ATE233240T1 - Neues amidinonaphthylderivat oder dessen salz - Google Patents

Neues amidinonaphthylderivat oder dessen salz

Info

Publication number: ATE233240T1
Authority: AT; Austria
Prior art keywords: group; formula; represented; chem; hydrogen atom
Prior art date: 1994-12-02

Application number

AT95938625T

Other languages

English (en)

Inventor

Fukushi Hirayama

Hiroyuki Koshio

Yuzo Matsumoto

Tomihisa Kawasaki

Seiji Kaku

Isao Yanagisawa

Original Assignee

Yamanouchi Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-02

Filing date

1995-12-01

Publication date

2003-03-15

1995-12-01 Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd

2003-03-15 Application granted granted Critical

2003-03-15 Publication of ATE233240T1 publication Critical patent/ATE233240T1/de

Links

-1 AMIDINONAPHTHYL Chemical class 0.000 title abstract 4
150000003839 salts Chemical class 0.000 title abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
108010074860 Factor Xa Proteins 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

AT95938625T 1994-12-02 1995-12-01 Neues amidinonaphthylderivat oder dessen salz ATE233240T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP29996394		1994-12-02
JP10520595		1995-04-28
JP19881695		1995-08-03
PCT/JP1995/002458 WO1996016940A1 (en)	1994-12-02	1995-12-01	Novel amidinonaphthyl derivative or salt thereof

Publications (1)

Publication Number	Publication Date
ATE233240T1 true ATE233240T1 (de)	2003-03-15

Family

ID=27310425

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95938625T ATE233240T1 (de)	1994-12-02	1995-12-01	Neues amidinonaphthylderivat oder dessen salz

Country Status (20)

Country	Link
US (1)	US5869501A (de)
EP (1)	EP0798295B1 (de)
JP (1)	JP3004362B2 (de)
KR (1)	KR100383161B1 (de)
CN (1)	CN1087736C (de)
AT (1)	ATE233240T1 (de)
AU (1)	AU688628B2 (de)
CA (1)	CA2206532C (de)
DE (1)	DE69529770T2 (de)
ES (1)	ES2193202T3 (de)
FI (1)	FI115051B (de)
HU (1)	HUT77313A (de)
MX (1)	MX9704059A (de)
NO (1)	NO309566B1 (de)
NZ (1)	NZ296210A (de)
PL (1)	PL184824B1 (de)
PT (1)	PT798295E (de)
RU (1)	RU2154633C2 (de)
TW (1)	TW300888B (de)
WO (1)	WO1996016940A1 (de)

