ATE270667T1 - 2-amino-benzoxazinone zur behandlung von viralen infektionen - Google Patents

2-amino-benzoxazinone zur behandlung von viralen infektionen

Info

Publication number
ATE270667T1
ATE270667T1 AT01110048T AT01110048T ATE270667T1 AT E270667 T1 ATE270667 T1 AT E270667T1 AT 01110048 T AT01110048 T AT 01110048T AT 01110048 T AT01110048 T AT 01110048T AT E270667 T1 ATE270667 T1 AT E270667T1
Authority
AT
Austria
Prior art keywords
treatment
viral infections
benzoxazinone
amino
compounds
Prior art date
Application number
AT01110048T
Other languages
English (en)
Inventor
Norman Abood
Daniel L Flynn
Daniel P Becker
Brian M Bax
Hui Li
Roger A Nosal
Lori A Schretzman
Clara I Villamil
Michael J Bennett
John L Bedell
Kenneth Williams
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Priority claimed from US09/502,038 external-priority patent/US6380189B1/en
Application granted granted Critical
Publication of ATE270667T1 publication Critical patent/ATE270667T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT01110048T 1995-05-24 1996-05-23 2-amino-benzoxazinone zur behandlung von viralen infektionen ATE270667T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/448,795 US5985872A (en) 1995-05-24 1995-05-24 2-amino-benzoxazinones for the treatment of viral infections
US95262498A 1998-05-15 1998-05-15
US09/502,038 US6380189B1 (en) 1995-05-24 2000-02-11 2-amino benzoxazinones for the treatment of viral infections
US10/035,433 US6683077B2 (en) 1995-05-24 2002-01-04 2-Amino-benzoxazinones for the treatment of viral infections

Publications (1)

Publication Number Publication Date
ATE270667T1 true ATE270667T1 (de) 2004-07-15

Family

ID=37772666

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01110048T ATE270667T1 (de) 1995-05-24 1996-05-23 2-amino-benzoxazinone zur behandlung von viralen infektionen
AT96914762T ATE208765T1 (de) 1995-05-24 1996-05-23 2-amino-benzoxazinone zur behandlung von viralen infektionen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT96914762T ATE208765T1 (de) 1995-05-24 1996-05-23 2-amino-benzoxazinone zur behandlung von viralen infektionen

Country Status (15)

