ES2193245T3 - Reactivos estables para la preparacion de radiofarmacos. - Google Patents

Reactivos estables para la preparacion de radiofarmacos.

Info

Publication number: ES2193245T3
Authority: ES; Spain
Prior art keywords: preparation; reagents; radiopharmacos; stable reagents; stable
Prior art date: 1995-06-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES96919289T

Other languages

English (en)

Spanish (es)

Inventor

Michael Sworin

Milind Rajopadhye

Thomas David Harris

David Scott Edwards

Edward Hollister Cheesman

Shuang Liu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bristol Myers Squibb Pharma Co

Original Assignee

Bristol Myers Squibb Pharma Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-07

Publication date

2003-11-01

1996-06-07 Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co

2003-11-01 Application granted granted Critical

2003-11-01 Publication of ES2193245T3 publication Critical patent/ES2193245T3/es

2016-06-07 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000003153 chemical reaction reagent Substances 0.000 title abstract 3
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
238000009007 Diagnostic Kit Methods 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
150000007857 hydrazones Chemical class 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
230000007115 recruitment Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Optics & Photonics (AREA)
Physics & Mathematics (AREA)
Zoology (AREA)
Toxicology (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ES96919289T 1995-06-07 1996-06-07 Reactivos estables para la preparacion de radiofarmacos. Expired - Lifetime ES2193245T3 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/476,296 US5750088A (en)	1993-03-30	1995-06-07	Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals

Publications (1)

Publication Number	Publication Date
ES2193245T3 true ES2193245T3 (es)	2003-11-01

Family

ID=23891282

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES96919289T Expired - Lifetime ES2193245T3 (es)	1995-06-07	1996-06-07	Reactivos estables para la preparacion de radiofarmacos.

Country Status (29)