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CA2293824A1 (en) *	1997-06-19	1998-12-23	Mimi Lifen Quan	(amidino)6-membered aromatics as factor xa inhibitors
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CA2348740A1 (en)	1998-12-23	2000-07-06	Ruth R. Wexler	Thrombin or factor xa inhibitors
EP1144373B1 (de)	1999-01-13	2005-10-19	Genentech, Inc.	Serinprotease-inhibitoren
WO2000043041A1 (fr) *	1999-01-22	2000-07-27	Yamanouchi Pharmaceutical Co., Ltd.	Compositions medicamenteuses presentant une meilleure absorption orale
EP1159273A1 (de)	1999-03-02	2001-12-05	Boehringer Ingelheim Pharmaceuticals Inc.	Verbindungen, verwendbar als reversible inhibitoren von cathepsin s
FR2793247B1 (fr) *	1999-05-04	2001-06-22	Synthelabo	Derives de 6-[[(aryl et heteroaryl)oxy]methyl]naphtalene-2- carboximidamide, leur preparation et leur application en therapeutique
US6858599B2 (en) *	1999-06-30	2005-02-22	Mochida Pharmaceutical Co., Ltd.	Tricyclic compound having spiro union
AU5570900A (en) *	1999-07-01	2001-01-22	Sankyo Company Limited	Indoline or tetrahydroquinoline derivatives
US6350761B1 (en) *	1999-07-30	2002-02-26	Berlex Laboratories, Inc.	Benzenamine derivatives as anti-coagulants
US6420364B1 (en)	1999-09-13	2002-07-16	Boehringer Ingelheim Pharmaceuticals, Inc.	Compound useful as reversible inhibitors of cysteine proteases
HK1047431B (en) *	1999-10-28	2006-07-14	三共株式会社	Benzamidine derivatives
EP1095933A1 (de) *	1999-10-30	2001-05-02	Aventis Pharma Deutschland GmbH	N-Guanidinoalkylamide, Verfahren zu ihrer Herstellung, ihre Verwendung und pharmazeutische Zusammensetzungen, die sie enthalten
WO2001056989A2 (en) *	2000-02-01	2001-08-09	Cor Therapeutics, Inc.	Inhibitors of factor xa
WO2001064642A2 (en)	2000-02-29	2001-09-07	Cor Therapeutics, Inc.	Benzamides and related inhibitors of factor xa
EP1272483A2 (de) *	2000-03-24	2003-01-08	Millenium Pharmaceuticals, Inc.	Oxindole als faktor xa inhibitoren
AU776053B2 (en) *	2000-03-31	2004-08-26	Astellas Pharma Inc.	Diazepan derivatives or salts thereof
US6495562B1 (en)	2000-04-25	2002-12-17	Abbott Laboratories	Naphthamidine urokinase inhibitors
CA2421548C (en)	2000-09-11	2007-10-30	Genentech, Inc.	Amidine inhibitors of serine proteases
PT1336605E (pt)	2000-11-22	2006-06-30	Astellas Pharma Inc	Derivados de fenol substituidos ou seus sais como inibidores do factor x de coagulacao
US6538017B2 (en)	2001-03-09	2003-03-25	Ortho-Mcneil Pharmaceutical, Inc.	Aminopyrrolidine sulfonamides as serine protease inhibitors
US6710061B2 (en)	2001-03-09	2004-03-23	Ortho-Mcneil Pharamceutical, Inc.	Aminopyrrolidine sulfonamides as serine protease inhibitors
US7312235B2 (en)	2001-03-30	2007-12-25	Millennium Pharmaceuticals, Inc.	Benzamide inhibitors of factor Xa
EP1375482A4 (de)	2001-04-05	2005-01-19	Sankyo Co	Benzamidinderivate
CN100410236C (zh) *	2002-01-29	2008-08-13	雪兰诺实验室有限公司	作为蛋白酪氨酸磷酸酶调节剂的取代亚甲基酰胺衍生物
RU2226392C1 (ru) *	2002-10-23	2004-04-10	Биологический факультет Московского государственного университета им. М.В. Ломоносова	Способ ингибирования агрегации тромбоцитов
US20070004736A1 (en)	2002-11-22	2007-01-04	Keiji Kubo	Imidazole derivative, process for producing the same, and use
AU2003302238A1 (en)	2002-12-03	2004-06-23	Axys Pharmaceuticals, Inc.	2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
PL378215A1 (pl) *	2002-12-24	2006-03-20	Daiichi Pharmaceutical Co., Ltd.	Nowe pochodne etylenodiaminy
CA2525713A1 (en)	2003-05-20	2004-12-29	Genentech, Inc.	Benzofuran inhibitors of factor viia
WO2004113278A2 (en)	2003-05-20	2004-12-29	Genentech, Inc.	Acylsulfamide inhibitors of factor viia
US7022695B2 (en)	2003-10-09	2006-04-04	Millennium Pharmaceuticals, Inc.	Thioether-substituted benzamides as inhibitors of Factor Xa
TWI396686B (zh)	2004-05-21	2013-05-21	Takeda Pharmaceutical	環狀醯胺衍生物、以及其製品和用法
KR101195801B1 (ko)	2004-06-18	2012-11-05	밀레니엄 파머슈티컬스 인코퍼레이티드	Ｘａ 인자 억제제
WO2006055951A2 (en)	2004-11-19	2006-05-26	Portola Pharmaceuticals, Inc.	Tetrahydroisoquinolines as factor xa inhibitors
WO2006063293A2 (en) *	2004-12-07	2006-06-15	Portola Pharmaceuticals, Inc.	THIOUREAS AS FACTOR Xa INHIBITORS
US7678913B2 (en)	2004-12-07	2010-03-16	Portola Pharmaceuticals, Inc.	Ureas as factor Xa inhibitors
EP1847527A4 (de)	2005-02-02	2009-04-08	Ajinomoto Kk	Neue benzamidinverbindungen
PE20070717A1 (es)	2005-11-08	2007-08-17	Millennium Pharm Inc	Sal de maleato y polimorfo de [2-({4-[(dimetilamino)iminometil]fenil}carbonilamino)-5-metoxifenil]-n-(5-cloro-(2-piridil))carboxamida
MX2008012404A (es) *	2006-03-28	2008-10-09	Novartis Ag	Derivados de amida y su aplicacion para el tratamiento de enfermedades relacionadas con proteina-g.
JP5253174B2 (ja) *	2006-10-12	2013-07-31	株式会社医薬分子設計研究所	Ｎ−フェニルオキサミド酸誘導体
CN101595092B (zh)	2006-11-02	2012-02-01	米伦纽姆医药公司	合成因子xa抑制剂的医药盐的方法
US20110045028A1 (en)	2006-11-30	2011-02-24	Takeda Pharmaceutical Company Limited	Sustained release preparation
US8633245B2 (en) *	2008-04-11	2014-01-21	Institute Of Medicinal Molecular Design, Inc.	PAI-1 inhibitor
EP2311810A4 (de) *	2008-07-11	2012-04-04	Ajinomoto Kk	Amidderivate
EA015918B1 (ru)	2010-03-03	2011-12-30	Дмитрий Геннадьевич ТОВБИН	УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa
WO2019241213A1 (en) *	2018-06-11	2019-12-19	The Regents Of The University Of Colorado, A Body Corporate	2-naphthimidamides, analogues thereof, and methods of treatment using same
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ZA928276B (en) *	1991-10-31	1993-05-06	Daiichi Seiyaku Co	Aromatic amidine derivates and salts thereof.

