ES2196028T3 - Liposomas fusogenicos y metodos de fabricacion y utilizacion. - Google Patents
Liposomas fusogenicos y metodos de fabricacion y utilizacion.Info
- Publication number
- ES2196028T3 ES2196028T3 ES94919976T ES94919976T ES2196028T3 ES 2196028 T3 ES2196028 T3 ES 2196028T3 ES 94919976 T ES94919976 T ES 94919976T ES 94919976 T ES94919976 T ES 94919976T ES 2196028 T3 ES2196028 T3 ES 2196028T3
- Authority
- ES
- Spain
- Prior art keywords
- liposoma
- lipidic
- external
- lipid
- fusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002502 liposome Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000002632 lipids Chemical class 0.000 abstract 5
- 230000004927 fusion Effects 0.000 abstract 4
- 239000007788 liquid Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000000232 Lipid Bilayer Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Abstract
SE FACILITA UN COMPUESTO DE LIPOSOMAS QUE CONTIENE UN LIPOSOMA QUE INCLUYE :(I) UNA BICAPA LIPIDICA EN SU PARTE MAS EXTERIOR QUE CONTIENE, ADEMAS DE UN LIPIDO PREFERIBLEMENTE BICAPADO NEUTRAL, UNA CANTIDAD EFECTIVA QUE FACILITE LA FUSION DE UN LIPIDO IONIZABLE QUE TENGA UNA CABECERA CATIONICA, GENERADORA DE PROTONES Y UNA CADENA DE ACIL INSATURADO; Y (II) UN COMPARTIMENTO ADYACENTE A LA BICAPA LIPIDICA EXTERIOR QUE CONTIENE UNA SOLUCION ACUOSA CON UN PRIMER PH. FUERA DEL LIPOSOMA EN LA COMPOSICION HAY UNA SOLUCION ACUOSA CON UN SEGUNDO PH. EL PRIMER PH ES INFERIOR AL PK{SUB,A} DEL LIPIDO IONIZABLE DE LA BICAPA LIPIDICA EXTERIOR Y EL SEGUNDO PH ES MAYOR QUE EL PK{SUB,A} DE UN LIPIDO IONIZABLE DE LA BICAPA LIPIDICA EXTERIOR, COMO PUEDE SER EL QUE EXISTE EN UN GRADIENTE DE PH A TRAVES DE LA BICAPA LIPIDICA EXTERIOR, ACUMULANDOSE EL LIPIDO IONIZABLE EN LA MONOCAPA INTERIOR DE LA BICAPA LIPIDICA EXTERIOR QUE RESPONDE AL GRADIENTE. EL LIPOSOMA PUEDE FUNDIRSE DE FORMA CONTROLADA CON OTRA BICAPA LIPIDICA, COMO POR EJEMPLO, LA MEMBRANA PLASMATICA DE LA CELULA DE UN MAMIFERO, MEDIANTE EL DEGRADADO DEL GRADIENTE DE PH CUANDO SE PRODUCE LA FUSION, DE FORMA QUE EL LIPIDO IONIZABLE ES NEUTRAL, INCLUSO CUANDO SE DISTRIBUYE EN LA BICAPA LIPIDICA EXTERIOR Y, FUSOGENICO. LA FUSION CONTROLADA PUEDE USARSE PARA CONTROLAR EL ENVIO DE UN AGENTE ACTIVO BIOLOGICAMENTE DENTRO DEL LIPOSOMA AL INTERIOR DE UNA CELULA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1994/003996 WO1995027478A1 (en) | 1994-04-12 | 1994-04-12 | Fusogenic liposomes and methods of making and using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2196028T3 true ES2196028T3 (es) | 2003-12-16 |
Family
ID=22242444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94919976T Expired - Lifetime ES2196028T3 (es) | 1994-04-12 | 1994-04-12 | Liposomas fusogenicos y metodos de fabricacion y utilizacion. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0758883B1 (es) |
| JP (1) | JP3804025B2 (es) |
| KR (1) | KR100315132B1 (es) |
| AT (1) | ATE234605T1 (es) |
| AU (1) | AU689479B2 (es) |
| CA (1) | CA2187748C (es) |
| DE (1) | DE69432320T2 (es) |
| DK (1) | DK0758883T3 (es) |
| ES (1) | ES2196028T3 (es) |
| FI (1) | FI964083A7 (es) |
| NO (1) | NO318814B1 (es) |
| NZ (1) | NZ268146A (es) |
| WO (1) | WO1995027478A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ336539A (en) * | 1996-10-15 | 2000-09-29 | Liposome Co Inc | Peptide-lipid conjugates, liposomes and liposomal drug delivery |
| US6339069B1 (en) | 1996-10-15 | 2002-01-15 | Elan Pharmaceuticalstechnologies, Inc. | Peptide-lipid conjugates, liposomes and lipsomal drug delivery |
| US6835395B1 (en) | 1997-05-14 | 2004-12-28 | The University Of British Columbia | Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles |
| CA2289702C (en) | 1997-05-14 | 2008-02-19 | Inex Pharmaceuticals Corp. | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
| CZ20021029A3 (cs) * | 1999-08-27 | 2002-08-14 | Inex Pharmaceuticals Corp. | Kompozice a její pouľití pro stimulaci sekrece cytokinů a indukci imunitní odpovědi |
| CA2520864A1 (en) | 2003-03-31 | 2004-10-21 | Alza Corporation | Lipid particles having asymmetric lipid coating and method of preparing same |
| EP1852177B1 (en) * | 2005-01-28 | 2014-02-26 | Japan Science and Technology Agency | Molecular aggregate capable of undergoing phase transition by dehydrating condensation and method of phase transition thereof |
