ES2194837T3 - Microbios de salmonella avirulentos que comprenden una mutacion en el gen cdt y usos de los mismos. - Google Patents

Microbios de salmonella avirulentos que comprenden una mutacion en el gen cdt y usos de los mismos.

Info

Publication number
ES2194837T3
ES2194837T3 ES92901722T ES92901722T ES2194837T3 ES 2194837 T3 ES2194837 T3 ES 2194837T3 ES 92901722 T ES92901722 T ES 92901722T ES 92901722 T ES92901722 T ES 92901722T ES 2194837 T3 ES2194837 T3 ES 2194837T3
Authority
ES
Spain
Prior art keywords
understanding
immunogenic compositions
mutation
cdt
avirulentos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92901722T
Other languages
English (en)
Inventor
Roy Curtiss Iii
Sandra M Kelly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Application granted granted Critical
Publication of ES2194837T3 publication Critical patent/ES2194837T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/255—Salmonella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/42—Salmonella
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA INVENCION SUMINISTRA COMPOSICIONES INMUNOGENICAS PARA LA INMUNIZACION DE UN VERTEBRADO O INVERTEBRADO QUE COMPRENDEN UN DERIVADO AVIRULENTO DE LA "S. TYPHI". LOS DERIVADOS TIENEN UNA MUTACION EN LOS GENES CYA Y/O CRP Y/O CDT. LA INVENCION TAMBIEN SUMINISTRA COMPOSICIONES INMUNOGENICAS PARA LA INMUNIZACION DE UN VERTEBRADO O INVERTEBRADO QUE COMPRENDEN UN DERIVADO AVIRULENTO DEL TIPO DESCRITO QUE ES CAPAZ DE EXPRESAR UN GEN RECOMBINANTE DERIVADO DE UN PATOGENO DE DICHO INDIVIDUO VERTEBRADO O INVERTEBRADO PARA PRODUCIR UN ANTIGENO CAPAZ DE INDUCIR UNA RESPUESTA INMUNE CONTRA DICHO PATOGENO. OTROS ASPECTOS DE LA INVENCION INCLUYEN METODOS PARA PREPARAR COMPOSICIONES INMUNOGENICAS A PARTIR DE ESTAS ESTIRPES, Y LAS ESTIRPES UTILES EN LA PREPARACION DE COMPOSICIONES INMUNOGENICAS, ASI COMO METODOS PARA ESTIMULAR LA RESPUESTA INMUNE PARA RESPONDER A UN ANTIGENO INMUNOGENICO DE LA "S.TYPHI" MEDIANTE LA ADMINISTRACION DE LA COMPOSICION INUMUNOGENICA.
ES92901722T 1990-11-09 1991-11-08 Microbios de salmonella avirulentos que comprenden una mutacion en el gen cdt y usos de los mismos. Expired - Lifetime ES2194837T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61200190A 1990-11-09 1990-11-09

Publications (1)

Publication Number Publication Date
ES2194837T3 true ES2194837T3 (es) 2003-12-01

Family

ID=24451304

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92901722T Expired - Lifetime ES2194837T3 (es) 1990-11-09 1991-11-08 Microbios de salmonella avirulentos que comprenden una mutacion en el gen cdt y usos de los mismos.

Country Status (14)

