expired - Lifetime ES2192221T3 (es) 1995-10-30 1996-10-28 Monoesteres de oleato de estrogenos para el tratamiento de la obesidad o el sobrepeso.

Country Status (7)

Country Link
US (1) US5798348A (es)
EP (1) EP0771817B1 (es)
AT (1) ATE235505T1 (es)
DE (1) DE69626927T2 (es)
DK (1) DK0771817T3 (es)
ES (1) ES2192221T3 (es)
PT (1) PT771817E (es)

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GB2321455A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Lipophilic derivatives of biologically active compounds
WO1999066915A2 (en) * 1998-06-23 1999-12-29 Southern Illinois University At Carbondale Therapeutic applications of estrogenic carboxylic acids
AU3579200A (en) * 1999-02-26 2000-09-14 Saltech I Goteborg Ab Method and composition for the regulation of hepatic and extrahepatic productionof insulin-like growth factor-1
DE60045751D1 (de) 1999-09-30 2011-04-28 Harbor Biosciences Inc Therapeutische Behandlung androgenrezeptorbedingter Leiden
AU2005242170B2 (en) * 2000-06-26 2008-12-18 The Procter & Gamble Company Compositions and methods for body weight management
US7025984B1 (en) 2000-06-26 2006-04-11 The Procter & Gamble Company Compositions and methods for body weight management
AU2002244247B2 (en) 2001-03-01 2007-12-13 Harbor Biosciences, Inc. Use of certain steroids for treatment of blood cell deficiencies
ES2173049B1 (es) * 2001-03-28 2004-01-16 Oleoyl Estrone Developments S Monoester de acido graso y estrogeno como agente antidiabetico e hipolipemiante.
US6635015B2 (en) * 2001-04-20 2003-10-21 The Procter & Gamble Company Body weight management system
US7125568B2 (en) 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
US20040157816A1 (en) * 2002-08-26 2004-08-12 Girouard Michael P. Monounsaturated fatty acids and perhydrocyclopentanophenanthrene nucleus combination molecules, and their precursors, and the use of all of these as weight-loss agents
WO2003018529A1 (en) * 2001-08-24 2003-03-06 Girouard Michael P Monounsaturated fatty acids of at least 20 carbon atoms and perhydrocyclopentanophenanthrene nucleus combination molecules and their use as weight-loss agents
ES2186576B1 (es) * 2001-10-11 2004-09-16 Universitat De Les Illes Balears Acido 2-hidroxioleico para utilizar como medicamento.
EP1594481A4 (en) * 2002-11-20 2006-05-17 Michael P Girouard MONOINSATURATED FATTY ACIDS AND COMBINATION MOLECULES OF PERHYDROCYCLOPENTANOPHENANTHRENE CORES, AND THEIR PRECURSORS, AND THEIR USE AS AMELITING AGENTS
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
JP2006519229A (ja) 2003-02-13 2006-08-24 アルバート・アインシュタイン・カレッジ・オヴ・メディシン・オヴ・イェシヴァ・ユニヴァーシティ 視床下部内の長鎖脂肪アシルＣｏＡレベルの変調による摂食量およびグルコース産生量の調節
CA2436650A1 (en) * 2003-08-06 2005-02-06 Naturia Inc. Conjugated linolenic acid (clnatm) compositions: synthesis, purification and uses
CA2582231A1 (en) 2004-09-29 2006-10-19 Hollis-Eden Pharmaceuticals, Inc. Steroid analogs and uses
US20060084636A1 (en) * 2004-10-18 2006-04-20 Maria Alemany Methods of using fatty-acid esters of estrogens and serotonin reuptake inhibiting compounds for reducing the body weight of a mammal and compositions containing the same
US20060084637A1 (en) * 2004-10-18 2006-04-20 Maria Alemany Methods of using fatty-acid esters of estrogens and thermogenic compounds for reducing the body weight of a mammal and compositions containing the same
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US7528791B2 (en) * 2005-08-08 2009-05-05 Wistron Neweb Corporation Antenna structure having a feed element formed on an opposite surface of a substrate from a ground portion and a radiating element
KR101106510B1 (ko) 2006-05-30 2012-01-20 인타르시아 세라퓨틱스 인코포레이티드 투피스, 내부채널 삼투압 전달 시스템 유동 조절기
WO2008147373A2 (en) * 2006-06-26 2008-12-04 Manhattan Pharmaceuticals, Inc. Methods and compositions for reducing body weight using an estrogen fatty ester in an oil
CA2670821C (en) 2006-08-09 2012-05-15 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies
ES2302449B1 (es) * 2006-10-30 2009-06-12 Oleoyl-Estrone Developments, S.L. Monoesteres de estrogenos con acido linoleico conjugado y usos de los mismos.
CA2683610C (en) 2007-04-23 2013-01-08 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
EP2085089A1 (en) * 2008-02-01 2009-08-05 KTB-Tumorforschungs GmbH Phospholipids Containing omega-3-Fatty Acids for the Treatment of Overweight, Obesity and Addictive Behavior
WO2009102467A2 (en) 2008-02-13 2009-08-20 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
MX378797B (es) 2009-09-28 2025-03-10 Intarcia Therapeutics Inc Establecimiento y/o terminacion rapidos de suministro de estado estable sustancial de farmaco.
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
WO2013102207A1 (en) * 2011-12-30 2013-07-04 Rosscreening, Inc. Estrogen receptor modulators for reducing body weight
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
CN113598842A (zh) 2015-06-03 2021-11-05 因塔西亚制药公司 植入物放置和移除系统
KR102574993B1 (ko) 2016-05-16 2023-09-06 인타르시아 세라퓨틱스 인코포레이티드 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
WO2018129058A1 (en) 2017-01-03 2018-07-12 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a glp-1 receptor agonist and co-adminstration of a drug
US10836788B2 (en) 2019-02-05 2020-11-17 SD Chem, Inc. Aqueous suspension compositions, formulations, and water dispersible dry compositions comprising 16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-ketone and hydrates, derivatives, and analogs thereof

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US2265976A (en) * 1937-10-25 1941-12-09 Schering Corp Tertiary alcohols of the estrane series and their derivatives and a process for their manufacture
GB531178A (en) * 1938-07-02 1940-12-31 Chem Ind Basel Manufacture of new esters of the oxy-stilbene series
JPH0610127B2 (ja) * 1985-02-09 1994-02-09 ライオン株式会社 養毛料
US4617298A (en) * 1985-10-22 1986-10-14 University Of Florida Method and compositions for weight control

Also Published As

Publication number Publication date
DE69626927T2 (de) 2003-11-20
EP0771817A3 (en) 1999-04-14
PT771817E (pt) 2003-06-30
US5798348A (en) 1998-08-25
ATE235505T1 (de) 2003-04-15
EP0771817B1 (en) 2003-03-26
DK0771817T3 (da) 2003-07-28
EP0771817A2 (en) 1997-05-07
DE69626927D1 (de) 2003-04-30

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