ES2193407T3 - Heterocomplejo de nitruro de metal de transicion radiactivo. - Google Patents

Heterocomplejo de nitruro de metal de transicion radiactivo.

Info

Publication number
ES2193407T3
ES2193407T3 ES97947953T ES97947953T ES2193407T3 ES 2193407 T3 ES2193407 T3 ES 2193407T3 ES 97947953 T ES97947953 T ES 97947953T ES 97947953 T ES97947953 T ES 97947953T ES 2193407 T3 ES2193407 T3 ES 2193407T3
Authority
ES
Spain
Prior art keywords
transition metal
radioactive
metal nitride
radioactive transition
heterocomplejo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97947953T
Other languages
English (en)
Inventor
Adriano Duatti
Cristina Bolzati
Licia Uccelli
Fiorenzo Refosco
Francesco Tisato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nihon Medi Physics Co Ltd
Original Assignee
Nihon Medi Physics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Medi Physics Co Ltd filed Critical Nihon Medi Physics Co Ltd
Application granted granted Critical
Publication of ES2193407T3 publication Critical patent/ES2193407T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5004—Acyclic saturated phosphines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Ceramic Products (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA UN HETEROCOMPLEJO DE NITRURO DE METAL DE TRANSICION RADIACTIVO, QUE PERMITE MARCAR UNA SUSTANCIA FISIOLOGICAMENTE ACTIVA, COMO UN PEPTIDO, HORMONA O SIMILAR, SIN DIFICULTAR LA ACTIVIDAD DE DICHA SUSTANCIA. EL HETEROCOMPLEJO DE NITRURO DE METAL DE TRANSICION RADIACTIVO DE LA PRESENTE INVENCION ESTA REPRESENTADO MEDIANTE LA SIGUIENTE FORMULA (I): DONDE EL METAL DE TRANSICION RADIACTIVO M ES TECNECIO O RENIO RADIACTIVO, N ES UN ATOMO DE NITROGENO, X ES UN COMPUESTO DIFOSFINA O DIARSINA E Y ES UN LIGANDO BIDENTADO QUE TIENE UNA COMBINACION DE ATOMOS DONADORES DE ELECTRONES.
ES97947953T 1996-12-18 1997-12-16 Heterocomplejo de nitruro de metal de transicion radiactivo. Expired - Lifetime ES2193407T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP33855396 1996-12-18

Publications (1)

Publication Number Publication Date
ES2193407T3 true ES2193407T3 (es) 2003-11-01

Family

ID=18319265

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97947953T Expired - Lifetime ES2193407T3 (es) 1996-12-18 1997-12-16 Heterocomplejo de nitruro de metal de transicion radiactivo.

Country Status (13)

Country Link
US (2) US6270745B1 (es)
EP (1) EP0949265B1 (es)
JP (1) JP3935218B2 (es)
KR (1) KR100554563B1 (es)
AT (1) ATE239745T1 (es)
AU (1) AU730120B2 (es)
CA (1) CA2275451C (es)
DE (1) DE69721820T2 (es)
DK (1) DK0949265T3 (es)
ES (1) ES2193407T3 (es)
NZ (1) NZ335950A (es)
PT (1) PT949265E (es)
WO (1) WO1998027100A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5855867A (en) * 1995-03-29 1999-01-05 The Curators Of The University Of Missouri Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same
AU3922601A (en) * 2000-01-28 2001-08-07 Molypharma, S.A. A radiopharmaceutical for radionuclide tumor therapy
AU2001276677B2 (en) 2000-07-28 2005-10-20 Nihon Medi-Physics Co., Ltd. Radiopharmaceutical for diagnostic imaging containing a technetium-99m nitride heterocomplex
EP1456153B1 (en) 2001-12-20 2012-06-13 Sasol Technology (Pty) Ltd Trimerisation and oligomerisation of olefins using a chromium based catalyst
US8980870B2 (en) * 2002-09-24 2015-03-17 Boehringer Ingelheim International Gmbh Solid telmisartan pharmaceutical formulations
EP1417977A1 (en) 2002-11-07 2004-05-12 BRACCO IMAGING S.p.A. Radioactive transition metal-imido hetero-diphosphine complexes, their preparation and radiopharmaceutical compositions thereof
WO2004096735A2 (en) * 2003-05-02 2004-11-11 Kamaluddin Abdur-Rashid Transfer hydrogenation processes and catalysts
JP2008037752A (ja) * 2004-11-19 2008-02-21 Nihon Medi Physics Co Ltd 新規放射性テクネチウム−ビスホスフィノアミン錯体および該錯体を含む放射性画像診断剤
WO2006080993A1 (en) * 2004-12-08 2006-08-03 Purdue Research Foundation Novel cationic metal complex radiopharmaceuticals
EP1973923B1 (en) 2006-01-20 2011-08-17 Nihon Medi-Physics Co., Ltd. Intermediate compound of technetium nitride complex for radiodiagnostic imaging
US20130195756A1 (en) 2012-01-31 2013-08-01 General Electric Company 99mTc IMAGING AGENTS AND METHODS OF USE
CN110072560A (zh) * 2016-12-15 2019-07-30 伯拉考成像股份公司 用于利用基于锝的化合物标记敏感和热敏性靶向生物分子的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8723438D0 (en) * 1987-10-06 1987-11-11 Amersham Int Plc Cationic complexes of technetium-99m
CA1340899C (en) * 1988-03-09 2000-02-15 Andre Bardy Procede de preparation de complexes nitruro 99m tc, 186 re ou 188 re utilisables comme produits radiopharmaceutiques
FR2664166A1 (fr) * 1990-07-04 1992-01-10 Cis Bio Int Procede de preparation de complexes nitruro de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques.
FR2679452B1 (fr) 1991-07-22 1993-11-12 Cis Bio International Produit radiopharmaceutique ayant notamment un tropisme cerebral, comportant un complexe nitruro d'un metal de transition, et son procede de preparation.
JPH07110869A (ja) 1993-10-12 1995-04-25 Fuji Xerox Co Ltd 図形編集装置