1995
- 1995-12-01 ES ES95938625T patent/ES2193202T3/es not_active Expired - Lifetime
- 1995-12-01 WO PCT/JP1995/002458 patent/WO1996016940A1/ja not_active Ceased
- 1995-12-01 DE DE69529770T patent/DE69529770T2/de not_active Expired - Fee Related
- 1995-12-01 CA CA002206532A patent/CA2206532C/en not_active Expired - Fee Related
- 1995-12-01 CN CN95196546A patent/CN1087736C/zh not_active Expired - Fee Related
- 1995-12-01 JP JP8518590A patent/JP3004362B2/ja not_active Expired - Fee Related
- 1995-12-01 US US08/849,391 patent/US5869501A/en not_active Expired - Fee Related
- 1995-12-01 TW TW084112820A patent/TW300888B/zh active
- 1995-12-01 AT AT95938625T patent/ATE233240T1/de not_active IP Right Cessation
- 1995-12-01 NZ NZ296210A patent/NZ296210A/en unknown
- 1995-12-01 KR KR1019970703620A patent/KR100383161B1/ko not_active Expired - Fee Related
- 1995-12-01 MX MX9704059A patent/MX9704059A/es not_active IP Right Cessation
- 1995-12-01 PL PL95320486A patent/PL184824B1/pl not_active IP Right Cessation
- 1995-12-01 EP EP95938625A patent/EP0798295B1/de not_active Expired - Lifetime
- 1995-12-01 RU RU97108576/04A patent/RU2154633C2/ru not_active IP Right Cessation
- 1995-12-01 PT PT95938625T patent/PT798295E/pt unknown
- 1995-12-01 AU AU39942/95A patent/AU688628B2/en not_active Ceased
- 1995-12-01 HU HU9702028A patent/HUT77313A/hu unknown
1997
- 1997-05-30 NO NO972482A patent/NO309566B1/no not_active IP Right Cessation
- 1997-06-02 FI FI972326A patent/FI115051B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0798295B1 (de)	2003-02-26
DE69529770T2 (de)	2003-12-24
FI115051B (fi)	2005-02-28
AU688628B2 (en)	1998-03-12
NO972482D0 (no)	1997-05-30
DE69529770D1 (de)	2003-04-03
TW300888B (de)	1997-03-21
US5869501A (en)	1999-02-09
HUT77313A (hu)	1998-03-30
CN1087736C (zh)	2002-07-17
WO1996016940A1 (en)	1996-06-06
EP0798295A1 (de)	1997-10-01
PL184824B1 (pl)	2002-12-31
PL320486A1 (en)	1997-09-29
NO972482L (no)	1997-08-01
JP3004362B2 (ja)	2000-01-31
FI972326A7 (fi)	1997-06-02
MX9704059A (es)	1997-08-30
CA2206532C (en)	2006-07-11
FI972326A0 (fi)	1997-06-02
NZ296210A (en)	1998-05-27
CA2206532A1 (en)	1996-06-06
ES2193202T3 (es)	2003-11-01
KR100383161B1 (ko)	2003-12-24
PT798295E (pt)	2003-07-31
NO309566B1 (no)	2001-02-19
RU2154633C2 (ru)	2000-08-20
CN1167484A (zh)	1997-12-10
AU3994295A (en)	1996-06-19
EP0798295A4 (de)	1998-03-04

