ES2193202T3 - Nuevo derivado de amidinonaftilo o sal de este. - Google Patents

Nuevo derivado de amidinonaftilo o sal de este.

Info

Publication number
ES2193202T3
ES2193202T3 ES95938625T ES95938625T ES2193202T3 ES 2193202 T3 ES2193202 T3 ES 2193202T3 ES 95938625 T ES95938625 T ES 95938625T ES 95938625 T ES95938625 T ES 95938625T ES 2193202 T3 ES2193202 T3 ES 2193202T3
Authority
ES
Spain
Prior art keywords
group
sup
formula
represented
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95938625T
Other languages
English (en)
Inventor
Fukushi Hirayama
Hiroyuki Koshio
Yuzo Matsumoto
Tomihisa Kawasaki
Seiji Kaku
Isao Yanagisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2193202T3 publication Critical patent/ES2193202T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN DERIVADO DE AMIDINONAFTILO REPRESENTADO POR LA SIGUIENTE FORMULA GENERAL (I) QUE TIENE UNA ACCION INHIBIDORA DE LA AGREGACION PLAQUETARIA BASADA EN LA ACCION INHIBIDORA ACTIVADA DEL FACTOR X DE COAGULACION DE LA SANGRE Y UTIL COMO AGENTE ANTITROMBOTICO Y SIMILAR, UNA SAL DE ESTE, UN PRODUCTO INTERMEDIO DE ESTE Y UNA COMPOSICION FARMACEUTICA QUE CONTIENE EL DERIVADO DE AMIDINONAFTILO. LA INVENCION SE REFIERE ASIMISMO A UN DERIVADO DE AMIDINONAFTILO REPRESENTADO POR LA SIGUIENTE FORMULA GENERAL (I) O UNA SAL ACEPTABLE FARMACEUTICAMENTE DE ESTE. (LOS SIMBOLOS DE LA FORMULA TIENEN LOS SIGUIENTES SIGNIFICADOS: R{SUP,1}): ATOMO DE HIDROGENO O UN GRUPO REPRESENTADO POR LA FORMULA - A - W - R {SUP,4}, A: UN GRUPO REPRESENTADO POR LA FORMULA: UN GRUPO REPRESENTADO POR LA FORMULA: O UN GRUPO REPRESENTADO POR LA FORMULA - SO {SUB,2}-, X ES UN ATOMO DE OXIGENO O UN ATOMO DE AZUFRE, W ES UN ENLACE SENCILLO O UN GRUPO REPRESENTADO POR LA FORMULA - NR{SUP,5} -, R{SUP,4} ES UN GRUPO HIDROXILO, UN GRUPOALCOXI INFERIOR, ETC., NO UN GRUPO HIDROXILO O UN GRUPO ALCOXI INFERIOR, R{SUP,5} ES UN ATOMO DE HIDROGENO, UN GRUPO CARBAMOILO, UN GRUPO ALCOXICARBONILO INFERIOR, ETC.; R{SUP,2} ES UN GRUPO ALQUILO INFERIOR, R{SUP,3} ES UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO CARBOXILO, B ES UN GRUPO ALQUILENO INFERIOR O UN GRUPO CARBONILO, Y N ES 0 O 1).
ES95938625T 1994-12-02 1995-12-01 Nuevo derivado de amidinonaftilo o sal de este. Expired - Lifetime ES2193202T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP29996394 1994-12-02
JP10520595 1995-04-28
JP19881695 1995-08-03

Publications (1)

Publication Number Publication Date
ES2193202T3 true ES2193202T3 (es) 2003-11-01

Family

ID=27310425

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95938625T Expired - Lifetime ES2193202T3 (es) 1994-12-02 1995-12-01 Nuevo derivado de amidinonaftilo o sal de este.

Country Status (20)