Also Published As

Publication number Publication date
CA2275451C (en) 2007-01-02
KR20000057661A (ko) 2000-09-25
DK0949265T3 (da) 2003-08-11
AU730120B2 (en) 2001-02-22
AU5412898A (en) 1998-07-15
US6270745B1 (en) 2001-08-07
JP3935218B2 (ja) 2007-06-20
CA2275451A1 (en) 1998-06-25
PT949265E (pt) 2003-08-29
NZ335950A (en) 2000-06-23
DE69721820D1 (de) 2003-06-12
US20020048549A1 (en) 2002-04-25
EP0949265A1 (en) 1999-10-13
EP0949265B1 (en) 2003-05-07
WO1998027100A1 (en) 1998-06-25
KR100554563B1 (ko) 2006-03-03
DE69721820T2 (de) 2004-02-26
ATE239745T1 (de) 2003-05-15
EP0949265A4 (en) 2001-03-07

Similar Documents

Publication Publication Date Title
TW239126B (es)
EP0949265A4 (en) NITRIDE HETEROCOMPLEXES OF RADIOACTIVE TRANSITION METALS
MY110526A (en) Thioether conjugates
ATE272608T1 (de) Bicyclo (2.2.1) heptane und verwandte verbindungen
FR2733244B1 (fr) Systeme de stabilisants a base de derives de polyalkylpiperidine
MXPA04004674A (es) Ligados de los receptors de los canabinodies.
MY113806A (en) Antiparasitic marcfortines and paraherquamides
ATE214055T1 (de) Retinoid-potenzierende verbindungen
IL135536A0 (en) Ortho-anthranilamide derivatives and pharmaceutical compositions containing the same
EP0976748A4 (en) PYRROLIDIN DERIVATIVES HAVING A PHOSPHOLIPASE A2 INHIBITING EFFECT
DZ2503A1 (fr) Formulation pure injectable d'un composé anesthésique.
PT956033E (pt) SíNTESE TOTAL DE ANALOGOS AMINO HIP DE DIDEMNINA A
ZA916268B (en) Tricyclic compound or salts thereof,method for producing the same and antimicrobial agent containing the same
EP0973518A4 (en) SEMISYNTHETIC METHOD FOR PRODUCING DIDEMNINE ANALOGS
MX9604368A (es) Antagonistas de receptores de endotelina.
NO982873L (no) 1-metylkarbapenemderivater
EP1073447A4 (en) N1-MODIFIED GLYCOPEPTIDES
ATE282608T1 (de) Chinoxalindionen
MY131533A (en) Insect-repellent formulations containing n-substituted 3-azabicyclo [ 3.1.0 ] hexane-2, 4-diones
DE69600714D1 (de) Antiallergische Zusammensetzung enthaltend eine Phosphorsäurediester-Verbindung
TW340788B (en) Ester compounds and household insects-controlling agents containing the same as an active ingredient