Country	Link
US (2)	US5750088A (2)
EP (1)	EP0832068B1 (2)
JP (1)	JPH11507364A (2)
KR (1)	KR19990022573A (2)
CN (1)	CN1192733A (2)
AR (1)	AR003959A1 (2)
AT (1)	ATE233241T1 (2)
AU (1)	AU718683B2 (2)
BR (1)	BR9609003A (2)
CA (1)	CA2222183A1 (2)
CZ (1)	CZ380197A3 (2)
DE (1)	DE69626392T2 (2)
EA (1)	EA000742B1 (2)
EE (1)	EE9700313A (2)
ES (1)	ES2193245T3 (2)
HR (1)	HRP960250A2 (2)
HU (1)	HUP9901469A3 (2)
IL (1)	IL118468A0 (2)
LT (1)	LT4380B (2)
LV (1)	LV12044B (2)
MX (1)	MX9709126A (2)
MY (1)	MY133974A (2)
NO (1)	NO975678L (2)
NZ (1)	NZ310799A (2)
PL (1)	PL323995A1 (2)
SI (1)	SI9620076B (2)
SK (1)	SK163497A3 (2)
WO (1)	WO1996040637A1 (2)
ZA (1)	ZA964854B (2)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0888130B1 (en) *	1996-03-13	2003-07-02	Bristol-Myers Squibb Pharma Company	New ternary radiopharmaceutical complexes
US20030124053A1 (en) *	1996-10-07	2003-07-03	Barrett John Andrew	Radiopharmaceuticals for imaging infection and inflammation
ATE240123T1 (de) *	1996-10-07	2003-05-15	Bristol Myers Squibb Pharma Co	Radiopharmazeutische mittel zur bildgebung von infektionen und entzündungen
US6416733B1 (en) *	1996-10-07	2002-07-09	Bristol-Myers Squibb Pharma Company	Radiopharmaceuticals for imaging infection and inflammation
US6403054B1 (en)	1997-05-28	2002-06-11	Bristol-Myers Squibb Pharma Company	Ternary ligand complexes useful as radiopharmaceuticals
US6524553B2 (en)	1998-03-31	2003-02-25	Bristol-Myers Squibb Pharma Company	Quinolone vitronectin receptor antagonist pharmaceuticals
US6537520B1 (en) *	1998-03-31	2003-03-25	Bristol-Myers Squibb Pharma Company	Pharmaceuticals for the imaging of angiogenic disorders
AU3119199A (en) *	1998-04-03	1999-10-25	Du Pont Pharmaceuticals Company	Radiopharmaceuticals for imaging infection and inflammation and for imaging and treatment of cancer
HRP990317A2 (en) *	1998-10-13	2000-06-30	Du Pont Pharm Co	A process for the preparation of a thrombus imaging agent
CA2349501A1 (en)	1998-12-18	2000-06-22	Du Pont Pharmaceuticals Company	Quinolone vitronectin receptor antagonist pharmaceuticals
US6511649B1 (en)	1998-12-18	2003-01-28	Thomas D. Harris	Vitronectin receptor antagonist pharmaceuticals
EP1140864A2 (en) *	1998-12-18	2001-10-10	Du Pont Pharmaceuticals Company	Vitronectin receptor antagonist pharmaceuticals
US6794518B1 (en) *	1998-12-18	2004-09-21	Bristol-Myers Squibb Pharma Company	Vitronectin receptor antagonist pharmaceuticals
CA2364753A1 (en) *	1999-03-26	2000-10-05	Joel Lazewatsky	Method for localization of blood clots
US6808698B1 (en)	1999-03-26	2004-10-26	Bristol-Myers Squibb Pharma Company	Method for localization of blood clots
US6656448B1 (en)	2000-02-15	2003-12-02	Bristol-Myers Squibb Pharma Company	Matrix metalloproteinase inhibitors
US20030220646A1 (en) *	2002-05-23	2003-11-27	Thelen Sarah L.	Method and apparatus for reducing femoral fractures
US6534038B2 (en) *	2000-04-07	2003-03-18	Bristol-Myers Squibb Pharma Company	Ternary ligand complexes useful as radiopharmaceuticals
HUP0400758A3 (en)	2000-11-03	2005-02-28	Bristol Myers Squibb Pharma Co	Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
GB0031592D0 (en) *	2000-12-28	2001-02-07	Nycomed Amersham Plc	Stabilised radiopharmaceutical compositions
MXPA04001113A (es) *	2001-08-08	2004-07-08	Bristol Myers Squibb Pharma Co	Formacion de imagenes simultaneas de perfusion cardiaca y agente formador de imagenes dirigido al receptor de vitronectina.
US6838074B2 (en)	2001-08-08	2005-01-04	Bristol-Myers Squibb Company	Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
US7297709B2 (en)	2003-05-22	2007-11-20	Abbott Laboratories	Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
US7319149B2 (en) *	2003-06-13	2008-01-15	Bristol-Myers Squibb Pharma Company	Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7317104B2 (en)	2003-06-13	2008-01-08	Bristol-Myers Squibb Pharma Company	Chelants and macrocyclic metal complex radiopharmaceuticals thereof
SG177216A1 (en) *	2003-07-24	2012-01-30	Bracco Imaging Spa	Stable radiopharmaceutical compositions and methods for their preparation
US20050106100A1 (en) *	2003-09-03	2005-05-19	Harris Thomas D.	Compounds containing matrix metalloproteinase substrates and methods of their use
KR20080022588A (ko) *	2005-06-30	2008-03-11	브리스톨-마이어스 스퀴브 파마 컴퍼니	영상화제로서의 히드라지드 컨쥬게이트
WO2007046411A1 (ja) *	2005-10-19	2007-04-26	Dainippon Sumitomo Pharma Co., Ltd.	イソキサゾール化合物の安定化方法
JP5148507B2 (ja) *	2005-12-20	2013-02-20	アストラゼネカ・アクチエボラーグ	Ｇａｂａａ受容体調節物質としての置換シンノリン誘導体及びその合成法
US7465795B2 (en) *	2005-12-20	2008-12-16	Astrazeneca Ab	Compounds and uses thereof
CA2673683C (en)	2007-01-11	2014-07-29	Critical Outcome Technologies, Inc.	Compounds and method for treatment of cancer
TW200911760A (en) *	2007-06-19	2009-03-16	Astrazeneca Ab	Compounds and uses thereof
CA2710039C (en)	2007-12-26	2018-07-03	Critical Outcome Technologies, Inc.	Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer
CA2730890C (en)	2008-07-17	2018-05-15	Critical Outcome Technologies Inc.	Thiosemicarbazone inhibitor compounds and cancer treatment methods
FR2940652B1 (fr) *	2008-12-29	2011-02-11	Sanofi Aventis	Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique
MX2011007061A (es) *	2008-12-29	2011-12-16	Sanofi Sa	Derivados de 2 piridin- 2-il-pirazol-3 (2h)-ona, su preparacion y aplicacion terapeutica.
FR2949468B1 (fr) *	2009-08-28	2011-09-30	Sanofi Aventis	Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique
HRP20140680T1 (hr)	2008-12-29	2014-10-10	Sanofi	Derivati 2-piridin-2-ilpirazol-3(2h)-ona, njihovo dobivanje i njihova upotreba u terapiji kao aktivatora hif
CA2794952C (en)	2010-04-01	2018-05-15	Critical Outcome Technologies Inc.	Compounds and method for treatment of hiv
FR2967671A1 (fr) *	2010-11-24	2012-05-25	Pf Medicament	Complexe de technetium 99m en tant qu'outil de diagnostic in vivo des tumeurs cancereuses
CN110818624B (zh) *	2019-11-22	2022-11-22	华东理工大学	吡啶季铵盐腙类化合物及制备方法与在抗菌或香料缓释中的应用
CN112999369B (zh) *	2021-03-03	2022-02-25	江苏元本生物科技有限公司	一种her2亲合体放射性核素标记物组合物及其应用

