ES2193700T3 - Metodos y aparatos para la formacion de particulas. - Google Patents

Metodos y aparatos para la formacion de particulas.

Info

Publication number
ES2193700T3
ES2193700T3 ES99919410T ES99919410T ES2193700T3 ES 2193700 T3 ES2193700 T3 ES 2193700T3 ES 99919410 T ES99919410 T ES 99919410T ES 99919410 T ES99919410 T ES 99919410T ES 2193700 T3 ES2193700 T3 ES 2193700T3
Authority
ES
Spain
Prior art keywords
fluid
solution
suspension
vehicle
particle formation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99919410T
Other languages
English (en)
Inventor
Mazen Hermiz Hanna
Peter York
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nektar Therapeutics UK Ltd
Original Assignee
Nektar Therapeutics UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics UK Ltd filed Critical Nektar Therapeutics UK Ltd
Application granted granted Critical
Publication of ES2193700T3 publication Critical patent/ES2193700T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0407—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solute
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0488—Flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
    • B01J3/008—Processes carried out under supercritical conditions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Glanulating (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un método para formar partículas de una sustancia buscada como objetivo, implicando el método: (a) preparar una solución buscada como objetivo, que contiene la sustancia buscada como objetivo disuelta en un vehículo que es un fluido casi crítico o un primer fluido supercrítico; (b) introducir la solución buscada como objetivo en un recipiente de formación de partículas; y (c) poner en contacto la solución buscada como objetivo, en el recipiente de formación de partículas, con un segundo fluido supercrítico bajo condiciones que permitan que el segundo fluido supercrítico provoque la precipitación de partículas de la sustancia buscada como objetivo en la solución buscada como objetivo; en donde el segundo fluido supercrítico es miscible o sustancialmente miscible con el vehículo y es un fluido en el que la sustancia buscada como objetivo es insoluble o sustancialmente insoluble.
ES99919410T 1998-05-15 1999-04-29 Metodos y aparatos para la formacion de particulas. Expired - Lifetime ES2193700T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9810559.6A GB9810559D0 (en) 1998-05-15 1998-05-15 Method and apparatus for particle formation

Publications (1)

Publication Number Publication Date
ES2193700T3 true ES2193700T3 (es) 2003-11-01

Family

ID=10832197

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99919410T Expired - Lifetime ES2193700T3 (es) 1998-05-15 1999-04-29 Metodos y aparatos para la formacion de particulas.

Country Status (12)

Country Link
US (2) US6576262B1 (es)
EP (1) EP1077760B1 (es)
JP (1) JP2002515324A (es)
AT (1) ATE232754T1 (es)
AU (1) AU751106B2 (es)
CA (1) CA2329902C (es)
DE (1) DE69905460T2 (es)
DK (1) DK1077760T3 (es)
ES (1) ES2193700T3 (es)
GB (1) GB9810559D0 (es)
MX (1) MXPA00011185A (es)
WO (1) WO1999059710A1 (es)

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Also Published As

Publication number Publication date
US6576262B1 (en) 2003-06-10
EP1077760B1 (en) 2003-02-19
DE69905460D1 (de) 2003-03-27
MXPA00011185A (es) 2003-05-19
DE69905460T2 (de) 2004-02-26
JP2002515324A (ja) 2002-05-28
ATE232754T1 (de) 2003-03-15
AU3720999A (en) 1999-12-06
US20040071783A1 (en) 2004-04-15
AU751106B2 (en) 2002-08-08
GB9810559D0 (en) 1998-07-15
EP1077760A1 (en) 2001-02-28
CA2329902A1 (en) 1999-11-25
DK1077760T3 (da) 2003-06-16
CA2329902C (en) 2008-07-15
WO1999059710A1 (en) 1999-11-25

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