Country Link
US (3) US5985872A (de)
EP (1) EP0828721B1 (de)
JP (1) JPH11505849A (de)
CN (1) CN1070480C (de)
AT (2) ATE270667T1 (de)
AU (1) AU711174B2 (de)
BR (1) BR9608506A (de)
CA (1) CA2222034A1 (de)
DE (2) DE69617005T2 (de)
DK (1) DK0828721T3 (de)
ES (2) ES2225339T3 (de)
NZ (1) NZ308398A (de)
PT (2) PT828721E (de)
TW (1) TW455583B (de)
WO (1) WO1996037485A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985872A (en) * 1995-05-24 1999-11-16 G.D. Searle & Co. 2-amino-benzoxazinones for the treatment of viral infections
EP1122245B1 (de) * 1995-05-24 2004-07-07 G.D. Searle & Co. 2-Amino-Benzoxazinone zur Behandlung von viralen Infektionen
AU3339797A (en) * 1996-06-20 1998-01-07 Smithkline Beecham Plc 4h-3,1-benzoxazin-4-one derivatives and analogs as antiviral agents
GB9710928D0 (en) * 1997-05-29 1997-07-23 Smithkline Beecham Plc Pharmaceuticals
AR022204A1 (es) * 1999-01-08 2002-09-04 Norgine Bv Compuesto, proceso para su preparacion, composicion farmaceutica y producto comestible que lo comprende.
GB9900416D0 (en) * 1999-01-08 1999-02-24 Alizyme Therapeutics Ltd Inhibitors
US6806269B1 (en) * 1999-07-12 2004-10-19 G. D. Searle & Cop 2-Amino-benzoxazinones for the treatment of herpes simplex virus
CA2378014A1 (en) * 1999-07-12 2001-01-18 G.D. Searle & Co. 2-amino-benzoxazinones for the treatment of herpes simplex virus
DE10036184A1 (de) * 2000-07-24 2002-02-14 Aventis Cropscience Gmbh Substituierte Sulfonylaminomethylbenzoesäure(derivate) und Verfahren zu ihrer Herstellung
EP1403269A1 (de) * 2001-06-13 2004-03-31 Asahi Kasei Pharma Corporation Heilmittel für infektiöse virenerkrankung
PT1565429E (pt) * 2002-11-21 2009-07-23 Neurosearch As Derivados de diaril-ureído e sua utilização médica
US7192471B2 (en) * 2004-09-24 2007-03-20 Honeywell International Inc. Aryl-ureido benzoxazinone compounds
ES2380135T3 (es) 2006-11-22 2012-05-08 Ajinomoto Co., Inc. Método de preparación de derivados de fenilalanina que tienen esqueleto de quinazolinadiona e intermedios para su preparación
JP2010525069A (ja) * 2007-04-27 2010-07-22 パラテック ファーマシューティカルズ インコーポレイテッド アミノアルキルテトラサイクリン化合物の合成方法および精製方法
US8356971B2 (en) * 2009-12-17 2013-01-22 Detch John W Disc turbine with streamlined hub vanes and co-axial exhaust tube
CN115109006B (zh) * 2022-05-20 2025-03-14 上海大学 一种3-取代-1,2-苯并噁嗪-4-酮类化合物的制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3297755A (en) * 1960-12-02 1967-01-10 Hoffmann La Roche 2-chloro-5-trifluoromethylbenzo-phenone compounds
US3450700A (en) * 1966-12-20 1969-06-17 Upjohn Co 2-tertiary amino-4h-3,1-benzoxazin-4-ones
DE2218302A1 (de) * 1972-04-15 1973-10-25 Bayer Ag Verfahren zur herstellung von trifluormethylimino-derivaten von benzoxazinonen
DE2315303A1 (de) * 1973-03-27 1974-10-17 Bayer Ag Verfahren zur herstellung von n-substituierten 2-amino-3,1-benzoxazin-4-onen
NZ210669A (en) * 1983-12-27 1988-05-30 Syntex Inc Benzoxazin-4-one derivatives and pharmaceutical compositions
US4657893A (en) * 1984-05-09 1987-04-14 Syntex (U.S.A.) Inc. 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors
US4665070A (en) * 1985-06-25 1987-05-12 Syntex (U.S.A.) Inc. 2-oxy-4H-3,1-benzoxazin-4-ones and pharmaceutical use
US4745116A (en) * 1985-06-25 1988-05-17 Syntex (U.S.A.) Inc. 2-oxy-4H-3,1-benzoxazin-4-ones and related compounds and pharmaceutical use
CA1309556C (en) * 1987-06-09 1992-10-27 Masayuki Kokubo 4h-3,1-benzoxazin-4-one compounds and pharmaceutical composition thereoffor the inhibition of serine proteases
AU635403B2 (en) * 1990-02-15 1993-03-18 Teijin Limited 4h-3,1-benzoxazin-4-one compound and elastase inhibitor composition containing the same
EP0533951A4 (en) * 1991-04-10 1993-09-01 Japan Tobacco Inc. Novel oxazinone derivative
NZ242739A (en) * 1991-05-24 1994-12-22 Arch Dev Corp Identification and purification of herpes protease nucleic acid segments and their use in the production of this protease
US5434074A (en) * 1991-07-05 1995-07-18 Gibson; D. Wade Cytomegalovirus proteinase
US5428021A (en) * 1994-01-27 1995-06-27 Sri International Human leukocyte elastase (HLE) inhibitors, and related pharmaceutical compositions and methods of use
US5652237A (en) * 1994-09-09 1997-07-29 Warner-Lambert Company 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes
EP1122245B1 (de) * 1995-05-24 2004-07-07 G.D. Searle & Co. 2-Amino-Benzoxazinone zur Behandlung von viralen Infektionen
US5985872A (en) * 1995-05-24 1999-11-16 G.D. Searle & Co. 2-amino-benzoxazinones for the treatment of viral infections