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4427646A (en)	1981-04-02	1984-01-24	Research Corporation	Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo
US4578079A (en)	1982-08-04	1986-03-25	La Jolla Cancer Research Foundation	Tetrapeptide
US4792525A (en)	1982-08-04	1988-12-20	La Jolla Cancer Research Foundation	Tetrapeptide
CA1300608C (en) *	1985-05-10	1992-05-12	Edward A. Deutsch	99 mtc (iii) myocardial imaging agents which are non-reducable in vivo
GB8624272D0 (en) *	1986-10-09	1986-11-12	Amersham Int Plc	Cationic complexes of tc-99m
US5217705A (en)	1987-09-25	1993-06-08	Neorx Corporation	Method of diagnosing blood clots using fibrin-binding proteins
AU639409B2 (en)	1987-12-10	1993-07-29	La Jolla Cancer Research Foundation	Conformationally stabilized cell adhesion peptides
AU619538B2 (en) *	1988-03-09	1992-01-30	Cis Bio International	Preparation of nitruro compounds usable as radio-pharmaceutical products
GB8808414D0 (en) *	1988-04-11	1988-05-11	Amersham Int Plc	Ligands & cationic complexes thereof with technetium-99m
AU3569189A (en)	1988-04-29	1989-11-24	New England Deaconess Hospital Corporation	Hybrid peptides and methods of their use
US5002754A (en) *	1988-06-15	1991-03-26	University Of Cincinnati	Technetium (III/II) imaging agents
WO1990003391A1 (en)	1988-09-29	1990-04-05	Biogen, Inc.	Hirudin peptides
US5066789A (en) *	1988-09-30	1991-11-19	Neorx Corporation	Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages
US5270030A (en)	1988-12-29	1993-12-14	Bio-Technology General Corp.	Fibrin binding domain polypeptide and method of producing
GB8902362D0 (en) *	1989-02-03	1989-03-22	Amersham Int Plc	Cationic complexes of technetium-99m
US5206370A (en) *	1989-02-24	1993-04-27	Johnson Matthey, Inc.	Certain pyridyl hydrazines and hydrazides useful for protein labeling
IL93432A (en) *	1989-02-24	1994-02-27	Johnson Mathey Inc	Hydrazines and hydrazides, their conjugates with macromolecules and such conjugates labelled with metal ions
US4917879A (en) *	1989-05-19	1990-04-17	University Of Cincinnati	99MTC(III) myocardial imaging agents that are effective in humans
US4957728A (en) *	1989-05-19	1990-09-18	University Of Cincinnati	Kit for preparing Tc (III)-99m myocardial imaging agents that are effective in humans
GB8914020D0 (en)	1989-06-19	1989-08-09	Antisoma Ltd	Synthetic peptides for use in thrombus detection
EP0410537A1 (en)	1989-07-28	1991-01-30	Merck & Co. Inc.	Fibrinogen receptor antagonists
GB8919488D0 (en) *	1989-08-29	1989-10-11	Amersham Int Plc	New cores for technetium radiopharmaceuticals
CA2026377A1 (en)	1989-10-03	1991-04-04	John L. Krstenansky	Radiolabeled anticoagulant peptides
US5086069A (en)	1990-02-05	1992-02-04	Rorer Pharmaceutical Corporation	Anti-thrombotic peptide and pseudopeptide derivatives
US5137877B1 (en) *	1990-05-14	1996-01-30	Bristol Myers Squibb Co	Bifunctional linking compounds conjugates and methods for their production
FR2664166A1 (fr) *	1990-07-04	1992-01-10	Cis Bio Int	Procede de preparation de complexes nitruro de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques.
IL99537A (en)	1990-09-27	1995-11-27	Merck & Co Inc	Fibrinogen receptor antagonists and pharmaceutical compositions containing them
ATE152917T1 (de) *	1990-09-28	1997-05-15	Neorx Corp	Polymere träger zur freisetzung kovalent gebundener wirkstoffe
US5112594A (en) *	1991-04-04	1992-05-12	Mallinckrodt Medical, Inc.	Kit for preparing a technetium-99m myocardial imaging agent
ATE188387T1 (de)	1991-02-08	2000-01-15	Diatide Inc	Technetium-99m markierte polypeptide zur bildformung
FR2679452B1 (fr) *	1991-07-22	1993-11-12	Cis Bio International	Produit radiopharmaceutique ayant notamment un tropisme cerebral, comportant un complexe nitruro d'un metal de transition, et son procede de preparation.
US5362852A (en) *	1991-09-27	1994-11-08	Pfizer Inc.	Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties
DE69334033D1 (de)	1992-05-21	2006-07-27	Diatide Inc	Technetium-99M markierte Peptide zur Bilderzeugung von Thrombus
GB2268494B (en)	1992-07-08	1996-08-21	Kenneth Francis Prendergast	Imaging compositions
FR2698272B1 (fr) *	1992-11-20	1994-12-30	Cis Bio Int	Procédé de marquage cellulaire au moyen de complexes nitruro-bis (dithiocarbamato)Tc-99m et trousse pour la mise en Óoeuvre de ce procédé.
US5879657A (en) *	1993-03-30	1999-03-09	The Dupont Merck Pharmaceutical Company	Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders

