ES2195905T3 - Compuestos de tiofen-etil-tiourea y su uso en el tratamiento de sida. - Google Patents

Compuestos de tiofen-etil-tiourea y su uso en el tratamiento de sida.

Info

Publication number
ES2195905T3
ES2195905T3 ES00941686T ES00941686T ES2195905T3 ES 2195905 T3 ES2195905 T3 ES 2195905T3 ES 00941686 T ES00941686 T ES 00941686T ES 00941686 T ES00941686 T ES 00941686T ES 2195905 T3 ES2195905 T3 ES 2195905T3
Authority
ES
Spain
Prior art keywords
compounds
treatment
tiofen
tiourea
etil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00941686T
Other languages
English (en)
Inventor
Fatih M Uckun
Taracad Venkatachalam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parker Hughes Institute
Original Assignee
Parker Hughes Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parker Hughes Institute filed Critical Parker Hughes Institute
Application granted granted Critical
Publication of ES2195905T3 publication Critical patent/ES2195905T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un compuesto de la fórmula: **(Fórmula)** n es 0 a 3; X es S u O; Z es -NH- o O; R es H, halógeno, alquilo (C1-C12), alcóxido (C1-C12), amino, ciano, nitro, o hidróxido; y R2 comprende cicloalquilo (C3-C12), cicloalquenilo (C3-C12), isotiazolilo, tetrazolilo, triazolilo, piridilo, imidazolilo, naftilo, benzoxazolilo, bencimidazolilo, oxazolilo, benzotiazolilo, piracinilo, piridacinilo, tiadiazolilo, benzotriazolilo, pirolilo, indolilo, benzotienilo, tienilo, benzofurilo, quinolilo, isoquinolilo o pirazolilo, sustituidos opcionalmente con uno o más sustituyentes seleccionados del grupo que consiste en H, alquilo (C1-C3), alcóxido (C1-C3), halo, alquilo -CO-, o hidróxido; o una la sal de adición de éste, farmacéuticamente aceptable.
ES00941686T 1999-06-23 2000-06-23 Compuestos de tiofen-etil-tiourea y su uso en el tratamiento de sida. Expired - Lifetime ES2195905T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/338,685 US6124324A (en) 1999-06-23 1999-06-23 Thiophene-ethyl thiourea compounds and use

Publications (1)

Publication Number Publication Date
ES2195905T3 true ES2195905T3 (es) 2003-12-16

Family

ID=23325726

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00941686T Expired - Lifetime ES2195905T3 (es) 1999-06-23 2000-06-23 Compuestos de tiofen-etil-tiourea y su uso en el tratamiento de sida.

Country Status (14)

Country Link
US (1) US6124324A (es)
EP (1) EP1194427B1 (es)
JP (1) JP2003502423A (es)
KR (1) KR20020012287A (es)
CN (1) CN1196697C (es)
AT (1) ATE233758T1 (es)
AU (2) AU6539900A (es)
BR (1) BR0009102A (es)
CA (1) CA2375261A1 (es)
DE (1) DE60001581T2 (es)
ES (1) ES2195905T3 (es)
IL (1) IL144874A0 (es)
MX (1) MXPA01009283A (es)
WO (2) WO2000078756A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001219672A1 (en) * 2000-10-18 2002-04-29 Parker Hughes Institute Phenoxyethyl-thiourea-pyridine compounds and their use for the treatment of hiv-infections
SE0100733D0 (sv) 2001-03-05 2001-03-05 Medivir Ab Non-nucleoside reverse transcriptase inhibitors
SE0102867D0 (sv) 2001-08-28 2001-08-28 Medivir Ab Non-nucleoside reverse transcriptase inhibitors
US7642277B2 (en) 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
JPWO2022107450A1 (es) * 2020-11-17 2022-05-27

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686428A (en) * 1989-04-07 1997-11-11 Aktiebolaget Astra Pharmaceutical composition
US5593993A (en) * 1991-08-02 1997-01-14 Medivir Ab Method for inhibition of HIV related viruses
IL102548A (en) * 1991-08-02 1998-08-16 Medivir Ab Thiourea derivatives for use in the preparation of medicaments for the inhibition of hiv and the treatment of aids and some such novel compounds

Also Published As

Publication number Publication date
WO2000078756A1 (en) 2000-12-28
US6124324A (en) 2000-09-26
JP2003502423A (ja) 2003-01-21
DE60001581T2 (de) 2004-02-19
EP1194427A1 (en) 2002-04-10
CN1196697C (zh) 2005-04-13
MXPA01009283A (es) 2002-04-10
IL144874A0 (en) 2002-06-30
CN1356997A (zh) 2002-07-03
BR0009102A (pt) 2002-01-08
DE60001581D1 (de) 2003-04-10
ATE233758T1 (de) 2003-03-15
AU6539900A (en) 2001-01-09
CA2375261A1 (en) 2000-12-28
EP1194427B1 (en) 2003-03-05
WO2000078755A1 (en) 2000-12-28
AU5635800A (en) 2001-01-09
KR20020012287A (ko) 2002-02-15

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