ES2193202T3 - Nuevo derivado de amidinonaftilo o sal de este. - Google Patents

Nuevo derivado de amidinonaftilo o sal de este.

Info

Publication number
ES2193202T3
ES2193202T3 ES95938625T ES95938625T ES2193202T3 ES 2193202 T3 ES2193202 T3 ES 2193202T3 ES 95938625 T ES95938625 T ES 95938625T ES 95938625 T ES95938625 T ES 95938625T ES 2193202 T3 ES2193202 T3 ES 2193202T3
Authority
ES
Spain
Prior art keywords
group
sup
formula
represented
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95938625T
Other languages
English (en)
Inventor
Fukushi Hirayama
Hiroyuki Koshio
Yuzo Matsumoto
Tomihisa Kawasaki
Seiji Kaku
Isao Yanagisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2193202T3 publication Critical patent/ES2193202T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

UN DERIVADO DE AMIDINONAFTILO REPRESENTADO POR LA SIGUIENTE FORMULA GENERAL (I) QUE TIENE UNA ACCION INHIBIDORA DE LA AGREGACION PLAQUETARIA BASADA EN LA ACCION INHIBIDORA ACTIVADA DEL FACTOR X DE COAGULACION DE LA SANGRE Y UTIL COMO AGENTE ANTITROMBOTICO Y SIMILAR, UNA SAL DE ESTE, UN PRODUCTO INTERMEDIO DE ESTE Y UNA COMPOSICION FARMACEUTICA QUE CONTIENE EL DERIVADO DE AMIDINONAFTILO. LA INVENCION SE REFIERE ASIMISMO A UN DERIVADO DE AMIDINONAFTILO REPRESENTADO POR LA SIGUIENTE FORMULA GENERAL (I) O UNA SAL ACEPTABLE FARMACEUTICAMENTE DE ESTE. (LOS SIMBOLOS DE LA FORMULA TIENEN LOS SIGUIENTES SIGNIFICADOS: R{SUP,1}): ATOMO DE HIDROGENO O UN GRUPO REPRESENTADO POR LA FORMULA - A - W - R {SUP,4}, A: UN GRUPO REPRESENTADO POR LA FORMULA: UN GRUPO REPRESENTADO POR LA FORMULA: O UN GRUPO REPRESENTADO POR LA FORMULA - SO {SUB,2}-, X ES UN ATOMO DE OXIGENO O UN ATOMO DE AZUFRE, W ES UN ENLACE SENCILLO O UN GRUPO REPRESENTADO POR LA FORMULA - NR{SUP,5} -, R{SUP,4} ES UN GRUPO HIDROXILO, UN GRUPOALCOXI INFERIOR, ETC., NO UN GRUPO HIDROXILO O UN GRUPO ALCOXI INFERIOR, R{SUP,5} ES UN ATOMO DE HIDROGENO, UN GRUPO CARBAMOILO, UN GRUPO ALCOXICARBONILO INFERIOR, ETC.; R{SUP,2} ES UN GRUPO ALQUILO INFERIOR, R{SUP,3} ES UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO CARBOXILO, B ES UN GRUPO ALQUILENO INFERIOR O UN GRUPO CARBONILO, Y N ES 0 O 1).
ES95938625T 1994-12-02 1995-12-01 Nuevo derivado de amidinonaftilo o sal de este. Expired - Lifetime ES2193202T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP29996394 1994-12-02
JP10520595 1995-04-28
JP19881695 1995-08-03

Publications (1)

Publication Number Publication Date
ES2193202T3 true ES2193202T3 (es) 2003-11-01

Family

ID=27310425

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95938625T Expired - Lifetime ES2193202T3 (es) 1994-12-02 1995-12-01 Nuevo derivado de amidinonaftilo o sal de este.

Country Status (20)

Country Link
US (1) US5869501A (es)
EP (1) EP0798295B1 (es)
JP (1) JP3004362B2 (es)
KR (1) KR100383161B1 (es)
CN (1) CN1087736C (es)
AT (1) ATE233240T1 (es)
AU (1) AU688628B2 (es)
CA (1) CA2206532C (es)
DE (1) DE69529770T2 (es)
ES (1) ES2193202T3 (es)
FI (1) FI115051B (es)
HU (1) HUT77313A (es)
MX (1) MX9704059A (es)
NO (1) NO309566B1 (es)
NZ (1) NZ296210A (es)
PL (1) PL184824B1 (es)
PT (1) PT798295E (es)
RU (1) RU2154633C2 (es)
TW (1) TW300888B (es)
WO (1) WO1996016940A1 (es)

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US6653340B1 (en) 1997-06-03 2003-11-25 Biocryst Pharmaceuticals, Inc. Compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation
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EP0937723A1 (de) * 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Sulfonamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
EP1066272A4 (en) * 1998-03-27 2002-03-13 Biocryst Pharm Inc NEW CONNECTIONS USEFUL IN THE COMPLEMENT, COAGULATE AND KALLIKREIN REACTION WAY AND METHOD FOR THEIR PRODUCTION
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US6284796B1 (en) 1998-08-06 2001-09-04 Abbott Laboratories Ukokinase inhibitors
US6504031B1 (en) 1998-08-06 2003-01-07 Milan Bruncko Naphthamidine urokinase inhibitors
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US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
DE60027204T2 (de) 1999-10-28 2006-11-23 Sankyo Co., Ltd. Benzamidinderivate
EP1095933A1 (en) * 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
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ES2254385T3 (es) 2000-02-29 2006-06-16 Millennium Pharmaceuticals, Inc. Benzamidas e inhibidores relacionados del factor xa.
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RU2256652C1 (ru) 2001-04-05 2005-07-20 Санкио Компани, Лимитед Соединение, фармацевтическая композиция, применение, способ предупреждения или лечения заболеваний
EP1569912B1 (en) 2002-12-03 2015-04-29 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
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RU2226392C1 (ru) * 2002-10-23 2004-04-10 Биологический факультет Московского государственного университета им. М.В. Ломоносова Способ ингибирования агрегации тромбоцитов
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Also Published As

Publication number Publication date
CA2206532C (en) 2006-07-11
MX9704059A (es) 1997-08-30
FI972326A0 (fi) 1997-06-02
ATE233240T1 (de) 2003-03-15
DE69529770D1 (de) 2003-04-03
US5869501A (en) 1999-02-09
EP0798295A4 (en) 1998-03-04
CA2206532A1 (en) 1996-06-06
PL184824B1 (pl) 2002-12-31
FI115051B (fi) 2005-02-28
JP3004362B2 (ja) 2000-01-31
RU2154633C2 (ru) 2000-08-20
AU688628B2 (en) 1998-03-12
NZ296210A (en) 1998-05-27
KR100383161B1 (ko) 2003-12-24
TW300888B (es) 1997-03-21
PT798295E (pt) 2003-07-31
AU3994295A (en) 1996-06-19
HUT77313A (hu) 1998-03-30
NO972482D0 (no) 1997-05-30
EP0798295B1 (en) 2003-02-26
WO1996016940A1 (en) 1996-06-06
FI972326A7 (fi) 1997-06-02
CN1087736C (zh) 2002-07-17
CN1167484A (zh) 1997-12-10
PL320486A1 (en) 1997-09-29
EP0798295A1 (en) 1997-10-01
DE69529770T2 (de) 2003-12-24
NO972482L (no) 1997-08-01
NO309566B1 (no) 2001-02-19

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