Legal Events

Date

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Description

2003-08-15

UEP

Publication of translation of european patent specification

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2007-09-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE233240T1 (de)	2003-03-15	Neues amidinonaphthylderivat oder dessen salz
HUT75031A (en)	1997-03-28	Azolylamine derivatives and pharmaceutical compositions of antifungal effect
PT1044967E (pt)	2004-10-29	Inibidores da uroquinase do tipo 2-piridinilguanidina
ATE183924T1 (de)	1999-09-15	Cholesterinspiegelsenkendes mittel
SI0672659T1 (en)	1999-04-30	Antithrombotic agents
PT992509E (pt)	2004-12-31	Novos derivados macrolidos
TW269687B (de)	1996-02-01
ATE174593T1 (de)	1999-01-15	Neue bisoxadiazolidinderivate
MX9206930A (es)	1993-06-01	Nuevos compuestos
DK0922054T3 (da)	2002-12-09	Antikoagulerende peptidylargininaldehydderivater
EP1121932A4 (de)	2001-12-19	Heilmittel für augenerkrankungen
AU655869B2 (en)	1995-01-12	An amphoteric tricyclic compound
EP0790247A4 (de)	2000-07-19	Tetrahydroisochinolin-derivate und diese enthaltende arzneimittel
EP1236712A4 (de)	2005-04-20	Amidinophenylbrenztraubensäure-derivat
ATE43594T1 (de)	1989-06-15	3-alkoxy-2-(n-pyrrolidino)-n-pyridyl-n-furyl(od r thienyl)-methyl-propylamine, ihre herstellung und diese enthaltende pharmazeutische mittel.
DK0566288T3 (da)	1995-10-02	Flavon-derivater
DE69908855D1 (de)	2003-07-24	9a, 11b-dehydro Derivative von 9-oxime-3-keto-6-0-methylerythromycin
PT777471E (pt)	2003-04-30	Metodo de inibicao da biosintese de leucotrieno
DE60006130D1 (de)	2003-11-27	Streptograminderivate, ihre herstellung und sie enthaltende zubereitungen