ES2194939T3 - Procedimiento para la eliminacion extracorporal simultanea del factor de necrosis de tumores alfa y de los lipopolisacaridos bacterianos a partir de sangre entera y/o plasma sanguineo. - Google Patents

Procedimiento para la eliminacion extracorporal simultanea del factor de necrosis de tumores alfa y de los lipopolisacaridos bacterianos a partir de sangre entera y/o plasma sanguineo.

Info

Publication number
ES2194939T3
ES2194939T3 ES96106691T ES96106691T ES2194939T3 ES 2194939 T3 ES2194939 T3 ES 2194939T3 ES 96106691 T ES96106691 T ES 96106691T ES 96106691 T ES96106691 T ES 96106691T ES 2194939 T3 ES2194939 T3 ES 2194939T3
Authority
ES
Spain
Prior art keywords
necrosis factor
simultaneous
blood
bacterial
lipopolisacarids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96106691T
Other languages
English (en)
Inventor
Karl-Siegfried Prof Dr Boos
Dietrich Prof Dr Med Seidel
Annette Trautwein
Gerold Morsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
B Braun Melsungen AG
Original Assignee
B Braun Melsungen AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by B Braun Melsungen AG filed Critical B Braun Melsungen AG
Application granted granted Critical
Publication of ES2194939T3 publication Critical patent/ES2194939T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • External Artificial Organs (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PARA LA ELIMINACION EXTRACORPORAL DEL FACTOR AL DE LA NECROSIS TUMORAL (TNF {AL}) O/Y DE LIPOPOLISACARIDOS BACTERIANOS (LPS, ENDOTOXINA) DE LA SANGRE Y/O DEL PLASMA SANGUINEO EN UN SISTEMA DE PERFUSION EXTRACORPORAL, SE LLEVA LA SANGRE O EL PLASMA POR UN MATERIAL INTERCAMBIADOR DE CATIONES Y POR UNO DE ANIONES. POR TANTO, UN DISPOSITIVO DE ACUERDO CON LA INVENCION PARA EL TRATAMIENTO EXTRACORPORAL DE LA SANGRE O PLASMA DE PACIENTES, CONTIENE UN MATERIAL INTERCAMBIADOR DE CATIONES Y OTRO DE ANIONES, ESTANDO ESTOS MATERIALES EN AL MENOS UNA PARTE DEL SISTEMA DE PERFUSION EXTRACORPORAL.
ES96106691T 1995-04-27 1996-04-26 Procedimiento para la eliminacion extracorporal simultanea del factor de necrosis de tumores alfa y de los lipopolisacaridos bacterianos a partir de sangre entera y/o plasma sanguineo. Expired - Lifetime ES2194939T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19515554A DE19515554C2 (de) 1995-04-27 1995-04-27 Verwendung eines Mittels und Vorrichtung zur simultanen extrakorporalen Elimination von Tumor-Nekrose-Faktor alpha und bakteriellen Lipopolysacchariden aus Vollblut oder/und Blutplasma

Publications (1)

Publication Number Publication Date
ES2194939T3 true ES2194939T3 (es) 2003-12-01

Family

ID=7760536

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96106691T Expired - Lifetime ES2194939T3 (es) 1995-04-27 1996-04-26 Procedimiento para la eliminacion extracorporal simultanea del factor de necrosis de tumores alfa y de los lipopolisacaridos bacterianos a partir de sangre entera y/o plasma sanguineo.

Country Status (6)