Also Published As

Publication number Publication date
WO1996037485A1 (en) 1996-11-28
PT828721E (pt) 2002-04-29
ATE208765T1 (de) 2001-11-15
TW455583B (en) 2001-09-21
EP0828721A1 (de) 1998-03-18
ES2225339T3 (es) 2005-03-16
US20030022895A1 (en) 2003-01-30
US5985872A (en) 1999-11-16
AU711174B2 (en) 1999-10-07
US20050032793A1 (en) 2005-02-10
DE69632876T2 (de) 2005-03-03
CA2222034A1 (en) 1996-11-28
DK0828721T3 (da) 2002-03-04
DE69617005T2 (de) 2002-07-04
JPH11505849A (ja) 1999-05-25
US6683077B2 (en) 2004-01-27
PT1122245E (pt) 2004-11-30
AU5803096A (en) 1996-12-11
ES2169242T3 (es) 2002-07-01
BR9608506A (pt) 1999-06-15
CN1190963A (zh) 1998-08-19
CN1070480C (zh) 2001-09-05
DE69632876D1 (de) 2004-08-12
DE69617005D1 (de) 2001-12-20
EP0828721B1 (de) 2001-11-14
NZ308398A (en) 1999-06-29

Similar Documents

Publication Publication Date Title
ATE208765T1 (de) 2-amino-benzoxazinone zur behandlung von viralen infektionen
ATE224374T1 (de) 1,2-substituierte imidazolylverbindungen zur behandlung von entzündungen
ATE206409T1 (de) N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1-h- benzo(b)(1,5)-diazepin-3-yl)-acetamide
EA200100412A1 (ru) Замещенные 3-цианохинолины в качестве ингибиторов протеинтирозинкиназ
NO20003233D0 (no) 4-hydrokykinolin-3-karboksamider og hydraziner som antivirale midler
BR9909844A (pt) Processo para sintetizar um composto, e, composto.
DK1200418T3 (da) Nematodicide trifluorbutener
BR9508308A (pt) Derivados de benzoíla e sintese dos mesmos
ES2193241T3 (es) Nuevas n-2-oxo2.3.4.5-tetrajodrp-1h-1,5-benzodiazepin-3-il)-3-amidas.
ATE256667T1 (de) Verbindungen und deren verwendung zur behandlung von infektiösen erkrankungen
DE69610628D1 (de) N-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3-yl)-3-amide
TR200002932T2 (tr) Azabisayklik 5HT1 Alıcı liganolları
BG101002A (bg) Заместени арилалкилтио-алкилтиопиридини и използване за борба с бактерии от рода helicobacter
TR200302288T2 (tr) Terapi için yeni bileşikler ve metotlar.
ES2194102T3 (es) Nuevas n-(2,4-dioxo-2,3,4,5-tetrahidro-1h-1,5-benzodiazepin-3-il)-3-amidas.
ATE209914T1 (de) Verwendung von pyridylmethylsulfinyl-1h- benzimidazol derivaten zur behandlung durch helicobacter verursachter erkrankungen
ATE223226T1 (de) Azazyklohexapeptid-verbindungen
MX9709016A (es) 2-amino-benzoxazinonas, composiciones que las contienen y uso de las mismas.
SE9602416D0 (sv) New forms of an organic salt of N'N-diacetylcystine
DK0772579T3 (da) Benzoylderivater og syntese deraf
PT1140932E (pt) Derivados de 1,8-benzonaftiridina
NO993650L (no) Nye forbindelser med hemoregulerende effekt
EA200001065A1 (ru) Применение фосфорорганических соединений для терапевтического и профилактического лечения инфекций

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1122245

Country of ref document: EP

REN Ceased due to non-payment of the annual fee