ES2196028T3 - Liposomas fusogenicos y metodos de fabricacion y utilizacion. - Google Patents
Liposomas fusogenicos y metodos de fabricacion y utilizacion.Info
- Publication number
- ES2196028T3 ES2196028T3 ES94919976T ES94919976T ES2196028T3 ES 2196028 T3 ES2196028 T3 ES 2196028T3 ES 94919976 T ES94919976 T ES 94919976T ES 94919976 T ES94919976 T ES 94919976T ES 2196028 T3 ES2196028 T3 ES 2196028T3
- Authority
- ES
- Spain
- Prior art keywords
- liposoma
- lipidic
- external
- lipid
- fusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002502 liposome Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000002632 lipids Chemical class 0.000 abstract 5
- 230000004927 fusion Effects 0.000 abstract 4
- 239000007788 liquid Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000000232 Lipid Bilayer Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Abstract
SE FACILITA UN COMPUESTO DE LIPOSOMAS QUE CONTIENE UN LIPOSOMA QUE INCLUYE :(I) UNA BICAPA LIPIDICA EN SU PARTE MAS EXTERIOR QUE CONTIENE, ADEMAS DE UN LIPIDO PREFERIBLEMENTE BICAPADO NEUTRAL, UNA CANTIDAD EFECTIVA QUE FACILITE LA FUSION DE UN LIPIDO IONIZABLE QUE TENGA UNA CABECERA CATIONICA, GENERADORA DE PROTONES Y UNA CADENA DE ACIL INSATURADO; Y (II) UN COMPARTIMENTO ADYACENTE A LA BICAPA LIPIDICA EXTERIOR QUE CONTIENE UNA SOLUCION ACUOSA CON UN PRIMER PH. FUERA DEL LIPOSOMA EN LA COMPOSICION HAY UNA SOLUCION ACUOSA CON UN SEGUNDO PH. EL PRIMER PH ES INFERIOR AL PK{SUB,A} DEL LIPIDO IONIZABLE DE LA BICAPA LIPIDICA EXTERIOR Y EL SEGUNDO PH ES MAYOR QUE EL PK{SUB,A} DE UN LIPIDO IONIZABLE DE LA BICAPA LIPIDICA EXTERIOR, COMO PUEDE SER EL QUE EXISTE EN UN GRADIENTE DE PH A TRAVES DE LA BICAPA LIPIDICA EXTERIOR, ACUMULANDOSE EL LIPIDO IONIZABLE EN LA MONOCAPA INTERIOR DE LA BICAPA LIPIDICA EXTERIOR QUE RESPONDE AL GRADIENTE. EL LIPOSOMA PUEDE FUNDIRSE DE FORMA CONTROLADA CON OTRA BICAPA LIPIDICA, COMO POR EJEMPLO, LA MEMBRANA PLASMATICA DE LA CELULA DE UN MAMIFERO, MEDIANTE EL DEGRADADO DEL GRADIENTE DE PH CUANDO SE PRODUCE LA FUSION, DE FORMA QUE EL LIPIDO IONIZABLE ES NEUTRAL, INCLUSO CUANDO SE DISTRIBUYE EN LA BICAPA LIPIDICA EXTERIOR Y, FUSOGENICO. LA FUSION CONTROLADA PUEDE USARSE PARA CONTROLAR EL ENVIO DE UN AGENTE ACTIVO BIOLOGICAMENTE DENTRO DEL LIPOSOMA AL INTERIOR DE UNA CELULA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1994/003996 WO1995027478A1 (en) | 1994-04-12 | 1994-04-12 | Fusogenic liposomes and methods of making and using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2196028T3 true ES2196028T3 (es) | 2003-12-16 |
Family
ID=22242444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94919976T Expired - Lifetime ES2196028T3 (es) | 1994-04-12 | 1994-04-12 | Liposomas fusogenicos y metodos de fabricacion y utilizacion. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0758883B1 (es) |
| JP (1) | JP3804025B2 (es) |
| KR (1) | KR100315132B1 (es) |
| AT (1) | ATE234605T1 (es) |
| AU (1) | AU689479B2 (es) |
| CA (1) | CA2187748C (es) |
| DE (1) | DE69432320T2 (es) |
| DK (1) | DK0758883T3 (es) |
| ES (1) | ES2196028T3 (es) |
| FI (1) | FI964083A7 (es) |
| NO (1) | NO318814B1 (es) |
| NZ (1) | NZ268146A (es) |
| WO (1) | WO1995027478A1 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6339069B1 (en) | 1996-10-15 | 2002-01-15 | Elan Pharmaceuticalstechnologies, Inc. | Peptide-lipid conjugates, liposomes and lipsomal drug delivery |
| EP0964690B1 (en) * | 1996-10-15 | 2003-07-09 | The Liposome Company, Inc. | Peptide-lipid conjugates, liposomes and liposomal drug delivery |
| US6835395B1 (en) | 1997-05-14 | 2004-12-28 | The University Of British Columbia | Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles |
| AU733310C (en) | 1997-05-14 | 2001-11-29 | University Of British Columbia, The | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
| EP1212085B1 (en) * | 1999-08-27 | 2007-10-31 | INEX Pharmaceuticals Corp. | Compositions for stimulating cytokine secretion and inducing an immune response |
| MXPA05010499A (es) * | 2003-03-31 | 2006-05-25 | Johnson & Johnson | Particulas lipidicas que tienen un revestimiento lipidico asimetrico y metodo de preparacion de las mismas. |