Country Link
US (1) US5869501A (es)
EP (1) EP0798295B1 (es)
JP (1) JP3004362B2 (es)
KR (1) KR100383161B1 (es)
CN (1) CN1087736C (es)
AT (1) ATE233240T1 (es)
AU (1) AU688628B2 (es)
CA (1) CA2206532C (es)
DE (1) DE69529770T2 (es)
ES (1) ES2193202T3 (es)
FI (1) FI115051B (es)
HU (1) HUT77313A (es)
MX (1) MX9704059A (es)
NO (1) NO309566B1 (es)
NZ (1) NZ296210A (es)
PL (1) PL184824B1 (es)
PT (1) PT798295E (es)
RU (1) RU2154633C2 (es)
TW (1) TW300888B (es)
WO (1) WO1996016940A1 (es)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69630214T2 (de) 1995-03-10 2004-07-15 Berlex Laboratories, Inc., Richmond Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
SE9602646D0 (sv) * 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
JP3390179B2 (ja) 1996-08-15 2003-03-24 シェーリング コーポレイション エーテルムスカリン様アンタゴニスト
EP0842941A1 (de) * 1996-11-16 1998-05-20 Roche Diagnostics GmbH Neue Phosphonate, Verfahren zu ihrer Herstellung und Arzneimittel
AU7808198A (en) 1997-06-03 1998-12-21 Biocryst Pharmaceuticals, Inc. Novel compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation
US6060491A (en) * 1997-06-19 2000-05-09 Dupont Pharmaceuticals 6-membered aromatics as factor Xa inhibitors
CA2293824A1 (en) * 1997-06-19 1998-12-23 Mimi Lifen Quan (amidino)6-membered aromatics as factor xa inhibitors
ZA986594B (en) * 1997-07-25 1999-01-27 Abbott Lab Urokinase inhibitors
US6258822B1 (en) 1997-08-06 2001-07-10 Abbott Laboratories Urokinase inhibitors
WO1999011617A1 (en) * 1997-09-01 1999-03-11 Yamanouchi Pharmaceutical Co., Ltd. Novel naphthamide derivatives or salts thereof
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
DE19754490A1 (de) * 1997-12-09 1999-06-10 Boehringer Ingelheim Pharma Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
AU1692399A (en) * 1997-12-26 1999-07-19 Mochida Pharmaceutical Co., Ltd. Aromatic compounds having cyclic amino or salts thereof
WO1999037643A1 (en) * 1998-01-26 1999-07-29 Yamanouchi Pharmaceutical Co., Ltd. Novel benzene-fused heterocyclic derivatives or salts thereof
EP0937723A1 (de) * 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Sulfonamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
EP1066272A4 (en) * 1998-03-27 2002-03-13 Biocryst Pharm Inc NEW CONNECTIONS USEFUL IN THE COMPLEMENT, COAGULATE AND KALLIKREIN REACTION WAY AND METHOD FOR THEIR PRODUCTION
PL343424A1 (en) * 1998-04-10 2001-08-13 Japan Tobacco Inc Amidine compounds
US6504031B1 (en) 1998-08-06 2003-01-07 Milan Bruncko Naphthamidine urokinase inhibitors
US6284796B1 (en) 1998-08-06 2001-09-04 Abbott Laboratories Ukokinase inhibitors
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
CA2348740A1 (en) 1998-12-23 2000-07-06 Ruth R. Wexler Thrombin or factor xa inhibitors
EP1144373B1 (en) 1999-01-13 2005-10-19 Genentech, Inc. Serine protease inhibitors
WO2000043041A1 (fr) * 1999-01-22 2000-07-27 Yamanouchi Pharmaceutical Co., Ltd. Compositions medicamenteuses presentant une meilleure absorption orale
EP1159273A1 (en) 1999-03-02 2001-12-05 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cathepsin s
FR2793247B1 (fr) * 1999-05-04 2001-06-22 Synthelabo Derives de 6-[[(aryl et heteroaryl)oxy]methyl]naphtalene-2- carboximidamide, leur preparation et leur application en therapeutique
US6858599B2 (en) * 1999-06-30 2005-02-22 Mochida Pharmaceutical Co., Ltd. Tricyclic compound having spiro union
AU5570900A (en) * 1999-07-01 2001-01-22 Sankyo Company Limited Indoline or tetrahydroquinoline derivatives
US6350761B1 (en) * 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
HK1047431B (en) * 1999-10-28 2006-07-14 三共株式会社 Benzamidine derivatives
EP1095933A1 (en) * 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
WO2001056989A2 (en) * 2000-02-01 2001-08-09 Cor Therapeutics, Inc. Inhibitors of factor xa
WO2001064642A2 (en) 2000-02-29 2001-09-07 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