1995
- 1995-06-07 US US08/476,296 patent/US5750088A/en not_active Expired - Fee Related
1996
- 1996-05-30 IL IL11846896A patent/IL118468A0/xx unknown
- 1996-06-04 HR HR08/476,296A patent/HRP960250A2/hr not_active Application Discontinuation
- 1996-06-06 MY MYPI96002227A patent/MY133974A/en unknown
- 1996-06-07 HU HU9901469A patent/HUP9901469A3/hu unknown
- 1996-06-07 MX MX9709126A patent/MX9709126A/es unknown
- 1996-06-07 JP JP9501990A patent/JPH11507364A/ja not_active Ceased
- 1996-06-07 ES ES96919289T patent/ES2193245T3/es not_active Expired - Lifetime
- 1996-06-07 AT AT96919289T patent/ATE233241T1/de not_active IP Right Cessation
- 1996-06-07 PL PL96323995A patent/PL323995A1/xx unknown
- 1996-06-07 CA CA002222183A patent/CA2222183A1/en not_active Abandoned
- 1996-06-07 CN CN96196141A patent/CN1192733A/zh active Pending
- 1996-06-07 EA EA199800025A patent/EA000742B1/ru not_active IP Right Cessation
- 1996-06-07 KR KR1019970709054A patent/KR19990022573A/ko not_active Ceased
- 1996-06-07 DE DE69626392T patent/DE69626392T2/de not_active Expired - Fee Related
- 1996-06-07 WO PCT/US1996/009766 patent/WO1996040637A1/en not_active Ceased
- 1996-06-07 BR BR9609003-0A patent/BR9609003A/pt not_active Application Discontinuation
- 1996-06-07 AU AU61661/96A patent/AU718683B2/en not_active Ceased
- 1996-06-07 ZA ZA9604854A patent/ZA964854B/xx unknown
- 1996-06-07 NZ NZ310799A patent/NZ310799A/xx unknown
- 1996-06-07 SK SK1634-97A patent/SK163497A3/sk unknown
- 1996-06-07 CZ CZ973801A patent/CZ380197A3/cs unknown
- 1996-06-07 AR ARP960103028A patent/AR003959A1/es not_active Application Discontinuation
- 1996-06-07 SI SI9620076A patent/SI9620076B/sl unknown
- 1996-06-07 EP EP96919289A patent/EP0832068B1/en not_active Expired - Lifetime
- 1996-06-07 EE EE9700313A patent/EE9700313A/xx unknown
1997
- 1997-10-23 US US08/956,313 patent/US6015904A/en not_active Expired - Fee Related
- 1997-12-05 LT LT97-191A patent/LT4380B/lt not_active IP Right Cessation
- 1997-12-05 NO NO975678A patent/NO975678L/no not_active Application Discontinuation
1998
- 1998-01-28 LV LVP-97-247A patent/LV12044B/en unknown