Country Link
US (1) US5679775A (es)
EP (1) EP0739630B1 (es)
JP (1) JP2804920B2 (es)
AT (1) ATE234104T1 (es)
DE (3) DE19515554C2 (es)
ES (1) ES2194939T3 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127528A (en) * 1995-02-16 2000-10-03 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for adsorbing and removing tumor necrosis factor-α
US6620382B1 (en) * 1998-05-22 2003-09-16 Biopheresis Technologies, Llc. Method and compositions for treatment of cancers
DE19831873A1 (de) * 1998-07-16 2000-03-30 Jens Altrichter Verfahren und Einrichtung zur therapeutischen Immunmodulation
US20030130194A1 (en) * 1998-07-16 2003-07-10 Jens Altrichter Method and device for increasing and/or decreasing the concentration of immunomodulatory-active substances in substance mixtures
DE19845286A1 (de) * 1998-10-01 2000-04-27 Udo Dunzendorfer Beschichtete Trägermaterialien für Blut-, Plasma- oder Gewebewäsche und mit diesen Trägermaterialien ausgerüstete Säulen
DE19913707A1 (de) * 1999-03-26 2000-10-05 Privates Inst Bioserv Gmbh Immunadsorber zur Sepsistherapie
US6270755B1 (en) 1999-05-13 2001-08-07 Geltex Pharmaceuticals, Inc. Anionic polymers as toxin binders
US6290946B1 (en) 1999-05-13 2001-09-18 Geltex Pharmaceuticals, Inc. Anionic polymers as toxin binders and antibacterial agents
CA2314494A1 (en) 2000-05-02 2001-11-02 Geltex Pharmaceuticals, Inc. Anionic polymers as species specific antibacterial agents
US6884228B2 (en) 2001-03-06 2005-04-26 Baxter International Inc. Automated system adaptable for use with different fluid circuits
US6582386B2 (en) 2001-03-06 2003-06-24 Baxter International Inc. Multi-purpose, automated blood and fluid processing systems and methods
US6706008B2 (en) 2001-03-06 2004-03-16 Baxter International Inc. Automated system and method for withdrawing compounds from blood
DE10118446A1 (de) * 2001-04-12 2002-10-17 Thomas Hartung Prüfverfahren zur Untersuchung fließfähiger Medien auf Gehalte an mikrobiellen Toxinen
US6803183B2 (en) 2002-07-18 2004-10-12 Clarigen, Inc. Method for removing pyrogens from plasma and blood for treatment of septic shock
NZ537594A (en) * 2002-07-22 2008-05-30 Genzyme Corp Poly (potassium and sodium styrene sulfonate), its manufacture and its uses
FR2848223B1 (fr) * 2002-12-09 2005-02-25 Centre Nat Rech Scient Nouveau procede d'isolement des endotoxines.
DE10258944A1 (de) * 2002-12-17 2004-07-01 B. Braun Medizintechnologie Gmbh Vorrichtung zur Entfernung von bakteriellen Lipopolysacchariden oder/und Lipoteichonsäuren aus proteinhaltigen Flüssigkeiten sowie deren Verwendung zur Behandlung von Sepsis
AU2003303198A1 (en) 2002-12-19 2004-07-14 New York University Method for treating amyloid disease
AT413336B (de) * 2003-09-12 2006-02-15 Mattner Frank Dr Apherese-vorrichtung
GB0408521D0 (en) * 2004-04-16 2004-05-19 Carbon Technologies Nv Treatment of sepsis
EP1602387B1 (de) * 2004-06-03 2007-03-14 B. Braun Medizintechnologie GmbH Vorrichtung zur Entfernung von bakteriellen Lipopolysacchariden oder/und Lipoteichonsäuren aus proteinhaltigen Flüssigkeiten sowie Verwendung zur Herstellung eines Mittels zur Entfernung dieser Stoffe
US8048419B2 (en) 2006-02-02 2011-11-01 Innovative Biotherapies, Inc. Extracorporeal cell-based therapeutic device and delivery system
US9101716B2 (en) 2008-02-01 2015-08-11 Baxter International Inc. Multi-pass dialysis
CA2728215A1 (en) 2008-06-18 2010-06-24 Innovative Biotherapies, Inc. Methods for enhanced propagation of cells
EP2679302A1 (de) 2012-06-28 2014-01-01 Zentrum für biomedizinische Technologie der Donau- Universität Krems Selektives Sorptionsmittel für die extrakorporale Blutreinigung
JP2017513636A (ja) 2014-04-24 2017-06-01 エクスセラ メディカル コーポレイション 高流量を用いて血液から細菌を除去するための方法
