ES2192533T3 - Derivados de echinocandina, su procedimiento de preparacion y su aplicacion como antifungicos. - Google Patents

Derivados de echinocandina, su procedimiento de preparacion y su aplicacion como antifungicos.

Info

Publication number
ES2192533T3
ES2192533T3 ES00942169T ES00942169T ES2192533T3 ES 2192533 T3 ES2192533 T3 ES 2192533T3 ES 00942169 T ES00942169 T ES 00942169T ES 00942169 T ES00942169 T ES 00942169T ES 2192533 T3 ES2192533 T3 ES 2192533T3
Authority
ES
Spain
Prior art keywords
echinocandina
antifungicos
derivatives
application
candida
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00942169T
Other languages
English (en)
Inventor
Patrick Fauveau
Stephen Hawser
Gilles Lebourg
Laurent Schio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of ES2192533T3 publication Critical patent/ES2192533T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Los compuestos de fórmula (I) presentan interesantes propiedades antifúngicas; son especialmente activos sobre Candida albicans y otras Candida como Candida glabrata, krusei, tropicalis, pseudotropicalis, parapsilosis y Aspergillus fumigatus, Aspergillus avus, Cryptococcus neoformans. Los compuestos de fórmula (I) pueden ser utilizados como medicamentos para el hombre o el animal, para luchar especialmente contra las candidiasis invasivas del inmunodeprimido, las candidiasis digestivas, urinarias, vaginales o cutáneas, las criptococosis, por ejemplo las criptococosis neuromeningeas, pulmonares o cutáneas y las aspergilosis broncopulmonares y pulmonares, y las aspergilosis invasivas del inmunodeprimido.
ES00942169T 1999-06-09 2000-06-08 Derivados de echinocandina, su procedimiento de preparacion y su aplicacion como antifungicos. Expired - Lifetime ES2192533T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9907251A FR2794746B1 (fr) 1999-06-09 1999-06-09 Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques

Publications (1)

Publication Number Publication Date
ES2192533T3 true ES2192533T3 (es) 2003-10-16

Family

ID=9546548

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00942169T Expired - Lifetime ES2192533T3 (es) 1999-06-09 2000-06-08 Derivados de echinocandina, su procedimiento de preparacion y su aplicacion como antifungicos.

Country Status (18)

Country Link
US (2) US7022669B1 (es)
EP (1) EP1189933B1 (es)
JP (1) JP4493891B2 (es)
AR (1) AR024316A1 (es)
AT (1) ATE236928T1 (es)
AU (1) AU5688400A (es)
CA (1) CA2376025C (es)
CO (1) CO5200766A1 (es)
DE (1) DE60002075T2 (es)
DK (1) DK1189933T3 (es)
ES (1) ES2192533T3 (es)
FR (1) FR2794746B1 (es)
GT (1) GT200000091A (es)
PE (1) PE20010332A1 (es)
PT (1) PT1189933E (es)
TN (1) TNSN00128A1 (es)
UY (1) UY26196A1 (es)
WO (1) WO2000075177A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
DE102004060750A1 (de) 2004-12-15 2006-07-13 Sanofi-Aventis Deutschland Gmbh Verfahren zur Deacylierung von Lipopeptiden

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5464903A (en) * 1994-10-31 1995-11-07 E. I. Du Pont De Nemours And Company Process for preparing ethylene copolymer plasticized PVC
UA72200C2 (uk) * 1997-12-10 2005-02-15 Авентіс Фарма С.А. Похідні ехінокандину, спосіб їх одержання, їх застосування, проміжні сполуки та фармацевтична композиція
FR2794747B1 (fr) * 1999-06-09 2004-04-16 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques

Also Published As

Publication number Publication date
PE20010332A1 (es) 2001-03-29
ATE236928T1 (de) 2003-04-15
US7022669B1 (en) 2006-04-04
TNSN00128A1 (fr) 2002-05-30
DE60002075D1 (de) 2003-05-15
US20060035820A1 (en) 2006-02-16
FR2794746A1 (fr) 2000-12-15
CA2376025A1 (fr) 2000-12-14
JP4493891B2 (ja) 2010-06-30
EP1189933A1 (fr) 2002-03-27
DE60002075T2 (de) 2003-11-20
EP1189933B1 (fr) 2003-04-09
PT1189933E (pt) 2003-08-29
FR2794746B1 (fr) 2002-12-06
GT200000091A (es) 2001-11-30
CA2376025C (fr) 2010-06-01
WO2000075177A1 (fr) 2000-12-14
JP2003501441A (ja) 2003-01-14
CO5200766A1 (es) 2002-09-27
DK1189933T3 (da) 2003-07-21
AR024316A1 (es) 2002-09-25
US7192920B2 (en) 2007-03-20
UY26196A1 (es) 2001-01-31
AU5688400A (en) 2000-12-28

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