Also Published As

Publication number	Publication date
LV12044A (lv)	1998-05-20
LV12044B (en)	1998-09-20
SK163497A3 (en)	1998-10-07
ZA964854B (en)	1997-12-08
KR19990022573A (ko)	1999-03-25
EP0832068A1 (en)	1998-04-01
ATE233241T1 (de)	2003-03-15
HRP960250A2 (en)	1997-12-31
EA199800025A1 (ru)	1998-06-25
HUP9901469A3 (en)	2000-02-28
MX9709126A (es)	1998-03-31
EA000742B1 (ru)	2000-02-28
MY133974A (en)	2007-11-30
CA2222183A1 (en)	1996-12-19
AU718683B2 (en)	2000-04-20
NO975678D0 (no)	1997-12-05
JPH11507364A (ja)	1999-06-29
CZ380197A3 (cs)	1998-07-15
AU6166196A (en)	1996-12-30
WO1996040637A1 (en)	1996-12-19
AR003959A1 (es)	1998-09-30
US6015904A (en)	2000-01-18
NO975678L (no)	1998-02-06
EP0832068B1 (en)	2003-02-26
SI9620076A (sl)	1998-08-31
DE69626392T2 (de)	2004-04-22
LT97191A (en)	1998-04-27
HUP9901469A2 (hu)	1999-08-30
PL323995A1 (en)	1998-04-27
EE9700313A (et)	1998-06-15
CN1192733A (zh)	1998-09-09
LT4380B (lt)	1998-09-25
SI9620076B (sl)	2000-02-29
NZ310799A (en)	2000-01-28
IL118468A0 (en)	1996-09-12
BR9609003A (pt)	1999-12-14
US5750088A (en)	1998-05-12
DE69626392D1 (de)	2003-04-03

Publication	Publication Date	Title
AR003959A1 (es)	1998-09-30	Reactivo para preparar un grupo biologicamente activo conectado a un grupo hidrazona estable, conjunto de elementos para preparar un agente radio-farmaceutico y compuesto de hidrazona estable.
ES2179196T3 (es)	2003-01-16	Complejos radiofarmacos ternarios.
CY1111787T1 (el)	2015-10-07	Χορηγηση μεσων για την αγωγη φλεγμονης
ES2061730T3 (es)	1994-12-16	Nuevos anticuerpos.
DK0841949T3 (da)	2006-08-21	Anvendelse af saccharid-konjugater
ES2167391T3 (es)	2002-05-16	Inmunoconjugados ii.
BRPI0410503B8 (pt)	2021-05-25	composição tópica e uso da composição
DE3687736D1 (de)	1993-03-25	Monoklonale antikoerper gegen humanen brustkrebs, korrespondierende hybridome, deren herstellung und verwendung.
DE69735367D1 (de)	2006-04-27	THERAPEUTISCHE MULTISPEZIFISCHE VERBINDUNGEN, DIE ANTIKÖRPER GEGEN DEN FCalpha-REZEPTOR ENTHALTEN
DE60210752D1 (de)	2006-05-24	Pharmazeutische zusammensetzung enthaltend proteoglykan und ihre verwendung zur behandlung von entzündlichen erkrankungen
BR0009537A (pt)	2002-01-08	Composições para tratamento e diagnóstico de câncer de mama e métodos para seu uso
MX2007004079A (es)	2007-06-15	Detecci??n de niveles elevados de prote??na her-2/neu en celulas cancerosas circulantes y tratamiento.
ATE311464T1 (de)	2005-12-15	Nk zellen-aktivierende rezeptoren und deren therapeutische und diagnostische verwendungen
GT200300294A (es)	2004-07-27	Compuestos de indazol y composiciones farmaceuticas para inhibir proteinquinasas y procedimientos para su uso
UA29466C2 (uk)	2000-11-15	Фармацевтична композиція з антипухлинною активністю
ES2121792T3 (es)	1998-12-16	Anticuerpo monoclonal.
ES2137353T3 (es)	1999-12-16	Nuevos derivados esteroides especificos del colon o del ileon.
ES2118058T3 (es)	1998-09-16	Factor de crecimiento de las celulas t.
DK1021534T3 (da)	2010-02-01	Hepatitis C-receptorprotein CD81
ES2059457T3 (es)	1994-11-16	Utilizacion de bezafibrato para el tratamiento de la diabetes.
BR0312483A (pt)	2005-08-09	Anticorpos e seus usos
MXPA03007317A (es)	2004-06-30	Derivados de biotina y sus conjugados con agentes quelantes.
ES2135811T3 (es)	1999-11-01	Indenoil-guanidinas sustituidas antiarritmicas y cardioprotectoras.
NO20050216L (no)	2005-04-14	Steroidkonjugater samt fremstilling og anvendelse derav
ES2036532T3 (es)	1993-06-01	Nucleosidos de isohexida, procedimientos para su preparacion y su uso como medicamentos.