| US20100215582A1 (en) | 2007-05-14 | 2010-08-26 | Konica Minolta Holdings, Inc. | Liposome and method for producing liposome |
| HUE037082T2 (hu) | 2008-11-10 | 2018-08-28 | Arbutus Biopharma Corp | Új lipidek és készítmények terápiás hatóanyagok szállítására |
| US9937128B2 (en) * | 2009-08-03 | 2018-04-10 | The University Of North Carolina At Chapel Hill | Liposomes comprising a calcium phosphate-containing precipitate |
| HUE042177T2 (hu) | 2009-12-01 | 2019-06-28 | Translate Bio Inc | Szteroidszármazék mRNS szállítására humán genetikai betegségekben |
| PL3586861T3 (pl) | 2011-06-08 | 2022-05-23 | Translate Bio, Inc. | Kompozycje nanocząstek lipidowych i sposoby dostarczania mrna |
| EP3536787A1 (en) | 2012-06-08 | 2019-09-11 | Translate Bio, Inc. | Nuclease resistant polynucleotides and uses thereof |
| PL3467108T3 (pl) | 2013-03-14 | 2024-09-30 | Translate Bio, Inc. | Sposoby oczyszczania informacyjnego rna |
| KR20210122917A (ko) | 2013-03-14 | 2021-10-12 | 샤이어 휴먼 지네틱 테라피즈 인크. | Cftr mrna 조성물 및 관련 방법 및 사용 |
| ES2707966T3 (es) | 2013-10-22 | 2019-04-08 | Translate Bio Inc | Terapia de ARNm para la deficiencia en síntesis de argininosuccinato |
| EA034103B1 (ru) | 2013-10-22 | 2019-12-27 | Транслейт Био, Инк. | СПОСОБ ЛЕЧЕНИЯ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК |
| PT3134506T (pt) | 2014-04-25 | 2019-10-31 | Translate Bio Inc | Métodos de purificação de rna mensageiro |
| EA201991747A1 (ru) | 2017-02-27 | 2020-06-04 | Транслейт Био, Инк. | НОВАЯ КОДОН-ОПТИМИЗИРОВАННАЯ мРНК CFTR |
| MX2019013752A (es) | 2017-05-16 | 2020-07-20 | Translate Bio Inc | Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr optimizado en codones. |
| CA3108544A1 (en) | 2018-08-24 | 2020-02-27 | Translate Bio, Inc. | Methods for purification of messenger rna |
| MX2021005969A (es) | 2018-11-21 | 2021-09-14 | Translate Bio Inc | Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr nebulizado. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946787A (en) * | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| DE3776763D1 (es) * | 1986-06-16 | 1992-03-26 | The Liposome Co.,Inc., Princeton, N.J., Us | |
| JPH0395118A (ja) * | 1989-09-07 | 1991-04-19 | Green Cross Corp:The | プロスタグランジン含有脂肪小体製剤 |
| DE4013632A1 (de) * | 1990-04-27 | 1991-10-31 | Max Planck Gesellschaft | Liposomen mit positiver ueberschussladung |
| US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
-
1994
- 1994-04-12 CA CA002187748A patent/CA2187748C/en not_active Expired - Fee Related
- 1994-04-12 DE DE69432320T patent/DE69432320T2/de not_active Expired - Fee Related
- 1994-04-12 AU AU70915/94A patent/AU689479B2/en not_active Ceased
- 1994-04-12 EP EP94919976A patent/EP0758883B1/en not_active Expired - Lifetime
- 1994-04-12 NZ NZ268146A patent/NZ268146A/en not_active IP Right Cessation
- 1994-04-12 DK DK94919976T patent/DK0758883T3/da active
- 1994-04-12 ES ES94919976T patent/ES2196028T3/es not_active Expired - Lifetime
- 1994-04-12 WO PCT/US1994/003996 patent/WO1995027478A1/en not_active Ceased
- 1994-04-12 KR KR1019960705605A patent/KR100315132B1/ko not_active Expired - Fee Related
- 1994-04-12 AT AT94919976T patent/ATE234605T1/de not_active IP Right Cessation
- 1994-04-12 JP JP52630695A patent/JP3804025B2/ja not_active Expired - Fee Related
-
1996
- 1996-10-09 NO NO19964284A patent/NO318814B1/no unknown
- 1996-10-11 FI FI964083A patent/FI964083A7/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ268146A (en) | 1997-10-24 |
| NO964284L (no) | 1996-10-09 |
| ATE234605T1 (de) | 2003-04-15 |
| DK0758883T3 (da) | 2003-06-02 |
| CA2187748A1 (en) | 1995-10-19 |
| EP0758883A1 (en) | 1997-02-26 |
| NO964284D0 (no) | 1996-10-09 |
| JP3804025B2 (ja) | 2006-08-02 |
| EP0758883B1 (en) | 2003-03-19 |
| JPH09511521A (ja) | 1997-11-18 |
| FI964083A0 (fi) | 1996-10-11 |
| FI964083A7 (fi) | 1996-10-11 |
| DE69432320T2 (de) | 2003-12-04 |
| AU689479B2 (en) | 1998-04-02 |
| NO318814B1 (no) | 2005-05-09 |
| KR100315132B1 (ko) | 2002-06-26 |
| AU7091594A (en) | 1995-10-30 |
| WO1995027478A1 (en) | 1995-10-19 |
| CA2187748C (en) | 2007-04-10 |
| DE69432320D1 (de) | 2003-04-24 |
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