NL2013880B1 (en) 2014-11-26 2016-10-11 Rousselot B V Gelatin purification.
CA3001698C (en) * 2015-10-22 2025-01-07 Cytosorbents Corporation Sorbant in the form of porous, blood-compatible polymer beads, multifunctional for the elimination of protein-based toxins and potassium from biological fluids
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
US11357608B2 (en) * 2019-02-16 2022-06-14 Eyal Israely Leech therapy device
CN113825517A (zh) 2019-05-16 2021-12-21 艾克塞拉医疗公司 调节内皮糖萼结构的方法
CN118320801B (zh) * 2024-04-15 2024-11-05 武汉大学人民医院（湖北省人民医院） 一种用于血液灌流的吸附剂及其制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1601333A (es) * 1968-12-03 1970-08-17
US3959128A (en) * 1974-12-27 1976-05-25 Preventive Systems, Inc Process for removing endotoxin from biological fluids
US4059512A (en) * 1974-12-27 1977-11-22 Preventive Systems, Inc. Process for removing endotoxin from biological fluids
JPS6040863B2 (ja) * 1976-07-02 1985-09-12 富田製薬株式会社 医療用吸着剤
NL7703937A (nl) * 1977-04-12 1978-10-16 Organon Teknika Bv Inrichting voorzien van een sorbent voor het zuiveren van bloed; een voor orale toepassing geschikt sorbent en een werkwijze voor vervaar- diging van het sorbent.
JPS56141833A (en) * 1980-04-03 1981-11-05 Honda Motor Co Ltd Urea selective adsorbent
DE3110128A1 (de) * 1981-03-16 1982-09-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München Verfahren und vorrichtung zur entgiftung und regeneration von blut, blutbestandteilen und bei der blutreinigung anfallenden loesungen sowie kit fuer die durchfuehrung des verfahrens
DE3135814A1 (de) * 1981-09-10 1983-03-24 B. Braun Melsungen Ag, 3508 Melsungen Verfahren und vorrichtung zur selektiven extrakorporalen praezipitation von low density lipoproteinen aus vollserum oder plasma
EP0174478B1 (de) * 1981-09-10 1991-12-11 B. Braun Holding AG Verfahren zur selektiven extrakorporalen Präzipitation von Low Density Lipoproteinen aus Vollserum oder Plasma
CA1221307A (en) * 1982-12-02 1987-05-05 Nobutaka Tani Adsorbent and process for preparing the same
US5059654A (en) * 1983-02-14 1991-10-22 Cuno Inc. Affinity matrices of modified polysaccharide supports
DE3422494A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Verfahren und vorrichtung zur spezifischen adsorption von heparin
JPS61124392A (ja) * 1984-11-22 1986-06-12 Asahi Chem Ind Co Ltd 遺伝子組換体の産生する生理活性物質の精製法
JPH0622624B2 (ja) * 1985-07-31 1994-03-30 旭化成工業株式会社 低比重リポ蛋白質吸着材の再生方法
JPS63502274A (ja) * 1985-12-18 1988-09-01 ビ−チ，リチヤ−ド　エル Ｌ↓−乳酸および／またはピルビン酸アニオンを用いた流体式治療法
US4777242A (en) * 1986-10-10 1988-10-11 Phillips Petroleum Company Purification of recombinant tumor necrosis factor
EP0377046B1 (en) * 1988-04-05 1993-08-04 Kanebo Ltd. Fine particles of porous ion-exchange cellulose, process for their production, and affinity carrier
US5055447A (en) * 1988-07-28 1991-10-08 Genentech, Inc. Method and compositions for the treatment and prevention of septic shock
US5178864A (en) * 1990-08-14 1993-01-12 Mit Lipoprotein removal by soluble enzymes
KR930007780B1 (ko) * 1990-11-19 1993-08-19 삼성전자 주식회사 로보트의 위치 제어방법
DE4209988A1 (de) * 1991-04-23 1993-03-04 Falkenhagen Dieter Dr Sc Med Endotoxinadsorber und verfahren zu seiner herstellung
US5252216A (en) * 1992-03-24 1993-10-12 Smithkline Beecham Corporation Protein purification
DE4331358A1 (de) * 1992-10-12 1994-04-14 Braun Melsungen Ag Verfahren zur quantitativen selektiven Entfernung oder präparativen Gewinnung von Tumor-Nekrose-Faktor (TNF) oder/und Lipopolysacchariden (LPS) aus wäßrigen Flüssigkeiten
DE4435612A1 (de) * 1994-10-05 1996-04-11 Braun Melsungen Ag Verfahren zur simultanen Entfernung von Tumor-Nekrose-Faktor alpha und bakteriellen Lipopolysacchariden aus einer wäßrigen Flüssigkeit