EP1272483A2 (en) * 2000-03-24 2003-01-08 Millenium Pharmaceuticals, Inc. OXINDOLE INHIBITORS OF FACTOR Xa
AU776053B2 (en) * 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
US6495562B1 (en) 2000-04-25 2002-12-17 Abbott Laboratories Naphthamidine urokinase inhibitors
CA2421548C (en) 2000-09-11 2007-10-30 Genentech, Inc. Amidine inhibitors of serine proteases
PT1336605E (pt) 2000-11-22 2006-06-30 Astellas Pharma Inc Derivados de fenol substituidos ou seus sais como inibidores do factor x de coagulacao
US6538017B2 (en) 2001-03-09 2003-03-25 Ortho-Mcneil Pharmaceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
US6710061B2 (en) 2001-03-09 2004-03-23 Ortho-Mcneil Pharamceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
US7312235B2 (en) 2001-03-30 2007-12-25 Millennium Pharmaceuticals, Inc. Benzamide inhibitors of factor Xa
EP1375482A4 (en) 2001-04-05 2005-01-19 Sankyo Co BENZAMIDINE DERIVATIVE
CN100410236C (zh) * 2002-01-29 2008-08-13 雪兰诺实验室有限公司 作为蛋白酪氨酸磷酸酶调节剂的取代亚甲基酰胺衍生物
RU2226392C1 (ru) * 2002-10-23 2004-04-10 Биологический факультет Московского государственного университета им. М.В. Ломоносова Способ ингибирования агрегации тромбоцитов
US20070004736A1 (en) 2002-11-22 2007-01-04 Keiji Kubo Imidazole derivative, process for producing the same, and use
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
PL378215A1 (pl) * 2002-12-24 2006-03-20 Daiichi Pharmaceutical Co., Ltd. Nowe pochodne etylenodiaminy
CA2525713A1 (en) 2003-05-20 2004-12-29 Genentech, Inc. Benzofuran inhibitors of factor viia
WO2004113278A2 (en) 2003-05-20 2004-12-29 Genentech, Inc. Acylsulfamide inhibitors of factor viia
US7022695B2 (en) 2003-10-09 2006-04-04 Millennium Pharmaceuticals, Inc. Thioether-substituted benzamides as inhibitors of Factor Xa
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
KR101195801B1 (ko) 2004-06-18 2012-11-05 밀레니엄 파머슈티컬스 인코퍼레이티드 Ｘａ 인자 억제제
WO2006055951A2 (en) 2004-11-19 2006-05-26 Portola Pharmaceuticals, Inc. Tetrahydroisoquinolines as factor xa inhibitors
WO2006063293A2 (en) * 2004-12-07 2006-06-15 Portola Pharmaceuticals, Inc. THIOUREAS AS FACTOR Xa INHIBITORS
US7678913B2 (en) 2004-12-07 2010-03-16 Portola Pharmaceuticals, Inc. Ureas as factor Xa inhibitors
EP1847527A4 (en) 2005-02-02 2009-04-08 Ajinomoto Kk NEW BENZAMIDINE DERIVATIVE
PE20070717A1 (es) 2005-11-08 2007-08-17 Millennium Pharm Inc Sal de maleato y polimorfo de [2-({4-[(dimetilamino)iminometil]fenil}carbonilamino)-5-metoxifenil]-n-(5-cloro-(2-piridil))carboxamida
MX2008012404A (es) * 2006-03-28 2008-10-09 Novartis Ag Derivados de amida y su aplicacion para el tratamiento de enfermedades relacionadas con proteina-g.
JP5253174B2 (ja) * 2006-10-12 2013-07-31 株式会社医薬分子設計研究所 Ｎ−フェニルオキサミド酸誘導体
CN101595092B (zh) 2006-11-02 2012-02-01 米伦纽姆医药公司 合成因子xa抑制剂的医药盐的方法
US20110045028A1 (en) 2006-11-30 2011-02-24 Takeda Pharmaceutical Company Limited Sustained release preparation
US8633245B2 (en) * 2008-04-11 2014-01-21 Institute Of Medicinal Molecular Design, Inc. PAI-1 inhibitor
EP2311810A4 (en) * 2008-07-11 2012-04-04 Ajinomoto Kk AMIDINE DERIVATIVE
EA015918B1 (ru) 2010-03-03 2011-12-30 Дмитрий Геннадьевич ТОВБИН УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa
WO2019241213A1 (en) * 2018-06-11 2019-12-19 The Regents Of The University Of Colorado, A Body Corporate 2-naphthimidamides, analogues thereof, and methods of treatment using same
CN117304076B (zh) * 2023-11-28 2024-02-20 苏州大学 一种n-磺酰基脒化合物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443462A (en) * 1979-08-06 1984-04-17 Merrell Dow Pharmaceuticals Inc. Antipsychotic 4-(naphthalenyloxy)piperidine derivatives
AU527371B2 (en) * 1980-09-16 1983-03-03 Torii & Co., Ltd. Amidine
JPS59139357A (ja) * 1983-01-28 1984-08-10 Torii Yakuhin Kk アミジン誘導体
US4563527A (en) * 1984-07-19 1986-01-07 Torii & Co., Ltd. Amidine compounds
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.