| US8449979B2 (en) | 2005-01-28 | 2013-05-28 | Japan Science And Technology Agency | Molecular aggregate capable of undergoing phase transition by dehydrating condensation and method of phase transition thereof |
| EP3494964B1 (en) * | 2007-05-14 | 2021-04-07 | Konica Minolta Holdings, Inc. | Liposome and method for producing liposome |
| CN111808084A (zh) | 2008-11-10 | 2020-10-23 | 阿布特斯生物制药公司 | 用于递送治疗剂的新型脂质和组合物 |
| WO2011017297A2 (en) | 2009-08-03 | 2011-02-10 | The University Of North Carolina At Chapel Hill | Biodegradable delivery system complexes for the delivery of bioactive compounds |
| EP3318248B1 (en) | 2009-12-01 | 2019-04-10 | Translate Bio, Inc. | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
| RU2013154295A (ru) | 2011-06-08 | 2015-07-20 | Шир Хьюман Дженетик Терапис, Инк. | КОМПОЗИЦИИ ЛИПИДНЫХ НАНОЧАСТИЦ И СПОСОБЫ ДЛЯ ДОСТАВКИ мРНК |
| WO2013185067A1 (en) | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
| RS57739B1 (sr) | 2013-03-14 | 2018-12-31 | Translate Bio Inc | Kompozicije cftr irnk i postupci i upotrebe u vezi sa njima |
| JP6586075B2 (ja) | 2013-03-14 | 2019-10-02 | トランスレイト バイオ， インコーポレイテッド | メッセンジャーｒｎａの精製方法 |
| CN106413811A (zh) | 2013-10-22 | 2017-02-15 | 夏尔人类遗传性治疗公司 | 精氨基琥珀酸合成酶缺乏症的mrna疗法 |
| JP6506749B2 (ja) | 2013-10-22 | 2019-04-24 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | フェニルケトン尿症のためのｍＲＮＡ療法 |
| US9850269B2 (en) | 2014-04-25 | 2017-12-26 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| EA201991747A1 (ru) | 2017-02-27 | 2020-06-04 | Транслейт Био, Инк. | НОВАЯ КОДОН-ОПТИМИЗИРОВАННАЯ мРНК CFTR |
| MX2019013752A (es) | 2017-05-16 | 2020-07-20 | Translate Bio Inc | Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr optimizado en codones. |
| KR102950141B1 (ko) | 2018-08-24 | 2026-04-07 | 트랜슬레이트 바이오 인코포레이티드 | 전령 rna의 정제 방법 |
| WO2020106946A1 (en) | 2018-11-21 | 2020-05-28 | Translate Bio, Inc. | TREATMENT OF CYSTIC FIBROSIS BY DELIVERY OF NEBULIZED mRNA ENCODING CFTR |
| EP4031662A1 (en) | 2019-09-20 | 2022-07-27 | Translate Bio, Inc. | Mrna encoding engineered cftr |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946787A (en) * | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| DE3776763D1 (es) * | 1986-06-16 | 1992-03-26 | The Liposome Co.,Inc., Princeton, N.J., Us | |
| JPH0395118A (ja) * | 1989-09-07 | 1991-04-19 | Green Cross Corp:The | プロスタグランジン含有脂肪小体製剤 |
| DE4013632A1 (de) * | 1990-04-27 | 1991-10-31 | Max Planck Gesellschaft | Liposomen mit positiver ueberschussladung |
| US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
-
1994
- 1994-04-12 WO PCT/US1994/003996 patent/WO1995027478A1/en not_active Ceased
- 1994-04-12 EP EP94919976A patent/EP0758883B1/en not_active Expired - Lifetime
- 1994-04-12 AT AT94919976T patent/ATE234605T1/de not_active IP Right Cessation
- 1994-04-12 DE DE69432320T patent/DE69432320T2/de not_active Expired - Fee Related
- 1994-04-12 KR KR1019960705605A patent/KR100315132B1/ko not_active Expired - Fee Related
- 1994-04-12 NZ NZ268146A patent/NZ268146A/en not_active IP Right Cessation
- 1994-04-12 AU AU70915/94A patent/AU689479B2/en not_active Ceased
- 1994-04-12 ES ES94919976T patent/ES2196028T3/es not_active Expired - Lifetime
- 1994-04-12 JP JP52630695A patent/JP3804025B2/ja not_active Expired - Fee Related
- 1994-04-12 DK DK94919976T patent/DK0758883T3/da active
- 1994-04-12 CA CA002187748A patent/CA2187748C/en not_active Expired - Fee Related
-
1996
- 1996-10-09 NO NO19964284A patent/NO318814B1/no unknown
- 1996-10-11 FI FI964083A patent/FI964083A7/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09511521A (ja) | 1997-11-18 |
| ATE234605T1 (de) | 2003-04-15 |
| NO318814B1 (no) | 2005-05-09 |
| NZ268146A (en) | 1997-10-24 |
| CA2187748C (en) | 2007-04-10 |
| JP3804025B2 (ja) | 2006-08-02 |
| EP0758883B1 (en) | 2003-03-19 |
| AU7091594A (en) | 1995-10-30 |
| NO964284L (no) | 1996-10-09 |
| EP0758883A1 (en) | 1997-02-26 |
| DE69432320D1 (de) | 2003-04-24 |
| FI964083A0 (fi) | 1996-10-11 |
| DE69432320T2 (de) | 2003-12-04 |
| FI964083A7 (fi) | 1996-10-11 |
| DK0758883T3 (da) | 2003-06-02 |
| AU689479B2 (en) | 1998-04-02 |
| WO1995027478A1 (en) | 1995-10-19 |
| CA2187748A1 (en) | 1995-10-19 |
| NO964284D0 (no) | 1996-10-09 |
| KR100315132B1 (ko) | 2002-06-26 |
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