Also Published As

Publication number Publication date
DE19515554C2 (de) 1999-06-17
JP2804920B2 (ja) 1998-09-30
JPH08299436A (ja) 1996-11-19
ATE234104T1 (de) 2003-03-15
US5679775A (en) 1997-10-21
EP0739630A3 (de) 1999-09-29
DE19549420A1 (de) 1997-09-18
EP0739630B1 (de) 2003-03-12
DE19515554A1 (de) 1996-10-31
EP0739630A2 (de) 1996-10-30
DE59610208D1 (de) 2003-04-17

Similar Documents

Publication Publication Date Title
ATE234104T1 (de) Verfahren zur simultanen extrakorporalen elimination von tumor-nekrose-faktor alpha und bakteriellen lipopolysacchariden aus vollblut oder/und blutplasma
ATE94048T1 (de) Vorrichtung zur behandlung von koerperteilen des menschen.
ES2054992T3 (es) Sistema de diagnostico ambulante para el tratamiento inmediato de la apnea del sueño.
ES2076724T3 (es) Riñon artificial y procedimiento de accionamiento.
ATE245997T1 (de) Therapien des chronischen nierenversagens
DK0472480T3 (da) Enkeltkanyle-kredsløb til cirkulation i blodbehandlingsapparater af blod uden for legemet
ES2085602T3 (es) Riñon artificial.
SE8505438D0 (sv) System for uppsamling, behandling och aterforing av en patients blod
CA2265507A1 (en) Intracorporeal light treatment of blood
IT9067168A0 (it) Apparecchiatura per la depurazione del sangue, particolarmente per il trattamento di pazienti affetti da insufficienza renale, e procedimentoo per produzione di liquido di reinfusione per emodiafiltrazione (hdf)
CA2100256A1 (en) A method and a system for enhanced in vivo clearance of diagnostic and/or therapeutic agents by extracorporeal depletion,and the use of said agents for said purpose
DE69721006D1 (de) Verwendung des modifizierten eigenen blutes zur behandlung von autoimmunerkrankungen
DE3372712D1 (en) A tube set intended for extracorporeal treatment of blood and similar perishable liquids
ES2020264B3 (es) Aparato de valvulas mejorado para sistemas de tratamiento de pacientes por fotoactivacion
AU2358688A (en) A device for extracorporeal treatment of diseased body fluid
ES2139332T3 (es) Procedimiento para la preparacion del trihidrato del (2r,3s)-3-benzoilamino-2-hidroxi-3-fenilpropionato de 4,10-diacetoxi-2alfa-benzoiloxi-5beta,20-epoxi-1,7beta-dihidroxi-9-oxo-tax-11-en-13alfa-ilo.
BR9712167A (pt) Processo de purificação de uma toxina de polissacarìdeo das bactérias gbs, toxina das bactérias gbc, composição farmacêutica, e, processos de tratamento de um paciente tendo uma condição médicae com um tumor.
ES2024695B3 (es) Proceso y dispositivo para la esterilizacion de los conductos de nebulizacion y/o alimentacion de aire de los instrumentos medicos, en especial instrumentos de cirujia dental.
US20040015119A1 (en) Blood disinfection method and system
ES538403A0 (es) Procedimiento para la obtencion de antipodas opticos del (+7-1,7-difenil-3-metilaza-7-ciano-8-metil-nonano
FI964604A0 (fi) Menetelmä ja reagensseja nivelreuman hoitamiseksi
RU2079310C1 (ru) Способ экстракорпорального облучения крови синим светом и устройство для его осуществления
RU2121384C1 (ru) Способ восстановления нормальной агрегации тромбоцитов
FR2684302B1 (fr) Appareil electronique pour la transfusion du sang.
RU93005676A (ru) Способ бужирования рубцовых стриктур пищевода