Also Published As

Publication number Publication date
EP0798295B1 (en) 2003-02-26
DE69529770T2 (de) 2003-12-24
FI115051B (fi) 2005-02-28
AU688628B2 (en) 1998-03-12
NO972482D0 (no) 1997-05-30
DE69529770D1 (de) 2003-04-03
TW300888B (es) 1997-03-21
US5869501A (en) 1999-02-09
HUT77313A (hu) 1998-03-30
CN1087736C (zh) 2002-07-17
WO1996016940A1 (en) 1996-06-06
EP0798295A1 (en) 1997-10-01
PL184824B1 (pl) 2002-12-31
PL320486A1 (en) 1997-09-29
NO972482L (no) 1997-08-01
JP3004362B2 (ja) 2000-01-31
FI972326A7 (fi) 1997-06-02
MX9704059A (es) 1997-08-30
CA2206532C (en) 2006-07-11
FI972326A0 (fi) 1997-06-02
NZ296210A (en) 1998-05-27
CA2206532A1 (en) 1996-06-06
KR100383161B1 (ko) 2003-12-24
PT798295E (pt) 2003-07-31
NO309566B1 (no) 2001-02-19
RU2154633C2 (ru) 2000-08-20
CN1167484A (zh) 1997-12-10
AU3994295A (en) 1996-06-19
EP0798295A4 (en) 1998-03-04
ATE233240T1 (de) 2003-03-15

Similar Documents

Publication Publication Date Title
ES2193202T3 (es) Nuevo derivado de amidinonaftilo o sal de este.
FR2710063B1 (fr) 3-Aryl-benzofurannones, utilisées en tant que stabilisants, compositions les contenant, et leur utilisation.
BG102689A (bg) Фармацевтичен аерозолен състав за използване при лечение на респираторни смущения
ES2180592T3 (es) Formulaciones en aerosol libres de clorofluorocarbonos.
ES2062632T3 (es) Composicion para tratamiento del cabello.
NO20091159L (no) Hoyselektive reopptaksinhibitorer for norepinefrin
PT100963A (pt) Composicoes farmaceuticas para aplicacao topica de elevada penetracao atraves da pele que compreendem certos polimeros nao-ionicos especificos
ATE320184T1 (de) Xylitolzusammensetzungen zur behandlung der oberen atmungsorgane
ATE146674T1 (de) Pharmazeutische zusammensetzung zur rektalen verabreichung von wirkstoffen mit topischer medizinischer wirkung im dickdarmniveau
GR1001503B (el) Μέ?οδος δια την παρασκευή φαρμακευτικών ενώσεων αι οποίαι περιέχουν ως δραστική ουσία καρβονικά οξέα τα οποία περιέχουν ?είον κα?ώς και η χρησιμοποίησις αυτών δια την καταπολέμησιν των ρετροιών.
TR199800019T1 (xx) Trombosit topaklanmas�n� �nleyici yeni maddeler.
GR3031577T3 (en) Quick-drying gel-type disinfectant for hands and fingers.
DE69435002D1 (de) Anti-angiogene Mittel enthaltend Taxol und einen nicht biodegradierbaren Träger und deren Verwendung
ES2143122T3 (es) Sulfonimidamidas sustituidas, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.
KR950002785A (ko) 골량을 증가시키기 위한 부갑상선 호르몬 및 랄옥시펜
BR0301945A (pt) Cassete cirúrgico
BR9911040A (pt) 2-fenil-1-[4-(2-aminoetóxi)-benzil]-indol em combinação com estrogêneos
MXPA97007996A (es) Preparado para el transporte de sustancias activas a traves de barreras.
SE9300581L (sv) Komposition för nasalbehandling
ATE243196T1 (de) Piperidine und pyrrolidine
DK0735877T3 (da) 6-(2-imidazolinylamino)quinoxalinforbindelser, der er egnede som alfa-2-adrenoceptoragonister.
ES2169113T3 (es) Nuevos compuestos amido-triciclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2151698T3 (es) Nuevos derivados de 6-hidroxi y 6-oxo-androstan activos sobre el sistema cardiovascular y composiciones farmaceuticas que los contienen.
ES2129112T3 (es) Compuestos aromaticos policiclicos, composiciones farmaceuticas y cosmeticas que los contienen y utilizaciones.
ATE401900T1 (de) Verwendung von polyethylenglycol ( peg ) zur herstellung eines medikamentes zur behandlung von verstopfung