Country Link
EP (2) EP0556333B1 (es)
JP (2) JP3601602B2 (es)
CN (1) CN1063416A (es)
AT (1) ATE234917T1 (es)
AU (1) AU666108B2 (es)
CA (1) CA2095534C (es)
DE (1) DE69133219T2 (es)
DK (1) DK0556333T3 (es)
ES (1) ES2194837T3 (es)
IE (1) IE913912A1 (es)
IL (1) IL100010A (es)
NZ (1) NZ240538A (es)
WO (1) WO1992008486A1 (es)
ZA (1) ZA918876B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9326425D0 (en) * 1993-12-24 1994-02-23 Secr Defence Vaccine compositions
GB9621091D0 (en) * 1996-10-09 1996-11-27 Fondation Pour Le Perfectionem Attenuated microorganisms strains and their uses
WO2009025888A2 (en) 2007-05-10 2009-02-26 The Arizona Board Of Regents For And On Behalf Of Arizona State University Regulated synthesis of antigen and/or regulated attentuation to enhance vaccine immunogenics and/or safety
US8465755B2 (en) 2007-10-05 2013-06-18 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium capable of eliciting an immune response against enteric pathogens
WO2010045620A1 (en) 2008-10-17 2010-04-22 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae
US9163219B2 (en) 2009-04-14 2015-10-20 Arizona Board Of Regents On Behalf Of Arizona State University Single expression vector for generation of a virus with a segmented genome
GB2483595B (en) 2009-05-22 2017-03-29 The Arizona Board Of Regents For And On Behalf Of Arizona State Univ Recombinant bacterium and methods of antigen and nucleic acid delivery
US9045742B2 (en) 2009-05-29 2015-06-02 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant Edwardsiella bacterium
US9062297B2 (en) 2010-01-13 2015-06-23 The Arizona Board Of Regents For And On Behalf Of Arizona State University Yersinia pestis vaccine
WO2011091291A1 (en) 2010-01-22 2011-07-28 The Arizona Board Of Regents For And On Behalf Of Arizona State University BACTERIUM COMPRISING A REGULATED rfaH NUCLEIC ACID
WO2011150421A2 (en) 2010-05-28 2011-12-01 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium to decrease tumor growth
US9303264B2 (en) 2012-05-18 2016-04-05 The Arizona Board Of Regents For And On Behalf Of Arizona State University Photosynthetic microorganisms expressing thermostable lipase
US9580718B2 (en) 2013-06-17 2017-02-28 Arizona Board Of Regents On Behalf Of Arizona State University Attenuated live bacteria with increased acid resistance and methods of use thereof
RU2707548C1 (ru) * 2019-01-24 2019-11-27 Федеральное бюджетное учреждение науки "Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии им. Пастера Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека" (ФБУН НИИ эпидемиологии и микробиологии имени Пастера) Штамм бактерий salmonella enterica subsp. enterica serovar typhi b-8453 с устойчивостью низкого уровня к фторхинолонам, используемый в качестве контрольного штамма для фенотипических и молекулярных исследований при диагностике брюшного тифа
RU2759396C1 (ru) * 2020-12-22 2021-11-12 Федеральное государственное бюджетное учреждение "Всероссийский государственный Центр качества и стандартизации лекарственных средств для животных и кормов" (ФГБУ "ВГНКИ") Штамм бактерий salmonella enterica (вкшм-б-849м) в качестве контрольного штамма для микробиологических и молекулярно-генетических исследований в определении антибиотикорезистентности
WO2024254447A1 (en) * 2023-06-07 2024-12-12 University Of Georgia Research Foundation, Inc. Compositions and methods for a differential diagnostic for salmonella typhimurium infection in poultry

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4550081A (en) * 1980-05-19 1985-10-29 The Board Of Trustees Of The Leland Stanford Jr. University Non-reverting salmonella
US4888170A (en) * 1981-10-22 1989-12-19 Research Corporation Vaccines obtained from antigenic gene products of recombinant genes
CA1338705C (en) * 1981-10-22 1996-11-12 Roy Curtiss Iii Vaccines obtained from antigenic gene products of recombinant genes
WO1985003521A1 (en) * 1984-02-01 1985-08-15 Enterovax Research Pty. Ltd. Bacterial strains
IL86583A0 (en) * 1987-06-04 1988-11-15 Molecular Eng Ass Vaccine containing a derivative of a microbe and method for the production thereof
DE3853683T2 (de) * 1987-10-07 1995-08-31 Univ Washington Verfahren zur erhaltung eines erwünschten rekombinanten gens in einer genetischen zellpopulation.
EP0465561A4 (en) * 1989-03-31 1992-04-08 Washington University Avirulent microbes and uses therefor
ES2090129T3 (es) * 1989-03-31 1996-10-16 Univ Washington Vacunas que contienen microorganismos tipo phop avirulentos.
ATE177787T1 (de) * 1990-11-21 1999-04-15 Univ Washington Rekombinante avirulente salmonella antifruchtbarkeitsimpfstoffe

Also Published As

Publication number Publication date
AU9120491A (en) 1992-06-11
DE69133219T2 (de) 2004-02-12
CA2095534A1 (en) 1992-05-10
NZ240538A (en) 1994-01-26
DE69133219D1 (de) 2003-04-24
EP1323428A2 (en) 2003-07-02
DK0556333T3 (da) 2003-07-14
IL100010A0 (en) 1992-08-18
CA2095534C (en) 2002-09-17
IL100010A (en) 1998-02-08
WO1992008486A1 (en) 1992-05-29
JP3601602B2 (ja) 2004-12-15
IE913912A1 (en) 1992-05-20
EP0556333B1 (en) 2003-03-19
EP1323428A3 (en) 2003-09-17
EP0556333A1 (en) 1993-08-25
JP2004337175A (ja) 2004-12-02
JPH06501849A (ja) 1994-03-03
CN1063416A (zh) 1992-08-12
AU666108B2 (en) 1996-02-01
EP0556333A4 (de) 1994-10-12
ZA918876B (en) 1992-08-26
ATE234917T1 (de) 2003-04-15

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